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Protein

Metallothionein-4

Gene

MT4

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6Divalent metal cation; cluster BBy similarity1
Metal bindingi8Divalent metal cation; cluster BBy similarity1
Metal bindingi14Divalent metal cation; cluster BBy similarity1
Metal bindingi16Divalent metal cation; cluster BBy similarity1
Metal bindingi20Divalent metal cation; cluster BBy similarity1
Metal bindingi22Divalent metal cation; cluster BBy similarity1
Metal bindingi25Divalent metal cation; cluster BBy similarity1
Metal bindingi27Divalent metal cation; cluster BBy similarity1
Metal bindingi30Divalent metal cation; cluster BBy similarity1
Metal bindingi34Divalent metal cation; cluster ABy similarity1
Metal bindingi35Divalent metal cation; cluster ABy similarity1
Metal bindingi37Divalent metal cation; cluster ABy similarity1
Metal bindingi38Divalent metal cation; cluster ABy similarity1
Metal bindingi42Divalent metal cation; cluster ABy similarity1
Metal bindingi45Divalent metal cation; cluster ABy similarity1
Metal bindingi49Divalent metal cation; cluster ABy similarity1
Metal bindingi51Divalent metal cation; cluster ABy similarity1
Metal bindingi58Divalent metal cation; cluster ABy similarity1
Metal bindingi60Divalent metal cation; cluster ABy similarity1
Metal bindingi61Divalent metal cation; cluster ABy similarity1

GO - Molecular functioni

  • metal ion binding Source: GO_Central

GO - Biological processi

Keywordsi

LigandCopper, Metal-binding, Metal-thiolate cluster, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-4
Short name:
MT-4
Alternative name(s):
Metallothionein-IV
Short name:
MT-IV
Gene namesi
Name:MT4
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 2

Organism-specific databases

VGNCiVGNC:52145 MT4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972541 – 62Metallothionein-4Add BLAST62

Proteomic databases

PaxDbiQ9TUI5
PRIDEiQ9TUI5

Expressioni

Gene expression databases

BgeeiENSCAFG00000009118 Expressed in 2 organ(s), highest expression level in adult mammalian kidney

Structurei

3D structure databases

ProteinModelPortaliQ9TUI5
SMRiQ9TUI5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J3IA Eukaryota
ENOG4111C2K LUCA
GeneTreeiENSGT00730000111475
HOGENOMiHOG000236262
InParanoidiQ9TUI5
KOiK14741
OMAiTCMSGGT
TreeFamiTF336054

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9TUI5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPGECTCMS GGICICGDNC KCTTCNCKTC RKSCCPCCPP GCAKCAQGCI
60
CKGGSDKCSC CA
Length:62
Mass (Da):6,249
Last modified:May 1, 2000 - v1
Checksum:i2858DA6D17AA3DC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028041 mRNA Translation: BAA87326.1
RefSeqiNP_001003150.1, NM_001003150.1
UniGeneiCfa.3632

Genome annotation databases

EnsembliENSCAFT00000014504; ENSCAFP00000013416; ENSCAFG00000009118
GeneIDi403769
KEGGicfa:403769

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028041 mRNA Translation: BAA87326.1
RefSeqiNP_001003150.1, NM_001003150.1
UniGeneiCfa.3632

3D structure databases

ProteinModelPortaliQ9TUI5
SMRiQ9TUI5
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ9TUI5
PRIDEiQ9TUI5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000014504; ENSCAFP00000013416; ENSCAFG00000009118
GeneIDi403769
KEGGicfa:403769

Organism-specific databases

CTDi84560
VGNCiVGNC:52145 MT4

Phylogenomic databases

eggNOGiENOG410J3IA Eukaryota
ENOG4111C2K LUCA
GeneTreeiENSGT00730000111475
HOGENOMiHOG000236262
InParanoidiQ9TUI5
KOiK14741
OMAiTCMSGGT
TreeFamiTF336054

Gene expression databases

BgeeiENSCAFG00000009118 Expressed in 2 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMT4_CANLF
AccessioniPrimary (citable) accession number: Q9TUI5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Metallothioneins
    Classification of metallothioneins and list of entries
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