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UniProtKB - Q9SUR6 (CORI3_ARATH)
Protein
Cystine lyase CORI3
Gene
CORI3
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Possesses cystine lyase activity in vitro. Does not possess tyrosine aminotransferase, alanine aminotransferase, aspartate aminotransferase and tryptophan aminotransferase activities.
1 PublicationMiscellaneous
Induction by wounding requires COI1.1 Publication
Caution
CORI3 was initially isolated by Lopukhina et al (PMID:11500565) as tyrosine aminotransferase (TAT). The authors also measured a TAT activity in vitro, even though relatively weak. Jones et al (PMID:12525491) showed that CORI3 possesses cystine lyase (CL) activity, but lacks TAT activity in vitro. In addition, CL activity is not inhibited by saturation of L-tyrosine in the medium. As CORI3 should bind L-tyrosine to catalyze TAT activity, this excludes a TAT activity for CORI3. Jones et al. made the statment that TAT activity resulted probably from residual native TAT-catalyzing proteins present in the purified preparations employed by Loupokhina et al.2 Publications
Catalytic activityi
- EC:4.4.1.351 Publication
Cofactori
pyridoxal 5'-phosphate1 Publication
GO - Molecular functioni
- cystathionine beta-lyase activity Source: TAIR
- L-cystine L-cysteine-lyase (deaminating) Source: RHEA
- pyridoxal phosphate binding Source: InterPro
- transaminase activity Source: TAIR
GO - Biological processi
- biosynthetic process Source: InterPro
- cellular amino acid metabolic process Source: TAIR
- hyperosmotic salinity response Source: TAIR
- response to abscisic acid Source: TAIR
- response to jasmonic acid Source: TAIR
- response to microbial phytotoxin Source: TAIR
- response to wounding Source: TAIR
Keywordsi
Molecular function | Lyase |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
BioCyci | ARA:AT4G23600-MONOMER |
BRENDAi | 4.4.1.35, 399 |
Names & Taxonomyi
Protein namesi | Recommended name: Cystine lyase CORI31 Publication (EC:4.4.1.351 Publication)Alternative name(s): Protein CORONATINE INDUCED 31 Publication Protein JASMONATE RESPONSIVE 21 Publication |
Gene namesi | Name:CORI31 Publication Synonyms:JR21 Publication Ordered Locus Names:At4g23600Imported ORF Names:F9D16.70Imported |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT4G23600 |
TAIRi | locus:2128459, AT4G23600 |
Subcellular locationi
Cytosol
- cytosol Source: TAIR
Extracellular region or secreted
- apoplast Source: TAIR
Vacuole
- plant-type vacuole Source: TAIR
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000412729 | 1 – 422 | Cystine lyase CORI3Add BLAST | 422 |
Proteomic databases
PaxDbi | Q9SUR6 |
PRIDEi | Q9SUR6 |
ProteomicsDBi | 241110 [Q9SUR6-1] |
Expressioni
Tissue specificityi
Expressed in cotyledons, sepals, pistils, flower buds, phloem companion cells and vascular tissues of petiole, leaf, filament and fruit.1 Publication
Inductioni
Induced by jasmonate (PubMed:11500565, PubMed:9342878). Induced by coronatine (PubMed:11500565, PubMed:16008101). Induced by 12-oxo-phytodienoic acid (OPDA) (PubMed:11500565). Induced by wounding (PubMed:11500565, PubMed:9342878, PubMed:18247047). Induced by abscisic acid (ABA) (PubMed:9342878). Induced by the cell wall elicitin from the non-pathogenic biocontrol agent Pythium oligandrum (PubMed:19304739).5 Publications
Gene expression databases
ExpressionAtlasi | Q9SUR6, baseline and differential |
Genevisiblei | Q9SUR6, AT |
Interactioni
Subunit structurei
Homodimer.
1 PublicationProtein-protein interaction databases
BioGRIDi | 13749, 1 interactor |
STRINGi | 3702.AT4G23600.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.Curated
Phylogenomic databases
eggNOGi | KOG0259, Eukaryota |
InParanoidi | Q9SUR6 |
OMAi | FCERHSA |
OrthoDBi | 734452at2759 |
PhylomeDBi | Q9SUR6 |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR004839, Aminotransferase_I/II IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR015422, PyrdxlP-dep_Trfase_small IPR005958, TyrNic_aminoTrfase |
Pfami | View protein in Pfam PF00155, Aminotran_1_2, 1 hit |
PIRSFi | PIRSF000517, Tyr_transaminase, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
TIGRFAMsi | TIGR01265, tyr_nico_aTase, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9SUR6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATLKCIDWQ FSGSEAAKDA AAASLGSYTS ALYALCDPHG KPILPPRNEI
60 70 80 90 100
LETSNTAEKA VVKAVLYGSG NAYAPSLGLA AAKSAVAEYL NQGLPKKLTA
110 120 130 140 150
DDVFMTLGCK QAIELAVDIL AKPKANVLLP SPGFPWDLVR SIYKNLEVRH
160 170 180 190 200
YNFLPEKNFE IDFDSVRALV DENTFAIFII NPHNPNGNTY SEAHLKQLAE
210 220 230 240 250
LAKELKIMVV SDEVFRWTLF GSNPFVPMGK FSSIVPVVTL GSISKGWKVP
260 270 280 290 300
GWRTGWLTLH DLDGVFRNTK VLQAAQDFLQ INNNPPTVIQ AAIPDILEKT
310 320 330 340 350
PQEFFDKRQS FLKDKVEFGY SKLKYIPSLT CYMKPEACTF LWTELDLSSF
360 370 380 390 400
VDIEDDQDFC NKLAKEENLV VLPGIAFSQK NWLRHSIDME TPVLEDALER
410 420
LKSFCDRHSN KKAPLKDVNG VK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF4JP99 | F4JP99_ARATH | Tyrosine transaminase family protei... | CORI3 CORONATINE INDUCED 1, JASMONIC ACID RESPONSIVE 2, JR2, At4g23600, F9D16.70 | 380 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041764 | 1 – 104 | Missing in isoform 2. 1 PublicationAdd BLAST | 104 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF268090 mRNA Translation: AAK82963.1 AL035394 Genomic DNA Translation: CAA23026.1 AL161559 Genomic DNA Translation: CAB79315.1 CP002687 Genomic DNA Translation: AEE84781.1 CP002687 Genomic DNA Translation: AEE84782.1 AY099811 mRNA Translation: AAM20662.1 BT000307 mRNA Translation: AAN15626.1 AK229608 mRNA Translation: BAF01453.1 |
PIRi | T05592 |
RefSeqi | NP_194091.1, NM_118491.3 [Q9SUR6-1] NP_849430.1, NM_179099.3 [Q9SUR6-2] |
Genome annotation databases
EnsemblPlantsi | AT4G23600.1; AT4G23600.1; AT4G23600 [Q9SUR6-1] AT4G23600.2; AT4G23600.2; AT4G23600 [Q9SUR6-2] |
GeneIDi | 828460 |
Gramenei | AT4G23600.1; AT4G23600.1; AT4G23600 [Q9SUR6-1] AT4G23600.2; AT4G23600.2; AT4G23600 [Q9SUR6-2] |
KEGGi | ath:AT4G23600 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF268090 mRNA Translation: AAK82963.1 AL035394 Genomic DNA Translation: CAA23026.1 AL161559 Genomic DNA Translation: CAB79315.1 CP002687 Genomic DNA Translation: AEE84781.1 CP002687 Genomic DNA Translation: AEE84782.1 AY099811 mRNA Translation: AAM20662.1 BT000307 mRNA Translation: AAN15626.1 AK229608 mRNA Translation: BAF01453.1 |
PIRi | T05592 |
RefSeqi | NP_194091.1, NM_118491.3 [Q9SUR6-1] NP_849430.1, NM_179099.3 [Q9SUR6-2] |
3D structure databases
AlphaFoldDBi | Q9SUR6 |
SMRi | Q9SUR6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 13749, 1 interactor |
STRINGi | 3702.AT4G23600.1 |
Proteomic databases
PaxDbi | Q9SUR6 |
PRIDEi | Q9SUR6 |
ProteomicsDBi | 241110 [Q9SUR6-1] |
Genome annotation databases
EnsemblPlantsi | AT4G23600.1; AT4G23600.1; AT4G23600 [Q9SUR6-1] AT4G23600.2; AT4G23600.2; AT4G23600 [Q9SUR6-2] |
GeneIDi | 828460 |
Gramenei | AT4G23600.1; AT4G23600.1; AT4G23600 [Q9SUR6-1] AT4G23600.2; AT4G23600.2; AT4G23600 [Q9SUR6-2] |
KEGGi | ath:AT4G23600 |
Organism-specific databases
Araporti | AT4G23600 |
TAIRi | locus:2128459, AT4G23600 |
Phylogenomic databases
eggNOGi | KOG0259, Eukaryota |
InParanoidi | Q9SUR6 |
OMAi | FCERHSA |
OrthoDBi | 734452at2759 |
PhylomeDBi | Q9SUR6 |
Enzyme and pathway databases
BioCyci | ARA:AT4G23600-MONOMER |
BRENDAi | 4.4.1.35, 399 |
Miscellaneous databases
PROi | PR:Q9SUR6 |
Gene expression databases
ExpressionAtlasi | Q9SUR6, baseline and differential |
Genevisiblei | Q9SUR6, AT |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR004839, Aminotransferase_I/II IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR015422, PyrdxlP-dep_Trfase_small IPR005958, TyrNic_aminoTrfase |
Pfami | View protein in Pfam PF00155, Aminotran_1_2, 1 hit |
PIRSFi | PIRSF000517, Tyr_transaminase, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
TIGRFAMsi | TIGR01265, tyr_nico_aTase, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CORI3_ARATH | |
Accessioni | Q9SUR6Primary (citable) accession number: Q9SUR6 Secondary accession number(s): Q0WN47 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 21, 2011 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families