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UniProtKB - Q9T0A0 (LACS4_ARATH)
Protein
Long chain acyl-CoA synthetase 4
Gene
LACS4
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitate, palmitoleate, oleate and linoleate.
Catalytic activityi
- EC:6.2.1.31 Publication
Cofactori
Mg2+By similarity
: fatty acid metabolism Pathwayi
This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 228 – 239 | ATPSequence analysisAdd BLAST | 12 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- long-chain fatty acid-CoA ligase activity Source: UniProtKB
GO - Biological processi
- fatty acid metabolic process Source: UniProtKB
Keywordsi
Molecular function | Ligase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Ligand | ATP-binding, Magnesium, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | ARA:AT4G23850-MONOMER |
SABIO-RKi | Q9T0A0 |
UniPathwayi | UPA00199 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:LACS4 Ordered Locus Names:At4g23850 ORF Names:T32A16_20 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT4G23850 |
TAIRi | locus:2138141, AT4G23850 |
Subcellular locationi
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
Golgi apparatus
- Golgi apparatus Source: TAIR
Other locations
- membrane Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000401412 | 1 – 666 | Long chain acyl-CoA synthetase 4Add BLAST | 666 |
Proteomic databases
PaxDbi | Q9T0A0 |
PRIDEi | Q9T0A0 |
ProteomicsDBi | 238406 |
PTM databases
iPTMneti | Q9T0A0 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q9T0A0, baseline and differential |
Genevisiblei | Q9T0A0, AT |
Interactioni
Protein-protein interaction databases
BioGRIDi | 13773, 4 interactors |
STRINGi | 3702.AT4G23850.1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 495 – 519 | Fatty acid-bindingSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the ATP-dependent AMP-binding enzyme family.Curated
Phylogenomic databases
eggNOGi | KOG1256, Eukaryota |
HOGENOMi | CLU_000022_45_4_1 |
InParanoidi | Q9T0A0 |
OMAi | HTHSTIQ |
OrthoDBi | 630541at2759 |
PhylomeDBi | Q9T0A0 |
Family and domain databases
CDDi | cd05927, LC-FACS_euk, 1 hit |
Gene3Di | 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf IPR045311, LC-FACS_euk |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9T0A0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQQKKYIFQ VEEGKEGSDG RPSVGPVYRS IFAKDGFPDP IEGMDSCWDV
60 70 80 90 100
FRMSVEKYPN NPMLGRREIV DGKPGKYVWQ TYQEVYDIVM KLGNSLRSVG
110 120 130 140 150
VKDEAKCGIY GANSPEWIIS MEACNAHGLY CVPLYDTLGA DAVEFIISHS
160 170 180 190 200
EVSIVFVEEK KISELFKTCP NSTEYMKTVV SFGGVSREQK EEAETFGLVI
210 220 230 240 250
YAWDEFLKLG EGKQYDLPIK KKSDICTIMY TSGTTGDPKG VMISNESIVT
260 270 280 290 300
LIAGVIRLLK SANEALTVKD VYLSYLPLAH IFDRVIEECF IQHGAAIGFW
310 320 330 340 350
RGDVKLLIED LAELKPTIFC AVPRVLDRVY SGLQKKLSDG GFLKKFIFDS
360 370 380 390 400
AFSYKFGYMK KGQSHVEASP LFDKLVFSKV KQGLGGNVRI ILSGAAPLAS
410 420 430 440 450
HVESFLRVVA CCHVLQGYGL TESCAGTFVS LPDELGMLGT VGPPVPNVDI
460 470 480 490 500
RLESVPEMEY DALASTARGE ICIRGKTLFS GYYKREDLTK EVLIDGWLHT
510 520 530 540 550
GDVGEWQPDG SMKIIDRKKN IFKLSQGEYV AVENIENIYG EVQAVDSVWV
560 570 580 590 600
YGNSFESFLI AIANPNQHIL ERWAAENGVS GDYDALCQNE KAKEFILGEL
610 620 630 640 650
VKMAKEKKMK GFEIIKAIHL DPVPFDMERD LLTPTFKKKR PQLLKYYQSV
660
IDEMYKTINA KFASRG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF503754 mRNA Translation: AAM28871.1 AL078468 Genomic DNA Translation: CAB43885.1 AL161560 Genomic DNA Translation: CAB81303.1 CP002687 Genomic DNA Translation: AEE84812.1 AY049239 mRNA Translation: AAK83581.1 |
PIRi | T08904 |
RefSeqi | NP_194116.1, NM_118516.5 |
Genome annotation databases
EnsemblPlantsi | AT4G23850.1; AT4G23850.1; AT4G23850 |
GeneIDi | 828484 |
Gramenei | AT4G23850.1; AT4G23850.1; AT4G23850 |
KEGGi | ath:AT4G23850 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF503754 mRNA Translation: AAM28871.1 AL078468 Genomic DNA Translation: CAB43885.1 AL161560 Genomic DNA Translation: CAB81303.1 CP002687 Genomic DNA Translation: AEE84812.1 AY049239 mRNA Translation: AAK83581.1 |
PIRi | T08904 |
RefSeqi | NP_194116.1, NM_118516.5 |
3D structure databases
SMRi | Q9T0A0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 13773, 4 interactors |
STRINGi | 3702.AT4G23850.1 |
PTM databases
iPTMneti | Q9T0A0 |
Proteomic databases
PaxDbi | Q9T0A0 |
PRIDEi | Q9T0A0 |
ProteomicsDBi | 238406 |
Genome annotation databases
EnsemblPlantsi | AT4G23850.1; AT4G23850.1; AT4G23850 |
GeneIDi | 828484 |
Gramenei | AT4G23850.1; AT4G23850.1; AT4G23850 |
KEGGi | ath:AT4G23850 |
Organism-specific databases
Araporti | AT4G23850 |
TAIRi | locus:2138141, AT4G23850 |
Phylogenomic databases
eggNOGi | KOG1256, Eukaryota |
HOGENOMi | CLU_000022_45_4_1 |
InParanoidi | Q9T0A0 |
OMAi | HTHSTIQ |
OrthoDBi | 630541at2759 |
PhylomeDBi | Q9T0A0 |
Enzyme and pathway databases
UniPathwayi | UPA00199 |
BioCyci | ARA:AT4G23850-MONOMER |
SABIO-RKi | Q9T0A0 |
Miscellaneous databases
PROi | PR:Q9T0A0 |
Gene expression databases
ExpressionAtlasi | Q9T0A0, baseline and differential |
Genevisiblei | Q9T0A0, AT |
Family and domain databases
CDDi | cd05927, LC-FACS_euk, 1 hit |
Gene3Di | 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf IPR045311, LC-FACS_euk |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LACS4_ARATH | |
Accessioni | Q9T0A0Primary (citable) accession number: Q9T0A0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 30, 2010 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families