UniProtKB - Q9TVC8 (HB21_BOVIN)
Protein
BoLa class II histocompatibility antigen, DQB*0101 beta chain
Gene
BoLA-DQB
Organism
Bos taurus (Bovine)
Status
Functioni
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
Keywordsi
Biological process | Adaptive immunity, Immunity |
Names & Taxonomyi
Protein namesi | Recommended name: BoLa class II histocompatibility antigen, DQB*0101 beta chainShort name: DQB1*1A |
Gene namesi | Name:BoLA-DQBImported Synonyms:DQB1Imported |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Other locations
- Membrane Sequence analysis; Single-pass type I membrane protein Curated
Plasma Membrane
- MHC class II protein complex Source: UniProtKB-KW
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 33 – 230 | ExtracellularSequence analysisAdd BLAST | 198 | |
Transmembranei | 231 – 251 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 252 – 261 | CytoplasmicSequence analysis | 10 |
Keywords - Cellular componenti
Membrane, MHC IIPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 32 | Sequence analysisAdd BLAST | 32 | |
ChainiPRO_5000147334 | 33 – 261 | BoLa class II histocompatibility antigen, DQB*0101 beta chainAdd BLAST | 229 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 47 ↔ 111 | PROSITE-ProRule annotationBy similarity | ||
Glycosylationi | 51 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 149 ↔ 205 | PROSITE-ProRule annotationBy similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PRIDEi | Q9TVC8 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 129 – 233 | Ig-like C1-typeSequence analysisAdd BLAST | 105 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 33 – 126 | Beta-1Sequence analysisAdd BLAST | 94 | |
Regioni | 127 – 220 | Beta-2Sequence analysisAdd BLAST | 94 | |
Regioni | 221 – 230 | Connecting peptideSequence analysis | 10 |
Sequence similaritiesi
Belongs to the MHC class II family.Sequence analysis
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RYBQ, Eukaryota |
InParanoidi | Q9TVC8 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR000353, MHC_II_b_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00969, MHC_II_beta, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00921, MHC_II_beta, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9TVC8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGMVALWIP RGLWTAVVMV TLVMLSTPGA EGRDSPKDFV YQFKGLCYFT
60 70 80 90 100
NGTERVRYVT RYIYNQEENV RFDSDWDEYR AVTPLGRPDA EYFNSQKDFL
110 120 130 140 150
EQTRAEADTV CRHNYQVEAP FTWQRQVEPT VTIFLSRTEA LNHHNLLVCS
160 170 180 190 200
VTDFYPGQIK VRWFRNDQEE TAGVVATPLI RNGDWTFQLF MMLEMTPQRG
210 220 230 240 250
DVYTCRVEHP SLQSPIMVEW RAQSESAQSK MLSGIGGFVL GLIFLGLGLI
260
VHHRSQKGLM R
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y18201 mRNA Translation: CAA77078.1 S83910 Genomic DNA Translation: AAB21511.1 |
PIRi | I47060 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y18201 mRNA Translation: CAA77078.1 S83910 Genomic DNA Translation: AAB21511.1 |
PIRi | I47060 |
3D structure databases
SMRi | Q9TVC8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000026100 |
Proteomic databases
PRIDEi | Q9TVC8 |
Phylogenomic databases
eggNOGi | ENOG502RYBQ, Eukaryota |
InParanoidi | Q9TVC8 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR000353, MHC_II_b_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00969, MHC_II_beta, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00921, MHC_II_beta, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HB21_BOVIN | |
Accessioni | Q9TVC8Primary (citable) accession number: Q9TVC8 Secondary accession number(s): O77825, Q95541 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | May 1, 2000 | |
Last modified: | August 12, 2020 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families