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Entry version 140 (18 Sep 2019)
Sequence version 1 (01 May 2000)
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Protein

Subtilisin-like protease SBT3.8

Gene

SBT3.8

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei143Charge relay systemPROSITE-ProRule annotation1
Active sitei218Charge relay systemPROSITE-ProRule annotation1
Active sitei553Charge relay systemPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S08.A45

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Subtilisin-like protease SBT3.81 Publication (EC:3.4.21.-PROSITE-ProRule annotation)
Alternative name(s):
Subtilase subfamily 3 member 81 Publication
Short name:
AtSBT3.81 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SBT3.81 Publication
Ordered Locus Names:At4g10540Imported
ORF Names:F3H7.2Imported, F7L13.120Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT4G10540

The Arabidopsis Information Resource

More...
TAIRi
locus:2127666 AT4G10540

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000043520027 – 109Activation peptideBy similarityAdd BLAST83
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_5004332765110 – ?Subtilisin-like protease SBT3.8
PropeptideiPRO_0000435201? – 775By similarity

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi129N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi174N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi202N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi395N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi410N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi538N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi645N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi721N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi756N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Autocatalytic cleavage, Glycoprotein, Zymogen

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9SZY3

PRoteomics IDEntifications database

More...
PRIDEi
Q9SZY3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9SZY3 differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT4G10540.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9SZY3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 108Inhibitor I9Sequence analysisAdd BLAST79
Domaini113 – 622Peptidase S8PROSITE-ProRule annotationAdd BLAST510
Domaini384 – 476PASequence analysisAdd BLAST93

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S8 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJJ6 Eukaryota
COG1404 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000238262

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9SZY3

Identification of Orthologs from Complete Genome Data

More...
OMAi
LCLMINI

Database of Orthologous Groups

More...
OrthoDBi
337164at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9SZY3

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04852 Peptidases_S8_3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.80, 1 hit
3.40.50.200, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003137 PA_domain
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR034197 Peptidases_S8_3
IPR010259 S8pro/Inhibitor_I9
IPR037045 S8pro/Inhibitor_I9_sf
IPR041469 Subtilisin-like_FN3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17766 fn3_6, 1 hit
PF05922 Inhibitor_I9, 1 hit
PF02225 PA, 1 hit
PF00082 Peptidase_S8, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00723 SUBTILISIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52743 SSF52743, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51892 SUBTILASE, 1 hit
PS00138 SUBTILASE_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SZY3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSCRTLIFV AIILNGLSTF VAHAGAESKV HIVYLGEKQH DDPEFVTESH
60 70 80 90 100
HRMLWSLLGS KEDAHSSMVH SYRHGFSGFA AKLTKSQAKK LADLPEVVHV
110 120 130 140 150
TPDSFYQLDT TRTWDYLGLS VANPKNLLND TNMGEEVIIG IVDSGVWPES
160 170 180 190 200
EVFNDNGIGP VPSHWKGGCV SGENFTSSQC NKKLIGAKYF INGFLATHES
210 220 230 240 250
FNSTESLDFI SPRDRSGHGT HVATIAGGSY VPSISYKGLA GGTVRGGAPR
260 270 280 290 300
ARIAMYKACW YLDRFDINTC SSADILKAMD EAMHDGVDVL SLSIGYRFPY
310 320 330 340 350
FPETDVRAVI ATGAFHAVLK GITVVCSGGN SGPAAQTVGN TAPWILTVAA
360 370 380 390 400
TTLDRSFPTP ITLGNNKLIL GQAMYTGPEL GFTSLVYPEN PGNSNESFSG
410 420 430 440 450
DCELLFFNSN HTMAGKVVLC FTTSTRYITV SSAVSYVKEA GGLGVIVARN
460 470 480 490 500
PGDNLSPCED DFPCVAVDYE LGTDILLYIR STGLPVVKIQ PSKTLVGQPV
510 520 530 540 550
GTKVADFSSR GPNSIEPAIL KPDIAAPGVS ILAATTTNKT FNDRGFIFLS
560 570 580 590 600
GTSMAAPTIS GVVALLKALH RDWSPAAIRS AIVTTAWRTD PFGEQIFAEG
610 620 630 640 650
SPRKLADPFD YGGGLVNPEK AAKPGLVYDL GLEDYVLYMC SVGYNETSIS
660 670 680 690 700
QLVGKGTVCS NPKPSVLDFN LPSITIPNLK DEVTLTRTLT NVGQLESVYK
710 720 730 740 750
VVIEPPIGIQ VTVTPETLLF NSTTKRVSFK VKVSTTHKIN TGYFFGSLTW
760 770
SDSLHNVTIP LSVRTQILQN YYDEN
Length:775
Mass (Da):83,518
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6294E442E580F508
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD03430 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF118222 Genomic DNA Translation: AAD03430.1 Sequence problems.
AL049524 Genomic DNA Translation: CAB40047.1
AL161517 Genomic DNA Translation: CAB78177.1
CP002687 Genomic DNA Translation: AEE82895.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T04189

NCBI Reference Sequences

More...
RefSeqi
NP_567361.1, NM_117122.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT4G10540.1; AT4G10540.1; AT4G10540

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
826646

Gramene; a comparative resource for plants

More...
Gramenei
AT4G10540.1; AT4G10540.1; AT4G10540

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT4G10540

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118222 Genomic DNA Translation: AAD03430.1 Sequence problems.
AL049524 Genomic DNA Translation: CAB40047.1
AL161517 Genomic DNA Translation: CAB78177.1
CP002687 Genomic DNA Translation: AEE82895.1
PIRiT04189
RefSeqiNP_567361.1, NM_117122.1

3D structure databases

SMRiQ9SZY3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G10540.1

Protein family/group databases

MEROPSiS08.A45

Proteomic databases

PaxDbiQ9SZY3
PRIDEiQ9SZY3

Genome annotation databases

EnsemblPlantsiAT4G10540.1; AT4G10540.1; AT4G10540
GeneIDi826646
GrameneiAT4G10540.1; AT4G10540.1; AT4G10540
KEGGiath:AT4G10540

Organism-specific databases

AraportiAT4G10540
TAIRilocus:2127666 AT4G10540

Phylogenomic databases

eggNOGiENOG410IJJ6 Eukaryota
COG1404 LUCA
HOGENOMiHOG000238262
InParanoidiQ9SZY3
OMAiLCLMINI
OrthoDBi337164at2759
PhylomeDBiQ9SZY3

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9SZY3

Gene expression databases

ExpressionAtlasiQ9SZY3 differential

Family and domain databases

CDDicd04852 Peptidases_S8_3, 1 hit
Gene3Di3.30.70.80, 1 hit
3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR003137 PA_domain
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR034197 Peptidases_S8_3
IPR010259 S8pro/Inhibitor_I9
IPR037045 S8pro/Inhibitor_I9_sf
IPR041469 Subtilisin-like_FN3
PfamiView protein in Pfam
PF17766 fn3_6, 1 hit
PF05922 Inhibitor_I9, 1 hit
PF02225 PA, 1 hit
PF00082 Peptidase_S8, 1 hit
PRINTSiPR00723 SUBTILISIN
SUPFAMiSSF52743 SSF52743, 1 hit
PROSITEiView protein in PROSITE
PS51892 SUBTILASE, 1 hit
PS00138 SUBTILASE_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSBT38_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9SZY3
Secondary accession number(s): Q9ZSB2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2016
Last sequence update: May 1, 2000
Last modified: September 18, 2019
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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