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Entry version 55 (29 Sep 2021)
Sequence version 1 (01 May 2000)
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Protein

Gamma-ECS

Gene

GCS

Organism
Plasmodium falciparum
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glutathione biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes glutathione from L-cysteine and L-glutamate.ARBA annotation This subpathway is part of the pathway glutathione biosynthesis, which is itself part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glutathione from L-cysteine and L-glutamate, the pathway glutathione biosynthesis and in Sulfur metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigaseImported

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00142;UER00209

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gamma-ECSARBA annotation (EC:6.3.2.2ARBA annotation)
Alternative name(s):
Gamma-glutamylcysteine synthetaseARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GCSImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparumImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5833 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
PlasmoDB:PF3D7_0918900
PlasmoDB:Pf7G8_090023700
PlasmoDB:PfCD01_090023200
PlasmoDB:PfDd2_090023900
PlasmoDB:PfGA01_090023100
PlasmoDB:PfGB4_090023800
PlasmoDB:PfGN01_090023700
PlasmoDB:PfHB3_090023500
PlasmoDB:PfIT_090023400
PlasmoDB:PfKE01_090023200
PlasmoDB:PfKH01_090023100
PlasmoDB:PfKH02_090023600
PlasmoDB:PfML01_090023300
PlasmoDB:PfSD01_090023800
PlasmoDB:PfSN01_090023400
PlasmoDB:PfTG01_090023200

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni293 – 321DisorderedSequence analysisAdd BLAST29
Regioni397 – 419DisorderedSequence analysisAdd BLAST23
Regioni807 – 828DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi293 – 307Acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glutamate--cysteine ligase type 3 family.ARBA annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004308, GCS
IPR014746, Gln_synth/guanido_kin_cat_dom

The PANTHER Classification System

More...
PANTHERi
PTHR11164, PTHR11164, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03074, GCS, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55931, SSF55931, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9TY17-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYIYICNNLY DLYITISIIT QKIHIYIYIY IYIYIDYFFF LNMGFLKIGT
60 70 80 90 100
PLSWDDVQDV KSLIRLYGIL QFVHVYKLNK DRYDENIMFG DEIEYIIIRN
110 120 130 140 150
DESLKESSAL LCASDLIDEM MNLESVIDCQ YGSHWTPEYS SFTIEGTPSV
160 170 180 190 200
PFKLDINSSC FVEDCMRIRR SKLNNVLSAV QGARAITLPC FPNVLLNNSV
210 220 230 240 250
LMARRITGHE STKKKFDSKG KVEFIENAKI KEKVHNSNNN IHKIINNKNN
260 270 280 290 300
ESKIVNNAFD QNKISSIEMV SYEMDENKST NFVNSDTVFA KNDEEGEVEE
310 320 330 340 350
EDENENEQQQ QQQQYQSNLQ QQYQSNLQQQ YQSNLQQQYQ SDLQQQYQSD
360 370 380 390 400
LQQQYQSDLQ QQYQSDLQQQ YQSDLQQQNV QPKQRQQMIQ YVYDDEIENK
410 420 430 440 450
NKEKDNTPRS CNDYNNVNDS SNTQDIFISS LKKTDSLFEC EVFKPEQTNK
460 470 480 490 500
YSKSALITDM TISPHARYVT LTQNIRKRRG TKIVSFNPIY KDINTEKMDH
510 520 530 540 550
WKMSLDCNDK RLFKKVKKKL TLDEHLIWNK SMTNKKIIDR KNNNPRDEVL
560 570 580 590 600
NTSNFTLAMT NKEENNNENS LMDRVLKNSL FANMDDEGDY IYVYNREFIQ
610 620 630 640 650
EYSEKCKNPI KNYVYLDAMF FGMSMCCQQL TMSFPTVDDA KYVYDQLAVI
660 670 680 690 700
APLFLALTAC TPYLGGFLTE TDTRWRVISN SVDCRTEEEL SYICKPRYSG
710 720 730 740 750
ISLYISSELP LKRNYYFYND VDVILDKNVY DKLKKENVDE YLARHIASLF
760 770 780 790 800
VRDPIVVFEG SYSERDIATI QKKIMELSND EDKIKGMVEG SSSNSLSSKV
810 820 830 840 850
LLDNEDRNKN DSSIKEMNKS NDNNHNNNCH IEYNNKKDIN MNKIYLSDNF
860 870 880 890 900
EFIEDYEEKV LSSHQHFENF QSTNWNSVRF KPPPILDNHF KGPSSIGWRV
910 920 930 940 950
EFRTPDIQIT DFENSCVVTL VMLLSKFILK ERLNLYIPMT LLEENLFRAS
960 970 980 990 1000
KREALTKEKF YFRKDLSYDT LNNEFEEKSI YDIFFNETNG LFFLCYKYVD
1010 1020 1030 1040 1050
ELFKEGLLNQ SAKNKIDEYI EFVKQRCSGK ICTGAMYLRN FILNHPAYEK
1060 1070 1080 1090 1100
NSYINSKINY DICKLIADIG KGLIIPQELL GVFVDPYKER IKSDIRQINE
1110 1120 1130 1140 1150
SQYLKSLAYK YISGEDYTQY LLLNEVLKDD QDYCTCTRRT IYEESMDNTV
1160
EFAKKMYELS A
Length:1,161
Mass (Da):136,744
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF96B04E26FCAF270
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y14674 mRNA Translation: CAA74990.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T18415, T18400

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14674 mRNA Translation: CAA74990.1
PIRiT18415, T18400

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Organism-specific databases

VEuPathDBiPlasmoDB:PF3D7_0918900
PlasmoDB:Pf7G8_090023700
PlasmoDB:PfCD01_090023200
PlasmoDB:PfDd2_090023900
PlasmoDB:PfGA01_090023100
PlasmoDB:PfGB4_090023800
PlasmoDB:PfGN01_090023700
PlasmoDB:PfHB3_090023500
PlasmoDB:PfIT_090023400
PlasmoDB:PfKE01_090023200
PlasmoDB:PfKH01_090023100
PlasmoDB:PfKH02_090023600
PlasmoDB:PfML01_090023300
PlasmoDB:PfSD01_090023800
PlasmoDB:PfSN01_090023400
PlasmoDB:PfTG01_090023200

Enzyme and pathway databases

UniPathwayiUPA00142;UER00209

Family and domain databases

InterProiView protein in InterPro
IPR004308, GCS
IPR014746, Gln_synth/guanido_kin_cat_dom
PANTHERiPTHR11164, PTHR11164, 1 hit
PfamiView protein in Pfam
PF03074, GCS, 2 hits
SUPFAMiSSF55931, SSF55931, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9TY17_PLAFA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9TY17
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: September 29, 2021
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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