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UniProtKB - Q9SZE1 (3HID1_ARATH)
Protein
Probable 3-hydroxyisobutyrate dehydrogenase-like 1, mitochondrial
Gene
At4g29120
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Catalytic activityi
- EC:1.1.1.31
: L-valine degradation Pathwayi
This protein is involved in the pathway L-valine degradation, which is part of Amino-acid degradation.View all proteins of this organism that are known to be involved in the pathway L-valine degradation and in Amino-acid degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 133 | NAD; via amide nitrogenBy similarity | 1 | |
Active sitei | 207 | By similarity | 1 | |
Binding sitei | 275 | NADBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 38 – 67 | NADBy similarityAdd BLAST | 30 |
GO - Molecular functioni
- 3-hydroxyisobutyrate dehydrogenase activity Source: UniProtKB-EC
- NAD binding Source: InterPro
- NADP binding Source: InterPro
GO - Biological processi
- valine catabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Branched-chain amino acid catabolism |
Ligand | NAD |
Enzyme and pathway databases
BioCyci | ARA:AT4G29120-MONOMER |
UniPathwayi | UPA00362 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable 3-hydroxyisobutyrate dehydrogenase-like 1, mitochondrial (EC:1.1.1.31)Short name: HIBADH-like |
Gene namesi | Ordered Locus Names:At4g29120 ORF Names:F19B15.150 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT4G29120 |
TAIRi | locus:2119921, AT4G29120 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 23 | MitochondrionSequence analysisCombined sourcesAdd BLAST | 23 | |
ChainiPRO_0000421117 | 24 – 334 | Probable 3-hydroxyisobutyrate dehydrogenase-like 1, mitochondrialAdd BLAST | 311 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 24 | N-acetylalanineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
PaxDbi | Q9SZE1 |
PRIDEi | Q9SZE1 |
ProteomicsDBi | 245106 [Q9SZE1-1] |
PTM databases
iPTMneti | Q9SZE1 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q9SZE1, baseline and differential |
Genevisiblei | Q9SZE1, AT |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGRIDi | 14320, 2 interactors |
IntActi | Q9SZE1, 2 interactors |
STRINGi | 3702.AT4G29120.1 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0409, Eukaryota |
HOGENOMi | CLU_035117_1_0_1 |
InParanoidi | Q9SZE1 |
OMAi | IFVDHTT |
PhylomeDBi | Q9SZE1 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR006115, 6PGDH_NADP-bd IPR015815, HIBADH-related IPR036291, NAD(P)-bd_dom_sf IPR029154, NADP-bd |
Pfami | View protein in Pfam PF14833, NAD_binding_11, 1 hit PF03446, NAD_binding_2, 1 hit |
PIRSFi | PIRSF000103, HIBADH, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative initiation. AlignAdd to basketIsoform 1 (identifier: Q9SZE1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPLLLRRFPS PSVVSSFFLR RSMASSTISS DIITPSNTKI GWIGTGVMGR
60 70 80 90 100
SMCGHLIKAG YTVTVFNRTI SKAQTLIDMG ANVADSPNSV AEQSDVVFTI
110 120 130 140 150
VGYPSDVRHV LLDPKSGALS GLRQGGVLVD MTTSEPSLAE EIAKAASFKN
160 170 180 190 200
CFSIDAPVSG GDLGAKNGKL SIFAGGDETT VKRLDPLFSL MGKVNFMGTS
210 220 230 240 250
GKGQFAKLAN QITIASTMLG LVEGLIYAHK AGLDVKKFLE AISTGAAGSK
260 270 280 290 300
SIDLYGDRIL KRDFDPGFYV NHFVKDLGIC LNECQRMGLA LPGLALAQQL
310 320 330
YLSLKAHGEG DLGTQALLLA LERLNNVSVQ SSDS
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_057959 | 1 – 22 | Missing in isoform 2. Add BLAST | 22 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL078470 Genomic DNA Translation: CAB43926.1 AL161574 Genomic DNA Translation: CAB79670.1 CP002687 Genomic DNA Translation: AEE85589.1 AF370197 mRNA Translation: AAK44012.1 AY062952 mRNA Translation: AAL33784.1 |
PIRi | T08967 |
RefSeqi | NP_194641.1, NM_119056.2 [Q9SZE1-1] |
Genome annotation databases
EnsemblPlantsi | AT4G29120.1; AT4G29120.1; AT4G29120 [Q9SZE1-1] |
GeneIDi | 829033 |
Gramenei | AT4G29120.1; AT4G29120.1; AT4G29120 [Q9SZE1-1] |
KEGGi | ath:AT4G29120 |
Keywords - Coding sequence diversityi
Alternative initiationSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL078470 Genomic DNA Translation: CAB43926.1 AL161574 Genomic DNA Translation: CAB79670.1 CP002687 Genomic DNA Translation: AEE85589.1 AF370197 mRNA Translation: AAK44012.1 AY062952 mRNA Translation: AAL33784.1 |
PIRi | T08967 |
RefSeqi | NP_194641.1, NM_119056.2 [Q9SZE1-1] |
3D structure databases
SMRi | Q9SZE1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 14320, 2 interactors |
IntActi | Q9SZE1, 2 interactors |
STRINGi | 3702.AT4G29120.1 |
PTM databases
iPTMneti | Q9SZE1 |
Proteomic databases
PaxDbi | Q9SZE1 |
PRIDEi | Q9SZE1 |
ProteomicsDBi | 245106 [Q9SZE1-1] |
Genome annotation databases
EnsemblPlantsi | AT4G29120.1; AT4G29120.1; AT4G29120 [Q9SZE1-1] |
GeneIDi | 829033 |
Gramenei | AT4G29120.1; AT4G29120.1; AT4G29120 [Q9SZE1-1] |
KEGGi | ath:AT4G29120 |
Organism-specific databases
Araporti | AT4G29120 |
TAIRi | locus:2119921, AT4G29120 |
Phylogenomic databases
eggNOGi | KOG0409, Eukaryota |
HOGENOMi | CLU_035117_1_0_1 |
InParanoidi | Q9SZE1 |
OMAi | IFVDHTT |
PhylomeDBi | Q9SZE1 |
Enzyme and pathway databases
UniPathwayi | UPA00362 |
BioCyci | ARA:AT4G29120-MONOMER |
Miscellaneous databases
PROi | PR:Q9SZE1 |
Gene expression databases
ExpressionAtlasi | Q9SZE1, baseline and differential |
Genevisiblei | Q9SZE1, AT |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR006115, 6PGDH_NADP-bd IPR015815, HIBADH-related IPR036291, NAD(P)-bd_dom_sf IPR029154, NADP-bd |
Pfami | View protein in Pfam PF14833, NAD_binding_11, 1 hit PF03446, NAD_binding_2, 1 hit |
PIRSFi | PIRSF000103, HIBADH, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | 3HID1_ARATH | |
Accessioni | Q9SZE1Primary (citable) accession number: Q9SZE1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2013 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families