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Protein

Peroxidase 51

Gene

PER51

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei63Transition state stabilizerPROSITE-ProRule annotation1
Active sitei67Proton acceptorPROSITE-ProRule annotation1
Metal bindingi68Calcium 1PROSITE-ProRule annotation1
Metal bindingi71Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi73Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi75Calcium 1PROSITE-ProRule annotation1
Metal bindingi77Calcium 1PROSITE-ProRule annotation1
Binding sitei167Substrate; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi197Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi198Calcium 2PROSITE-ProRule annotation1
Metal bindingi249Calcium 2PROSITE-ProRule annotation1
Metal bindingi252Calcium 2PROSITE-ProRule annotation1
Metal bindingi257Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT4G37530-MONOMER

Protein family/group databases

PeroxiBasei217 AtPrx51

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 51 (EC:1.11.1.7)
Short name:
Atperox P51
Alternative name(s):
ATP37
Gene namesi
Name:PER51
Synonyms:P51
Ordered Locus Names:At4g37530
ORF Names:F19F18.20, F6G17.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G37530
TAIRilocus:2120061 AT4G37530

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000002371626 – 329Peroxidase 51Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 119PROSITE-ProRule annotation
Disulfide bondi69 ↔ 74PROSITE-ProRule annotation
Disulfide bondi125 ↔ 325PROSITE-ProRule annotation
Disulfide bondi204 ↔ 236PROSITE-ProRule annotation
Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9SZE7
PRIDEiQ9SZE7

Expressioni

Gene expression databases

ExpressionAtlasiQ9SZE7 baseline and differential
GenevisibleiQ9SZE7 AT

Interactioni

Protein-protein interaction databases

BioGridi15189, 1 interactor
IntActiQ9SZE7, 1 interactor
STRINGi3702.AT4G37530.1

Structurei

3D structure databases

ProteinModelPortaliQ9SZE7
SMRiQ9SZE7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJ72 Eukaryota
ENOG4111FDS LUCA
HOGENOMiHOG000237556
InParanoidiQ9SZE7
KOiK00430
OMAiQMFAANG
OrthoDBiEOG09360FB9
PhylomeDBiQ9SZE7

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced. According to EST sequences.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9SZE7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVVMNKTNLL LLILSLFLAI NLSSAQLRGD FYAGTCPNVE QIVRNAVQKK
60 70 80 90 100
IQQTFTTIPA TLRLYFHDCF VNGCDASVMI ASTNTNKAEK DHEDNLSLAG
110 120 130 140 150
DGFDTVIKAK EAVDAVPNCR NKVSCADILT MATRDVVNLA GGPQYAVELG
160 170 180 190 200
RRDGLSSSAS SVTGKLPKPT FDLNQLNALF AENGLSPNDM IALSGAHTLG
210 220 230 240 250
FAHCTKVFNR LYNFNKTNNV DPTINKDYVT ELKASCPQNI DPRVAINMDP
260 270 280 290 300
NTPRQFDNVY YKNLQQGKGL FTSDQVLFTD SRSKPTVDLW ANNGQLFNQA
310 320
FISSMIKLGR VGVKTGSNGN IRRDCGAFN
Length:329
Mass (Da):35,989
Last modified:May 1, 2000 - v1
Checksum:iDF4D71BB1503F145
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MRF4A8MRF4_ARATH
Peroxidase
At4g37530, F19F18.20, F19F18_20
282Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31F → L in AAL49862 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF469928 mRNA Translation: AAL79842.1
AL035601 Genomic DNA No translation available.
AL035605 Genomic DNA Translation: CAB38292.1
AL161591 Genomic DNA Translation: CAB80418.1
CP002687 Genomic DNA Translation: AEE86806.1
AY070459 mRNA Translation: AAL49862.1
AY150515 mRNA Translation: AAN13031.1
PIRiT04710
RefSeqiNP_195469.1, NM_119917.3 [Q9SZE7-1]
UniGeneiAt.68229

Genome annotation databases

EnsemblPlantsiAT4G37530.1; AT4G37530.1; AT4G37530 [Q9SZE7-1]
GeneIDi829908
GrameneiAT4G37530.1; AT4G37530.1; AT4G37530 [Q9SZE7-1]
KEGGiath:AT4G37530

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF469928 mRNA Translation: AAL79842.1
AL035601 Genomic DNA No translation available.
AL035605 Genomic DNA Translation: CAB38292.1
AL161591 Genomic DNA Translation: CAB80418.1
CP002687 Genomic DNA Translation: AEE86806.1
AY070459 mRNA Translation: AAL49862.1
AY150515 mRNA Translation: AAN13031.1
PIRiT04710
RefSeqiNP_195469.1, NM_119917.3 [Q9SZE7-1]
UniGeneiAt.68229

3D structure databases

ProteinModelPortaliQ9SZE7
SMRiQ9SZE7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi15189, 1 interactor
IntActiQ9SZE7, 1 interactor
STRINGi3702.AT4G37530.1

Protein family/group databases

PeroxiBasei217 AtPrx51

Proteomic databases

PaxDbiQ9SZE7
PRIDEiQ9SZE7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G37530.1; AT4G37530.1; AT4G37530 [Q9SZE7-1]
GeneIDi829908
GrameneiAT4G37530.1; AT4G37530.1; AT4G37530 [Q9SZE7-1]
KEGGiath:AT4G37530

Organism-specific databases

AraportiAT4G37530
TAIRilocus:2120061 AT4G37530

Phylogenomic databases

eggNOGiENOG410IJ72 Eukaryota
ENOG4111FDS LUCA
HOGENOMiHOG000237556
InParanoidiQ9SZE7
KOiK00430
OMAiQMFAANG
OrthoDBiEOG09360FB9
PhylomeDBiQ9SZE7

Enzyme and pathway databases

BioCyciARA:AT4G37530-MONOMER

Miscellaneous databases

PROiPR:Q9SZE7

Gene expression databases

ExpressionAtlasiQ9SZE7 baseline and differential
GenevisibleiQ9SZE7 AT

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS50873 PEROXIDASE_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPER51_ARATH
AccessioniPrimary (citable) accession number: Q9SZE7
Secondary accession number(s): Q8VYK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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