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Protein

Hairy/enhancer-of-split related with YRPW motif protein 1

Gene

HEY1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processNotch signaling pathway, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Hairy/enhancer-of-split related with YRPW motif protein 1
Alternative name(s):
Hairy and enhancer of split-related protein 1
Short name:
HESR-1
Gene namesi
Name:HEY1
Synonyms:HESR1
ORF Names:BC8
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272161 – 304Hairy/enhancer-of-split related with YRPW motif protein 1Add BLAST304

Proteomic databases

PaxDbiQ9TSZ2

Interactioni

Subunit structurei

Self-associates. Interacts with HES1 and HEYL. Interacts with HDAC1, NCOR1 and SIN3A. Interacts with GATA4 and GATA6. Interacts with CCDC89/BOIP.By similarity

GO - Molecular functioni

Protein-protein interaction databases

ELMiQ9TSZ2
STRINGi9615.ENSCAFP00000012336

Structurei

3D structure databases

ProteinModelPortaliQ9TSZ2
SMRiQ9TSZ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 104bHLHPROSITE-ProRule annotationAdd BLAST56
Domaini122 – 158OrangePROSITE-ProRule annotationAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni48 – 117Transcriptional repression and interaction with NCOR1 and SIN3ABy similarityAdd BLAST70

Sequence similaritiesi

Belongs to the HEY family.Curated

Phylogenomic databases

eggNOGiKOG4304 Eukaryota
ENOG4111F0X LUCA
HOGENOMiHOG000286035
HOVERGENiHBG003275
InParanoidiQ9TSZ2
KOiK09091

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF07527 Hairy_orange, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00511 ORANGE, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9TSZ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRAHPDYSS SDSELDETVE VEKESADENG NLSSALGSMS PTTSSQILAR
60 70 80 90 100
KRRRGIIEKR RRDRINNSLS ELRRLVPSAF EKQGSAKLEK AEILQMTVDH
110 120 130 140 150
LKMLHTAGGK GYFDAHALAM DYRSLGFREC LAEVARYLSI IEGLDASDPL
160 170 180 190 200
RVRLVSHLNN YASQREAASG AHAGLGHLPW GSAFGHHPHV AHPLLLPQSG
210 220 230 240 250
HGNTGTSASP TDPHHQGRLA AAHPEAPALR APPSGGLGPV LPVVTSASKL
260 270 280 290 300
SPPLLSSVAS LSAFPFSFGS FHLLSPNALS PSAPTQAANL GKPYRPWGTE

IGAF
Length:304
Mass (Da):32,472
Last modified:May 1, 2000 - v1
Checksum:i191D5BD42970F412
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ388551 mRNA Translation: CAB65543.1
RefSeqiNP_001002953.1, NM_001002953.1
UniGeneiCfa.121

Genome annotation databases

GeneIDi403420
KEGGicfa:403420

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ388551 mRNA Translation: CAB65543.1
RefSeqiNP_001002953.1, NM_001002953.1
UniGeneiCfa.121

3D structure databases

ProteinModelPortaliQ9TSZ2
SMRiQ9TSZ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiQ9TSZ2
STRINGi9615.ENSCAFP00000012336

Proteomic databases

PaxDbiQ9TSZ2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403420
KEGGicfa:403420

Organism-specific databases

CTDi23462

Phylogenomic databases

eggNOGiKOG4304 Eukaryota
ENOG4111F0X LUCA
HOGENOMiHOG000286035
HOVERGENiHBG003275
InParanoidiQ9TSZ2
KOiK09091

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF07527 Hairy_orange, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00511 ORANGE, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHEY1_CANLF
AccessioniPrimary (citable) accession number: Q9TSZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: February 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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