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Protein

Peroxisome biogenesis factor 10

Gene

PEX10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the formation of peroxisomes, lipid bodies and protein bodies. Required for normal-shaped peroxisomes that can physically associate with the outer membrane of the chloroplast envelope. Not involved in beta-oxidation and glyoxylate cycle. Acts as an E3 ubiquitin-protein ligase.6 Publications

Miscellaneous

Travels directly from the cytosol to the peroxisomes.

Cofactori

Zn2+1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri327 – 365RING-typePROSITE-ProRule annotationAdd BLAST39

GO - Molecular functioni

  • ubiquitin-protein transferase activity Source: TAIR
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Biological processPeroxisome biogenesis, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-ATH-9033241 Peroxisomal protein import

Protein family/group databases

TCDBi3.A.20.1.2 the peroxisomal protein importer (ppi) family

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome biogenesis factor 10
Alternative name(s):
PER10
Peroxin-10
Peroxisomal biogenesis factor 10
Short name:
AtPEX10
Short name:
AthPEX10
Peroxisome assembly protein 10
Pex10p
Gene namesi
Name:PEX10
Ordered Locus Names:At2g26350
ORF Names:T9J22.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G26350
TAIRilocus:2057780 AT2G26350

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Peroxisome

Pathology & Biotechi

Disruption phenotypei

Embryo lethality at the heart stage.3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi93G → E: Deformed peroxisomes, but no effect on contacts with chloroplasts and on protein import. 1 Publication1
Mutagenesisi126P → S: No effects on preoxisome shape, contacts with chloroplasts and protein import. 1 Publication1
Mutagenesisi342C → G: Embryo lethality; when associated with L-344; G-347 and G-350. 1 Publication1
Mutagenesisi344H → L: Embryo lethality; when associated with G-342; G-347 and G-350. 1 Publication1
Mutagenesisi347C → G: Embryo lethality; when associated with G-342; L-344 and G-350. 1 Publication1
Mutagenesisi350C → G: Embryo lethality; when associated with G-342; L-344 and G-347. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000563821 – 381Peroxisome biogenesis factor 10Add BLAST381

Proteomic databases

PaxDbiQ9SYU4
PRIDEiQ9SYU4

Expressioni

Tissue specificityi

Expressed in roots, stems, leaves, flowers and siliques.1 Publication

Developmental stagei

Increased expression in early post-germinative growth.

Inductioni

Up-regulated by hydrogen peroxide.1 Publication

Gene expression databases

ExpressionAtlasiQ9SYU4 baseline and differential
GenevisibleiQ9SYU4 AT

Interactioni

Subunit structurei

Interacts (via C-terminus) with PEX19-1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX19-1Q9SRQ32EBI-1151983,EBI-1151789

Protein-protein interaction databases

BioGridi2527, 2 interactors
IntActiQ9SYU4, 3 interactors
STRINGi3702.AT2G26350.1

Structurei

3D structure databases

ProteinModelPortaliQ9SYU4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pex2/pex10/pex12 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri327 – 365RING-typePROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0317 Eukaryota
COG5574 LUCA
HOGENOMiHOG000005805
InParanoidiQ9SYU4
KOiK13346
OMAiSYHGFAS
OrthoDBiEOG09360DKJ
PhylomeDBiQ9SYU4

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR025654 PEX10
IPR006845 Pex_N
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR23350 PTHR23350, 1 hit
PfamiView protein in Pfam
PF04757 Pex2_Pex12, 1 hit
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

Q9SYU4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLNGDSGPG QDEPGSSGFH GGIRRFPLAA QPEIMRAAEK DDQYASFIHE
60 70 80 90 100
ACRDAFRHLF GTRIALAYQK EMKLLGQMLY YVLTTGSGQQ TLGEEYCDII
110 120 130 140 150
QVAGPYGLSP TPARRALFIL YQTAVPYIAE RISTRAATQA VTFDESDEFF
160 170 180 190 200
GDSHIHSPRM IDLPSSSQVE TSTSVVSRLN DRLMRSWHRA IQRWPVVLPV
210 220 230 240 250
AREVLQLVLR ANLMLFYFEG FYYHISKRAS GVRYVFIGKQ LNQRPRYQIL
260 270 280 290 300
GVFLLIQLCI LAAEGLRRSN LSSITSSIQQ ASIGSYQTSG GRGLPVLNEE
310 320 330 340 350
GNLITSEAEK GNWSTSDSTS TEAVGKCTLC LSTRQHPTAT PCGHVFCWSC
360 370 380
IMEWCNEKQE CPLCRTPNTH SSLVCLYHSD F
Length:381
Mass (Da):42,614
Last modified:May 1, 2000 - v1
Checksum:i41AFF2C25E65584A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8AYB2A0A1P8AYB2_ARATH
Peroxin 10
PEX10 ATPEX10, peroxin 10, At2g26350, T9J22.2
310Annotation score:
A0A1P8AY59A0A1P8AY59_ARATH
Peroxin 10
PEX10 ATPEX10, peroxin 10, At2g26350, T9J22.2
325Annotation score:
A0A1P8AYA6A0A1P8AYA6_ARATH
Peroxin 10
PEX10 ATPEX10, peroxin 10, At2g26350, T9J22.2
326Annotation score:

Sequence cautioni

The sequence AAM14959 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti184M → K in CAB87983 (PubMed:10961948).Curated1
Sequence conflicti184M → K in AAM64667 (Ref. 7) Curated1
Sequence conflicti199P → L in CAB87983 (PubMed:10961948).Curated1
Sequence conflicti218F → S in AAM64667 (Ref. 7) Curated1
Sequence conflicti358K → N in AAM64667 (Ref. 7) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119572 mRNA Translation: AAD18035.1
AJ276134 mRNA Translation: CAB87983.1
AC002505 Genomic DNA Translation: AAC14514.2
AC004484 Genomic DNA Translation: AAM14959.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC07828.1
AK117879 mRNA Translation: BAC42519.1
BT005340 mRNA Translation: AAO63404.1
AY087109 mRNA Translation: AAM64667.1
PIRiT00968
RefSeqiNP_001323819.1, NM_001336060.1
NP_565621.1, NM_128192.2
UniGeneiAt.22386

Genome annotation databases

EnsemblPlantsiAT2G26350.1; AT2G26350.1; AT2G26350
GeneIDi817175
GrameneiAT2G26350.1; AT2G26350.1; AT2G26350
KEGGiath:AT2G26350

Similar proteinsi

Entry informationi

Entry nameiPEX10_ARATH
AccessioniPrimary (citable) accession number: Q9SYU4
Secondary accession number(s): O65895
, Q8LBN2, Q8S8Q5, Q9M400
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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