UniProtKB - Q9TWL1 (SCX7_CENNO)
Protein
Beta-toxin Cn7
Gene
N/A
Organism
Centruroides noxius (Mexican scorpion)
Status
Functioni
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.1 Publication
GO - Molecular functioni
- ion channel inhibitor activity Source: InterPro
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- defense response Source: InterPro
Keywordsi
Molecular function | Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Beta-toxin Cn7Short name: Toxin-7 Alternative name(s): Toxin II-13.3 |
Organismi | Centruroides noxius (Mexican scorpion) |
Taxonomic identifieri | 6878 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Centruroides |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000066768 | 1 – ›55 | Beta-toxin Cn7Add BLAST | ›55 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 16 ↔ 41 | PROSITE-ProRule annotation | ||
Disulfide bondi | 25 ↔ 46 | PROSITE-ProRule annotation | ||
Disulfide bondi | 29 ↔ 48 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.
Structurei
3D structure databases
ProteinModelPortali | Q9TWL1 |
SMRi | Q9TWL1 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – ›55 | LCN-type CS-alpha/betaPROSITE-ProRule annotationAdd BLAST | ›55 |
Sequence similaritiesi
Belongs to the long (3 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.Curated
Family and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR003614 Scorpion_toxin-like IPR036574 Scorpion_toxin-like_sf IPR018218 Scorpion_toxinL IPR002061 Scorpion_toxinL/defensin |
Pfami | View protein in Pfam PF00537 Toxin_3, 1 hit |
PRINTSi | PR00285 SCORPNTOXIN |
SMARTi | View protein in SMART SM00505 Knot1, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS51863 LCN_CSAB, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q9TWL1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
KEGYIVNYHD GCKYECYKLG DNDYCLRECK LRVGKGAGGY CYAFACWCTH
LYEQA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 55 | 1 |
Similar proteinsi
Cross-referencesi
3D structure databases
ProteinModelPortali | Q9TWL1 |
SMRi | Q9TWL1 |
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR003614 Scorpion_toxin-like IPR036574 Scorpion_toxin-like_sf IPR018218 Scorpion_toxinL IPR002061 Scorpion_toxinL/defensin |
Pfami | View protein in Pfam PF00537 Toxin_3, 1 hit |
PRINTSi | PR00285 SCORPNTOXIN |
SMARTi | View protein in SMART SM00505 Knot1, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS51863 LCN_CSAB, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | SCX7_CENNO | |
Accessioni | Q9TWL1Primary (citable) accession number: Q9TWL1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | May 1, 2000 | |
Last modified: | July 18, 2018 | |
This is version 62 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families