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Entry version 113 (02 Jun 2021)
Sequence version 1 (01 May 2000)
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Protein

AFP homolog 2

Gene

AFPH2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional repressor. Negative regulator of jasmonate responses. Connects the JAZ proteins and the non-JAZ protein TIFY8 with the TOPLESS corepressors.

3 Publications

Miscellaneous

Unlike the JAZ proteins, the stability of AFPH2/NINJA is unaffected by jasmonate.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processJasmonic acid signaling pathway, Plant defense, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AFP homolog 21 Publication
Alternative name(s):
Novel interactor of JAZ1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AFPH21 Publication
Synonyms:NINJA1 Publication
Ordered Locus Names:At4g28910Imported
ORF Names:F25O24.30Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT4G28910

The Arabidopsis Information Resource

More...
TAIRi
locus:2123573, AT4G28910

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi9L → A: Loss of interaction with TOPLESS, but no effect on the interaction with TIFY10A/JAZ1; when associated with A-11 and A-13. 1 Publication1
Mutagenesisi11L → A: Loss of interaction with TOPLESS, but no effect on the interaction with TIFY10A/JAZ1; when associated with A-9 and A-13. 1 Publication1
Mutagenesisi13L → A: Loss of interaction with TOPLESS, but no effect on the interaction with TIFY10A/JAZ1; when associated with A-9 and A-11. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003696181 – 425AFP homolog 2Add BLAST425

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9SV55

PRoteomics IDEntifications database

More...
PRIDEi
Q9SV55

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
249437

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9SV55

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By jasmonate.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9SV55, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9SV55, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a complex at least composed of TOPLESS, TPR2, TPR3, TIFY4B/PPD2, MYC3/ATR2 and TIFY3B/JAZ12.

Interacts (via C-terminus) with TIFY10A/JAZ1; TIFY10B/JAZ2; TIFY6B/JAZ3; TIFY6A/JAZ4; TIFY11A/JAZ5; TIFY11B/JAZ6; TIFY7/JAZ9; TIFY9/JAZ10; TIFY3A/JAZ11; TIFY3B/JAZ12; TIFY4A/PPD1; TIFY4B/PPD2 and TIFY8 (via TIFY domain).

Interacts with TOPLESS (PubMed:20360743, PubMed:24416306).

Interacts with PAT1H1 (PubMed:26956135).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
14299, 18 interactors

Database of interacting proteins

More...
DIPi
DIP-40581N

Protein interaction database and analysis system

More...
IntActi
Q9SV55, 21 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT4G28910.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9SV55

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 207DisorderedSequence analysisAdd BLAST207
Regioni7 – 17Necessary and sufficient for the interaction with TOPLESSAdd BLAST11
Regioni288 – 327DisorderedSequence analysisAdd BLAST40
Regioni322 – 425Necessary and sufficient for the interaction with the JAZ proteinsAdd BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi19 – 39Polar residuesSequence analysisAdd BLAST21
Compositional biasi60 – 95Polar residuesSequence analysisAdd BLAST36
Compositional biasi100 – 148Basic and acidic residuesSequence analysisAdd BLAST49
Compositional biasi167 – 207Polar residuesSequence analysisAdd BLAST41

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Ninja family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSTR, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_049096_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9SV55

Identification of Orthologs from Complete Genome Data

More...
OMAi
GFPGMND

Database of Orthologous Groups

More...
OrthoDBi
641759at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9SV55

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032308, Jas
IPR031307, Ninja_fam

The PANTHER Classification System

More...
PANTHERi
PTHR31413, PTHR31413, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16135, TDBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9SV55-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDDDNGLELS LGLSCGGSTG KAKGNNNNNA GSSSENYRAE GGDRSAKVID
60 70 80 90 100
DFKNFLHPTS QRPAEPSSGS QRSDSGQQPP QNFFNDLSKA PTTEAEASTK
110 120 130 140 150
PLWVEDESRK EAGNKRKFGF PGMNDDKKKE KDSSHVDMHE KKTKASHVST
160 170 180 190 200
ATDEGSTAEN EDVAESEVGG GSSSNHAKEV VRPPTDTNIV DNLTGQRRSN
210 220 230 240 250
HGGSGTEEFT MRNMSYTVPF TVHPQNVVTS MPYSLPTKES GQHAAATSLL
260 270 280 290 300
QPNANAGNLP IMFGYSPVQL PMLDKDGSGG IVALSQSPFA GRVPSNSATA
310 320 330 340 350
KGEGKQPVAE EGSSEDASER PTGDNSNLNT AFSFDFSAIK PGMAADVKFG
360 370 380 390 400
GSGARPNLPW VSTTGSGPHG RTISGVTYRY NANQIKIVCA CHGSHMSPEE
410 420
FVRHASEEYV SPESSMGMTA ASAHT
Length:425
Mass (Da):44,938
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1796FB2FAAB0FB89
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti106D → E in AAK96863 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL078469 Genomic DNA Translation: CAB43905.1
AL161573 Genomic DNA Translation: CAB81479.1
CP002687 Genomic DNA Translation: AEE85560.1
CP002687 Genomic DNA Translation: AEE85561.1
CP002687 Genomic DNA Translation: AEE85562.1
AY054672 mRNA Translation: AAK96863.1
AY065350 mRNA Translation: AAL38791.1
AY096726 mRNA Translation: AAM20360.1
AK316690 mRNA Translation: BAH19417.1
AY085087 mRNA Translation: AAM61641.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T08946

NCBI Reference Sequences

More...
RefSeqi
NP_001078466.1, NM_001084997.1
NP_194620.1, NM_119035.3
NP_849467.1, NM_179136.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT4G28910.1; AT4G28910.1; AT4G28910
AT4G28910.2; AT4G28910.2; AT4G28910
AT4G28910.3; AT4G28910.3; AT4G28910

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
829012

Gramene; a comparative resource for plants

More...
Gramenei
AT4G28910.1; AT4G28910.1; AT4G28910
AT4G28910.2; AT4G28910.2; AT4G28910
AT4G28910.3; AT4G28910.3; AT4G28910

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT4G28910

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL078469 Genomic DNA Translation: CAB43905.1
AL161573 Genomic DNA Translation: CAB81479.1
CP002687 Genomic DNA Translation: AEE85560.1
CP002687 Genomic DNA Translation: AEE85561.1
CP002687 Genomic DNA Translation: AEE85562.1
AY054672 mRNA Translation: AAK96863.1
AY065350 mRNA Translation: AAL38791.1
AY096726 mRNA Translation: AAM20360.1
AK316690 mRNA Translation: BAH19417.1
AY085087 mRNA Translation: AAM61641.1
PIRiT08946
RefSeqiNP_001078466.1, NM_001084997.1
NP_194620.1, NM_119035.3
NP_849467.1, NM_179136.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5C6VX-ray3.10E/F/G/H4-14[»]
SMRiQ9SV55
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi14299, 18 interactors
DIPiDIP-40581N
IntActiQ9SV55, 21 interactors
STRINGi3702.AT4G28910.2

PTM databases

iPTMnetiQ9SV55

Proteomic databases

PaxDbiQ9SV55
PRIDEiQ9SV55
ProteomicsDBi249437

Genome annotation databases

EnsemblPlantsiAT4G28910.1; AT4G28910.1; AT4G28910
AT4G28910.2; AT4G28910.2; AT4G28910
AT4G28910.3; AT4G28910.3; AT4G28910
GeneIDi829012
GrameneiAT4G28910.1; AT4G28910.1; AT4G28910
AT4G28910.2; AT4G28910.2; AT4G28910
AT4G28910.3; AT4G28910.3; AT4G28910
KEGGiath:AT4G28910

Organism-specific databases

AraportiAT4G28910
TAIRilocus:2123573, AT4G28910

Phylogenomic databases

eggNOGiENOG502QSTR, Eukaryota
HOGENOMiCLU_049096_0_0_1
InParanoidiQ9SV55
OMAiGFPGMND
OrthoDBi641759at2759
PhylomeDBiQ9SV55

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9SV55

Gene expression databases

ExpressionAtlasiQ9SV55, baseline and differential
GenevisibleiQ9SV55, AT

Family and domain databases

InterProiView protein in InterPro
IPR032308, Jas
IPR031307, Ninja_fam
PANTHERiPTHR31413, PTHR31413, 1 hit
PfamiView protein in Pfam
PF16135, TDBD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNINJA_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9SV55
Secondary accession number(s): Q940F7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 1, 2000
Last modified: June 2, 2021
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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