UniProtKB - Q9TY03 (FRDA_CAEEL)
Protein
Frataxin, mitochondrial
Gene
frh-1
Organism
Caenorhabditis elegans
Status
Functioni
Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+. May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization.1 Publication
Catalytic activityi
- EC:1.16.3.1
GO - Molecular functioni
- 2 iron, 2 sulfur cluster binding Source: GO_Central
- ferric iron binding Source: GO_Central
- ferrous iron binding Source: GO_Central
- ferroxidase activity Source: GO_Central
- iron chaperone activity Source: GO_Central
GO - Biological processi
- cellular iron ion homeostasis Source: GO_Central
- determination of adult lifespan Source: WormBase
- heme biosynthetic process Source: UniProtKB-KW
- ion transport Source: UniProtKB-KW
- iron incorporation into metallo-sulfur cluster Source: GO_Central
- iron-sulfur cluster assembly Source: WormBase
- response to hydrogen peroxide Source: WormBase
- response to superoxide Source: WormBase
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Heme biosynthesis, Ion transport, Iron storage, Iron transport, Transport |
Ligand | Iron |
Enzyme and pathway databases
Reactomei | R-CEL-1362409, Mitochondrial iron-sulfur cluster biogenesis |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:frh-1 ORF Names:F59G1.7 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | F59G1.7 ; CE19476 ; WBGene00001486 ; frh-1 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Mitochondrion
- mitochondrion Source: WormBase
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – ? | MitochondrionSequence analysis | ||
ChainiPRO_0000193925 | ? – 136 | Frataxin, mitochondrial |
Proteomic databases
EPDi | Q9TY03 |
PaxDbi | Q9TY03 |
PeptideAtlasi | Q9TY03 |
Expressioni
Gene expression databases
Bgeei | WBGene00001486, Expressed in germ line (C elegans) and 5 other tissues |
Interactioni
Subunit structurei
Monomer. Oligomer (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 39343, 3 interactors |
IntActi | Q9TY03, 1 interactor |
STRINGi | 6239.F59G1.7 |
Family & Domainsi
Sequence similaritiesi
Belongs to the frataxin family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG3413, Eukaryota |
GeneTreei | ENSGT00390000005811 |
HOGENOMi | CLU_080880_4_0_1 |
InParanoidi | Q9TY03 |
OMAi | VYAHDGV |
OrthoDBi | 1372185at2759 |
PhylomeDBi | Q9TY03 |
Family and domain databases
Gene3Di | 3.30.920.10, 1 hit |
InterProi | View protein in InterPro IPR017789, Frataxin IPR002908, Frataxin/CyaY IPR036524, Frataxin/CyaY_sf IPR020895, Frataxin_CS |
PANTHERi | PTHR16821, PTHR16821, 1 hit |
Pfami | View protein in Pfam PF01491, Frataxin_Cyay, 1 hit |
PRINTSi | PR00904, FRATAXIN |
SMARTi | View protein in SMART SM01219, Frataxin_Cyay, 1 hit |
SUPFAMi | SSF55387, SSF55387, 1 hit |
TIGRFAMsi | TIGR03421, FeS_CyaY, 1 hit TIGR03422, mito_frataxin, 1 hit |
PROSITEi | View protein in PROSITE PS01344, FRATAXIN_1, 1 hit PS50810, FRATAXIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9TY03-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLSTILRNNF VRRSFSSRIF SQNEYETAAD STLERLSDYF DQIADSFPVS
60 70 80 90 100
EQFDVSHAMG VLTVNVSKSV GTYVINKQSP NKQIWLSSPM SGPKRYDLEE
110 120 130
EGKWTYAHDG EQLDSLLNRE FRKILADDRI DFSRHV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY048153 mRNA Translation: AAL05950.1 FO081244 Genomic DNA Translation: CCD70156.1 |
PIRi | T34316 |
RefSeqi | NP_495183.1, NM_062782.3 |
Genome annotation databases
EnsemblMetazoai | F59G1.7.1; F59G1.7.1; WBGene00001486 |
GeneIDi | 174002 |
KEGGi | cel:CELE_F59G1.7 |
UCSCi | F59G1.7.1, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY048153 mRNA Translation: AAL05950.1 FO081244 Genomic DNA Translation: CCD70156.1 |
PIRi | T34316 |
RefSeqi | NP_495183.1, NM_062782.3 |
3D structure databases
SMRi | Q9TY03 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 39343, 3 interactors |
IntActi | Q9TY03, 1 interactor |
STRINGi | 6239.F59G1.7 |
Proteomic databases
EPDi | Q9TY03 |
PaxDbi | Q9TY03 |
PeptideAtlasi | Q9TY03 |
Genome annotation databases
EnsemblMetazoai | F59G1.7.1; F59G1.7.1; WBGene00001486 |
GeneIDi | 174002 |
KEGGi | cel:CELE_F59G1.7 |
UCSCi | F59G1.7.1, c. elegans |
Organism-specific databases
CTDi | 174002 |
WormBasei | F59G1.7 ; CE19476 ; WBGene00001486 ; frh-1 |
Phylogenomic databases
eggNOGi | KOG3413, Eukaryota |
GeneTreei | ENSGT00390000005811 |
HOGENOMi | CLU_080880_4_0_1 |
InParanoidi | Q9TY03 |
OMAi | VYAHDGV |
OrthoDBi | 1372185at2759 |
PhylomeDBi | Q9TY03 |
Enzyme and pathway databases
Reactomei | R-CEL-1362409, Mitochondrial iron-sulfur cluster biogenesis |
Miscellaneous databases
PROi | PR:Q9TY03 |
Gene expression databases
Bgeei | WBGene00001486, Expressed in germ line (C elegans) and 5 other tissues |
Family and domain databases
Gene3Di | 3.30.920.10, 1 hit |
InterProi | View protein in InterPro IPR017789, Frataxin IPR002908, Frataxin/CyaY IPR036524, Frataxin/CyaY_sf IPR020895, Frataxin_CS |
PANTHERi | PTHR16821, PTHR16821, 1 hit |
Pfami | View protein in Pfam PF01491, Frataxin_Cyay, 1 hit |
PRINTSi | PR00904, FRATAXIN |
SMARTi | View protein in SMART SM01219, Frataxin_Cyay, 1 hit |
SUPFAMi | SSF55387, SSF55387, 1 hit |
TIGRFAMsi | TIGR03421, FeS_CyaY, 1 hit TIGR03422, mito_frataxin, 1 hit |
PROSITEi | View protein in PROSITE PS01344, FRATAXIN_1, 1 hit PS50810, FRATAXIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FRDA_CAEEL | |
Accessioni | Q9TY03Primary (citable) accession number: Q9TY03 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families