UniProtKB - Q9TST0 (BMI1_FELCA)
Polycomb complex protein BMI-1
BMI1
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 18 – 57 | RING-typePROSITE-ProRule annotationAdd BLAST | 40 |
GO - Molecular functioni
- promoter-specific chromatin binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
- ubiquitin-protein transferase activator activity Source: Ensembl
- zinc ion binding Source: UniProtKB
GO - Biological processi
- brain development Source: Ensembl
- chromatin silencing Source: GO_Central
- DNA methylation Source: Ensembl
- embryonic skeletal system morphogenesis Source: Ensembl
- histone acetylation Source: Ensembl
- histone H2A-K119 monoubiquitination Source: UniProtKB
- humoral immune response Source: Ensembl
- in utero embryonic development Source: Ensembl
- negative regulation of apoptotic signaling pathway Source: Ensembl
- negative regulation of gene expression, epigenetic Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- positive regulation of B cell proliferation Source: Ensembl
- positive regulation of immature T cell proliferation in thymus Source: Ensembl
- positive regulation of ubiquitin-protein transferase activity Source: UniProtKB
- regulation of adaxial/abaxial pattern formation Source: Ensembl
- rostrocaudal neural tube patterning Source: Ensembl
- somatic stem cell division Source: Ensembl
Keywordsi
Molecular function | Chromatin regulator, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Polycomb complex protein BMI-1Alternative name(s): Polycomb group RING finger protein 4 |
Gene namesi | Name:BMI1 Synonyms:BMI-1, PCGF4 |
Organismi | Felis catus (Cat) (Felis silvestris catus) |
Taxonomic identifieri | 9685 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis |
Proteomesi |
|
Subcellular locationi
Nucleus
- nuclear body Source: Ensembl
- PcG protein complex Source: UniProtKB
- PRC1 complex Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
- heterochromatin Source: Ensembl
- ubiquitin ligase complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000055986 | 1 – 326 | Polycomb complex protein BMI-1Add BLAST | 326 |
Post-translational modificationi
Keywords - PTMi
Ubl conjugationExpressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSFCAG00000007230, Expressed in uterus and 10 other tissues |
Interactioni
Subunit structurei
Component of a PRC1-like complex.
Identified in a PRC1-like HPRC-H complex with CBX2, CBX4, CBX8, PHC1, PHC2, PHC3 RING1 and RNF2.
Interacts with RNF2/RING2 (By similarity).
Interacts with RING1 (By similarity).
Part of a complex that contains RNF2, UB2D3 and BMI1, where RNF2 and BMI1 form a tight heterodimer, and UB2D3 interacts only with RNF2. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A.
Interacts with CBX7 and CBX8.
Interacts with SPOP.
Part of a complex consisting of BMI1, CUL3 and SPOP.
Interacts with E4F1.
Interacts with PHC2 (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 9685.ENSFCAP00000016848 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 162 – 182 | Interaction with PHC2By similarityAdd BLAST | 21 | |
Regioni | 164 – 228 | Interaction with E4F1By similarityAdd BLAST | 65 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 81 – 95 | Nuclear localization signalSequence analysisAdd BLAST | 15 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 251 – 326 | Pro/Ser-richAdd BLAST | 76 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 18 – 57 | RING-typePROSITE-ProRule annotationAdd BLAST | 40 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG2660, Eukaryota |
GeneTreei | ENSGT00940000156042 |
HOGENOMi | CLU_046427_0_0_1 |
InParanoidi | Q9TST0 |
OMAi | HLICALC |
OrthoDBi | 1344247at2759 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR032443, RAWUL IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF16207, RAWUL, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MHRTTRIKIT ELNPHLMCVL CGGYFIDATT IIECLHSFCK TCIVRYLETS
60 70 80 90 100
KYCPICDVQV HKTRPLLNIR SDKTLQDIVY KLVPGLFKNE MKRRRDFYAA
110 120 130 140 150
HPSADAANGS NEDRGEVADE DKRIITDDEI ISLSIEFFDQ NRLDRKVNKD
160 170 180 190 200
KEKPKEEVND KRYLRCPAAM TVMHLRKFLR SKMDIPNTFQ IDVMYEEEPL
210 220 230 240 250
KDYYTLMDIA YIYTWRRNGP LPLKYRVRPT CKRMKISHQR DGLTNAGELE
260 270 280 290 300
SDSGSDKANS PAGGIPSTSS CLPSPSTPVQ SPHPQFPHIS STMNGTSSSP
310 320
SGNHQSSFAN RPRKSSVNGS SATSSG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ132013 mRNA Translation: CAB57313.1 |
RefSeqi | NP_001020133.1, NM_001024962.1 XP_006933308.1, XM_006933246.3 XP_006933309.1, XM_006933247.3 XP_006933310.1, XM_006933248.3 XP_011281909.1, XM_011283607.2 |
Genome annotation databases
Ensembli | ENSFCAT00000049314; ENSFCAP00000027047; ENSFCAG00000036566 |
GeneIDi | 554342 |
KEGGi | fca:554342 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ132013 mRNA Translation: CAB57313.1 |
RefSeqi | NP_001020133.1, NM_001024962.1 XP_006933308.1, XM_006933246.3 XP_006933309.1, XM_006933247.3 XP_006933310.1, XM_006933248.3 XP_011281909.1, XM_011283607.2 |
3D structure databases
SMRi | Q9TST0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9685.ENSFCAP00000016848 |
Genome annotation databases
Ensembli | ENSFCAT00000049314; ENSFCAP00000027047; ENSFCAG00000036566 |
GeneIDi | 554342 |
KEGGi | fca:554342 |
Organism-specific databases
CTDi | 648 |
Phylogenomic databases
eggNOGi | KOG2660, Eukaryota |
GeneTreei | ENSGT00940000156042 |
HOGENOMi | CLU_046427_0_0_1 |
InParanoidi | Q9TST0 |
OMAi | HLICALC |
OrthoDBi | 1344247at2759 |
Gene expression databases
Bgeei | ENSFCAG00000007230, Expressed in uterus and 10 other tissues |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR032443, RAWUL IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF16207, RAWUL, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BMI1_FELCA | |
Accessioni | Q9TST0Primary (citable) accession number: Q9TST0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 2002 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |