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UniProtKB - Q9SYC8 (LPAT3_ARATH)
Protein
1-acyl-sn-glycerol-3-phosphate acyltransferase 3
Gene
LPAT3
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position. Has preference for C-18-CoA substrates compared to C-16-CoA substrates.
Catalytic activityi
- a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA1 PublicationEC:2.3.1.511 Publication
: CDP-diacylglycerol biosynthesis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate. This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.
GO - Molecular functioni
- 1-acylglycerol-3-phosphate O-acyltransferase activity Source: TAIR
- acyltransferase activity Source: GO_Central
GO - Biological processi
- CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Enzyme and pathway databases
BioCyci | ARA:AT1G51260-MONOMER |
BRENDAi | 2.3.1.51, 399 |
UniPathwayi | UPA00557;UER00613 |
Names & Taxonomyi
Protein namesi | Recommended name: 1-acyl-sn-glycerol-3-phosphate acyltransferase 3 (EC:2.3.1.51)Alternative name(s): Lysophosphatidyl acyltransferase 3 |
Gene namesi | Name:LPAT3 Synonyms:LPAAT3 Ordered Locus Names:At1g51260 ORF Names:F11M15.12 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT1G51260 |
TAIRi | locus:2008226, AT1G51260 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- endomembrane system Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 14 – 34 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 49 – 69 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 98 – 118 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 306 – 326 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 335 – 355 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000208182 | 1 – 376 | 1-acyl-sn-glycerol-3-phosphate acyltransferase 3Add BLAST | 376 |
Proteomic databases
PaxDbi | Q9SYC8 |
ProteomicsDBi | 238667 |
PTM databases
iPTMneti | Q9SYC8 |
Expressioni
Tissue specificityi
Predominantly expressed in pollen.1 Publication
Gene expression databases
ExpressionAtlasi | Q9SYC8, baseline and differential |
Genevisiblei | Q9SYC8, AT |
Structurei
3D structure databases
AlphaFoldDBi | Q9SYC8 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 92 – 97 | HXXXXD motif | 6 |
Domaini
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.By similarity
Sequence similaritiesi
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1505, Eukaryota |
HOGENOMi | CLU_041844_5_0_1 |
InParanoidi | Q9SYC8 |
OMAi | HLMQELP |
OrthoDBi | 959325at2759 |
PhylomeDBi | Q9SYC8 |
Family and domain databases
InterProi | View protein in InterPro IPR032098, Acyltransf_C IPR002123, Plipid/glycerol_acylTrfase |
Pfami | View protein in Pfam PF16076, Acyltransf_C, 1 hit PF01553, Acyltransferase, 1 hit |
SMARTi | View protein in SMART SM00563, PlsC, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9SYC8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKIPAALVFI PVGVLFLISG LIVNIIQLVF FIIVRPFSRS LYRRINKNVA
60 70 80 90 100
ELLWLQLIWL FDWWACIKIN LYVDAETLEL IGKEHALVLS NHRSDIDWLI
110 120 130 140 150
GWVMAQRVGC LGSSLAIMKK EAKYLPIIGW SMWFSDYIFL ERSWAKDENT
160 170 180 190 200
LKAGFKRLED FPMTFWLALF VEGTRFTQEK LEAAQEYASI RSLPSPRNVL
210 220 230 240 250
IPRTKGFVSA VSEIRSFVPA IYDCTLTVHN NQPTPTLLRM FSGQSSEINL
260 270 280 290 300
QMRRHKMSEL PETDDGIAQW CQDLFITKDA QLEKYFTKDV FSDLEVHQIN
310 320 330 340 350
RPIKPLIVVI IWLGFLVFGG FKLLQWLSIV ASWKIILLFV FFLVIATITM
360 370
QILIQSSESQ RSTPAKRPLQ EQLISA
Sequence cautioni
The sequence BX813937 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 354 | I → S in BX813937 (PubMed:14993207).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC006085 Genomic DNA Translation: AAD30638.1 CP002684 Genomic DNA Translation: AEE32642.1 BX813937 mRNA No translation available. |
PIRi | D96550 |
RefSeqi | NP_175537.1, NM_104004.3 |
Genome annotation databases
EnsemblPlantsi | AT1G51260.1; AT1G51260.1; AT1G51260 |
GeneIDi | 841549 |
Gramenei | AT1G51260.1; AT1G51260.1; AT1G51260 |
KEGGi | ath:AT1G51260 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC006085 Genomic DNA Translation: AAD30638.1 CP002684 Genomic DNA Translation: AEE32642.1 BX813937 mRNA No translation available. |
PIRi | D96550 |
RefSeqi | NP_175537.1, NM_104004.3 |
3D structure databases
AlphaFoldDBi | Q9SYC8 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 3702.AT1G51260.1 |
PTM databases
iPTMneti | Q9SYC8 |
Proteomic databases
PaxDbi | Q9SYC8 |
ProteomicsDBi | 238667 |
Genome annotation databases
EnsemblPlantsi | AT1G51260.1; AT1G51260.1; AT1G51260 |
GeneIDi | 841549 |
Gramenei | AT1G51260.1; AT1G51260.1; AT1G51260 |
KEGGi | ath:AT1G51260 |
Organism-specific databases
Araporti | AT1G51260 |
TAIRi | locus:2008226, AT1G51260 |
Phylogenomic databases
eggNOGi | KOG1505, Eukaryota |
HOGENOMi | CLU_041844_5_0_1 |
InParanoidi | Q9SYC8 |
OMAi | HLMQELP |
OrthoDBi | 959325at2759 |
PhylomeDBi | Q9SYC8 |
Enzyme and pathway databases
UniPathwayi | UPA00557;UER00613 |
BioCyci | ARA:AT1G51260-MONOMER |
BRENDAi | 2.3.1.51, 399 |
Miscellaneous databases
PROi | PR:Q9SYC8 |
Gene expression databases
ExpressionAtlasi | Q9SYC8, baseline and differential |
Genevisiblei | Q9SYC8, AT |
Family and domain databases
InterProi | View protein in InterPro IPR032098, Acyltransf_C IPR002123, Plipid/glycerol_acylTrfase |
Pfami | View protein in Pfam PF16076, Acyltransf_C, 1 hit PF01553, Acyltransferase, 1 hit |
SMARTi | View protein in SMART SM00563, PlsC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LPAT3_ARATH | |
Accessioni | Q9SYC8Primary (citable) accession number: Q9SYC8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families