UniProtKB - Q9TV98 (ESR1_HORSE)
Estrogen receptor
ESR1
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 185 – 250 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 66 | |
Zinc fingeri | 185 – 205 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 221 – 245 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- estrogen receptor activity Source: InterPro
- nuclear receptor activity Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: UniProtKB
- steroid binding Source: UniProtKB
- zinc ion binding Source: InterPro
GO - Biological processi
- cellular response to estradiol stimulus Source: UniProtKB
- intracellular steroid hormone receptor signaling pathway Source: UniProtKB
- negative regulation of DNA-binding transcription factor activity Source: UniProtKB
- negative regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: UniProtKB
- positive regulation of cytosolic calcium ion concentration Source: UniProtKB
- positive regulation of DNA-binding transcription factor activity Source: UniProtKB
- positive regulation of nitric oxide biosynthetic process Source: UniProtKB
- positive regulation of nitric-oxide synthase activity Source: UniProtKB
- positive regulation of phospholipase C activity Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Lipid-binding, Metal-binding, Steroid-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Estrogen receptorShort name: ER Alternative name(s): ER-alpha Estradiol receptor Nuclear receptor subfamily 3 group A member 1 |
Gene namesi | Name:ESR1 Synonyms:ESR, NR3A1 |
Organismi | Equus caballus (Horse) |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Subcellular locationi
Golgi apparatus
- Golgi apparatus By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Plasma membrane
- Cell membrane By similarity
Nucleus
- Nucleus PROSITE-ProRule annotation
Note: Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated.By similarity
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Golgi apparatus, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053617 | 1 – 594 | Estrogen receptorAdd BLAST | 594 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 10 | O-linked (GlcNAc) serineBy similarity | 1 | |
Modified residuei | 104 | Phosphoserine; by CDK2By similarity | 1 | |
Modified residuei | 106 | Phosphoserine; by CDK2By similarity | 1 | |
Modified residuei | 118 | PhosphoserineBy similarity | 1 | |
Modified residuei | 167 | Phosphoserine; by CK2By similarity | 1 | |
Modified residuei | 260 | Asymmetric dimethylarginine; by PRMT1By similarity | 1 | |
Lipidationi | 447 | S-palmitoyl cysteineBy similarity | 1 | |
Modified residuei | 536 | Phosphotyrosine; by Tyr-kinasesBy similarity | 1 | |
Glycosylationi | 570 | O-linked (GlcNAc) threonineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, Lipoprotein, Methylation, Palmitate, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q9TV98 |
Interactioni
Subunit structurei
Binds DNA as a homodimer. Can form a heterodimer with ESR2.
Interacts with coactivator NCOA5.
Interacts with NCOA7; the interaction is ligand-inducible.
Interacts with AKAP13, CUEDC2, HEXIM1, KDM5A, MAP1S, PELP1, SMARD1, and UBE1C.
Interacts with MUC1; the interaction is stimulated by 7 beta-estradiol (E2) and enhances ERS1-mediated transcription.
Interacts with DNTTIP2, and UIMC1.
Interacts with KMT2D/MLL2.
Interacts with ATAD2; the interaction is enhanced by estradiol.
Interacts with KIF18A and LDB1.
Interacts with RLIM (via its C-terminus).
Interacts with MACROD1.
Interacts with SH2D4A and PLCG.
Interacts with SH2D4A; the interaction blocks binding to PLCG and inhibits estrogen-induced cell proliferation.
Interacts with DYNLL1.
Interacts with CCDC62; the interaction requires estradiol and appears to enhance the transcription of target genes.
Interacts with NR2C1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth.
Interacts with DNAAF4.
Interacts with PRMT2.
Interacts with PI3KR1 or PIK3R2, SRC and PTK2/FAK1.
Interacts with RBFOX2.
Interacts with EP300; the interaction is estrogen-dependent and enhanced by CITED1.
Interacts with CITED1; the interaction is estrogen-dependent.
Interacts with FAM120B, FOXL2, PHB2 and SLC30A9.
Interacts with coactivators NCOA3 and NCOA6.
Interacts with STK3/MST2 only in the presence of SAV1 and vice-versa. Binds to CSNK1D.
Interacts with NCOA2; NCOA2 can interact with ESR1 AF-1 and AF-2 domains simultaneously and mediate their transcriptional synergy.
Interacts with DDX5.
Interacts with NCOA1; the interaction seems to require a self-association of N-terminal and C-terminal regions.
Interacts with ZNF366, DDX17, NFKB1, RELA, SP1 and SP3.
Interacts with NRIP1.
Interacts with GPER1; the interaction occurs in an estrogen-dependent manner.
Interacts with CLOCK and the interaction is stimulated by estrogen.
Interacts with TRIP4 (ufmylated); estrogen dependent.
Interacts with LMTK3; the interaction phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation.
Interacts with CCAR2 (via N-terminus) in a ligand-independent manner.
Interacts with ZFHX3.
Interacts with SFR1 in a ligand-dependent and -independent manner.
Interacts with DCAF13, LATS1 and DCAF1; regulates ESR1 ubiquitination and ubiquitin-mediated proteasomal degradation.
Interacts (via DNA-binding domain) with POU4F2 (C-terminus); this interaction increases the estrogen receptor ESR1 transcriptional activity in a DNA- and ligand 17-beta-estradiol-independent manner.
Interacts with ESRRB isoform 1.
Interacts with UBE3A and WBP2.
Interacts with GTF2B.
Interacts with RBM39. In the absence of hormonal ligand, interacts with TACC1 (By similarity).
By similarityFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 311 – 546 | NR LBDPROSITE-ProRule annotationAdd BLAST | 236 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 184 | Modulating (transactivation AF-1); mediates interaction with MACROD1By similarityAdd BLAST | 184 | |
Regioni | 35 – 174 | Interaction with DDX5; self-associationBy similarityAdd BLAST | 140 | |
Regioni | 35 – 47 | Required for interaction with NCOA1By similarityAdd BLAST | 13 | |
Regioni | 185 – 310 | Mediates interaction with DNTTIP2By similarityAdd BLAST | 126 | |
Regioni | 251 – 310 | HingeAdd BLAST | 60 | |
Regioni | 262 – 594 | Interaction with AKAP13By similarityAdd BLAST | 333 | |
Regioni | 264 – 594 | Self-associationBy similarityAdd BLAST | 331 | |
Regioni | 311 – 594 | Transactivation AF-2By similarityAdd BLAST | 284 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 64 – 70 | Poly-Ala | 7 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 185 – 205 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 221 – 245 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
InParanoidi | Q9TV98 |
OrthoDBi | 487299at2759 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR024178, Oest_rcpt/oest-rel_rcp IPR001292, Oestr_rcpt IPR024736, Oestrogen-typ_rcpt_final_C_dom IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF12743, ESR1_C, 1 hit PF00104, Hormone_recep, 1 hit PF02159, Oest_recep, 1 hit PF00105, zf-C4, 1 hit |
PIRSFi | PIRSF500101, ER-a, 1 hit PIRSF002527, ER-like_NR, 1 hit |
PRINTSi | PR00543, OESTROGENR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MTMTLHTKAS GMALLHQIQG NELETLNLPQ FKIPLERPLG EVYVESSKPP
60 70 80 90 100
VYDYPEGAAY DFNAAAAASA SVYGQSGLAY GPGSEAAAFG ANGLGGFPPL
110 120 130 140 150
NSVSPSQLML LHPPPQLSPY LHPPGQQVPY YLENEPSGYS VCEAGPQAFY
160 170 180 190 200
RPNADNRRQG GRERLASSGD KGSMAMESAK ETRYCAVCND YASGYHYGVW
210 220 230 240 250
SCEGCKAFFK RSIQGHNDYM CPATNQCTID KNRRKSCQAC RLRKCYEVGM
260 270 280 290 300
MKGGIRKDRR GGRMLKHKRQ RDDGEGRNEA GPSGDRRPAN FWPSPLLIKH
310 320 330 340 350
TKKISPVLSL TAEQMISALL DAEPPVLYSE YDATRPFNEA SMMGLLTNLA
360 370 380 390 400
DRELVHMINW AKRVPGFVDL SLHDQVHLLE CAWLEILMIG LVWRSMEHPG
410 420 430 440 450
KLLFAPNLLL DRNQGKCVEG MVEIFDMLLA TSSRLRMMNL QGEEFVCLKS
460 470 480 490 500
IILLNSGVYT FLSSTLKSLE EKDHIHRVLD KMTDTLIHLM AKAGLTLQQH
510 520 530 540 550
RRLAQLLLIL SHIRHMSNKG MEHLYSMKCK NVVPLYDLLL EMLDAHRLHA
560 570 580 590
PANHGGAPME ETNQSQLATT GSTSPHSMQT YYITGEAEGF PNTI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF124093 mRNA Translation: AAD17316.1 |
RefSeqi | NP_001075241.1, NM_001081772.1 |
Genome annotation databases
GeneIDi | 791249 |
KEGGi | ecb:791249 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF124093 mRNA Translation: AAD17316.1 |
RefSeqi | NP_001075241.1, NM_001081772.1 |
3D structure databases
SMRi | Q9TV98 |
ModBasei | Search... |
Proteomic databases
PaxDbi | Q9TV98 |
Genome annotation databases
GeneIDi | 791249 |
KEGGi | ecb:791249 |
Organism-specific databases
CTDi | 2099 |
Phylogenomic databases
InParanoidi | Q9TV98 |
OrthoDBi | 487299at2759 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR024178, Oest_rcpt/oest-rel_rcp IPR001292, Oestr_rcpt IPR024736, Oestrogen-typ_rcpt_final_C_dom IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF12743, ESR1_C, 1 hit PF00104, Hormone_recep, 1 hit PF02159, Oest_recep, 1 hit PF00105, zf-C4, 1 hit |
PIRSFi | PIRSF500101, ER-a, 1 hit PIRSF002527, ER-like_NR, 1 hit |
PRINTSi | PR00543, OESTROGENR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ESR1_HORSE | |
Accessioni | Q9TV98Primary (citable) accession number: Q9TV98 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | May 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families