EIF6

Functionⁱ

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (By similarity). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (By similarity). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity).UniRule annotationBy similarity

GO - Molecular functionⁱ

ribosomal large subunit binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ribosome binding Source: InterPro
translation initiation factor activity Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

assembly of large subunit precursor of preribosome
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
gene silencing by miRNA Source: UniProtKB
mature ribosome assembly Source: UniProtKB-UniRule
miRNA mediated inhibition of translation Source: UniProtKB
positive regulation of translation Source: UniProtKB
regulation of fatty acid biosynthetic process Source: UniProtKB
regulation of glycolytic process Source: UniProtKB
regulation of megakaryocyte differentiation Source: UniProtKB
regulation of reactive oxygen species metabolic process Source: UniProtKB
response to insulin Source: UniProtKB
ribosomal large subunit biogenesis Source: UniProtKB-UniRule
ribosomal subunit export from nucleus
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Initiation factor
Biological process	Protein biosynthesis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Eukaryotic translation initiation factor 6UniRule annotation Short name: eIF-6UniRule annotation Alternative name(s): Imc-415 homolog
Gene namesⁱ	Name:EIF6UniRule annotation Synonyms:ITGB4BPUniRule annotation
Organismⁱ	Bos taurus (Bovine)
Taxonomic identifierⁱ	9913 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesⁱ	UP000009136 Componentⁱ: Chromosome 13

Organism-specific databases

VGNCⁱ	VGNC:57006 EIF6

VGNCⁱ

VGNC:57006 EIF6

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000259426	1 – 245	Eukaryotic translation initiation factor 6Add BLAST		245

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	113	PhosphotyrosineBy similarity	1
Modified residueⁱ	165	PhosphothreonineUniRule annotationBy similarity	1
Modified residueⁱ	166	PhosphoserineUniRule annotationBy similarity	1
Modified residueⁱ	174	Phosphoserine; by CK1UniRule annotationBy similarity	1
Modified residueⁱ	175	Phosphoserine; by CK1UniRule annotationBy similarity	1
Modified residueⁱ	235	Phosphoserine; by PKCUniRule annotationBy similarity	1
Modified residueⁱ	239	PhosphoserineUniRule annotationBy similarity	1
Modified residueⁱ	243	PhosphoserineUniRule annotationBy similarity	1

Post-translational modificationⁱ

Phosphorylation at Ser-174 and Ser-175 by CSNK1D/CK1 promotes nuclear export.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q9TU47
PRIDEⁱ	Q9TU47

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSBTAG00000011263 Expressed in 9 organ(s), highest expression level in adult mammalian kidney

Bgeeⁱ

ENSBTAG00000011263 Expressed in 9 organ(s), highest expression level in adult mammalian kidney

Interactionⁱ

Subunit structureⁱ

Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1 (By similarity). Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC) (By similarity).UniRule annotationBy similarity

Protein-protein interaction databases

IntActⁱ	Q9TU47, 2 interactors
STRINGⁱ	9913.ENSBTAP00000014966

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9TU47
SMRⁱ	Q9TU47
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG3185 Eukaryota COG1976 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015972
HOGENOMⁱ	HOG000230605
HOVERGENⁱ	HBG001300
InParanoidⁱ	Q9TU47
KEGG Orthology (KO) More...KOⁱ	K03264
OMAⁱ	NDWCAFT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HYF
TreeFamⁱ	TF105396

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00527 IF6, 1 hit
HAMAPⁱ	MF_00032 eIF_6, 1 hit
InterProⁱ	View protein in InterPro IPR002769 eIF6
PANTHERⁱ	PTHR10784 PTHR10784, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01912 eIF-6, 1 hit
PIRSFⁱ	PIRSF006413 IF-6, 1 hit
SMARTⁱ	View protein in SMART SM00654 eIF6, 1 hit
TIGRFAMsⁱ	TIGR00323 eIF-6, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9TU47-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAVRASFENN CEIGCFAKLT NSYCLVAIGG SENFYSVFEG ELAGTIPVVH 
        60         70         80         90        100
ASIAGCRIIG RMCVGNRHGL LVPNNTTDQE LQHIRNCLPD SVQIRRVEER 
       110        120        130        140        150
LSALGNVTTC NDYVALVHPD LDRETEEILA DVLKVEVFRQ TVADQVLVGS 
       160        170        180        190        200
YCVFSNQGGL VHPKTSIEDQ DELSSLLQVP LVAGTVNRGS EVIAAGMVVN 
       210        220        230        240 
DWCAFCGLDT TSTELSVVES VFKLNEAQPS TIATSMRDSL IDSLT

Length:245

Mass (Da):26,513

Last modified:October 31, 2006 - v2

Checksum:ⁱC62D76AD25402243

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	141	T → K in AAF00595 (PubMed:10879479).Curated	1
Sequence conflictⁱ	198	V → A in AAF00595 (PubMed:10879479).Curated	1
Sequence conflictⁱ	210	T → A in AAF00595 (PubMed:10879479).Curated	1
Sequence conflictⁱ	222 – 224	FKL → SKP in AAF00595 (PubMed:10879479).Curated	3
Sequence conflictⁱ	241	I → T in AAF00595 (PubMed:10879479).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF141872 mRNA Translation: AAF00595.1 BC109922 mRNA Translation: AAI09923.1
PIRⁱ	JC7273
NCBI Reference Sequences More...RefSeqⁱ	NP_777255.1, NM_174830.1 XP_005214560.1, XM_005214503.3
UniGeneⁱ	Bt.4426

Genome annotation databases

Ensemblⁱ	ENSBTAT00000014966; ENSBTAP00000014966; ENSBTAG00000011263
GeneIDⁱ	286811
KEGGⁱ	bta:286811

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9TU47	Eukaryotic translation initiation factor 6		SHEEP		245	UniRef100_Q9TU47

Protein	Similar proteins		Species	Score	Length	Source
Q9TU47	Eukaryotic translation initiation factor 6		HUMAN		245	UniRef90_P56537
Eukaryotic translation initiation factor 6		XENLA		245
Eukaryotic translation initiation factor 6		DANRE		245
Eukaryotic translation initiation factor 6		RAT		245
Eukaryotic translation initiation factor 6		PANTR		245
+159

Protein	Similar proteins		Species	Score	Length	Source
Q9TU47	Eukaryotic translation initiation factor 6		HUMAN		245	UniRef50_P56537
Eukaryotic translation initiation factor 6		DANRE		245
Eukaryotic translation initiation factor 6		XENLA		245
Eukaryotic translation initiation factor 6		RAT		245
Eukaryotic translation initiation factor 6		TOXGV		264
+641

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF141872 mRNA Translation: AAF00595.1 BC109922 mRNA Translation: AAI09923.1
PIRⁱ	JC7273
RefSeqⁱ	NP_777255.1, NM_174830.1 XP_005214560.1, XM_005214503.3
UniGeneⁱ	Bt.4426

3D structure databases

ProteinModelPortalⁱ	Q9TU47
SMRⁱ	Q9TU47
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q9TU47, 2 interactors
STRINGⁱ	9913.ENSBTAP00000014966

Proteomic databases

PaxDbⁱ	Q9TU47
PRIDEⁱ	Q9TU47

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSBTAT00000014966; ENSBTAP00000014966; ENSBTAG00000011263
GeneIDⁱ	286811
KEGGⁱ	bta:286811

Organism-specific databases

CTDⁱ	3692
VGNCⁱ	VGNC:57006 EIF6

Phylogenomic databases

eggNOGⁱ	KOG3185 Eukaryota COG1976 LUCA
GeneTreeⁱ	ENSGT00390000015972
HOGENOMⁱ	HOG000230605
HOVERGENⁱ	HBG001300
InParanoidⁱ	Q9TU47
KOⁱ	K03264
OMAⁱ	NDWCAFT
OrthoDBⁱ	EOG091G0HYF
TreeFamⁱ	TF105396

Gene expression databases

Bgeeⁱ	ENSBTAG00000011263 Expressed in 9 organ(s), highest expression level in adult mammalian kidney

Bgeeⁱ

ENSBTAG00000011263 Expressed in 9 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

CDDⁱ	cd00527 IF6, 1 hit
HAMAPⁱ	MF_00032 eIF_6, 1 hit
InterProⁱ	View protein in InterPro IPR002769 eIF6
PANTHERⁱ	PTHR10784 PTHR10784, 1 hit
Pfamⁱ	View protein in Pfam PF01912 eIF-6, 1 hit
PIRSFⁱ	PIRSF006413 IF-6, 1 hit
SMARTⁱ	View protein in SMART SM00654 eIF6, 1 hit
TIGRFAMsⁱ	TIGR00323 eIF-6, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IF6_BOVIN
Accessionⁱ	Q9TU47Primary (citable) accession number: Q9TU47 Secondary accession number(s): Q2TBM1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
	Last sequence update:	October 31, 2006
	Last modified:	November 7, 2018
	This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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Proteomes

Annotation systems

Supporting data

UniProtKB - Q9TU47 (IF6_BOVIN)

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Eukaryotic translation initiation factor 6

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytoskeleton

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ