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Entry version 157 (13 Feb 2019)
Sequence version 1 (01 May 2000)
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Protein

Serine/threonine-protein kinase par-1

Gene

par-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis (PubMed:7758115). Phosphorylates and restricts the asymmetry effector mex-5 (and possibly also mex-6) to the anterior cytoplasm of the zygote (PubMed:18842813). Regulates mes-1 expression during early embryogenesis (PubMed:11003841). Critical role in postembryonic vulval morphogenesis (PubMed:12490197). Involved in the establishment of neuronal polarity (PubMed:20023164).5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei199ATPPROSITE-ProRule annotationBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei292Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi176 – 184ATPPROSITE-ProRule annotationBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • myosin II tail binding Source: WormBase
  • protein serine/threonine kinase activity Source: WormBase
  • tau-protein kinase activity Source: GO_Central
  • ubiquitin protein ligase binding Source: WormBase

GO - Biological processi

  • asymmetric neuroblast division Source: WormBase
  • asymmetric protein localization involved in cell fate determination Source: WormBase
  • embryonic pattern specification Source: WormBase
  • establishment of cell polarity Source: WormBase
  • establishment or maintenance of cell polarity Source: WormBase
  • intracellular signal transduction Source: GO_Central
  • microtubule cytoskeleton organization Source: GO_Central
  • peptidyl-serine phosphorylation Source: WormBase
  • polarity specification of anterior/posterior axis Source: WormBase
  • protein phosphorylation Source: WormBase
  • vulval development Source: WormBase

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9TW45

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase par-11 PublicationImported (EC:2.7.11.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:par-1Imported
ORF Names:H39E23.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
H39E23.1a ; CE23838 ; WBGene00003916 ; par-1
H39E23.1b ; CE27768 ; WBGene00003916 ; par-1
H39E23.1c ; CE40085 ; WBGene00003916 ; par-1
H39E23.1d ; CE44808 ; WBGene00003916 ; par-1
H39E23.1e ; CE44733 ; WBGene00003916 ; par-1
H39E23.1f ; CE45159 ; WBGene00003916 ; par-1
H39E23.1g ; CE45263 ; WBGene00003916 ; par-1
H39E23.1h ; CE45267 ; WBGene00003916 ; par-1
H39E23.1i ; CE45299 ; WBGene00003916 ; par-1
H39E23.1j ; CE46555 ; WBGene00003916 ; par-1
H39E23.1k ; CE46628 ; WBGene00003916 ; par-1
H39E23.1l ; CE48381 ; WBGene00003916 ; par-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Maternal effect lethality. Blastomeres cleave synchronously until the fourth or fifth round, when synchrony breaks down. Cells also fail to segregate P granules. Terminal stage embryos fail to produce intestinal cells. Disruption post-hatching results in a protruding vulva, the two mirror-symmetric halves of the vulva fail to join into a single, coherent organ.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003833221 – 1192Serine/threonine-protein kinase par-1Add BLAST1192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei325Phosphothreonine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at Thr-325 probably by par-4.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9TW45

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9TW45

PeptideAtlas

More...
PeptideAtlasi
Q9TW45

PRoteomics IDEntifications database

More...
PRIDEi
Q9TW45

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9TW45

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Asymmetrically localized to the posterior of the zygote before mitotic division, then differentially distributed to the germline precursor cells (at protein level).1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Maternally expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003916 Expressed in 5 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9TW45 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
let-99Q213412EBI-1811687,EBI-1811800

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9TW45, 2 interactors

STRING: functional protein association networks

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STRINGi
6239.H39E23.1d

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9TW45

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9TW45

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini170 – 421Protein kinasePROSITE-ProRule annotationAdd BLAST252
Domaini440 – 482UBAPROSITE-ProRule annotationAdd BLAST43
Domaini1143 – 1192KA1PROSITE-ProRule annotationAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi24 – 156Ser-richSequence analysisAdd BLAST133
Compositional biasi498 – 584Ser-richSequence analysisAdd BLAST87
Compositional biasi737 – 743Poly-SerSequence analysis7
Compositional biasi871 – 972Ser-richSequence analysisAdd BLAST102

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0586 Eukaryota
ENOG410XNQ0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160886

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000233025

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9TW45

KEGG Orthology (KO)

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KOi
K08798

Identification of Orthologs from Complete Genome Data

More...
OMAi
HVGPSIP

Database of Orthologous Groups

More...
OrthoDBi
1127668at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9TW45

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028375 KA1/Ssp2_C
IPR001772 KA1_dom
IPR011009 Kinase-like_dom_sf
IPR033624 MARK/par1
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR015940 UBA

The PANTHER Classification System

More...
PANTHERi
PTHR24346 PTHR24346, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02149 KA1, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103243 SSF103243, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50032 KA1, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50030 UBA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (12+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 12 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 12 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform a2 Publications (identifier: Q9TW45-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSASVGKKP EHVNTPPGDN QQKSSKENQK SNKDKQSSNQ PPGQIPHSTN
60 70 80 90 100
SGTRKSSGSG LKTANLKHPA RPSTESSTSS SHHRRPAQEM NGTSTATATG
110 120 130 140 150
GGGTSGATTT ASSGAPAASS GGSSARYSSS GRSHPTSGSS SSHARSTGQS
160 170 180 190 200
GMSSRSAARR NDQDVHVGKY KLLKTIGKGN FAKVKLAKHV ITGHEVAIKI
210 220 230 240 250
IDKTALNPSS LQKLFREVKI MKQLDHPNIV KLYQVMETEQ TLYLVLEYAS
260 270 280 290 300
GGEVFDYLVA HGRMKEKEAR AKFRQIVSAV QYLHSKNIIH RDLKAENLLL
310 320 330 340 350
DQDMNIKIAD FGFSNTFSLG NKLDTFCGSP PYAAPELFSG KKYDGPEVDV
360 370 380 390 400
WSLGVILYTL VSGSLPFDGQ NLKELRERVL RGKYRIPFYM STDCENLLKK
410 420 430 440 450
FLVINPQRRS SLDNIMKDRW MNVGYEDDEL KPFIEPPKDQ IDEQRIEKLI
460 470 480 490 500
QIFQLGFNKA AILESVEKEK FEDIHATYLL LGERKSDMDA SEITMAQSLL
510 520 530 540 550
SHSSINVSSS LGQHPAGVIT REHVTSSSAS GSSASPSRYS RSSATATGAS
560 570 580 590 600
ITAGSALASA ANAQKHQQSS AAPSSGSSSS RRSSQNDAAA TAAGGTVVMS
610 620 630 640 650
GTRHGGVQMR AQPTSRQATI SLLQPPSYKP SSNTTQIAQI PPLFNRNSTA
660 670 680 690 700
TSSAAQPSTG ITGTRKIADP KGRIPLNSTA VQGHRTATGA VAANNGGIPS
710 720 730 740 750
HRDHAQQQQY MNQLTSSTMM SKLINKTPAA GGTAATSSSS SSSATSTAPL
760 770 780 790 800
QKSGSQISHA PTEPVIREDD DENNSENQNG NVPLIGGVGP QTSPAVQVPT
810 820 830 840 850
EDATSSSDKE QQQQKASSET PKESKPSMIH QSPSMPPSQM MTAMESLKLS
860 870 880 890 900
ESGQTGGPTV ATGGPPQRAT SQQMSRSATT NSANMGASSG GAAAAASATN
910 920 930 940 950
QLSGAPSSTG ASSQQYHPKA PSSSSSSSTN PPHQHQLTHN ASFSVTPSSY
960 970 980 990 1000
QIPTSTAVNV TSTGMPTSSS SSAFPRNTRN RQTFHGKTEK DKGGDDSSDE
1010 1020 1030 1040 1050
IGETPGNVSI GATGPSANNA EATIWSKLSK LTRRDHNRES MTQPVSGRAG
1060 1070 1080 1090 1100
TIGASQGQQT AAALAAIREQ SGPIAPGAGQ VAPSLPIHEG DVKPRSLRFT
1110 1120 1130 1140 1150
WSMKTTSSLA PDDMMREIRK VLDANGCDYE QRERYMILCV HGDPNTDSLV
1160 1170 1180 1190
QWEMEVCKLP RLSLNGVRFK RISGTSIGFK NIASKIAQEL NL
Length:1,192
Mass (Da):126,349
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i32517D17BCAB46E0
GO
Isoform b1 Publication (identifier: Q9TW45-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.
     50-66: NSGTRKSSGSGLKTANL → MSRVSGYFMGISKKNGQK
     488-535: Missing.

Show »
Length:1,096
Mass (Da):116,654
Checksum:iB15A1CB5AFA6C77C
GO
Isoform c1 Publication (identifier: Q9TW45-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-130: Missing.
     131-139: GRSHPTSGS → MKFMWKPPD

Note: No experimental confirmation available.Curated
Show »
Length:1,062
Mass (Da):113,668
Checksum:iA24E250456BEC7DA
GO
Isoform d1 Publication (identifier: Q9TW45-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.
     65-139: NLKHPARPST...SGRSHPTSGS → MFNAAYSSLL...GDHVTHNRKN
     1034-1034: R → RSSTAAAHQP...LSEEAMAIRR

Note: No experimental confirmation available.Curated
Show »
Length:1,216
Mass (Da):130,022
Checksum:iC13854BDB8F84C23
GO
Isoform e (identifier: Q9TW45-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.
     65-139: NLKHPARPST...SGRSHPTSGS → MFNAAYSSLL...GDHVTHNRKN
     825-1030: KPSMIHQSPS...EATIWSKLSK → NPIVWQNLHL...TANVSFGNNQ
     1031-1192: Missing.

Note: No experimental confirmation available.
Show »
Length:966
Mass (Da):104,589
Checksum:i8292B7DAB7DDB85A
GO
Isoform f (identifier: Q9TW45-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.

Note: No experimental confirmation available.
Show »
Length:1,103
Mass (Da):116,884
Checksum:i80C69107E7DE45DC
GO
Isoform g (identifier: Q9TW45-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.

Note: No experimental confirmation available.
Show »
Length:1,041
Mass (Da):111,363
Checksum:i82EEE97D3213595F
GO
Isoform h (identifier: Q9TW45-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-487: Missing.

Note: No experimental confirmation available.
Show »
Length:705
Mass (Da):72,747
Checksum:iE4ACBB4CC93FA144
GO
Isoform i (identifier: Q9TW45-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-963: Missing.
     964-1032: GMPTSSSSSA...TIWSKLSKLT → MSMTQSPSQL...RKLSEEAMAI

Note: No experimental confirmation available.
Show »
Length:229
Mass (Da):24,898
Checksum:i3B801C2D7C89D8BD
GO
Isoform j (identifier: Q9TW45-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     535-535: S → SVSDHHHPY

Note: No experimental confirmation available.
Show »
Length:1,200
Mass (Da):127,322
Checksum:i7CDD3EAA316C2BD8
GO
Isoform k (identifier: Q9TW45-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-598: Missing.

Note: No experimental confirmation available.
Show »
Length:594
Mass (Da):62,027
Checksum:i1A1CD6AD60BB535A
GO
Isoform l (identifier: Q9TW45-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-86: Missing.
     87-138: AQEMNGTSTA...SSGRSHPTSG → MTKKSYAFAL...RTFFPEYELT

Note: No experimental confirmation available.
Show »
Length:1,106
Mass (Da):118,634
Checksum:i2E9CD90B86AF78D6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2C9C376A0A2C9C376_CAEEL
Serine/threonine-protein kinase par...
par-1 CELE_H39E23.1, H39E23.1
1,129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti84R → Q in AAA97437 (PubMed:7758115).Curated1
Sequence conflicti96A → P in AAA97437 (PubMed:7758115).Curated1
Sequence conflicti1141H → Y in AAA97437 (PubMed:7758115).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0536341 – 963Missing in isoform i. CuratedAdd BLAST963
Alternative sequenceiVSP_0536351 – 598Missing in isoform k. CuratedAdd BLAST598
Alternative sequenceiVSP_0536361 – 487Missing in isoform h. CuratedAdd BLAST487
Alternative sequenceiVSP_0536371 – 151Missing in isoform g. CuratedAdd BLAST151
Alternative sequenceiVSP_0531401 – 130Missing in isoform c. 1 PublicationAdd BLAST130
Alternative sequenceiVSP_0536381 – 89Missing in isoform f. CuratedAdd BLAST89
Alternative sequenceiVSP_0536391 – 86Missing in isoform l. CuratedAdd BLAST86
Alternative sequenceiVSP_0531411 – 64Missing in isoform d and isoform e. CuratedAdd BLAST64
Alternative sequenceiVSP_0531421 – 49Missing in isoform b. 2 PublicationsAdd BLAST49
Alternative sequenceiVSP_05314350 – 66NSGTR…KTANL → MSRVSGYFMGISKKNGQK in isoform b. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_05314465 – 139NLKHP…PTSGS → MFNAAYSSLLARFMCQPSSS SVTPIPEEEESLIPKRKVSE VVTTAPMAPTLTSSGKRRTV KVSPDGDHVTHNRKN in isoform d and isoform e. CuratedAdd BLAST75
Alternative sequenceiVSP_05364087 – 138AQEMN…HPTSG → MTKKSYAFALDLDDLCCDDH PYSYSPPSTSSRHSAYYPSQ QPRTFFPEYELT in isoform l. CuratedAdd BLAST52
Alternative sequenceiVSP_053145131 – 139GRSHPTSGS → MKFMWKPPD in isoform c. 1 Publication9
Alternative sequenceiVSP_053146488 – 535Missing in isoform b. 2 PublicationsAdd BLAST48
Alternative sequenceiVSP_053641535S → SVSDHHHPY in isoform j. Curated1
Alternative sequenceiVSP_053642825 – 1030KPSMI…SKLSK → NPIVWQNLHLNSLLKSLLDS SAATSYETPRRPGIAGRRSE PSAATPRRRHQTMVVDARHL QTPPDTDRPYHFEDTTLDRQ MRALYVSTASSRMTRGVLPT PPTSNSTSSSFIVEPLTHVA AASPDITTTTPTKSTVTTSP YFRRTPSFRMAVDDPPISIN ASITDDDCDGIIEIEREWSN GGTDSGDGRSTTTSHITANV SFGNNQ in isoform e. CuratedAdd BLAST206
Alternative sequenceiVSP_053643964 – 1032GMPTS…LSKLT → MSMTQSPSQLSSRFTSNYVA PIVRSKPPAPVSTPAAPSAT APIPVIVSPAVTKMLKENRR KLSEEAMAI in isoform i. CuratedAdd BLAST69
Alternative sequenceiVSP_0536441031 – 1192Missing in isoform e. CuratedAdd BLAST162
Alternative sequenceiVSP_0531481034R → RSSTAAAHQPRGSSLHHSMS MTQSPSQLSSRFTSNYVAPI VRSKPPAPVSTPAAPSATAP IPVIVSPAVTKMLKENRRKL SEEAMAIRR in isoform d. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U22183 mRNA Translation: AAA97437.1
U40858 mRNA Translation: AAA83272.1
Z96102, Z81027 Genomic DNA Translation: CAB54262.2
Z96102, Z81027 Genomic DNA Translation: CAB54263.1
Z96102, Z81027 Genomic DNA Translation: CAJ85756.1
Z96102, Z81027 Genomic DNA Translation: CAQ16148.2
Z96102, Z81027 Genomic DNA Translation: CBL43447.1
Z96102, Z81027 Genomic DNA Translation: CBO24859.1
Z96102 Genomic DNA Translation: CBW44387.1
Z96102 Genomic DNA Translation: CBW44388.1
Z96102 Genomic DNA Translation: CBW48399.1
Z96102 Genomic DNA Translation: CCE71393.1
Z96102, Z81027 Genomic DNA Translation: CCE71394.1
Z96102, Z81027 Genomic DNA Translation: CCW45975.1

Protein sequence database of the Protein Information Resource

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PIRi
T18611

NCBI Reference Sequences

More...
RefSeqi
NP_001024018.1, NM_001028847.2 [Q9TW45-1]
NP_001024019.1, NM_001028848.2 [Q9TW45-2]
NP_001041145.1, NM_001047680.2 [Q9TW45-3]
NP_001122967.2, NM_001129495.2 [Q9TW45-4]
NP_001256559.1, NM_001269630.1 [Q9TW45-6]
NP_001256560.1, NM_001269631.1 [Q9TW45-10]
NP_001256561.1, NM_001269632.1 [Q9TW45-7]
NP_001256562.1, NM_001269633.1 [Q9TW45-8]
NP_001256563.1, NM_001269634.1 [Q9TW45-11]
NP_001256564.1, NM_001269635.1 [Q9TW45-9]
NP_001256565.1, NM_001269636.1 [Q9TW45-5]
NP_001294690.1, NM_001307761.1 [Q9TW45-12]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Cel.6280

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
H39E23.1a; H39E23.1a; WBGene00003916 [Q9TW45-1]
H39E23.1b; H39E23.1b; WBGene00003916 [Q9TW45-2]
H39E23.1c; H39E23.1c; WBGene00003916 [Q9TW45-3]
H39E23.1d; H39E23.1d; WBGene00003916 [Q9TW45-4]
H39E23.1e.1; H39E23.1e.1; WBGene00003916 [Q9TW45-5]
H39E23.1e.2; H39E23.1e.2; WBGene00003916 [Q9TW45-5]
H39E23.1e.3; H39E23.1e.3; WBGene00003916 [Q9TW45-5]
H39E23.1e.4; H39E23.1e.4; WBGene00003916 [Q9TW45-5]
H39E23.1e.5; H39E23.1e.5; WBGene00003916 [Q9TW45-5]
H39E23.1f.1; H39E23.1f.1; WBGene00003916 [Q9TW45-6]
H39E23.1f.2; H39E23.1f.2; WBGene00003916 [Q9TW45-6]
H39E23.1g; H39E23.1g; WBGene00003916 [Q9TW45-7]
H39E23.1h.1; H39E23.1h.1; WBGene00003916 [Q9TW45-8]
H39E23.1h.2; H39E23.1h.2; WBGene00003916 [Q9TW45-8]
H39E23.1i; H39E23.1i; WBGene00003916 [Q9TW45-9]
H39E23.1j; H39E23.1j; WBGene00003916 [Q9TW45-10]
H39E23.1k.1; H39E23.1k.1; WBGene00003916 [Q9TW45-11]
H39E23.1k.2; H39E23.1k.2; WBGene00003916 [Q9TW45-11]
H39E23.1k.3; H39E23.1k.3; WBGene00003916 [Q9TW45-11]
H39E23.1l; H39E23.1l; WBGene00003916 [Q9TW45-12]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
179912

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_H39E23.1

UCSC genome browser

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UCSCi
H39E23.1b c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22183 mRNA Translation: AAA97437.1
U40858 mRNA Translation: AAA83272.1
Z96102, Z81027 Genomic DNA Translation: CAB54262.2
Z96102, Z81027 Genomic DNA Translation: CAB54263.1
Z96102, Z81027 Genomic DNA Translation: CAJ85756.1
Z96102, Z81027 Genomic DNA Translation: CAQ16148.2
Z96102, Z81027 Genomic DNA Translation: CBL43447.1
Z96102, Z81027 Genomic DNA Translation: CBO24859.1
Z96102 Genomic DNA Translation: CBW44387.1
Z96102 Genomic DNA Translation: CBW44388.1
Z96102 Genomic DNA Translation: CBW48399.1
Z96102 Genomic DNA Translation: CCE71393.1
Z96102, Z81027 Genomic DNA Translation: CCE71394.1
Z96102, Z81027 Genomic DNA Translation: CCW45975.1
PIRiT18611
RefSeqiNP_001024018.1, NM_001028847.2 [Q9TW45-1]
NP_001024019.1, NM_001028848.2 [Q9TW45-2]
NP_001041145.1, NM_001047680.2 [Q9TW45-3]
NP_001122967.2, NM_001129495.2 [Q9TW45-4]
NP_001256559.1, NM_001269630.1 [Q9TW45-6]
NP_001256560.1, NM_001269631.1 [Q9TW45-10]
NP_001256561.1, NM_001269632.1 [Q9TW45-7]
NP_001256562.1, NM_001269633.1 [Q9TW45-8]
NP_001256563.1, NM_001269634.1 [Q9TW45-11]
NP_001256564.1, NM_001269635.1 [Q9TW45-9]
NP_001256565.1, NM_001269636.1 [Q9TW45-5]
NP_001294690.1, NM_001307761.1 [Q9TW45-12]
UniGeneiCel.6280

3D structure databases

ProteinModelPortaliQ9TW45
SMRiQ9TW45
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9TW45, 2 interactors
STRINGi6239.H39E23.1d

PTM databases

iPTMnetiQ9TW45

Proteomic databases

EPDiQ9TW45
PaxDbiQ9TW45
PeptideAtlasiQ9TW45
PRIDEiQ9TW45

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiH39E23.1a; H39E23.1a; WBGene00003916 [Q9TW45-1]
H39E23.1b; H39E23.1b; WBGene00003916 [Q9TW45-2]
H39E23.1c; H39E23.1c; WBGene00003916 [Q9TW45-3]
H39E23.1d; H39E23.1d; WBGene00003916 [Q9TW45-4]
H39E23.1e.1; H39E23.1e.1; WBGene00003916 [Q9TW45-5]
H39E23.1e.2; H39E23.1e.2; WBGene00003916 [Q9TW45-5]
H39E23.1e.3; H39E23.1e.3; WBGene00003916 [Q9TW45-5]
H39E23.1e.4; H39E23.1e.4; WBGene00003916 [Q9TW45-5]
H39E23.1e.5; H39E23.1e.5; WBGene00003916 [Q9TW45-5]
H39E23.1f.1; H39E23.1f.1; WBGene00003916 [Q9TW45-6]
H39E23.1f.2; H39E23.1f.2; WBGene00003916 [Q9TW45-6]
H39E23.1g; H39E23.1g; WBGene00003916 [Q9TW45-7]
H39E23.1h.1; H39E23.1h.1; WBGene00003916 [Q9TW45-8]
H39E23.1h.2; H39E23.1h.2; WBGene00003916 [Q9TW45-8]
H39E23.1i; H39E23.1i; WBGene00003916 [Q9TW45-9]
H39E23.1j; H39E23.1j; WBGene00003916 [Q9TW45-10]
H39E23.1k.1; H39E23.1k.1; WBGene00003916 [Q9TW45-11]
H39E23.1k.2; H39E23.1k.2; WBGene00003916 [Q9TW45-11]
H39E23.1k.3; H39E23.1k.3; WBGene00003916 [Q9TW45-11]
H39E23.1l; H39E23.1l; WBGene00003916 [Q9TW45-12]
GeneIDi179912
KEGGicel:CELE_H39E23.1
UCSCiH39E23.1b c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2768852
WormBaseiH39E23.1a ; CE23838 ; WBGene00003916 ; par-1
H39E23.1b ; CE27768 ; WBGene00003916 ; par-1
H39E23.1c ; CE40085 ; WBGene00003916 ; par-1
H39E23.1d ; CE44808 ; WBGene00003916 ; par-1
H39E23.1e ; CE44733 ; WBGene00003916 ; par-1
H39E23.1f ; CE45159 ; WBGene00003916 ; par-1
H39E23.1g ; CE45263 ; WBGene00003916 ; par-1
H39E23.1h ; CE45267 ; WBGene00003916 ; par-1
H39E23.1i ; CE45299 ; WBGene00003916 ; par-1
H39E23.1j ; CE46555 ; WBGene00003916 ; par-1
H39E23.1k ; CE46628 ; WBGene00003916 ; par-1
H39E23.1l ; CE48381 ; WBGene00003916 ; par-1

Phylogenomic databases

eggNOGiKOG0586 Eukaryota
ENOG410XNQ0 LUCA
GeneTreeiENSGT00940000160886
HOGENOMiHOG000233025
InParanoidiQ9TW45
KOiK08798
OMAiHVGPSIP
OrthoDBi1127668at2759
PhylomeDBiQ9TW45

Enzyme and pathway databases

SignaLinkiQ9TW45

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9TW45

Gene expression databases

BgeeiWBGene00003916 Expressed in 5 organ(s), highest expression level in pharyngeal muscle cell (C elegans)
ExpressionAtlasiQ9TW45 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR028375 KA1/Ssp2_C
IPR001772 KA1_dom
IPR011009 Kinase-like_dom_sf
IPR033624 MARK/par1
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR015940 UBA
PANTHERiPTHR24346 PTHR24346, 2 hits
PfamiView protein in Pfam
PF02149 KA1, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF103243 SSF103243, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50032 KA1, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50030 UBA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAR1_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9TW45
Secondary accession number(s): B1Q266
, E0AHE2, E0AHE3, E1B6W1, G5EE60, G5EE76, H2L2K6, H2L2K7, N1NTJ6, Q17346, Q17368, Q1ZXR3, Q9TVG6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 1, 2000
Last modified: February 13, 2019
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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