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Protein

Eukaryotic translation initiation factor 6

Gene

EIF6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (By similarity). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (By similarity). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity).UniRule annotationBy similarity

GO - Molecular functioni

  • ribosomal large subunit binding Source: GO_Central
  • ribosome binding Source: InterPro
  • translation initiation factor activity Source: UniProtKB-UniRule

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Alternative name(s):
Imc-415 homolog
Gene namesi
Name:EIF6UniRule annotation
Synonyms:ITGB4BPUniRule annotation
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Organism-specific databases

VGNCiVGNC:57006 EIF6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002594261 – 245Eukaryotic translation initiation factor 6Add BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei113PhosphotyrosineBy similarity1
Modified residuei165PhosphothreonineUniRule annotationBy similarity1
Modified residuei166PhosphoserineUniRule annotationBy similarity1
Modified residuei174Phosphoserine; by CK1UniRule annotationBy similarity1
Modified residuei175Phosphoserine; by CK1UniRule annotationBy similarity1
Modified residuei235Phosphoserine; by PKCUniRule annotationBy similarity1
Modified residuei239PhosphoserineUniRule annotationBy similarity1
Modified residuei243PhosphoserineUniRule annotationBy similarity1

Post-translational modificationi

Phosphorylation at Ser-174 and Ser-175 by CSNK1D/CK1 promotes nuclear export.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9TU47
PRIDEiQ9TU47

Expressioni

Gene expression databases

BgeeiENSBTAG00000011263 Expressed in 9 organ(s), highest expression level in adult mammalian kidney

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1 (By similarity). Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC) (By similarity).UniRule annotationBy similarity

Protein-protein interaction databases

IntActiQ9TU47, 2 interactors
STRINGi9913.ENSBTAP00000014966

Structurei

3D structure databases

ProteinModelPortaliQ9TU47
SMRiQ9TU47
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3185 Eukaryota
COG1976 LUCA
GeneTreeiENSGT00390000015972
HOGENOMiHOG000230605
HOVERGENiHBG001300
InParanoidiQ9TU47
KOiK03264
OMAiNDWCAFT
OrthoDBiEOG091G0HYF
TreeFamiTF105396

Family and domain databases

CDDicd00527 IF6, 1 hit
HAMAPiMF_00032 eIF_6, 1 hit
InterProiView protein in InterPro
IPR002769 eIF6
PANTHERiPTHR10784 PTHR10784, 1 hit
PfamiView protein in Pfam
PF01912 eIF-6, 1 hit
PIRSFiPIRSF006413 IF-6, 1 hit
SMARTiView protein in SMART
SM00654 eIF6, 1 hit
TIGRFAMsiTIGR00323 eIF-6, 1 hit

Sequencei

Sequence statusi: Complete.

Q9TU47-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVRASFENN CEIGCFAKLT NSYCLVAIGG SENFYSVFEG ELAGTIPVVH
60 70 80 90 100
ASIAGCRIIG RMCVGNRHGL LVPNNTTDQE LQHIRNCLPD SVQIRRVEER
110 120 130 140 150
LSALGNVTTC NDYVALVHPD LDRETEEILA DVLKVEVFRQ TVADQVLVGS
160 170 180 190 200
YCVFSNQGGL VHPKTSIEDQ DELSSLLQVP LVAGTVNRGS EVIAAGMVVN
210 220 230 240
DWCAFCGLDT TSTELSVVES VFKLNEAQPS TIATSMRDSL IDSLT
Length:245
Mass (Da):26,513
Last modified:October 31, 2006 - v2
Checksum:iC62D76AD25402243
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti141T → K in AAF00595 (PubMed:10879479).Curated1
Sequence conflicti198V → A in AAF00595 (PubMed:10879479).Curated1
Sequence conflicti210T → A in AAF00595 (PubMed:10879479).Curated1
Sequence conflicti222 – 224FKL → SKP in AAF00595 (PubMed:10879479).Curated3
Sequence conflicti241I → T in AAF00595 (PubMed:10879479).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF141872 mRNA Translation: AAF00595.1
BC109922 mRNA Translation: AAI09923.1
PIRiJC7273
RefSeqiNP_777255.1, NM_174830.1
XP_005214560.1, XM_005214503.3
UniGeneiBt.4426

Genome annotation databases

EnsembliENSBTAT00000014966; ENSBTAP00000014966; ENSBTAG00000011263
GeneIDi286811
KEGGibta:286811

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF141872 mRNA Translation: AAF00595.1
BC109922 mRNA Translation: AAI09923.1
PIRiJC7273
RefSeqiNP_777255.1, NM_174830.1
XP_005214560.1, XM_005214503.3
UniGeneiBt.4426

3D structure databases

ProteinModelPortaliQ9TU47
SMRiQ9TU47
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9TU47, 2 interactors
STRINGi9913.ENSBTAP00000014966

Proteomic databases

PaxDbiQ9TU47
PRIDEiQ9TU47

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000014966; ENSBTAP00000014966; ENSBTAG00000011263
GeneIDi286811
KEGGibta:286811

Organism-specific databases

CTDi3692
VGNCiVGNC:57006 EIF6

Phylogenomic databases

eggNOGiKOG3185 Eukaryota
COG1976 LUCA
GeneTreeiENSGT00390000015972
HOGENOMiHOG000230605
HOVERGENiHBG001300
InParanoidiQ9TU47
KOiK03264
OMAiNDWCAFT
OrthoDBiEOG091G0HYF
TreeFamiTF105396

Gene expression databases

BgeeiENSBTAG00000011263 Expressed in 9 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

CDDicd00527 IF6, 1 hit
HAMAPiMF_00032 eIF_6, 1 hit
InterProiView protein in InterPro
IPR002769 eIF6
PANTHERiPTHR10784 PTHR10784, 1 hit
PfamiView protein in Pfam
PF01912 eIF-6, 1 hit
PIRSFiPIRSF006413 IF-6, 1 hit
SMARTiView protein in SMART
SM00654 eIF6, 1 hit
TIGRFAMsiTIGR00323 eIF-6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIF6_BOVIN
AccessioniPrimary (citable) accession number: Q9TU47
Secondary accession number(s): Q2TBM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 7, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Translation initiation factors
    List of translation initiation factor entries
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Main funding by: National Institutes of Health

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