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UniProtKB - Q9TW65 (DMD_CAEEL)

Entry version 156 (12 Aug 2020)
Sequence version 2 (01 Oct 2001)
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Protein

Dystrophin-1

Gene

dys-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in cholinergic transmission and as a functional partner of dystrobrevin (dyb-1), necessary for muscle maintenance. Required for neuronal positioning.5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri3300 – 3347ZZ-typePROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding, Zinc

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.66.1.1, the dystrophin (dystrophin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dystrophin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dys-1
ORF Names:F15D3.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...WormBasei		F15D3.1a ; CE27129 ; WBGene00001131 ; dys-1
F15D3.1b ; CE24904 ; WBGene00001131 ; dys-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutants display a phenotype of hyperactive locomotion and are hypersensitive to the acetylcholinesterase inhibitor aldicarb and are defective in maintaining neuronal positioning. Dys-1 and hlh-1 double mutants synergistically exhibit progressive myopathy.4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000760791 – 3674Dystrophin-1Add BLAST3674

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9TW65

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9TW65

PeptideAtlas

More...PeptideAtlasi		Q9TW65

PRoteomics IDEntifications database

More...PRIDEi		Q9TW65

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9TW65

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in body wall, head, pharyngeal and vulval muscles, from late embryogenesis to adulthood (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		WBGene00001131, Expressed in multi-cellular organism and 5 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9TW65, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the dystrophin glycoprotein complex (DGC).

Interacts with dyb-1 and stn-1 to form the DGC.

Interacts with stn-2.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		38445, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q9TW65, 3 interactors

STRING: functional protein association networks

More...STRINGi		6239.F15D3.1a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9TW65

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini129 – 234Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST106
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati327 – 435Spectrin 1Add BLAST109
Repeati436 – 541Spectrin 2Add BLAST106
Repeati612 – 656Spectrin 3Add BLAST45
Repeati2576 – 2673Spectrin 4Add BLAST98
Repeati2725 – 2789Spectrin 5Add BLAST65
Repeati2792 – 2905Spectrin 6Add BLAST114
Repeati2926 – 3032Spectrin 7Add BLAST107
Domaini3047 – 3081WWPROSITE-ProRule annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni30 – 39Actin-binding10

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3300 – 3347ZZ-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4286, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000246_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9TW65

Identification of Orthologs from Complete Genome Data

More...OMAi		KARIHQQ

Database of Orthologous Groups

More...OrthoDBi		629209at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9TW65

Family and domain databases

Conserved Domains Database

More...CDDi		cd00014, CH, 1 hit
cd00201, WW, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.418.10, 1 hit
3.30.60.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR011992, EF-hand-dom_pair
IPR015153, EF-hand_dom_typ1
IPR015154, EF-hand_dom_typ2
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
IPR001202, WW_dom
IPR036020, WW_dom_sf
IPR013087, Znf_C2H2_type
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00307, CH, 1 hit
PF09068, EF-hand_2, 1 hit
PF09069, EF-hand_3, 1 hit
PF00435, Spectrin, 2 hits
PF00569, ZZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00033, CH, 1 hit
SM00150, SPEC, 7 hits
SM00456, WW, 1 hit
SM00291, ZnF_ZZ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 2 hits
SSF47576, SSF47576, 1 hit
SSF51045, SSF51045, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS50021, CH, 1 hit
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 1 hit
PS50135, ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform a (identifier: Q9TW65-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLFSGASTAK PKKDEKKDKK SDRDPKNELQ EWVFVRWANH LLGTERLTDY 
        60         70         80         90        100
KSLQDGSNAI FVYQAIIGQT MAVLGNPSDD WPNVLQNIGD SKTNPQEVME 
       110        120        130        140        150
GQQKAVLSAW WQLVQFFWKN NAPVQLREEK LSEAIKQWCI EVMKSYEEID 
       160        170        180        190        200
VYDFTSSFRD GHAFNYLIHS YDRKLINLTK TAEMSAIDRI ENAFAVAEKT 
       210        220        230        240        250
WNVPRLLNPK DLHSDQLDSH SVLCYLMSLY LAMISTSKIE TELEAQQIQQ 
       260        270        280        290        300
QKVAALLASH KMLSSQPSTS SSSALQIPPQ TPPTAHHQAM LDRGKSFEQS 
       310        320        330        340        350
AEGEVRSRKS SSSSQKSGKS KKARREEQLA EFKSCIEQVL TWLLEAEDEL 
       360        370        380        390        400
TTLTQMPRVE LASVRSQFSD FESFMSSLTD SQDTVGRVLL RGQMLSNKSE 
       410        420        430        440        450
SEEEKESIGA NLHLVNTRWE ALREQAMQEQ AVLQQQIHLL QQSELDTISQ 
       460        470        480        490        500
WLDAAELEIE SFGPLAADSS QALRQIELHT KFQQKLNDFQ ETIDKLESFV 
       510        520        530        540        550
AVVDEENDAS VATLEDALSA VSVRWGHVCE WAEKRATKLD GLADLLDKTN 
       560        570        580        590        600
EVFENLSGWL AERENELMTG LKSAHHLENE EQVAQQVRRL QKTEEQLEQE 
       610        620        630        640        650
HASFVRLSQL SCELVGRLDD SNGAAANAVR LSLDSITQRW DNLVARIEEH 
       660        670        680        690        700
GKTLVKSGKA DVKQVQESQN EQKEQPASSE GLSTDTEGEE QKNQLVDKFL 
       710        720        730        740        750
LHISKLSHEL EPLQDWSEKF EVSRKKDDIR KMMNTCQEKL IQIKEQEARV 
       760        770        780        790        800
NRLQLELEHL HVAKLNARQL KRANDAFEQF AKGWARIVTK ISEAMNVLTG 
       810        820        830        840        850
QEAGGNGNGS EEAAVAAKIE QWIEAVDKVI NELSQLPVNE RRSRIDKLEQ 
       860        870        880        890        900
QLQVQDKNVG FIEKDLLKKA ILKKGLEIAG KRLAALKVEE KPVEKEEQLV 
       910        920        930        940        950
LSNSEEPEAE KHVTFVQETT EKPAPLQEPT SEAQLLEELD GPWSRVGDVV 
       960        970        980        990       1000
AIEHDLLRAK RAVDTARNSQ MSNETVEKAE TRKAEMEEKR RVTMSARSKF 
      1010       1020       1030       1040       1050
RMAEETLEEI ERNLDRLQVS DLEIADLVRG LEQEAAKLGE RVSQRKEAER 
      1060       1070       1080       1090       1100
TAEKILSMDD DEISQEIVIK TKDSTEKLIK RWNQLELDLE ENLRKAKRDQ 
      1110       1120       1130       1140       1150
DVFIQKRLRE GEEALNEIKT AIEGKRESLD AETAAENLDH LESSLDNISS 
      1160       1170       1180       1190       1200
LFGEIGSLPM DDNSREKLSK LAKAKDQITA RANEALAALT RTVSECEDFE 
      1210       1220       1230       1240       1250
KQIMLFQNWS ARIGFLLQAR KSADISAFDI PHEYHEDLGN EAELIPKLSR 
      1260       1270       1280       1290       1300
EFEEWTVKLN EMNSTATEKD DSARMREQLN HANETMAELK RKFNEFKRPK 
      1310       1320       1330       1340       1350
GFEEKLEKVI TTLSNVEMGL DDTTGIDGSE CGGALMEVRA LVRMLDGAQE 
      1360       1370       1380       1390       1400
KWKDLAENRE QLVKDRVLDE ETSKETLQKL QYAKTKSKEL YERSSTCIER 
      1410       1420       1430       1440       1450
LEDCVEMYQR LKMESDEIER FLEEMEGKLD QYAASDRPEE AEIVNELISE 
      1460       1470       1480       1490       1500
WNRNEAAMKN AEHLQRQLNE RAIKIPDDVL SLKRLRADAL KNRLNSWCRT 
      1510       1520       1530       1540       1550
IQEMSEDDES ALLEIDELHQ NLEKELKLVS DKEPSKIAEK LRFLRADRDR 
      1560       1570       1580       1590       1600
LSSRTRKLAA KNPRLAATSS DVLAGLNQKW KELEVKASAE KAPAPELRDA 
      1610       1620       1630       1640       1650
RLSSPSEQPF DKRVQELCDL FENLEAQLDF NGSPVSMVTE YQKRVENLDE 
      1660       1670       1680       1690       1700
YLDEYRPALD DTIEEGRKIA ETGRLELQTH SAIEKLDELT NRIEQVEVEL 
      1710       1720       1730       1740       1750
DKHRDKVPSL VEQHEQLKKD IDSFLLVLDV FTDRNLDDVD IAKSTRKELA 
      1760       1770       1780       1790       1800
ERDSHIVSLT SRATAIHCAL PGKGPQLHDV TLDKLRDRIE KLEARLSATE 
      1810       1820       1830       1840       1850
KKPVETVKST IPDRPEVPEE PEKSSPDRTS RSSLQLAMEA YGTATEDDSV 
      1860       1870       1880       1890       1900
ISEAVTVGQK SVDQVDPVEQ LEPVEPVEPK LEVKQLKDEA TEEEEKRTII 
      1910       1920       1930       1940       1950
LPDETEKVIE TIPAARPSAG PSEGTVAEVS TSEILKARPA QESIERTVRE 
      1960       1970       1980       1990       2000
VPVDEYEETA NISSGDELQD HKISSAVPDS ESEIASMFEV LDSIEDSHTN 
      2010       2020       2030       2040       2050
FEEFPFDYLD SADDDLKKTL LKLESCEKTL AKNEMTINIA QAENARERIT 
      2060       2070       2080       2090       2100
MLRQMALQRK DKLPKFNEEW NAMQELIQLA DALVDEAERY ESDQIPQMDR 
      2110       2120       2130       2140       2150
KSAPNVLGEL RKRVANAEGP VIDLVKKLSQ LVPRMQEDSP KSQDIRQKVY 
      2160       2170       2180       2190       2200
GIEDRFRRVG QAEGAAISKA LSSALTEPEL KLELDEVVRW CEMAEKEAAQ 
      2210       2220       2230       2240       2250
NVNSLDGDGL EKLDGRLAQF TKELQERKDD MVQLEMAKNM IIPSLKGDAH 
      2260       2270       2280       2290       2300
HDLRRNFSDT AKRVAMVRDE LSDAHKWVAT SRDTCDTFWA DIDSLEQLAR 
      2310       2320       2330       2340       2350
DVVRRANGIR MAVIYTPSRE NVEGVLRDVQ RLKMSIGDVK KRVQTANLPP 
      2360       2370       2380       2390       2400
AIKLAGKNAK RVVQVLTETA TTIADCHDIP TYLIDEMNDS GGDTTESRST 
      2410       2420       2430       2440       2450
VVEMTSVHTK QSSSSSSNKT PSAGGESDDA HTLNGDDEQS EEDQKIYSRE 
      2460       2470       2480       2490       2500
SSSTLPRGVS SLGSTGSSGV LDPVAVQLTH TRHWLHDVER DASITVDLAQ 
      2510       2520       2530       2540       2550
WQPARELWQS IQGIIDEIRL RSVHVTGAHD ASPNRQVRQQ AAQLLTEMRR 
      2560       2570       2580       2590       2600
TIENCEKRCL ILNQISDIAR QNEASRNEME LWLKSASDVI GERRVEELSE 
      2610       2620       2630       2640       2650
EVVRQELQVL ERVVEQLTER KDKMAEINSQ ANKIVDTYTK DEAHNLSHLL 
      2660       2670       2680       2690       2700
SRLNMSWTKF NDNIRIRRAV LEASLRSRRD FHSALSEFEK WLSRQEDNCS 
      2710       2720       2730       2740       2750
KLSADTSNHQ AIKDTSKRKN WTQSFKTLNA ELNAHEDVMK SVEKMGKMLA 
      2760       2770       2780       2790       2800
ESLESGNEKV ELLKRVGETT RRWTALRKTT NEIGERLEKA EQEWEKLSDG 
      2810       2820       2830       2840       2850
LADLLSWVEA KKQAIMDEQP TGGSLSAVMQ QASFVKGLQR EIESKTANYK 
      2860       2870       2880       2890       2900
STVEEAHSFL MQHDLRPKLH SPHVLDDDYE KEELANLEQR RRGLEINANC 
      2910       2920       2930       2940       2950
ERLKKNWAEL GIEVESWDKL VQHAMQRLQE LERNLAECQL HLTSSENEIE 
      2960       2970       2980       2990       3000
TMKAVEKIHL EDLKIAREET DQISKRIDEV RLFVDDVNDA AARLLAEDLK 
      3010       3020       3030       3040       3050
LDEHAKGQIE HVNKRYSTLK RAIRIRQAAV RNAASDFGPT SEHFLNQSVT 
      3060       3070       3080       3090       3100
LPWQRAISKS NLLPYYIEQT SEKTQWEHPV WVEIVKELSQ FNRVKFLAYR 
      3110       3120       3130       3140       3150
TAMKLRALQK RLCLDLVDLT LLEKAFVRLK GLSAEECPGL EGMVCALLPM 
      3160       3170       3180       3190       3200
YEALHAKYPN QVQSVSLAVD ICINFLLNLF DQSRDGIMRV LSFKIAMIVF 
      3210       3220       3230       3240       3250
SNIPLEEKYR YLFKLVSQDG HATQKQIALL LYDLIHIPRL VGESAAFGGT 
      3260       3270       3280       3290       3300
NVEPSVRSCF ETVRLAPTIS EGAFIDWVKK EPQSIVWLAV MHRLVISEST 
      3310       3320       3330       3340       3350
KHASKCNVCK MFPIIGIRYR CLTCFNCDLC QNCFFSQRTA KSHRTNHPMQ 
      3360       3370       3380       3390       3400
EYCEKTTSSD DARDFAKMIR NKFRASKRQK GYLPIDVAEE GIPLTCPPAK 
      3410       3420       3430       3440       3450
VTNQATEQMN ADTSQMTAHL AKLSAEHGGG AEHMEPVQSP LQIINQVEQL 
      3460       3470       3480       3490       3500
QRDEMDQMLH RLQFENKQLR KELEWKRGAA STMEIDRSSK RHQERHQSES 
      3510       3520       3530       3540       3550
RGGTLPLRNG RSVVSLKSTQ SQNDVMDEAK ALRLHKQRLE HRSRILEQQN 
      3560       3570       3580       3590       3600
EQLEMQLQRL KKVIDAQKQQ APLSTNSLLR GSHHQPWSPE RARSGSASTL 
      3610       3620       3630       3640       3650
DRGLIVSSRH QEQAEAAGGG AEDSSDEAGG AGGGPRGSSV GQMQNLMTAC 
      3660       3670 
DDLGKAMESL VVSVVYDSDD EEND
Length:3,674
Mass (Da):417,427
Last modified:October 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i793FD9E5A81008FF
GO
Isoform b (identifier: Q9TW65-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3410: Missing.
     3411-3446: ADTSQMTAHLAKLSAEHGGGAEHMEPVQSPLQIINQ → MCSLLKLLKISGKSVSDDDPIERYIKCEQCKCKRHW

Show »
Length:264
Mass (Da):29,727
Checksum:i6543358AC332ED91
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V6CLV8V6CLV8_CAEEL
Dystrophin-1
dys-1 CELE_F15D3.1, F15D3.1
3,663Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V6CJD7V6CJD7_CAEEL
Dystrophin-1
dys-1 CELE_F15D3.1, F15D3.1
3,448Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V6CKJ6V6CKJ6_CAEEL
Dystrophin-1
dys-1 CELE_F15D3.1, F15D3.1
2,515Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V6CLW7V6CLW7_CAEEL
Dystrophin-1
dys-1 CELE_F15D3.1, F15D3.1
1,577Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V6CLR8V6CLR8_CAEEL
Dystrophin-1
dys-1 CELE_F15D3.1, F15D3.1
3,437Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V6CJE3V6CJE3_CAEEL
Dystrophin-1
dys-1 CELE_F15D3.1, F15D3.1
2,504Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V6CIR0V6CIR0_CAEEL
Dystrophin-1
dys-1 CELE_F15D3.1, F15D3.1
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V6CL65V6CL65_CAEEL
Dystrophin-1
dys-1 CELE_F15D3.1, F15D3.1
220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0516141 – 3410Missing in isoform b. CuratedAdd BLAST3410
Alternative sequenceiVSP_0516153411 – 3446ADTSQ…QIINQ → MCSLLKLLKISGKSVSDDDP IERYIKCEQCKCKRHW in isoform b. CuratedAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ012469 mRNA Translation: CAA10033.1
Z81063, Z81522 Genomic DNA Translation: CAB61012.2
Z81522 Genomic DNA Translation: CAB61004.1

Protein sequence database of the Protein Information Resource

More...PIRi		T21635

NCBI Reference Sequences

More...RefSeqi		NP_492946.1, NM_060545.5 [Q9TW65-1]
NP_492947.1, NM_060546.6 [Q9TW65-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		F15D3.1a.1; F15D3.1a.1; WBGene00001131 [Q9TW65-1]
F15D3.1b.1; F15D3.1b.1; WBGene00001131 [Q9TW65-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		173038

UCSC genome browser

More...UCSCi		F15D3.1b, c. elegans [Q9TW65-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012469 mRNA Translation: CAA10033.1
Z81063, Z81522 Genomic DNA Translation: CAB61012.2
Z81522 Genomic DNA Translation: CAB61004.1
PIRiT21635
RefSeqiNP_492946.1, NM_060545.5 [Q9TW65-1]
NP_492947.1, NM_060546.6 [Q9TW65-2]

3D structure databases

SMRiQ9TW65
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi38445, 1 interactor
IntActiQ9TW65, 3 interactors
STRINGi6239.F15D3.1a

Protein family/group databases

TCDBi8.A.66.1.1, the dystrophin (dystrophin) family

PTM databases

iPTMnetiQ9TW65

Proteomic databases

EPDiQ9TW65
PaxDbiQ9TW65
PeptideAtlasiQ9TW65
PRIDEiQ9TW65

Genome annotation databases

EnsemblMetazoaiF15D3.1a.1; F15D3.1a.1; WBGene00001131 [Q9TW65-1]
F15D3.1b.1; F15D3.1b.1; WBGene00001131 [Q9TW65-2]
GeneIDi173038
UCSCiF15D3.1b, c. elegans [Q9TW65-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		173038
WormBaseiF15D3.1a ; CE27129 ; WBGene00001131 ; dys-1
F15D3.1b ; CE24904 ; WBGene00001131 ; dys-1

Phylogenomic databases

eggNOGiKOG4286, Eukaryota
HOGENOMiCLU_000246_3_0_1
InParanoidiQ9TW65
OMAiKARIHQQ
OrthoDBi629209at2759
PhylomeDBiQ9TW65

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q9TW65

Gene expression databases

BgeeiWBGene00001131, Expressed in multi-cellular organism and 5 other tissues
ExpressionAtlasiQ9TW65, baseline and differential

Family and domain databases

CDDicd00014, CH, 1 hit
cd00201, WW, 1 hit
Gene3Di1.10.418.10, 1 hit
3.30.60.90, 1 hit
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR011992, EF-hand-dom_pair
IPR015153, EF-hand_dom_typ1
IPR015154, EF-hand_dom_typ2
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
IPR001202, WW_dom
IPR036020, WW_dom_sf
IPR013087, Znf_C2H2_type
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf
PfamiView protein in Pfam
PF00307, CH, 1 hit
PF09068, EF-hand_2, 1 hit
PF09069, EF-hand_3, 1 hit
PF00435, Spectrin, 2 hits
PF00569, ZZ, 1 hit
SMARTiView protein in SMART
SM00033, CH, 1 hit
SM00150, SPEC, 7 hits
SM00456, WW, 1 hit
SM00291, ZnF_ZZ, 1 hit
SUPFAMiSSF47473, SSF47473, 2 hits
SSF47576, SSF47576, 1 hit
SSF51045, SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS50021, CH, 1 hit
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 1 hit
PS50135, ZF_ZZ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDMD_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9TW65
Secondary accession number(s): Q9TYG9, Q9U3H3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 1, 2001
Last modified: August 12, 2020
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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