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Entry version 122 (12 Aug 2020)
Sequence version 1 (01 May 2000)
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Protein

CSC1-like protein At4g35870

Gene

GFS10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an osmosensitive calcium-permeable cation channel.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • protein targeting to vacuole Source: TAIR

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CSC1-like protein At4g35870
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GFS10
Ordered Locus Names:At4g35870
ORF Names:F4B14_140
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

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Araporti
AT4G35870

The Arabidopsis Information Resource

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TAIRi
locus:2125394, AT4G35870

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
Transmembranei463 – 483HelicalSequence analysisAdd BLAST21
Transmembranei506 – 526HelicalSequence analysisAdd BLAST21
Transmembranei569 – 589HelicalSequence analysisAdd BLAST21
Transmembranei676 – 696HelicalSequence analysisAdd BLAST21
Transmembranei729 – 749HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Accumulated 12S globulin precursors in seeds.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004298121 – 817CSC1-like protein At4g35870Add BLAST817

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9SZT4

PRoteomics IDEntifications database

More...
PRIDEi
Q9SZT4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
220353

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9SZT4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9SZT4, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT4G35870.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1134, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007889_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9SZT4

Identification of Orthologs from Complete Genome Data

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OMAi
LIEGGSC

Database of Orthologous Groups

More...
OrthoDBi
395194at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9SZT4

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032880, Csc1_N
IPR027815, PHM7_cyt
IPR003864, RSN1_7TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14703, PHM7_cyt, 1 hit
PF02714, RSN1_7TM, 2 hits
PF13967, RSN1_TM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9SZT4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRNFSPAAM PPISSMTIDN SFSPPPSSGD LPEIPDAWYG NIQYLLNISV
60 70 80 90 100
IGLLCCVSIF LFVKLRSDHR RMPGPSALFS KLLAVWKATC REIARHCGAD
110 120 130 140 150
AAQFLLIEGG SFVLLFSIAV LAVSVMLPLN LYAGTALLSD ELSKTMITHI
160 170 180 190 200
QKGSALLWLH FVFVVIVVVI SHFGIAAIEA RLKFTRFRDG NGNISDPNAN
210 220 230 240 250
STAVFTIMVQ GLPKNLGSDR VEFEDCFRLK YPGKVYKFIV PMDLCALDDL
260 270 280 290 300
ATELVRVRDE ITWLVAKMDS RLLPDEYENV GDNGLVFCVC SLWVRVKVLW
310 320 330 340 350
SQITERFGFT DDEKLRKLQE LRADLESQLA AYKEGRAQGA GVAFVMFKDV
360 370 380 390 400
YTANKAVQDF RNERSRRTGK FFSVTELRLQ RNQWKVDRAP LATDIYWNHL
410 420 430 440 450
GLTKVALIVR RVIVNTILLL ILVFFSSPLA LISALVSAGR IFNAEALDSA
460 470 480 490 500
QYWLTWVQTS GWIGSLIFQF LPNVFIFVSM YIVIPSALSY LSKFERHLTV
510 520 530 540 550
SGEQRAALLK MVCFFLVNLI ILKALVESSL ESALLKMSRC YLDGEDCKRI
560 570 580 590 600
EEYMSPSFLS RSCVSALAFL ITSTFLGISF DLLAPIPWIK KKIQKFRKND
610 620 630 640 650
MLQLVPEQNE EYALENQEPS SNLETPLLPE NMFESPRFGD IEPMSQDLSE
660 670 680 690 700
YPISRTSPIP KQKFDFAQYY AFNLTIFALT MIYSSFAPLV VPVGAVYFGY
710 720 730 740 750
RYIVDKYNFL YVYRVRGFPA GNEGKLMDTV LCIMRFCVDL YLVSMLLFFS
760 770 780 790 800
VKGDSTKLQA IFTLGVLVMY KLLPSDTDRY HPALLRSIQT VDSIIDGPVD
810
YEAYSHPNFD WDTYNNR
Length:817
Mass (Da):92,585
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1BE1DE4956F2145E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL031986 Genomic DNA Translation: CAA21473.1
AL161588 Genomic DNA Translation: CAB81496.1
CP002687 Genomic DNA Translation: AEE86583.1
AY090251 mRNA Translation: AAL90913.1
AY096495 mRNA No translation available.

Protein sequence database of the Protein Information Resource

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PIRi
T04697

NCBI Reference Sequences

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RefSeqi
NP_195312.1, NM_119753.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT4G35870.1; AT4G35870.1; AT4G35870

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
829741

Gramene; a comparative resource for plants

More...
Gramenei
AT4G35870.1; AT4G35870.1; AT4G35870

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT4G35870

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031986 Genomic DNA Translation: CAA21473.1
AL161588 Genomic DNA Translation: CAB81496.1
CP002687 Genomic DNA Translation: AEE86583.1
AY090251 mRNA Translation: AAL90913.1
AY096495 mRNA No translation available.
PIRiT04697
RefSeqiNP_195312.1, NM_119753.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi3702.AT4G35870.1

Proteomic databases

PaxDbiQ9SZT4
PRIDEiQ9SZT4
ProteomicsDBi220353

Genome annotation databases

EnsemblPlantsiAT4G35870.1; AT4G35870.1; AT4G35870
GeneIDi829741
GrameneiAT4G35870.1; AT4G35870.1; AT4G35870
KEGGiath:AT4G35870

Organism-specific databases

AraportiAT4G35870
TAIRilocus:2125394, AT4G35870

Phylogenomic databases

eggNOGiKOG1134, Eukaryota
HOGENOMiCLU_007889_0_0_1
InParanoidiQ9SZT4
OMAiLIEGGSC
OrthoDBi395194at2759
PhylomeDBiQ9SZT4

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9SZT4

Gene expression databases

ExpressionAtlasiQ9SZT4, baseline and differential
GenevisibleiQ9SZT4, AT

Family and domain databases

InterProiView protein in InterPro
IPR032880, Csc1_N
IPR027815, PHM7_cyt
IPR003864, RSN1_7TM
PfamiView protein in Pfam
PF14703, PHM7_cyt, 1 hit
PF02714, RSN1_7TM, 2 hits
PF13967, RSN1_TM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSCLE_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9SZT4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: May 1, 2000
Last modified: August 12, 2020
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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