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UniProtKB - Q9TTF5 (Q9TTF5_BOVIN)
Protein
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Gene
CD38
Organism
Bos taurus (Bovine)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 112 | UniRule annotation | 1 | |
Active sitei | 193 | UniRule annotation | 1 |
GO - Molecular functioni
- NAD(P)+ nucleosidase activity Source: UniProtKB-EC
- NAD+ nucleotidase, cyclic ADP-ribose generating Source: UniProtKB-EC
- transferase activity Source: UniProtKB-KW
GO - Biological processi
- metabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | GlycosidaseImported, Hydrolase, TransferaseARBA annotation |
Enzyme and pathway databases
BRENDAi | 3.2.2.6, 908 |
Names & Taxonomyi
Protein namesi | Recommended name: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1ARBA annotation (EC:2.4.99.20ARBA annotation, EC:3.2.2.6ARBA annotation)Alternative name(s): 2'-phospho-ADP-ribosyl cyclaseARBA annotation 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferaseARBA annotation 2'-phospho-cyclic-ADP-ribose transferaseARBA annotation ADP-ribosyl cyclase 1ARBA annotation Cyclic ADP-ribose hydrolase 1ARBA annotation |
Gene namesi | Name:CD38Imported |
Organismi | Bos taurus (Bovine)Imported |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000013569 |
VGNCi | VGNC:27027, CD38 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type II membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_5015100005 | 27 – 278 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1Sequence analysisAdd BLAST | 252 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 59 ↔ 75 | UniRule annotationCombined sources | ||
Disulfide bondi | 92 ↔ 172 | UniRule annotationCombined sources | ||
Disulfide bondi | 112 ↔ 193 | Combined sources | ||
Disulfide bondi | 152 ↔ 165 | UniRule annotationCombined sources | ||
Glycosylationi | 201 | N-linked (GlcNAc...) asparagineCombined sources | 1 | |
Glycosylationi | 218 | O-linked (GlcNAc...) glutamateCombined sources | 1 | |
Disulfide bondi | 244 ↔ 265 | UniRule annotationCombined sources |
Keywords - PTMi
Disulfide bondUniRule annotationARBA annotation, GlycoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSBTAG00000013569, Expressed in abdominal lymph node and 94 other tissues |
Structurei
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the ADP-ribosyl cyclase family.ARBA annotation
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixARBA annotationPhylogenomic databases
eggNOGi | ENOG502S1HV, Eukaryota |
GeneTreei | ENSGT00390000017291 |
HOGENOMi | CLU_067834_0_1_1 |
OrthoDBi | 1460460at2759 |
TreeFami | TF332530 |
Family and domain databases
CDDi | cd04759, Rib_hydrolase, 1 hit |
InterProi | View protein in InterPro IPR003193, ADP-ribosyl_cyclase IPR033567, CD38 |
PANTHERi | PTHR10912, PTHR10912, 1 hit PTHR10912:SF5, PTHR10912:SF5, 1 hit |
Pfami | View protein in Pfam PF02267, Rib_hydrolayse, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9TTF5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADCCTPRKK LCWCVLLFFL VAGITGGAIG IYKWHYSGLN RWHGAGSTAD
60 70 80 90 100
FQKIIQERCD TYTQTIRPGS RSRNCQAIRQ AFMSAFISKD PCKATKEDYN
110 120 130 140 150
SLINLAPPTV PCGQQVFWSK TKELAHEYAK RRRLMTLEDT LLGYLADGLR
160 170 180 190 200
WCGEPGSSDL NIWSCPDWRK DCRTNYLSVF WEVLSERFAE SACNTVRVVL
210 220 230 240 250
NGSLENAFDS MSIFGRVEAP NLRPQVELEA WLVHDTGKPP SDSCSGSSIR
260 270
KLKSILDGRN VKFRCMDNLS RDQFLQRS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1N5J2 | A0A3Q1N5J2_BOVIN | ADP-ribosyl cyclase/cyclic ADP-ribo... | CD38 | 299 | Annotation score: | ||
A0A3Q1LJV2 | A0A3Q1LJV2_BOVIN | ADP-ribosyl cyclase/cyclic ADP-ribo... | CD38 | 265 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF101437 mRNA Translation: AAF21892.1 BC126708 mRNA Translation: AAI26709.1 |
RefSeqi | NP_786992.1, NM_175798.3 |
Genome annotation databases
Ensembli | ENSBTAT00000018042.6; ENSBTAP00000018042.5; ENSBTAG00000013569.6 |
GeneIDi | 327677 |
KEGGi | bta:327677 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF101437 mRNA Translation: AAF21892.1 BC126708 mRNA Translation: AAI26709.1 |
RefSeqi | NP_786992.1, NM_175798.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3GC6 | X-ray | 1.51 | A/B | 32-278 | [»] | |
3GH3 | X-ray | 1.80 | A/B | 32-278 | [»] | |
3GHH | X-ray | 1.94 | A/B | 32-278 | [»] | |
3KOU | X-ray | 1.78 | A/B | 32-278 | [»] | |
3P5S | X-ray | 1.95 | A/B | 1-278 | [»] | |
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000018042 |
Genome annotation databases
Ensembli | ENSBTAT00000018042.6; ENSBTAP00000018042.5; ENSBTAG00000013569.6 |
GeneIDi | 327677 |
KEGGi | bta:327677 |
Organism-specific databases
CTDi | 952 |
VEuPathDBi | HostDB:ENSBTAG00000013569 |
VGNCi | VGNC:27027, CD38 |
Phylogenomic databases
eggNOGi | ENOG502S1HV, Eukaryota |
GeneTreei | ENSGT00390000017291 |
HOGENOMi | CLU_067834_0_1_1 |
OrthoDBi | 1460460at2759 |
TreeFami | TF332530 |
Enzyme and pathway databases
BRENDAi | 3.2.2.6, 908 |
Gene expression databases
Bgeei | ENSBTAG00000013569, Expressed in abdominal lymph node and 94 other tissues |
Family and domain databases
CDDi | cd04759, Rib_hydrolase, 1 hit |
InterProi | View protein in InterPro IPR003193, ADP-ribosyl_cyclase IPR033567, CD38 |
PANTHERi | PTHR10912, PTHR10912, 1 hit PTHR10912:SF5, PTHR10912:SF5, 1 hit |
Pfami | View protein in Pfam PF02267, Rib_hydrolayse, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9TTF5_BOVIN | |
Accessioni | Q9TTF5Primary (citable) accession number: Q9TTF5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |