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Protein

Receptor protein kinase CLAVATA1

Gene

CLV1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the detection of CLV3 and CLV3-like (CLE) peptides, that act as extracellular signals regulating meristem maintenance. Acts with CLV3p as a ligand-receptor pair in a signal transduction pathway coordinating growth between adjacent meristematic regions and controlling the balance between meristem cell proliferation and differentiation.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei720ATPPROSITE-ProRule annotation1
Active sitei817Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi698 – 706ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein self-association Source: UniProtKB
  • protein serine/threonine kinase activity Source: TAIR
  • receptor serine/threonine kinase binding Source: UniProtKB

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • peptidyl-serine autophosphorylation Source: TAIR
  • regulation of floral meristem growth Source: EnsemblPlants
  • regulation of meristem structural organization Source: TAIR
  • specification of floral organ number Source: EnsemblPlants

Keywordsi

Molecular functionDevelopmental protein, Kinase, Receptor, Serine/threonine-protein kinase, Transferase
Biological processDifferentiation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2 399

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein kinase CLAVATA1 (EC:2.7.11.1)
Gene namesi
Name:CLV1
Ordered Locus Names:At1g75820
ORF Names:T4O12.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G75820
TAIRilocus:2204350 AT1G75820

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 638ExtracellularSequence analysisAdd BLAST614
Transmembranei639 – 659HelicalSequence analysisAdd BLAST21
Topological domaini660 – 980CytoplasmicSequence analysisAdd BLAST321

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Ectopic fruit organ initiation after floral meristem termination (PubMed:21705761). Enhanced disease resistance response to the bacterial pathogen Ralstonia solanacearum and to the biotrophic oomycete pathogen Hyaloperonospora arabidopsidis (PubMed:26990325).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000002431725 – 980Receptor protein kinase CLAVATA1Add BLAST956

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi276N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi314N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi348N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi422N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi510N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi558N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi574N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi602N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi631N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei766PhosphotyrosineBy similarity1
Modified residuei804PhosphotyrosineBy similarity1
Modified residuei852PhosphoserineBy similarity1
Modified residuei860PhosphotyrosineBy similarity1
Modified residuei867PhosphotyrosineBy similarity1
Modified residuei868PhosphothreonineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9SYQ8
PRIDEiQ9SYQ8

Expressioni

Tissue specificityi

In a central region of the shoot and in early flower meristems.

Gene expression databases

ExpressionAtlasiQ9SYQ8 baseline and differential
GenevisibleiQ9SYQ8 AT

Interactioni

Subunit structurei

Self-interacts. Interacts with CRN; this interaction is direct. Interacts with CLV3 and CLE2 mature peptides (MCLV3 and CLE2p, respectively) via its extracellular leucine-rich repeat region.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
KAPPP460146EBI-1646111,EBI-1646157

GO - Molecular functioni

  • protein self-association Source: UniProtKB
  • receptor serine/threonine kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi29134, 16 interactors
ELMiQ9SYQ8
IntActiQ9SYQ8, 4 interactors
STRINGi3702.AT1G75820.1

Structurei

3D structure databases

ProteinModelPortaliQ9SYQ8
SMRiQ9SYQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati93 – 119LRR 1Sequence analysisAdd BLAST27
Repeati121 – 142LRR 2Sequence analysisAdd BLAST22
Repeati143 – 167LRR 3Sequence analysisAdd BLAST25
Repeati168 – 193LRR 4Sequence analysisAdd BLAST26
Repeati215 – 239LRR 5Sequence analysisAdd BLAST25
Repeati240 – 264LRR 6Sequence analysisAdd BLAST25
Repeati265 – 288LRR 7Sequence analysisAdd BLAST24
Repeati289 – 312LRR 8Sequence analysisAdd BLAST24
Repeati314 – 336LRR 9Sequence analysisAdd BLAST23
Repeati337 – 360LRR 10Sequence analysisAdd BLAST24
Repeati361 – 384LRR 11Sequence analysisAdd BLAST24
Repeati386 – 408LRR 12Sequence analysisAdd BLAST23
Repeati409 – 432LRR 13Sequence analysisAdd BLAST24
Repeati434 – 455LRR 14Sequence analysisAdd BLAST22
Repeati456 – 479LRR 15Sequence analysisAdd BLAST24
Repeati480 – 503LRR 16Sequence analysisAdd BLAST24
Repeati505 – 527LRR 17Sequence analysisAdd BLAST23
Repeati528 – 551LRR 18Sequence analysisAdd BLAST24
Repeati552 – 575LRR 19Sequence analysisAdd BLAST24
Repeati577 – 600LRR 20Sequence analysisAdd BLAST24
Domaini692 – 968Protein kinasePROSITE-ProRule annotationAdd BLAST277

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGYE Eukaryota
COG4886 LUCA
HOGENOMiHOG000116551
InParanoidiQ9SYQ8
KOiK00924
OMAiVYHGVTH
OrthoDBiEOG093601AP
PhylomeDBiQ9SYQ8

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR013210 LRR_N_plant-typ
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00560 LRR_1, 2 hits
PF13855 LRR_8, 1 hit
PF08263 LRRNT_2, 1 hit
PF07714 Pkinase_Tyr, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 6 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SYQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMRLLKTHL LFLHLYLFFS PCFAYTDMEV LLNLKSSMIG PKGHGLHDWI
60 70 80 90 100
HSSSPDAHCS FSGVSCDDDA RVISLNVSFT PLFGTISPEI GMLTHLVNLT
110 120 130 140 150
LAANNFTGEL PLEMKSLTSL KVLNISNNGN LTGTFPGEIL KAMVDLEVLD
160 170 180 190 200
TYNNNFNGKL PPEMSELKKL KYLSFGGNFF SGEIPESYGD IQSLEYLGLN
210 220 230 240 250
GAGLSGKSPA FLSRLKNLRE MYIGYYNSYT GGVPPEFGGL TKLEILDMAS
260 270 280 290 300
CTLTGEIPTS LSNLKHLHTL FLHINNLTGH IPPELSGLVS LKSLDLSINQ
310 320 330 340 350
LTGEIPQSFI NLGNITLINL FRNNLYGQIP EAIGELPKLE VFEVWENNFT
360 370 380 390 400
LQLPANLGRN GNLIKLDVSD NHLTGLIPKD LCRGEKLEML ILSNNFFFGP
410 420 430 440 450
IPEELGKCKS LTKIRIVKNL LNGTVPAGLF NLPLVTIIEL TDNFFSGELP
460 470 480 490 500
VTMSGDVLDQ IYLSNNWFSG EIPPAIGNFP NLQTLFLDRN RFRGNIPREI
510 520 530 540 550
FELKHLSRIN TSANNITGGI PDSISRCSTL ISVDLSRNRI NGEIPKGINN
560 570 580 590 600
VKNLGTLNIS GNQLTGSIPT GIGNMTSLTT LDLSFNDLSG RVPLGGQFLV
610 620 630 640 650
FNETSFAGNT YLCLPHRVSC PTRPGQTSDH NHTALFSPSR IVITVIAAIT
660 670 680 690 700
GLILISVAIR QMNKKKNQKS LAWKLTAFQK LDFKSEDVLE CLKEENIIGK
710 720 730 740 750
GGAGIVYRGS MPNNVDVAIK RLVGRGTGRS DHGFTAEIQT LGRIRHRHIV
760 770 780 790 800
RLLGYVANKD TNLLLYEYMP NGSLGELLHG SKGGHLQWET RHRVAVEAAK
810 820 830 840 850
GLCYLHHDCS PLILHRDVKS NNILLDSDFE AHVADFGLAK FLVDGAASEC
860 870 880 890 900
MSSIAGSYGY IAPEYAYTLK VDEKSDVYSF GVVLLELIAG KKPVGEFGEG
910 920 930 940 950
VDIVRWVRNT EEEITQPSDA AIVVAIVDPR LTGYPLTSVI HVFKIAMMCV
960 970 980
EEEAAARPTM REVVHMLTNP PKSVANLIAF
Length:980
Mass (Da):107,598
Last modified:August 16, 2004 - v3
Checksum:i2B2DC41AFF733B08
GO

Sequence cautioni

The sequence AAF26772 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD94816 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence BX815769 differs from that shown. Sequencing errors.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti235P → R in AAB58929 (PubMed:9160749).Curated1
Sequence conflicti235P → R in AAD02501 (PubMed:10080719).Curated1
Sequence conflicti703A → S in AAD02501 (PubMed:10080719).Curated1
Sequence conflicti856G → D in AAD02501 (PubMed:10080719).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96879 Genomic DNA Translation: AAB58929.1
AF049870 Genomic DNA Translation: AAD02501.1
AC007396 Genomic DNA Translation: AAF26772.1 Different initiation.
CP002684 Genomic DNA Translation: AEE35762.1
BX815769 mRNA No translation available.
AK221523 mRNA Translation: BAD94816.1 Sequence problems.
RefSeqiNP_177710.1, NM_106232.4
UniGeneiAt.25465

Genome annotation databases

EnsemblPlantsiAT1G75820.1; AT1G75820.1; AT1G75820
GeneIDi843915
GrameneiAT1G75820.1; AT1G75820.1; AT1G75820
KEGGiath:AT1G75820

Similar proteinsi

Entry informationi

Entry nameiCLV1_ARATH
AccessioniPrimary (citable) accession number: Q9SYQ8
Secondary accession number(s): O04380, Q56Y00, Q9LQT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: August 16, 2004
Last modified: July 18, 2018
This is version 160 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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