UniProtKB - Q9TSZ3 (KCNH2_CANLF)
Potassium voltage-gated channel subfamily H member 2
KCNH2
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 741 – 858 | cNMPAdd BLAST | 118 |
GO - Molecular functioni
- voltage-gated potassium channel activity Source: UniProtKB
GO - Biological processi
- potassium ion transmembrane transport Source: GO_Central
- regulation of ion transmembrane transport Source: UniProtKB-KW
- regulation of membrane potential Source: GO_Central
Keywordsi
Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium voltage-gated channel subfamily H member 2Alternative name(s): Ether-a-go-go-related gene potassium channel 1 Short name: DERG Short name: ERG-1 Short name: Eag-related protein 1 Short name: Ether-a-go-go-related protein 1 Short name: c-ERG Voltage-gated potassium channel subunit Kv11.1 |
Gene namesi | Name:KCNH2 Synonyms:CERG, ERG |
Organismi | Canis lupus familiaris (Dog) (Canis familiaris) |
Taxonomic identifieri | 9615 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 402 | CytoplasmicSequence analysisAdd BLAST | 402 | |
Transmembranei | 403 – 423 | Helical; Name=Segment S1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 424 – 449 | ExtracellularSequence analysisAdd BLAST | 26 | |
Transmembranei | 450 – 470 | Helical; Name=Segment S2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 471 – 494 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 495 – 515 | Helical; Name=Segment S3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 516 – 519 | ExtracellularSequence analysis | 4 | |
Transmembranei | 520 – 540 | Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 541 – 546 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 547 – 567 | Helical; Name=Segment S5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 568 – 610 | ExtracellularSequence analysisAdd BLAST | 43 | |
Intramembranei | 611 – 631 | Pore-forming; Name=Segment H5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 632 – 637 | ExtracellularSequence analysis | 6 | |
Transmembranei | 638 – 658 | Helical; Name=Segment S6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 659 – 1158 | CytoplasmicSequence analysisAdd BLAST | 500 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053997 | 1 – 1158 | Potassium voltage-gated channel subfamily H member 2Add BLAST | 1158 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 239 | PhosphoserineBy similarity | 1 | |
Modified residuei | 283 | PhosphoserineBy similarity | 1 | |
Modified residuei | 284 | PhosphoserineBy similarity | 1 | |
Modified residuei | 319 | PhosphoserineBy similarity | 1 | |
Modified residuei | 350 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 597 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 870 | PhosphoserineBy similarity | 1 | |
Modified residuei | 873 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1013 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 1136 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, Methylation, PhosphoproteinProteomic databases
PaxDbi | Q9TSZ3 |
PRIDEi | Q9TSZ3 |
Expressioni
Tissue specificityi
Interactioni
Subunit structurei
The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.
Interacts with DNAJB12 and DNAJB14; chaperones DNAJB12 and DNAJB14 promote tetramerization (By similarity). Heteromultimer with KCNH6/ERG2 and KCNH7/ERG3 (By similarity).
Interacts with ALG10B (By similarity). Heteromultimer with KCNE1 and KCNE2.
Interacts with CANX. The core-glycosylated, but not the fully glycosylated form interacts with RNF207.
Interacts with NDFIP1 and NDFIP2 (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 9612.ENSCAFP00000035370 |
Chemistry databases
BindingDBi | Q9TSZ3 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 17 – 88 | PASPROSITE-ProRule annotationAdd BLAST | 72 | |
Domaini | 92 – 144 | PACPROSITE-ProRule annotationAdd BLAST | 53 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 623 – 628 | Selectivity filterBy similarity | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 296 – 299 | Poly-Pro | 4 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0498 Eukaryota ENOG410XPSE LUCA |
HOGENOMi | HOG000230793 |
InParanoidi | Q9TSZ3 |
KOi | K04905 |
OrthoDBi | 247304at2759 |
Family and domain databases
CDDi | cd00038 CAP_ED, 1 hit cd00130 PAS, 1 hit |
Gene3Di | 1.20.120.350, 1 hit 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR018490 cNMP-bd-like IPR000595 cNMP-bd_dom IPR005821 Ion_trans_dom IPR003938 K_chnl_volt-dep_EAG/ELK/ERG IPR003967 K_chnl_volt-dep_ERG IPR001610 PAC IPR000014 PAS IPR000700 PAS-assoc_C IPR035965 PAS-like_dom_sf IPR014710 RmlC-like_jellyroll IPR027359 Volt_channel_dom_sf |
Pfami | View protein in Pfam PF00027 cNMP_binding, 1 hit PF00520 Ion_trans, 1 hit PF13426 PAS_9, 1 hit |
PRINTSi | PR01463 EAGCHANLFMLY PR01470 ERGCHANNEL |
SMARTi | View protein in SMART SM00100 cNMP, 1 hit SM00086 PAC, 1 hit |
SUPFAMi | SSF51206 SSF51206, 1 hit SSF55785 SSF55785, 1 hit |
TIGRFAMsi | TIGR00229 sensory_box, 1 hit |
PROSITEi | View protein in PROSITE PS50042 CNMP_BINDING_3, 1 hit PS50113 PAC, 1 hit PS50112 PAS, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MPVRRGHVAP QNTFLDTIIR KFEGQSRKFI IANARVENCA VIYCNDGFCE
60 70 80 90 100
LCGYSRAEVM QRPCTCDFLH GPRTQRRAAA QIAQALLGAE ERKVEIAFYR
110 120 130 140 150
KDGSCFLCLV DVVPVKNEDG AVIMFILNFE VVMEKDMVGS PTHDTNHRGP
160 170 180 190 200
PTSWLAPGRA KTFRLKLPAL LALTTRESSA RPGGVGSAGA PGAVVVDVDL
210 220 230 240 250
SPAVPSRESL ALDEVTAMDN HVAGLGPMEE QRALVGSSSP PAGAPEPLPS
260 270 280 290 300
PRAHSLNPDA SGSSCSLART RSRESCASVR RASSADDIEA MRAGLPPPPR
310 320 330 340 350
HASTGAMHPL RGGLLNSTSD SDLVRYRTIS KIPQITLNFV DLKGDPFLAS
360 370 380 390 400
PTSDREIIAP KIKERTHNVT EKVTQVLSLG ADVLPEYKLQ APRIHRWTIL
410 420 430 440 450
HYSPFKAVWD WLILLLVIYT AVFTPYSAAF LLKETEEGPP APDCGYACQP
460 470 480 490 500
LAVVDFIVDI MFIVDILINF RTTYVNANEE VVSHPGRIAV HYFKGWFLID
510 520 530 540 550
MVAAIPFDLL IFGSGSEELI GLLKTARLLR LVRVARKLDR YSEYGAAVLF
560 570 580 590 600
LLMCTFALIA HWLACIWYAI GNMEQPHMDS RIGWLHNLGD QIGKPYNSSG
610 620 630 640 650
LGGPSIKDKY VTALYFTFSS LTSVGFGNVS PNTNSEKIFS ICVMLIGSLM
660 670 680 690 700
YASIFGNVSA IIQRLYSGTA RYHTQMLRVR EFIRFHQIPN PLRQRLEEYF
710 720 730 740 750
QHAWSYTNGI DMNAVLKGFP ECLQADICLH LNRSLLQHCK PFRGATKGCL
760 770 780 790 800
RALAMKFKTT HAPPGDTLVH AGDLLTALYF ISRGSIEILR GDVVVAILGK
810 820 830 840 850
NDIFGEPLNL YARPGKSNGD VRALTYCDLH KIHRDDLLEV LDMYPEFSDH
860 870 880 890 900
FWSSLEITFN LRDTNMIPGS PGSAELEGGF NRQRKRKLSF RRRTDRDPEQ
910 920 930 940 950
PGEVSALGPG RAGAGPSGRG RPGGPWGESP SSGPSSPESS EDEGPGRSSS
960 970 980 990 1000
PLRLVPFSSP RPPGEPPGGE PLTEDGEKSS DTCNPLSGAF SGVSNIFSFW
1010 1020 1030 1040 1050
GDSRGHQYQE LPRCPAPTPS LLNIPLSSPC RRPRGDVEGR LDALQRQLNR
1060 1070 1080 1090 1100
LETRLSADMA TVLQLLQRQM TLIPPAYSAV TTPGPGPTST SSLLPVSPIP
1110 1120 1130 1140 1150
TLTLDSLSQV SQFMAFEELP PGAPELPQDG PPRRLSLPGQ LGALTSQPLH
RHGSDPGS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 442 | P → T in AAC48722 (PubMed:9012748).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ243344 mRNA Translation: CAB64868.1 U75213 mRNA Translation: AAC48722.1 AF017429 mRNA Translation: AAB70524.1 |
RefSeqi | NP_001003145.1, NM_001003145.1 |
Genome annotation databases
GeneIDi | 403761 |
KEGGi | cfa:403761 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ243344 mRNA Translation: CAB64868.1 U75213 mRNA Translation: AAC48722.1 AF017429 mRNA Translation: AAB70524.1 |
RefSeqi | NP_001003145.1, NM_001003145.1 |
3D structure databases
SMRi | Q9TSZ3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9612.ENSCAFP00000035370 |
Chemistry databases
BindingDBi | Q9TSZ3 |
ChEMBLi | CHEMBL3085616 |
Proteomic databases
PaxDbi | Q9TSZ3 |
PRIDEi | Q9TSZ3 |
Genome annotation databases
GeneIDi | 403761 |
KEGGi | cfa:403761 |
Organism-specific databases
CTDi | 3757 |
Phylogenomic databases
eggNOGi | KOG0498 Eukaryota ENOG410XPSE LUCA |
HOGENOMi | HOG000230793 |
InParanoidi | Q9TSZ3 |
KOi | K04905 |
OrthoDBi | 247304at2759 |
Family and domain databases
CDDi | cd00038 CAP_ED, 1 hit cd00130 PAS, 1 hit |
Gene3Di | 1.20.120.350, 1 hit 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR018490 cNMP-bd-like IPR000595 cNMP-bd_dom IPR005821 Ion_trans_dom IPR003938 K_chnl_volt-dep_EAG/ELK/ERG IPR003967 K_chnl_volt-dep_ERG IPR001610 PAC IPR000014 PAS IPR000700 PAS-assoc_C IPR035965 PAS-like_dom_sf IPR014710 RmlC-like_jellyroll IPR027359 Volt_channel_dom_sf |
Pfami | View protein in Pfam PF00027 cNMP_binding, 1 hit PF00520 Ion_trans, 1 hit PF13426 PAS_9, 1 hit |
PRINTSi | PR01463 EAGCHANLFMLY PR01470 ERGCHANNEL |
SMARTi | View protein in SMART SM00100 cNMP, 1 hit SM00086 PAC, 1 hit |
SUPFAMi | SSF51206 SSF51206, 1 hit SSF55785 SSF55785, 1 hit |
TIGRFAMsi | TIGR00229 sensory_box, 1 hit |
PROSITEi | View protein in PROSITE PS50042 CNMP_BINDING_3, 1 hit PS50113 PAC, 1 hit PS50112 PAS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCNH2_CANLF | |
Accessioni | Q9TSZ3Primary (citable) accession number: Q9TSZ3 Secondary accession number(s): O02719, O18820 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2002 |
Last sequence update: | May 1, 2000 | |
Last modified: | September 18, 2019 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families