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Entry version 140 (17 Jun 2020)
Sequence version 1 (01 May 2000)
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Protein

Poly [ADP-ribose] polymerase tankyrase

Gene

tank-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Poly[ADP-ribose] polymerases modify various nuclear proteins by poly(ADP-ribosyl)ation, a post-translational modification synthesized after DNA damage that appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks and programmed cell death.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.By similarity EC:2.4.2.30

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processDNA damage, DNA repair
LigandNAD

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase tankyrase1 Publication (EC:2.4.2.30By similarity)
Alternative name(s):
Poly ADP-ribose metabolism enzyme 51 Publication
Protein poly-ADP-ribosyltransferase tankyraseCurated (EC:2.4.2.-By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tank-1Imported
Synonyms:pme-51 Publication
ORF Names:ZK1005.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
ZK1005.1a ; CE24712 ; WBGene00004053 ; tank-1
ZK1005.1b ; CE33259 ; WBGene00004053 ; tank-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002113371 – 2276Poly [ADP-ribose] polymerase tankyraseCuratedAdd BLAST2276

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9TXQ1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9TXQ1

PeptideAtlas

More...
PeptideAtlasi
Q9TXQ1

PRoteomics IDEntifications database

More...
PRIDEi
Q9TXQ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed throughout the head and tail, in germ cells and somatic cells.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected at all stages (PubMed:14706351, PubMed:19104912). Expressed at low level in embryos compared to larvae (PubMed:14706351). Peaks in young adults (PubMed:14706351).2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By irradiation (PubMed:14706351, PubMed:19104912). This induction is dependent on hus-1 (PubMed:14706351).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004053 Expressed in material anatomical entity and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
43692, 2 interactors

STRING: functional protein association networks

More...
STRINGi
6239.ZK1005.1a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9TXQ1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati345 – 374ANK 1Add BLAST30
Repeati378 – 407ANK 2Add BLAST30
Repeati411 – 440ANK 3Add BLAST30
Repeati461 – 490ANK 4Add BLAST30
Repeati498 – 527ANK 5Add BLAST30
Repeati531 – 560ANK 6Add BLAST30
Repeati564 – 593ANK 7Add BLAST30
Repeati598 – 627ANK 8Add BLAST30
Repeati675 – 725ANK 9Add BLAST51
Repeati729 – 758ANK 10Add BLAST30
Repeati970 – 999ANK 11Add BLAST30
Repeati1171 – 1200ANK 12Add BLAST30
Repeati1204 – 1233ANK 13Add BLAST30
Repeati1472 – 1501ANK 14Add BLAST30
Repeati1505 – 1535ANK 15Add BLAST31
Repeati1662 – 1706ANK 16Add BLAST45
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1910 – 2045PARP alpha-helicalPROSITE-ProRule annotationAdd BLAST136
Domaini2047 – 2276PARP catalyticPROSITE-ProRule annotationAdd BLAST230

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi55 – 100Lys-richAdd BLAST46
Compositional biasi1613 – 1621Poly-Asp9

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1037 Eukaryota
ENOG410XP18 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170301

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9TXQ1

Identification of Orthologs from Complete Genome Data

More...
OMAi
ISNSTHM

Database of Orthologous Groups

More...
OrthoDBi
18682at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9TXQ1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.142.10, 1 hit
1.25.40.20, 4 hits
2.20.140.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR004102 Poly(ADP-ribose)pol_reg_dom
IPR036616 Poly(ADP-ribose)pol_reg_dom_sf
IPR036930 WGR_dom_sf
IPR008893 WGR_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF00644 PARP, 1 hit
PF02877 PARP_reg, 1 hit
PF05406 WGR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 16 hits
SM00773 WGR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF142921 SSF142921, 1 hit
SSF47587 SSF47587, 1 hit
SSF48403 SSF48403, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 3 hits
PS50088 ANK_REPEAT, 6 hits
PS51060 PARP_ALPHA_HD, 1 hit
PS51059 PARP_CATALYTIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a (identifier: Q9TXQ1-1) [UniParc]FASTAAdd to basket
Also known as: PME-5L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARRVNKKKS PVKAARKIDG QIGRRVVDGV RAKSSRQRHQ AVLYQAPTPT
60 70 80 90 100
VIRRKTTKTA IVKKTVVVVK KGGKVVKKSS KTGQKVKAVK APKVKAPSKK
110 120 130 140 150
GNDRLTPRVI TEYQENPFFY DPQVPEYISA SVYHRWITRA VRNGNMKEIK
160 170 180 190 200
DYYKSKKCQK SAIYTSFAYS FDTSACDEAL RQDIKFATEF FKMNNKMEVD
210 220 230 240 250
NSYHPGKEPN LLQKKTTGRK NYYMLGRHTR QIEMGRGGKE GNNALLNYDT
260 270 280 290 300
RTDEPNPLTK LIEDNVTYTK LYQLCKIPDG PIVEHHIEMH FVTAVRMGHR
310 320 330 340 350
DLASALAQGP VKMHCNDLHR ATLKDQKLPA KILPVSVAKK AYMNKNITPL
360 370 380 390 400
HTAAISNSTH MLEAMRAVYP TINIPDQDNW YTMHYAACAP GTAPMEFLLK
410 420 430 440 450
NGGSVTMLTK QTETPLHVAA RAGRAVNCTF LMKEMLDLEK GDDGESTIRA
460 470 480 490 500
DRSIINARTR SGNSALHLAV LRNNLDVVDA LLAEPTIVVD NPTSTGQNRL
510 520 530 540 550
TPLMMACGKG YLEMAKKLVE KGALVEGKDK KKRTPLIHAM LNGQIHTAAF
560 570 580 590 600
LLAKGASLTL ADSSGNTAAH YAAAYGFLDC LKLLASIDDN ILSEPNDWQL
610 620 630 640 650
YPLSVAYLKG HYGIVTWLLE GPHKDKANIN AKDNNGATLL SNLLSYADET
660 670 680 690 700
MHKELLSQIE YLVARKADAS LADSSGQTPL HLFSMQRIIL KGSGEAAEND
710 720 730 740 750
AMRMTLDNYK KCFNTLIKAG AKVDVYDHED NTPLHYALTN GNLMLFNLML
760 770 780 790 800
DKVANKRNLF EKWANHQNFL HEILALPMKV YGDQVLWKGE TLTKPAYDVL
810 820 830 840 850
PILKELHENL PDLFEKWISE VNKAGYSPIV EAIKQYQALA ANKKLRGEAD
860 870 880 890 900
QNGNPGFGNA IARGRVHNQF GRDRMNQSQA PHCDSYELKT FISTVNELFE
910 920 930 940 950
WVIRLGPFQL TQKYINSENS AAVTLANLAM SIPIECGRHQ QNQLALFKIL
960 970 980 990 1000
IKLSKEFNKV DEFLTQKNEK DDVLIVQAIM FDKPNVVELI LDTASEMHLI
1010 1020 1030 1040 1050
HGTHNAIKEN ELEVVVHKTI IMYMIEMRMW ELIPKVNASS EFWKSKDAKG
1060 1070 1080 1090 1100
NSVWHYAARV NSHKTVGLFK MIESKGVRRE TNDDGRSVLH VATLACDGSA
1110 1120 1130 1140 1150
DSVLEPIAWL STRCPIDAVD KFNRTALHYA FGNENDFKEG NVPFGESDPI
1160 1170 1180 1190 1200
AVVSLLSSLI RPEQIEIADV NGNTILHLAA IKNSTICLMT LIRKKCHVDL
1210 1220 1230 1240 1250
KNKDGNTPLA LAVHHGRQSS ALTLIQANAD VTEKIFVPAL KPTSDFDQNS
1260 1270 1280 1290 1300
SGTEAEKFWK WHGKEKKVLE DLHTTIPASV VSKGGSWEAM VYVLLDVLGQ
1310 1320 1330 1340 1350
NTGSMAQLTD AALRRGQLNL ANQLLKSIEA LIDGAVLNSS YDLLDTFAEK
1360 1370 1380 1390 1400
CFGALTSEET IEKTVLNRII LTRGLGLKQP ETMKIIRTAL QNGNWNLLNF
1410 1420 1430 1440 1450
LKSEMGTAWK NQKIETPTEN PIRSLLIYMN EKSVSSEAIG FLEELRQMRG
1460 1470 1480 1490 1500
VNIDALCQLE IPGKFKKILD YGLIPPISFA VLQENPNMIR ALRNAGASLK
1510 1520 1530 1540 1550
TQDDYGRTPL MYAIMTNNRS VVDAIVGDGK LAVVLHKQKA VATGPRCVAV
1560 1570 1580 1590 1600
PMRFGATSRA FIPAAAFASV PARVESDEEE EDNSGSESGE DGAASENKSE
1610 1620 1630 1640 1650
HGSENGESGN GSDDEDDDDD DSSPPPAKKS RIAKEAAGPS TGPKRKKLVI
1660 1670 1680 1690 1700
TDPSLFSARD HKENNPLHYF IEPLAWENVE LLGDLAAANK TAIVQCLIDK
1710 1720 1730 1740 1750
RSPNPIELAA MKMNRRMKSE MLKIVKNAAF PRPIKETKLT LQQVHIEPLS
1760 1770 1780 1790 1800
DVDEDAAKFL AKWVEEKDKK KTSEAPKPHK SSTYSTNGLV SFCDETQQYF
1810 1820 1830 1840 1850
DVLMNKTDLM YGRCGFHNFY RMQIIKRRDA ELFILFTNWG RIGSGMGEFQ
1860 1870 1880 1890 1900
TTPFNSLELA AKEFKSIFKS KSGNEWAPLA NFRDMPKKYR LVETDSTPTS
1910 1920 1930 1940 1950
LAEIELTWKK NTEKDPIRRM IADISDAKTL KTYASQVQMY GGSSQPFGRF
1960 1970 1980 1990 2000
TKENIEKAKL VLDKLEKNAN RIKQMVEAQT GVVESNLLDA YITTSELSGD
2010 2020 2030 2040 2050
YYSLIPSGEY EFSNLTRLDN VEEIARHRAR LNRCQEIETA TRLLCAAEFR
2060 2070 2080 2090 2100
QDLDRVDYIR SAIQCEYRLE TPDSDISQRL LQWIHNSGGK QAKVKMILEI
2110 2120 2130 2140 2150
SPMLSTEKFE PFVNDDNQKF LWHGTKATNL MSILKNGFLI DPPSACKNGN
2160 2170 2180 2190 2200
LFGSGIYLAD SFEKSTHYCQ PSAGGINYML VCQTALGKVR TLDTIPYHYM
2210 2220 2230 2240 2250
NQSSSSAEKY EDTLHYIGDR FPAGSLTNDG VGMPLLPLRK RDPIQGSNYG
2260 2270
FGTLDFSEYI VRNPNRVLPK YIVMYK
Length:2,276
Mass (Da):254,576
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8D1ADA31DBD2794F
GO
Isoform b (identifier: Q9TXQ1-2) [UniParc]FASTAAdd to basket
Also known as: PME-5S

The sequence of this isoform differs from the canonical sequence as follows:
     852-889: Missing.

Show »
Length:2,238
Mass (Da):250,351
Checksum:i324E3802BD22C20C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012461852 – 889Missing in isoform b. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF548287 mRNA Translation: AAN40683.1
FO081160 Genomic DNA Translation: CCD69563.1
FO081160 Genomic DNA Translation: CCD69564.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C88948
D88948

NCBI Reference Sequences

More...
RefSeqi
NP_001024306.1, NM_001029135.3 [Q9TXQ1-2]
NP_503401.3, NM_071000.6 [Q9TXQ1-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
ZK1005.1a.1; ZK1005.1a.1; WBGene00004053 [Q9TXQ1-1]
ZK1005.1b.1; ZK1005.1b.1; WBGene00004053 [Q9TXQ1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
178623

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_ZK1005.1

UCSC genome browser

More...
UCSCi
ZK1005.1b c. elegans [Q9TXQ1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF548287 mRNA Translation: AAN40683.1
FO081160 Genomic DNA Translation: CCD69563.1
FO081160 Genomic DNA Translation: CCD69564.1
PIRiC88948
D88948
RefSeqiNP_001024306.1, NM_001029135.3 [Q9TXQ1-2]
NP_503401.3, NM_071000.6 [Q9TXQ1-1]

3D structure databases

SMRiQ9TXQ1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi43692, 2 interactors
STRINGi6239.ZK1005.1a

Proteomic databases

EPDiQ9TXQ1
PaxDbiQ9TXQ1
PeptideAtlasiQ9TXQ1
PRIDEiQ9TXQ1

Genome annotation databases

EnsemblMetazoaiZK1005.1a.1; ZK1005.1a.1; WBGene00004053 [Q9TXQ1-1]
ZK1005.1b.1; ZK1005.1b.1; WBGene00004053 [Q9TXQ1-2]
GeneIDi178623
KEGGicel:CELE_ZK1005.1
UCSCiZK1005.1b c. elegans [Q9TXQ1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
178623
WormBaseiZK1005.1a ; CE24712 ; WBGene00004053 ; tank-1
ZK1005.1b ; CE33259 ; WBGene00004053 ; tank-1

Phylogenomic databases

eggNOGiKOG1037 Eukaryota
ENOG410XP18 LUCA
GeneTreeiENSGT00940000170301
InParanoidiQ9TXQ1
OMAiISNSTHM
OrthoDBi18682at2759
PhylomeDBiQ9TXQ1

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9TXQ1

Gene expression databases

BgeeiWBGene00004053 Expressed in material anatomical entity and 4 other tissues

Family and domain databases

Gene3Di1.20.142.10, 1 hit
1.25.40.20, 4 hits
2.20.140.10, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR004102 Poly(ADP-ribose)pol_reg_dom
IPR036616 Poly(ADP-ribose)pol_reg_dom_sf
IPR036930 WGR_dom_sf
IPR008893 WGR_domain
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF00644 PARP, 1 hit
PF02877 PARP_reg, 1 hit
PF05406 WGR, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 16 hits
SM00773 WGR, 1 hit
SUPFAMiSSF142921 SSF142921, 1 hit
SSF47587 SSF47587, 1 hit
SSF48403 SSF48403, 4 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 3 hits
PS50088 ANK_REPEAT, 6 hits
PS51060 PARP_ALPHA_HD, 1 hit
PS51059 PARP_CATALYTIC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNKS1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9TXQ1
Secondary accession number(s): Q8I0N5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: May 1, 2000
Last modified: June 17, 2020
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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