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Protein

Kappa-actitoxin-Avd6a

Gene
N/A
Organism
Anemonia sulcata (Mediterranean snakelocks sea anemone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Blocks voltage-gated potassium channels Kv1.2/KCNA2 (IC50=140 nM).1 Publication

Caution

Opinions are divided on whether Anemonia viridis (Forsskal, 1775) and Anemonia sulcata (Pennant, 1777) are separate species.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei6Important for binding to potassium channelsBy similarity1
Sitei13Important for binding to potassium channelsBy similarity1
Sitei22Important for binding to potassium channelsBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-actitoxin-Avd6a1 Publication
Short name:
Kappa-AITX-Avd6a1 Publication
Alternative name(s):
Kaliseptine1 Publication
Short name:
AsKS1 Publication
OrganismiAnemonia sulcata (Mediterranean snakelocks sea anemone)
Taxonomic identifieri6108 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaActiniidaeAnemonia

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nematocyst, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000448651 – 36Kappa-actitoxin-Avd6a1 PublicationAdd BLAST36

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2 ↔ 36PROSITE-ProRule annotation
Disulfide bondi11 ↔ 29PROSITE-ProRule annotation
Disulfide bondi20 ↔ 33PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

SMRiQ9TWG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 36ShKTPROSITE-ProRule annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 25Crucial for binding to potassium channelsBy similarity2

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR003582 ShKT_dom
PROSITEiView protein in PROSITE
PS51670 SHKT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9TWG1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30 
ACKDNFAAAT CKHVKENKNC GSQKYATNCA KTCGKC
Length:36
Mass (Da):3,840
Last modified:May 1, 2000 - v1
Checksum:i832A2936C3962CF1
GO

Similar proteinsi

Cross-referencesi

3D structure databases

SMRiQ9TWG1
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR003582 ShKT_dom
PROSITEiView protein in PROSITE
PS51670 SHKT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK1B_ANESU
AccessioniPrimary (citable) accession number: Q9TWG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 1, 2000
Last modified: January 31, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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