UniProtKB - Q9TTT7 (CX6A1_RABIT)
Cytochrome c oxidase subunit 6A1, mitochondrial
COX6A1
Functioni
: oxidative phosphorylation Pathwayi
This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.By similarityView all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.
GO - Molecular functioni
- cytochrome-c oxidase activity Source: InterPro
GO - Biological processi
- oxidative phosphorylation Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Enzyme and pathway databases
UniPathwayi | UPA00705 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome c oxidase subunit 6A1, mitochondrialAlternative name(s): Cytochrome c oxidase polypeptide VIa-liver |
Gene namesi | Name:COX6A1 Synonyms:COXVIA2 |
Organismi | Oryctolagus cuniculus (Rabbit) |
Taxonomic identifieri | 9986 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus |
Proteomesi |
|
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Single-pass membrane protein By similarity
Mitochondrion
- mitochondrial respiratory chain complex IV Source: InterPro
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 34 | Mitochondrial matrixBy similarity | 10 | |
Transmembranei | 35 – 59 | HelicalBy similarityAdd BLAST | 25 | |
Topological domaini | 60 – 109 | Mitochondrial intermembraneBy similarityAdd BLAST | 50 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 24 | MitochondrionBy similarityAdd BLAST | 24 | |
ChainiPRO_0000006121 | 25 – 109 | Cytochrome c oxidase subunit 6A1, mitochondrialAdd BLAST | 85 |
Interactioni
Subunit structurei
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI1III2IV1 and megacomplex MCI2III2IV2).
By similarityProtein-protein interaction databases
STRINGi | 9986.ENSOCUP00000008500 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptide, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3469, Eukaryota |
InParanoidi | Q9TTT7 |
OrthoDBi | 1591077at2759 |
Family and domain databases
CDDi | cd00925, Cyt_c_Oxidase_VIa, 1 hit |
Gene3Di | 4.10.95.10, 1 hit |
InterProi | View protein in InterPro IPR001349, Cyt_c_oxidase_su6a IPR018507, Cyt_c_oxidase_su6a_CS IPR036418, Cyt_c_oxidase_su6a_sf |
PANTHERi | PTHR11504, PTHR11504, 1 hit |
Pfami | View protein in Pfam PF02046, COX6A, 1 hit |
PIRSFi | PIRSF000277, COX6A1, 1 hit |
SUPFAMi | SSF81411, SSF81411, 1 hit |
PROSITEi | View protein in PROSITE PS01329, COX6A, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MAAAAWSRVS QLLGRSRLQV GRPMSSGAHG EEGSARMWKA LTYFVALPGV
60 70 80 90 100
GVSMLNVYLK SHHEEHERPE FIAYPHLRIR SKPFPWGDGN HTLFHNPHVN
PLPTGYEDV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF198089 mRNA Translation: AAF13255.1 |
RefSeqi | NP_001164354.1, NM_001170883.2 |
Genome annotation databases
GeneIDi | 100327270 |
KEGGi | ocu:100327270 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF198089 mRNA Translation: AAF13255.1 |
RefSeqi | NP_001164354.1, NM_001170883.2 |
3D structure databases
SMRi | Q9TTT7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9986.ENSOCUP00000008500 |
Genome annotation databases
GeneIDi | 100327270 |
KEGGi | ocu:100327270 |
Organism-specific databases
CTDi | 1337 |
Phylogenomic databases
eggNOGi | KOG3469, Eukaryota |
InParanoidi | Q9TTT7 |
OrthoDBi | 1591077at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00705 |
Family and domain databases
CDDi | cd00925, Cyt_c_Oxidase_VIa, 1 hit |
Gene3Di | 4.10.95.10, 1 hit |
InterProi | View protein in InterPro IPR001349, Cyt_c_oxidase_su6a IPR018507, Cyt_c_oxidase_su6a_CS IPR036418, Cyt_c_oxidase_su6a_sf |
PANTHERi | PTHR11504, PTHR11504, 1 hit |
Pfami | View protein in Pfam PF02046, COX6A, 1 hit |
PIRSFi | PIRSF000277, COX6A1, 1 hit |
SUPFAMi | SSF81411, SSF81411, 1 hit |
PROSITEi | View protein in PROSITE PS01329, COX6A, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CX6A1_RABIT | |
Accessioni | Q9TTT7Primary (citable) accession number: Q9TTT7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 2001 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families