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Entry version 119 (29 Sep 2021)
Sequence version 1 (01 May 2000)
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Protein

Lysosomal-trafficking regulator

Gene

LYST

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysosomal-trafficking regulator
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LYST
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in LYST are the cause of Chediak-Higashi syndrome of cattle (CHS) CHS is an autosomal recessive bleeding disorder with light coat color which has been reported in a population of Japanese black cattle.

Keywords - Diseasei

Disease variant

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002446221 – 3796Lysosomal-trafficking regulatorAdd BLAST3796

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei164PhosphoserineBy similarity1
Modified residuei165PhosphothreonineBy similarity1
Modified residuei166PhosphoserineBy similarity1
Modified residuei1504PhosphoserineBy similarity1
Modified residuei1505PhosphoserineBy similarity1
Modified residuei2100PhosphoserineBy similarity1
Modified residuei2119PhosphoserineBy similarity1
Modified residuei2208PhosphoserineBy similarity1
Modified residuei2212PhosphoserineBy similarity1
Modified residuei2259PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9TTK4

PRoteomics IDEntifications database

More...
PRIDEi
Q9TTK4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CENPJ, LIP8 and ZNF521.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000022355

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9TTK4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati662 – 700WD 1Add BLAST39
Repeati1577 – 1621WD 2Add BLAST45
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3004 – 3110BEACH-type PHPROSITE-ProRule annotationAdd BLAST107
Domaini3115 – 3417BEACHPROSITE-ProRule annotationAdd BLAST303
Repeati3558 – 3597WD 3Add BLAST40
Repeati3609 – 3648WD 4Add BLAST40
Repeati3651 – 3694WD 5Add BLAST44
Repeati3695 – 3739WD 6Add BLAST45
Repeati3744 – 3783WD 7Add BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni143 – 170DisorderedSequence analysisAdd BLAST28
Regioni1178 – 1201DisorderedSequence analysisAdd BLAST24

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1786, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9TTK4

Database of Orthologous Groups

More...
OrthoDBi
101142at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06071, Beach, 1 hit
cd01201, PH_BEACH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1540.10, 1 hit
2.130.10.10, 2 hits
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000409, BEACH_dom
IPR036372, BEACH_dom_sf
IPR030464, LYST
IPR023362, PH-BEACH_dom
IPR011993, PH-like_dom_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR036322, WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13743:SF86, PTHR13743:SF86, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02138, Beach, 1 hit
PF14844, PH_BEACH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01026, Beach, 1 hit
SM00320, WD40, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 1 hit
SSF81837, SSF81837, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50197, BEACH, 1 hit
PS51783, PH_BEACH, 1 hit
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9TTK4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTDSNSLAR EFLTDVNRLC NAVVQRVEAR EEEEEETHMA TLGQYLVHGR
60 70 80 90 100
GFLLLTKLNS IIDQALTCRE ELLTLLLSLL PLVWKIPVQE EKATDFNLPF
110 120 130 140 150
SAGIILTKEK NSSSQRSTQE KLYLEGSAPA GQVSAKVNVF RKSRRQRKTT
160 170 180 190 200
HRYSVRDARK TQLSTSDSEV NSDDKSIVMT KYRRSHVLQH FVKQCPKEDH
210 220 230 240 250
LTAKLNHLST KEQTPPDTMA LENSREIIPR EESNTDILSE PAALSTISHM
260 270 280 290 300
NNSPFDLCHV LLSLLEKVCK FDITLNHNSA LAASVVPTLT EFLAGFGDCC
310 320 330 340 350
NLSDNLEGQM VSAGWTEEPV ALIQRMLFRT VLHLMSVDIS MAEVMPENLR
360 370 380 390 400
KNLTELLRAA LKIRTFLEKQ PDPFAPRQKK TLQEVQDDFV FSKYCHRVLL
410 420 430 440 450
LPELLEGVLQ ILICCLQSAA SNPFFFSQAM DLVQEFIQHH GFHLFETAVL
460 470 480 490 500
QMEWLVVRDG VPPEASGHLK ALINNVMKIM STVKKVKSEQ LHHSMCTRKR
510 520 530 540 550
HRRCEYSHFM HHHRDLSGLL VSAFKNQVSK NPFEETADGD VYYPERCCCI
560 570 580 590 600
AVCAHQCLRL LQQASLSSTC VQILSGVQNI GICCCMDPKS VIVPLLHAFK
610 620 630 640 650
LPALKSCQQH ILNILNKLIL DQLGGAEIPQ KTKKAACNIC TVDSDQLAKL
660 670 680 690 700
EETLQGSSYN AEPSSGLSSP SYRFQGILPS SGSEDLLWKW DALEAYQNFV
710 720 730 740 750
FEEDRLQSVQ IANHICSLIQ KGNVVVQWKL YNCIFNPVLQ RGVELAHHCQ
760 770 780 790 800
QLSISSAQTH VCSHHNQCLP QEVLQIYLKT LPTLLKSRVI RDLFLSCNGV
810 820 830 840 850
NQIIELNYLD GIRNHSLKAF ETLIISLGEQ QKDSSIPGID GIDLEQKELS
860 870 880 890 900
SLNVGTLYNQ QAYSDSQSLS KFYARLKDAY PKKRKSVVQD IHISTINLFL
910 920 930 940 950
CVAFLCVSKE AESDRESAND SEDTSGYDST ASEPLQHMLP CFSLESLVLP
960 970 980 990 1000
SPRHMHQAAD VWSMCRWIYM LSPIFRKQFY RLGGFQVCHK LIFMVIQDLF
1010 1020 1030 1040 1050
RNPEEEQGRK EGDRTMNENQ DLNRISQPEI TVKEDLLSLT VKIDPTPTEL
1060 1070 1080 1090 1100
SSLKKSADSL GRLESEHLSS INVEQIPAVE AVPEETKVFM SRESETLLQG
1110 1120 1130 1140 1150
IRLLEALLAI CLHGTRASQQ KLELELPNQN LSVETILLEM RDHLSKSKVT
1160 1170 1180 1190 1200
ETELAKPLFD ALLRVALGNH SADFEHDDAM TEKSHQSEEE LSSQPGDFSE
1210 1220 1230 1240 1250
EAEDSQCCSF KLLVEEEGYE ADSESNPEDS ETWDDGVDLK PEAESFIASS
1260 1270 1280 1290 1300
SPNDLLENLS QGEIIYPEIC TLELNLLSTG KAKLDVLAHV FESFLKIIRQ
1310 1320 1330 1340 1350
KEKNIFLLMQ QGTVKNLLGG FLSILTQTDS DFQACQRVLV DLLVSLMSSR
1360 1370 1380 1390 1400
TCSEELTLLL RIFLEKSPCT EILLLGILKI VESDITMSPS QYLTFPLLHT
1410 1420 1430 1440 1450
PNLSNGVSSQ KCPGILNSKA MGLLRRARVS QSKKEGDSES FPQQLLSSWH
1460 1470 1480 1490 1500
IAPVHLPLLG QPHLSEGFSI SLWFNVECIH EPESTTEKGK KTRKRNKSLV
1510 1520 1530 1540 1550
LLDSSFDGTE NNRLEGAAYV NPGERLIEEG CVHMISLGSK ALIIQVWADP
1560 1570 1580 1590 1600
HTGTFIFRVC MDSNDDTKVV LLAQVESQEN IFLPSKWQHL VLTYLQQPQG
1610 1620 1630 1640 1650
KKNIHGKISI WISGQRKPDV TLDFMLPRKT SLSSDSNKTF CMIGHCLSSQ
1660 1670 1680 1690 1700
EESLQLAGKW DLGNLLLFNG AKIGSQEAFY LYACGPNHTS IMPCKYGKPV
1710 1720 1730 1740 1750
NDYSKYINTE ILQCEQIREL FMTSKDVDIG LLIESLSVVY TTYCPAQYTI
1760 1770 1780 1790 1800
YEPVIRLKGQ MKTQLSQRPF SSKEVHNILL EPHHLKNLQP TECKTLQGIL
1810 1820 1830 1840 1850
HEIGGTGIFV FLFARVVELS SCEETQALAL RVILSLIKYN QQRIHELENC
1860 1870 1880 1890 1900
NGLSMIHQVL IKQKCIVGFH ILKTLLEGCC GEDIIHINEN GELKLDVESN
1910 1920 1930 1940 1950
AIIQDVKLLE ELLLDWKIWN KAEHGVWETL LAALEVLIRA DHQQQMFNIK
1960 1970 1980 1990 2000
QLLKARVVHH FLLTCQVLQE HKEGQLISMP QEVCRSFVKI TAEVLGSPPD
2010 2020 2030 2040 2050
LELLTIIFNF LLAVHPPTNT YVCHNPTNFY FSLHIDGKIF QEKVQSIMYL
2060 2070 2080 2090 2100
RHSSSGGKSV TSPGFMIISP SDFTASPPEG NNSSSAVPKQ VTASMLRSRS
2110 2120 2130 2140 2150
LPAFPTASPH IKPRKLTGSL GCSIDKLQSF VDDGVASQPE KWSPLRSSET
2160 2170 2180 2190 2200
LEKSKQDAFI SSCESAKMVC ETEPALLAQA SVSDIPKGAL ELPAVNIDHK
2210 2220 2230 2240 2250
DFGAEPRSDD DSPGDESCPR RPLYLKGLAS FQRSHSTIAS LGLAFPSQNG
2260 2270 2280 2290 2300
SAAVGRWPSL VDRNADDWEN FALSLGYEPH HSRTAGAHSV TEDCLVPICC
2310 2320 2330 2340 2350
GLYELLSGVL LILPDVMLED VMDRLIQADT LLVLVNHPSP AVQQEVIKLL
2360 2370 2380 2390 2400
DAYFNRASKE QKDKFLKNRG FSLLANQLYL HRGTQELLEC FIEMFFGRRI
2410 2420 2430 2440 2450
GLDEEFDLED VKNMGLFQKW SVIPILGLIE TSLYDNVLLH NALLLLLQIL
2460 2470 2480 2490 2500
NSCSKVADML LDNGLLYVLC NTVATLNGLE KIIPLNEYRL LACDIQQLFI
2510 2520 2530 2540 2550
AVTIHACSSS GSQYFRVIED LIVLLGYLQN SKNKRTQNMA VALQFRVLQA
2560 2570 2580 2590 2600
AMEFIRTTAN HDSENLTDSL QSPSVPHHTM FQKRKSIAGP RKFLLAQTDS
2610 2620 2630 2640 2650
LLMKMRSVAS DELHVMMQRR MSQENPVQAT ETELAQRLQR LTVFAVNRIV
2660 2670 2680 2690 2700
YQEFNPDIID ILSTPESTTQ SRTSASQTEI SEENIHHEQP SVFNPFQKEM
2710 2720 2730 2740 2750
FMYLVEGFKV SSASGKTSSS KQQWAKILWS CKETFRMQLG RLLVHMLSPA
2760 2770 2780 2790 2800
HPSQERKQIF EIVREPNHQE ILRECLSPSL QHGAKLVLYL SELIHNHKDE
2810 2820 2830 2840 2850
LTEEELDTAE LLMNALKLCG HKCIPPSAST KSDLIRVIKE EQRKYETEEG
2860 2870 2880 2890 2900
VNKANWQKTV NNNQQSLFQR LDSKSKDISK IAADITQAVS LSQGIERKKV
2910 2920 2930 2940 2950
IQHIRGMYKV DLSASRHWQE LIQQLTHDRA VWYDPIYYPT SWQLDPTEGP
2960 2970 2980 2990 3000
NRERRRLQRC YLTIPNKYLL RDRQKSEDVV KPPLSYLFED KTHSSFSSTV
3010 3020 3030 3040 3050
KDKAASESIR VNRRCISVAP SRETAGELLL GKCGMYFVED NASDTVECSN
3060 3070 3080 3090 3100
LQGELEPASF SWTYEEIKEV HKRWWQLRDN AVEIFLTNGR TLLLAFDNTK
3110 3120 3130 3140 3150
VRNDVYHSIL TNNLPNLLEY GNITALTHLW YTGQITNFEY LTHLNKHAGR
3160 3170 3180 3190 3200
SFNDLMQYPV FPFILADYVS ETLDLSDPSV YRNLSKPIAV QYKEKEDRYV
3210 3220 3230 3240 3250
DTYKYLEEEY RKGAREDDPM PPVQPYHYGS HYSNSGTVLH FLVRMPPFTK
3260 3270 3280 3290 3300
MFLAYQDQSF DIPDRTFHST NTTWRLSSFE SMTDVKELIP EFFYLPEFLV
3310 3320 3330 3340 3350
NREGFDFGVR QNGERVNHVN LPPWARNDPR LFILIHRQAL ESDYVSQNIC
3360 3370 3380 3390 3400
QWIDLVFGYK QKGKASVQAI NVFHPATYFG MDVSAVEDPV QRRALETMIK
3410 3420 3430 3440 3450
TYGQTPRQLF QSAHASRPGS KLNIEGELPA AVGLLVQFAF RETREQVKEI
3460 3470 3480 3490 3500
TYPSPLSWIK GLKWGEYVGS PSAPVPVVCF SQPHGERFGS LQALPTRAIC
3510 3520 3530 3540 3550
GLSRNFCLLM TYSKEQGVRS MNSTDIQWSA ILSWGYADNI LRLKSKQSEP
3560 3570 3580 3590 3600
PINFIQSSQQ YQVTSCAWVP DSCQLFTGSK CGVITAYSNR FTSGTPSEIE
3610 3620 3630 3640 3650
MESQIHLYGH TEEISSLFVC KPYSIMISVS RDGTCIIWDL NRLCYVQSLA
3660 3670 3680 3690 3700
GHKSPVTAVS ASETTGDIAT VCDSAGGGSD LRLWTVNGDL VGHVHCREII
3710 3720 3730 3740 3750
CSVAFSNQPE GISINVIAGG LENGIVRLWS TWDLKPVREI TFPKSNKPIV
3760 3770 3780 3790
SLTFSCDGHH LYTANSDGTV IAWCRKDQQR LKHPMFYSFL SSYAAG
Length:3,796
Mass (Da):428,601
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4AC00E9928E882B7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1062R → K in AAD13618 (PubMed:10690356).Curated1
Sequence conflicti1434K → I in AAD13618 (PubMed:10690356).Curated1
Sequence conflicti2060V → G in AAD13618 (PubMed:10690356).Curated1
Sequence conflicti3396E → R in AAD13618 (PubMed:10690356).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti2015H → R in CHS. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB026620 mRNA Translation: BAA77267.1
AF114785 mRNA Translation: AAD13618.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T18514

NCBI Reference Sequences

More...
RefSeqi
NP_776445.1, NM_174020.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
281072

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:281072

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026620 mRNA Translation: BAA77267.1
AF114785 mRNA Translation: AAD13618.1
PIRiT18514
RefSeqiNP_776445.1, NM_174020.2

3D structure databases

SMRiQ9TTK4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022355

Proteomic databases

PaxDbiQ9TTK4
PRIDEiQ9TTK4

Genome annotation databases

GeneIDi281072
KEGGibta:281072

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1130

Phylogenomic databases

eggNOGiKOG1786, Eukaryota
InParanoidiQ9TTK4
OrthoDBi101142at2759

Family and domain databases

CDDicd06071, Beach, 1 hit
cd01201, PH_BEACH, 1 hit
Gene3Di1.10.1540.10, 1 hit
2.130.10.10, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000409, BEACH_dom
IPR036372, BEACH_dom_sf
IPR030464, LYST
IPR023362, PH-BEACH_dom
IPR011993, PH-like_dom_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR036322, WD40_repeat_dom_sf
PANTHERiPTHR13743:SF86, PTHR13743:SF86, 1 hit
PfamiView protein in Pfam
PF02138, Beach, 1 hit
PF14844, PH_BEACH, 1 hit
SMARTiView protein in SMART
SM01026, Beach, 1 hit
SM00320, WD40, 4 hits
SUPFAMiSSF50978, SSF50978, 1 hit
SSF81837, SSF81837, 1 hit
PROSITEiView protein in PROSITE
PS50197, BEACH, 1 hit
PS51783, PH_BEACH, 1 hit
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLYST_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9TTK4
Secondary accession number(s): O97699
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 1, 2000
Last modified: September 29, 2021
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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