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Entry version 110 (17 Jun 2020)
Sequence version 1 (01 May 2000)
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Protein

Lysine histidine transporter-like 8

Gene

AATL1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Amino acid transporter.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.18.2.8 the amino acid/auxin permease (aaap) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysine histidine transporter-like 8
Alternative name(s):
Amino acid transporter-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AATL1
Ordered Locus Names:At1g47670
ORF Names:F16N3.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G47670

The Arabidopsis Information Resource

More...
TAIRi
locus:2015383 AT1G47670

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 114CytoplasmicSequence analysisAdd BLAST114
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 176CytoplasmicSequence analysisAdd BLAST20
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Topological domaini198 – 217ExtracellularSequence analysisAdd BLAST20
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 243CytoplasmicSequence analysis5
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Topological domaini265 – 282ExtracellularSequence analysisAdd BLAST18
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Topological domaini304 – 333CytoplasmicSequence analysisAdd BLAST30
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Topological domaini355 – 377ExtracellularSequence analysisAdd BLAST23
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Topological domaini399 – 427CytoplasmicSequence analysisAdd BLAST29
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Topological domaini449ExtracellularSequence analysis1
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21
Topological domaini471 – 485CytoplasmicSequence analysisAdd BLAST15
Transmembranei486 – 506HelicalSequence analysisAdd BLAST21
Topological domaini507 – 519ExtracellularSequence analysisAdd BLAST13

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003879781 – 519Lysine histidine transporter-like 8Add BLAST519

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9SX98

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
238380

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9SX98

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9SX98 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9SX98 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
26402, 31 interactors

Protein interaction database and analysis system

More...
IntActi
Q9SX98, 30 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT1G47670.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1303 Eukaryota
COG0814 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_031160_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9SX98

Identification of Orthologs from Complete Genome Data

More...
OMAi
IVCGPIC

Database of Orthologous Groups

More...
OrthoDBi
570025at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9SX98

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013057 AA_transpt_TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01490 Aa_trans, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9SX98-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDERPETELI SIPATPRVST PEILTPSGQR SPRPATKPSS ATWTPTSFIS
60 70 80 90 100
PRFLSPIGTP MKRVLVNMKG YLEEVGHLTK LNPQDAWLPI TESRNGNAHY
110 120 130 140 150
AAFHNLNAGV GFQALVLPVA FAFLGWSWGI LSLTIAYCWQ LYTLWILVQL
160 170 180 190 200
HEAVPGKRYN RYVELAQAAF GERLGVWLAL FPTVYLSAGT ATALILIGGE
210 220 230 240 250
TMKLFFQIVC GPLCTSNPLT TVEWYLVFTS LCIVLSQLPN LNSIAGLSLI
260 270 280 290 300
GAVTAITYST MVWVLSVSQP RPATISYEPL SMPSTSGSLF AVLNALGIIA
310 320 330 340 350
FAFRGHNLVL EIQSTMPSTF KHPAHVPMWR GAKISYFLIA LCIFPISIGG
360 370 380 390 400
FWAYGNLMPS GGMLAALYAF HIHDIPRGLL ATAFLLVVFS CLSSFQIYSM
410 420 430 440 450
PAFDSFEAGY TSRTNKPCSI WVRSGFRVFF GFVSFFIGVA LPFLSSLAGL
460 470 480 490 500
LGGLTLPVTF AYPCFMWVLI KKPAKYSFNW YFHWGLGWLG VAFSLAFSIG
510
GIWSMVTNGL KLKFFKPPN
Length:519
Mass (Da):57,119
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC578D98AC2C813D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti240N → D in BAA82706 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB030586 Genomic DNA Translation: BAA82706.1
AC007519 Genomic DNA Translation: AAD46019.1
CP002684 Genomic DNA Translation: AEE32199.1
AY065445 mRNA Translation: AAL38886.1
AY117276 mRNA Translation: AAM51351.1

Protein sequence database of the Protein Information Resource

More...
PIRi
F96517

NCBI Reference Sequences

More...
RefSeqi
NP_175198.1, NM_103660.6

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G47670.1; AT1G47670.1; AT1G47670

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
841177

Gramene; a comparative resource for plants

More...
Gramenei
AT1G47670.1; AT1G47670.1; AT1G47670

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G47670

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030586 Genomic DNA Translation: BAA82706.1
AC007519 Genomic DNA Translation: AAD46019.1
CP002684 Genomic DNA Translation: AEE32199.1
AY065445 mRNA Translation: AAL38886.1
AY117276 mRNA Translation: AAM51351.1
PIRiF96517
RefSeqiNP_175198.1, NM_103660.6

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi26402, 31 interactors
IntActiQ9SX98, 30 interactors
STRINGi3702.AT1G47670.1

Protein family/group databases

TCDBi2.A.18.2.8 the amino acid/auxin permease (aaap) family

PTM databases

iPTMnetiQ9SX98

Proteomic databases

PaxDbiQ9SX98
ProteomicsDBi238380

Genome annotation databases

EnsemblPlantsiAT1G47670.1; AT1G47670.1; AT1G47670
GeneIDi841177
GrameneiAT1G47670.1; AT1G47670.1; AT1G47670
KEGGiath:AT1G47670

Organism-specific databases

AraportiAT1G47670
TAIRilocus:2015383 AT1G47670

Phylogenomic databases

eggNOGiKOG1303 Eukaryota
COG0814 LUCA
HOGENOMiCLU_031160_2_1_1
InParanoidiQ9SX98
OMAiIVCGPIC
OrthoDBi570025at2759
PhylomeDBiQ9SX98

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9SX98

Gene expression databases

ExpressionAtlasiQ9SX98 baseline and differential
GenevisibleiQ9SX98 AT

Family and domain databases

InterProiView protein in InterPro
IPR013057 AA_transpt_TM
PfamiView protein in Pfam
PF01490 Aa_trans, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLHTL8_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9SX98
Secondary accession number(s): Q9SXF7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 1, 2000
Last modified: June 17, 2020
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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