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Entry version 115 (02 Jun 2021)
Sequence version 2 (01 Oct 2001)
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Protein
Submitted name:

Na-ATPase

Gene

HANA

Organism
Heterosigma akashiwo (Chromophytic alga) (Heterosigma carterae)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocaseARBA annotation
LigandATP-bindingARBA annotation, Nucleotide-binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.3.1.3, the p-type atpase (p-atpase) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Na-ATPaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HANAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHeterosigma akashiwo (Chromophytic alga) (Heterosigma carterae)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri2829 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarStramenopilesOchrophytaRaphidophyceaeChattonellalesChattonellaceaeHeterosigma

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei82 – 101HelicalSequence analysisAdd BLAST20
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Transmembranei270 – 294HelicalSequence analysisAdd BLAST25
Transmembranei300 – 325HelicalSequence analysisAdd BLAST26
Transmembranei893 – 914HelicalSequence analysisAdd BLAST22
Transmembranei1251 – 1272HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 100Cation_ATPase_NInterPro annotationAdd BLAST74

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. [View classification]ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1110.10, 1 hit
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006068, ATPase_P-typ_cation-transptr_C
IPR004014, ATPase_P-typ_cation-transptr_N
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR005775, P-type_ATPase_IIC
IPR001757, P_typ_ATPase
IPR044492, P_typ_ATPase_HD_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00689, Cation_ATPase_C, 2 hits
PF00690, Cation_ATPase_N, 1 hit

Structure-Function Linkage Database

More...
SFLDi
SFLDF00027, p-type_atpase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00831, Cation_ATPase_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01106, ATPase-IIC_X-K, 1 hit
TIGR01494, ATPase_P-type, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9SXK5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLMKKKAGG DSNSRRVDDL KKNVVMTEHK EEWEELFAKL GSSVEGLSQE
60 70 80 90 100
EAQKRNREFG DDRLTPPPTT PKWVKFLKEM TGFFSLLLWG GGILCFIRYG
110 120 130 140 150
LRKEVDNMYL GIVLFAVVFV TGCFSFFQNS KSENLMKSFE KLLPPSINAK
160 170 180 190 200
RNGEFIKVPS EKLVKGDVIR LEGGELVPCD VRIITCTDNC VVDNASLTGE
210 220 230 240 250
AEPQKRKNEA THDEPLETAN LAFFGTNVPE GSLEGVVVNI GDDTVMGRIA
260 270 280 290 300
SLTLQVGAQQ TPINKEIHHF ILIISSIAIF LGVTFFIIGL ALGTELIENL
310 320 330 340 350
VFLISIIVAN VPEGLLATVT VCLTLTARRM HSKMVLVKNL EGVETLGSTS
360 370 380 390 400
CICSDKTGTL TQNIMTVAQI VYGNQDAVHI QDTGSSLSHG LKTYNPENAA
410 420 430 440 450
FQSLLRCAML NNTSTFGKYR LDENGDPTDE LLPFKAEVVQ GDGSVIEQVM
460 470 480 490 500
WRVNGNASEA AMIKFAQNHE DVDDFRKRNP MVFQIPFNSR NKYQVHVHCQ
510 520 530 540 550
EKFNQEDGTN SGPRVVLMKG APERVLARCS QAKLGGNIVP MTPELMAEIE
560 570 580 590 600
RLQVQMSANG LRVLGFAERE LPKTKFPADY KYHDGSEEDK STPNFPLGEF
610 620 630 640 650
AMEAEREKNP PKLPVHDASM QGLIFIGLMA LIDPPRPAVP GAVEKCKTAG
660 670 680 690 700
VKVIMVTGDH PVTAQAIAQK VGILWSKTRA EAMAHNEAYQ LNPGDAGFED
710 720 730 740 750
PEECKAIVVP GWELNNDMTE EAWDAILDNP QVVFARTSPQ QKLVIVSENQ
760 770 780 790 800
KRGHIVAVTG DGVNDSPALK QADIGVAMGI SGSEVSKQAA DMILLDDNFA
810 820 830 840 850
SIVAGVEEGR LIFDNLKKSI CYTLTSNIPE ISPFLCFIVI GTPLPLSTVL
860 870 880 890 900
ILGIDLGTDM VPAISMAYEQ AEADIMKRPP RDSQLDRLVT KKLIVFAYLQ
910 920 930 940 950
IGMIQAAAGF YTWMVVLNDY GFPPHILPGL GRGGFWQQHP LYCKFDGGQY
960 970 980 990 1000
VSLDGEASSD LDPSSDAPTR AYPFWDVGDH GNIVNCEFPI KNLRGGSGVP
1010 1020 1030 1040 1050
SGFDISEADT YDDSSTSGFN QMTYESLLAL EAQNYFHYVP WRARQSPFWK
1060 1070 1080 1090 1100
NSWFFWDVED EETPGGAFGG AADITYFLHQ KAGLWSLCAK DEDLSEGTGN
1110 1120 1130 1140 1150
SDFLGTQAAW DLYENDFDFT GVGACSVNSA TMKNQMYKDA YFCNNYPHSS
1160 1170 1180 1190 1200
GYASGAKPGC EAGANTHPLN NVWCADSCSQ ACYEAGGDGG DAYNCANVAS
1210 1220 1230 1240 1250
RMAQKEALHH AQGSYFVSIV IVQWADLLIC KTRWLSLRQQ GMKNSTMNFA
1260 1270 1280 1290 1300
LFFETLLAGW LCYCLPINVG LGTRNLRFTH WFPAIPFSVA IFVYDEVRKY
1310 1320 1330
LMRTTSPETT DKATGQVTRI AGWLETNTYY
Length:1,330
Mass (Da):146,517
Last modified:October 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEDFB870FC0949751
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB017481 mRNA Translation: BAA82752.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017481 mRNA Translation: BAA82752.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi3.A.3.1.3, the p-type atpase (p-atpase) superfamily

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR006068, ATPase_P-typ_cation-transptr_C
IPR004014, ATPase_P-typ_cation-transptr_N
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR005775, P-type_ATPase_IIC
IPR001757, P_typ_ATPase
IPR044492, P_typ_ATPase_HD_dom
PfamiView protein in Pfam
PF00689, Cation_ATPase_C, 2 hits
PF00690, Cation_ATPase_N, 1 hit
SFLDiSFLDF00027, p-type_atpase, 1 hit
SMARTiView protein in SMART
SM00831, Cation_ATPase_N, 1 hit
SUPFAMiSSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 2 hits
TIGRFAMsiTIGR01106, ATPase-IIC_X-K, 1 hit
TIGR01494, ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9SXK5_HETAK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9SXK5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2001
Last modified: June 2, 2021
This is version 115 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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