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Entry version 131 (12 Aug 2020)
Sequence version 1 (01 May 2000)
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Protein

Ryanodine receptor 3

Gene
N/A
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca2+ release by other calcium channels. Calcium channel that mediates Ca2+-induced Ca2+ release from the endoplasmic reticulum in non-muscle cells. Plays a role in cellular calcium signaling. Contributes to cellular calcium ion homeostasis. Isoform 2 lacks a predicted transmembrane segment and does not form functional calcium channels by itself; however, it can form tetramers with isoforms that contain the full complement of transmembrane segments and modulate their activity.6 Publications

Miscellaneous

Channel activity is modulated by the alkaloid ryanodine that binds to the open calcium-release channel with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High ryanodine concentrations inhibit channel activity. Channel activity is regulated by calmodulin (CALM). The calcium release is activated by elevated cytoplasmic calcium levels in the micromolar range, by caffeine and adenine nucleotides, such as AMP and ATP. Inhibited by Mg2+ and ruthenium red.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei3885Important for activation by Ca(2+)1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Calmodulin-binding, Ion channel, Ligand-gated ion channel, Receptor
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ryanodine receptor 3
Short name:
RYR-3
Short name:
RyR3
Alternative name(s):
Brain ryanodine receptor-calcium release channel
Brain-type ryanodine receptor
Type 3 ryanodine receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryctolagus cuniculus (Rabbit)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9986 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001811 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 4188CytoplasmicSequence analysisAdd BLAST4188
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4189 – 4209HelicalSequence analysisAdd BLAST21
Transmembranei4412 – 4432HelicalSequence analysisAdd BLAST21
Transmembranei4487 – 4507HelicalSequence analysisAdd BLAST21
Transmembranei4612 – 4632HelicalSequence analysisAdd BLAST21
Transmembranei4635 – 4655HelicalSequence analysisAdd BLAST21
Transmembranei4674 – 4694HelicalSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei4725 – 4734Pore-formingBy similarity10
Transmembranei4755 – 4775HelicalSequence analysisAdd BLAST21
Topological domaini4776 – 4872CytoplasmicSequence analysisAdd BLAST97

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome, Sarcoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi3885E → A: Reduces calcium-sensitivity by over 10000-fold. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004156491 – 4872Ryanodine receptor 3Add BLAST4872

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9TS33

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in skeletal muscle from young rabbits and in adult diaphragm muscle (at protein level). Detected in brain, especially in corpus striatum, thalamus and hippocampus. Detected in taenia coli, uterus, vas deferens, aorta, stomach, small intestine, heart, diaphragm and ureter. Isoform 2 is highly expressed in uterus and aorta, and at much lower levels in heart, brain and diaphragm.6 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Ubiquitous in skeletal muscle in neonates and in 15 day old rabbits. In adult, detected in diaphragm muscle, and in a subset of skeletal muscles including digastricus, pterygoideus, tongue and masseter.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer. Isoform 2 can form tetramers with isoform 1. Heterotetramer with RYR2.

Interacts with FKBP1A.

Interacts with CALM.

Interacts with SELENON (PubMed:18713863).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9TS33
With#Exp.IntAct
itself2EBI-9542578,EBI-9542578

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3157, Ryanodine 3 complex [Q9TS33-1]

STRING: functional protein association networks

More...
STRINGi
9986.ENSOCUP00000009882

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini100 – 155MIR 1PROSITE-ProRule annotationAdd BLAST56
Domaini162 – 207MIR 2PROSITE-ProRule annotationAdd BLAST46
Domaini215 – 269MIR 3PROSITE-ProRule annotationAdd BLAST55
Domaini275 – 333MIR 4PROSITE-ProRule annotationAdd BLAST59
Domaini343 – 400MIR 5PROSITE-ProRule annotationAdd BLAST58
Domaini585 – 796B30.2/SPRY 1PROSITE-ProRule annotationAdd BLAST212
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati840 – 9531Add BLAST114
Repeati954 – 10682Add BLAST115
Domaini1012 – 1208B30.2/SPRY 2PROSITE-ProRule annotationAdd BLAST197
Domaini1254 – 1466B30.2/SPRY 3PROSITE-ProRule annotationAdd BLAST213
Repeati2592 – 27103Add BLAST119
Repeati2711 – 28234Add BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni840 – 28234 X approximate repeatsAdd BLAST1984
Regioni2325 – 2338Interaction with FKBP1ABy similarityAdd BLAST14
Regioni3472 – 3501Interaction with CALM1 PublicationAdd BLAST30

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The calcium release channel activity resides in the C-terminal region while the remaining part of the protein resides in the cytoplasm.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2243, Eukaryota

KEGG Orthology (KO)

More...
KOi
K04963

Database of Orthologous Groups

More...
OrthoDBi
5161at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12877, SPRY1_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.920, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR002048, EF_hand_dom
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035910, RyR/IP3R_RIH_dom_sf
IPR035761, SPRY1_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00795, RYANODINER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909, SSF100909, 2 hits
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 3 hits
SSF82109, SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50919, MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q9TS33-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEGGEGGED EIQFLRTEDE VVLQCIATVH KEQRKFCLAA EGLGNRLCFL
60 70 80 90 100
EPTSEAKFIP PDLCVCNFVL EQSLSVRALQ EMLANTGENG GEGAAQGGGH
110 120 130 140 150
RTLLYGHAIL LRHSFSGMYL TCLTTSRSQT DKLAFDVGLR EHATGEACWW
160 170 180 190 200
TIHPASKQRS EGEKVRIGDD LILVSVSSER YLHLSISNGN IQVDASFMQT
210 220 230 240 250
LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH DECLTIPSTD QNDSQHRRIF
260 270 280 290 300
YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHLT TGHYLALTED
310 320 330 340 350
QGLLLQDRGK ADTKSTAFSF RPSKETKEKL DSSHKRDIEG MGVPEIKYGD
360 370 380 390 400
SVCFVQHIAS GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC
410 420 430 440 450
QREESQAARI IRNTTALFSQ FVSGNNRTAA PVTLPIEEVL QTLHDLIAYF
460 470 480 490 500
QPPEEEMQHE DKQNKLRSLK NRQNLFKEEG MLALVLNCID RLNIYNSVAH
510 520 530 540 550
FAGIAREESG MAWKEVLSLL YKLLAALIRG NRNTCAQFSN NLDWLISKLD
560 570 580 590 600
RLESSSGILE VLHCILIESP EALNLIAEGH IKSIISLLDK HGRNHKVLDV
610 620 630 640 650
LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV
660 670 680 690 700
AEGSAQYKKW YFELIIDQVD PFLTAEPTHL RVGWASSSGY APYPGGGEGW
710 720 730 740 750
GGNGVGDDLY SYGFDGLHLW SGRIPRAVAS INQHLLKSDD VVSCCLDLGV
760 770 780 790 800
PSISFRINGQ PVQGMFENFN TDGLFFPVMS FSAGVKVRFL MGGRHGEFKF
810 820 830 840 850
LPPSGYAPCY EALLPKEKMR LEPVKEYKRD AEGVRDLLGT TQFLSQASFI
860 870 880 890 900
PCPIDTSQVV LPPHLEKIRD RLAENIHELW GMNKIELGWT FGKMRDDNKR
910 920 930 940 950
QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEEDLKK
960 970 980 990 1000
VKLPKNYMMS NGYKPAPLDL SDVKLLPPQE ILVDKLAENA HNVWAKDRIK
1010 1020 1030 1040 1050
QGWTYGIQQD LKNKRNPRLV PYALLDERTK KSNRDSLREA VRTFVGYGYN
1060 1070 1080 1090 1100
IEPSDQELAD PAVEKVSIDK IRFFRVERSY AVRSGKWYFE FEVVTGGDMR
1110 1120 1130 1140 1150
VGWARPGCRP DIELGPMTKP LCLKAAGASV GTKVVGILGV PWQPGDVVGC
1160 1170 1180 1190 1200
MINLDDASMI FTLNGELLIT NKGSELAFAD YEIENGFVPI CSLGLSQIGR
1210 1220 1230 1240 1250
MNLGTDASTF KFYTMCGLQE GFEPFAVNMN RDVAMWFSKR LPTFVNVPKD
1260 1270 1280 1290 1300
HPHIEVVRID GTMDSPPCLK VTHKTFGTQN SNANMIYCRL SMPVECHSSF
1310 1320 1330 1340 1350
SHSPCLDSEA FQKRKQMQEI LSHTTTQCFY SIRIFAGQDP SCVWVGWVTP
1360 1370 1380 1390 1400
DYHLYSEKFD LNKNCTVTVT LGDERGRVHE SVKRSNCYMV WGGDVVASSQ
1410 1420 1430 1440 1450
RSSRSNVDLE IGCLVDLAMG MLSFSANGKE LGTCYQVEPN TKVFPAVFLQ
1460 1470 1480 1490 1500
PTSTSLFQFE LGKLKNAMPL SAAIFKSEEK NPVPQCPPRL DVQTIQPVLW
1510 1520 1530 1540 1550
SRMPNSFLKV ETERVSERHG WVVQCLEPLQ MMALHIPEEN RCVDILELCE
1560 1570 1580 1590 1600
QEDLMQFHYH TLRLYSAVCA LGNSRVAYAL CSHVDLSQLF HAIDNKYLPG
1610 1620 1630 1640 1650
LLRSGFYDLL ISIHLANAKE RKLMMKNEYI IPITSTTRNI RLYPDESKKH
1660 1670 1680 1690 1700
GLPGVGPRTC LKPGFKFSTP CFVVTNEERQ KQSPEIPLEI LKMKALSMLT
1710 1720 1730 1740 1750
EAVQCSGAHI RDPVGGSVEF QFVPVLKLVG TLLVMGVFCD DDVRQILLLI
1760 1770 1780 1790 1800
DPSVFGEHSA DTEEGAEKEE VSQVEEKAVE AGEKTSKEAR KEAPVRGLLQ
1810 1820 1830 1840 1850
TRLPESVKLQ MCELLSYLCD CELQHRVEAI VAFGDIYVSK LQANQKFRYN
1860 1870 1880 1890 1900
ELMQALNMSA ALTARKTREF RSPPQEQINM LLNFQLGENC PCPEEIREEL
1910 1920 1930 1940 1950
YDFHEDLLVH CGVPLEEEEE EEEDTSWTGK LRTLVYKIKG PPKPEKEQPT
1960 1970 1980 1990 2000
EEEERCPTTL KELISQTMIR WAQEDQIQDA ELVRMMFNLL RRQYDSIGEL
2010 2020 2030 2040 2050
LQALRKTYTI SHASVSDTIN LLAALGQIRS LLSVRMGREE ELLMINGLGD
2060 2070 2080 2090 2100
IMNNKVFYQH PNLMRVLGMH ETVMEVMVNV LGTEKSQIAF PKMVASCCRF
2110 2120 2130 2140 2150
LCYFCRISRQ NQKAMFEHLS YLLENSSVGL ASPSMRGSTP LDVAASSVMD
2160 2170 2180 2190 2200
NNELALGLEE PDLEKVVTYL AGCGLQSCPM LLAKGYPDVG WNPIEGERYL
2210 2220 2230 2240 2250
SFLRFAVFVN SESVEENASV VVKLLIRRPE CFGPALRGEG GNGLLAAMQG
2260 2270 2280 2290 2300
AIKISESPAL DLPSQGYKRE VPEDGEEEEE IVHMGNAIMS FYSALIDLLG
2310 2320 2330 2340 2350
RCAPEMHLIQ TGKGEAIRIR SILRSLVPTE DLVGIISIPL KLPSLNKDGS
2360 2370 2380 2390 2400
VSEPDMAANF CPDHKAPMVL FLDRVYGIKD QTFLLHLLEV GFLPDLRASA
2410 2420 2430 2440 2450
SLDTVALSTT ESALALNRYI CSAVLPLLTR CAPLFAGTEH YTSLIDSTLQ
2460 2470 2480 2490 2500
TIYRLSKGRS LTKAQRDTIE ECLLAICNHL RPSMLQQLLR RLVFDVPQLN
2510 2520 2530 2540 2550
DYCKMPLKLL TNHFEQCWKY YCLPSGWGSY GLAVEEELHL TEKLFWGIFD
2560 2570 2580 2590 2600
SLSHKKYDPD LFRMSLPCLS AIAGALPPDY LDTRITATLE KQVSVDADGN
2610 2620 2630 2640 2650
FDPKPINTIN FSLPEKLEYI VTKYAEHSHD KWACEKSQSG WKYGISLDEN
2660 2670 2680 2690 2700
VKTHPLIRPF KTLTEKEKEI YRWPARESLK TMLAVGWTVE RTKEGEALVQ
2710 2720 2730 2740 2750
LRENEKLRSV SQTSQGNSYN PAPLDLSNVV LSRELQGMVE VVAENYHNIW
2760 2770 2780 2790 2800
AKKKKLELES KGGGSHPLLV PYDTLTAKEK FRDREKAQDL FKFLQVNGVI
2810 2820 2830 2840 2850
VSRGMKDMEL DAFSMEKRFA YKFLKKILKY VDSAQEFIAH LEAIVSSGKT
2860 2870 2880 2890 2900
EKSPHDQEIK FFAKVLLPLV DQYFTNHRLY FLSSPLKPLS SSGYASHKEK
2910 2920 2930 2940 2950
EMVASLFCKL AALVRHRISL FGSDSTTMVS CLHILAQTLD TRTVMKSGSE
2960 2970 2980 2990 3000
LVKAGLRAFF ESAAEDLEKT SENLKLGKFT HSRTQIKGVS QNINYTTVAL
3010 3020 3030 3040 3050
LPILTSIFEH VAQHQFGVDL LLGDVQISCY RILCSLYSLG TGKNIYVERQ
3060 3070 3080 3090 3100
RPALGECLAS LAAAIPVAFL EPTLNRYNAL SVFNTKTPRE RSILGMPDTV
3110 3120 3130 3140 3150
EEMCPDIPQL EGLMKEINDL AESGARYTEM PHVIEVILPM LCNYLSYWWE
3160 3170 3180 3190 3200
RGPENLSPST GPCCSKVTSE HLSLILGNIL KIINNNLGID EASWMKRIAV
3210 3220 3230 3240 3250
YAQPIISKAR PDLLRSHFIP TLEKLKKKAV KTVQEEEQLK ADGKGDTQEA
3260 3270 3280 3290 3300
ELLILDEFAI LCRDLYAFYP MLIRYVDNNR SNWLKSPDGD SDQLFRMVAE
3310 3320 3330 3340 3350
VFILWCKSHN FKREEQNFVI QNEINNLAFL TGDSKSKMSK AMQVKSGGQD
3360 3370 3380 3390 3400
QERKKTKRRG DLYSIQTSLI VAALKKMLPI GLNMCTPGDQ ELISLAKSRY
3410 3420 3430 3440 3450
SYRDTDEEVK EHLRNNLHLQ EKSDDPAVKW QLNLYKDVLK SEEPSNPEKT
3460 3470 3480 3490 3500
VERVQRISAA VFHLEQVEQP LRSKKAVWHK LLSKQRKRAV VACFRMAPLY
3510 3520 3530 3540 3550
NLPRHRSINL FLHGYQRFWI ETEEYSFEEK LVQDLAKSPK VEEEEEEEME
3560 3570 3580 3590 3600
KQPDPLHQII LHFSRNALTE RSKLEDDPLY TSYSSMMAKS CQSGEDEEEE
3610 3620 3630 3640 3650
DKEKTFEEKE MEKQKTLYQQ ARLHERGAAE MVLQMISASK GEMSPMVVET
3660 3670 3680 3690 3700
LKLGIAILNG GNAGVQQKML DYLKVKKDAG FFQSLSGLMQ SCSVLDLNAF
3710 3720 3730 3740 3750
ERQNKAEGLG MVTEEGTLIV RERGEKVLQN DEFTRDLFRF LQLLCEGHNS
3760 3770 3780 3790 3800
DFQNFLRTQM GNTTTVNVII STVDYLLRLQ ESISDFYWYY SGKDIIDESG
3810 3820 3830 3840 3850
QHNFSKALAV TKQIFNSLTE YIQGPCIGNQ QSLAHSRLWD AVVGFLHVFA
3860 3870 3880 3890 3900
NMQMKLSQDS SQIELLKELL DLLQDMVVML LSLLEGNVVN GTIGKQMVDT
3910 3920 3930 3940 3950
LVESSTNVEM ILKFFDMFLK LKDLTSSDTF KEYDPDGKGI ISKKEFQKAM
3960 3970 3980 3990 4000
EGQKQYTQSE IDFLLSCAEA DENDMFNYID FVDRFHEPAK DIGFNVAVLL
4010 4020 4030 4040 4050
TNLSEHMPND SRLKCLLDPA ESVLNYFEPY LGRIEIMGGA KKIERVYFEI
4060 4070 4080 4090 4100
SESSRTQWEK PQVKESKRQF IFDVVNEGGE QEKMELFVNF CEDTIFEMQL
4110 4120 4130 4140 4150
ASQISESDSA DRPEEEEGDE ESSYVLEING EEEEDKSFES ASAFAMACAS
4160 4170 4180 4190 4200
LKRNITNLLR KATLKNLRKQ YRNVKKMTAK ELVKVFFSFF WMLFVGLFQL
4210 4220 4230 4240 4250
FFTIVGGIFQ ILWSTVFGGG LVEGAKNIRV TKILGDMPDP TQFGIHDDAM
4260 4270 4280 4290 4300
EAERAEVAEA GITTELVHFV KGERGDTELM SDLFGLHPKK EGGVKHGPEV
4310 4320 4330 4340 4350
GLGDLSEIIG KDEPPTLEST VRKKRKAQAA ETKAEHEAEG KVESEKADLE
4360 4370 4380 4390 4400
DGEKEDKAKE EERAEYLWAE VTKKKKRRRG QKVEKPEAFM ANFFKGLEIY
4410 4420 4430 4440 4450
QTKLLHYLAR NFYNLRFLAL FVAFAINFIL LFYKVTEEPL EEETEDVANL
4460 4470 4480 4490 4500
WNSLNDEEEE EAMVFFVLQE STGYMAPTLR ALAVVHTIIS LVCVVGYYCL
4510 4520 4530 4540 4550
KVPLVVFKRE KEIARKLEFD GLYITEQPSE DDIKGQWDRL VINTPSFPHN
4560 4570 4580 4590 4600
YWDKFVKRKV INKYGDLYGA ERIAELLGLD KNALDFSPVE ETTAEAASLV
4610 4620 4630 4640 4650
SWLSSIDMKY HIWKLGVVFT DNSFLYLAWY TTMSVLGHYN NFFFAAHLLD
4660 4670 4680 4690 4700
IAMGFKTLRT ILSSVTHNGK QLVLTVGLLA VVVYLYTVVA FNFFRKFYNK
4710 4720 4730 4740 4750
SEDDDEPDMK CDDMMTCYLF HMYVGVRAGG GIGDEIEDPA GDPYEMYRIV
4760 4770 4780 4790 4800
FDITFFFFVI VILLAIIQGL IIDAFGELRD QQEQVREDME TKCFICGIGN
4810 4820 4830 4840 4850
DYFDTTPHGF ETHTLQEHNL ANYLFFLMYL INKDETEHTG QESYVWKMYQ
4860 4870
ERCWDFFPAG DCFRKQYEDQ LG
Length:4,872
Mass (Da):551,929
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1DC6B85CD6B93E6
GO
Isoform 2 (identifier: Q9TS33-2) [UniParc]FASTAAdd to basket
Also known as: AS-8a

The sequence of this isoform differs from the canonical sequence as follows:
     4406-4434: Missing.

Note: Lacks a predicted transmembrane segment and does not form functional calcium channels.Curated
Show »
Length:4,843
Mass (Da):548,348
Checksum:i834E5BC3E3BEA2A7
GO
Isoform 3 (identifier: Q9TS33-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3341-3345: Missing.

Show »
Length:4,867
Mass (Da):551,372
Checksum:i6BC79827C396EE7C
GO
Isoform 4 (identifier: Q9TS33-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4791-4841: Missing.

Show »
Length:4,821
Mass (Da):545,978
Checksum:iB4CEFFA01341F104
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0423053341 – 3345Missing in isoform 3. 2 Publications5
Alternative sequenceiVSP_0423064406 – 4434Missing in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_0423074791 – 4841Missing in isoform 4. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X68650 mRNA Translation: CAC16153.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S27272

NCBI Reference Sequences

More...
RefSeqi
NP_001076231.1, NM_001082762.1 [Q9TS33-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100009545

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ocu:100009545

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68650 mRNA Translation: CAC16153.1
PIRiS27272
RefSeqiNP_001076231.1, NM_001082762.1 [Q9TS33-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

ComplexPortaliCPX-3157, Ryanodine 3 complex [Q9TS33-1]
STRINGi9986.ENSOCUP00000009882

Proteomic databases

PRIDEiQ9TS33

Genome annotation databases

GeneIDi100009545
KEGGiocu:100009545

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6263

Phylogenomic databases

eggNOGiKOG2243, Eukaryota
KOiK04963
OrthoDBi5161at2759

Family and domain databases

CDDicd12877, SPRY1_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit
Gene3Di2.60.120.920, 3 hits
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR002048, EF_hand_dom
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035910, RyR/IP3R_RIH_dom_sf
IPR035761, SPRY1_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom
PfamiView protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits
PRINTSiPR00795, RYANODINER
SMARTiView protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits
SUPFAMiSSF100909, SSF100909, 2 hits
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 3 hits
SSF82109, SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50919, MIR, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRYR3_RABIT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9TS33
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: May 1, 2000
Last modified: August 12, 2020
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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