UniProtKB - Q9SU63 (AL2B4_ARATH)
Protein
Aldehyde dehydrogenase family 2 member B4, mitochondrial
Gene
ALDH2B4
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Possesses activity on acetaldehyde and glycolaldehyde in vitro.1 Publication
Catalytic activityi
- EC:1.2.1.3
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 206 | Transition state stabilizerBy similarity | 1 | |
Active sitei | 305 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Active sitei | 339 | NucleophilePROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 282 – 287 | NADBy similarity | 6 |
GO - Molecular functioni
- aldehyde dehydrogenase (NAD+) activity Source: TAIR
- ATP binding Source: TAIR
- glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity Source: UniProtKB-EC
GO - Biological processi
- response to cadmium ion Source: TAIR
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
BioCyci | ARA:AT3G48000-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Aldehyde dehydrogenase family 2 member B4, mitochondrial (EC:1.2.1.3)Short name: ALDH2a |
Gene namesi | Name:ALDH2B4 Synonyms:ALDH2 Ordered Locus Names:At3g48000 ORF Names:T17F15.130 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT3G48000 |
TAIRi | locus:2097845, AT3G48000 |
Subcellular locationi
Mitochondrion
- Mitochondrion matrix 1 Publication
Cytosol
- cytosol Source: TAIR
Mitochondrion
- mitochondrial matrix Source: UniProtKB-SubCell
- mitochondrion Source: TAIR
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 38 | Mitochondrion1 PublicationAdd BLAST | 38 | |
ChainiPRO_0000256056 | 39 – 538 | Aldehyde dehydrogenase family 2 member B4, mitochondrialAdd BLAST | 500 |
Proteomic databases
PaxDbi | Q9SU63 |
PRIDEi | Q9SU63 |
ProteomicsDBi | 244707 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q9SU63, baseline and differential |
Genevisiblei | Q9SU63, AT |
Interactioni
Subunit structurei
Homotetramer.
By similarityProtein-protein interaction databases
BioGRIDi | 9274, 2 interactors |
STRINGi | 3702.AT3G48000.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the aldehyde dehydrogenase family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2450, Eukaryota |
HOGENOMi | CLU_005391_0_1_1 |
InParanoidi | Q9SU63 |
OMAi | RHVMIKH |
OrthoDBi | 153834at2759 |
PhylomeDBi | Q9SU63 |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9SU63-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAARRVSSLL SRSFSASSPL LFRSQGRNCY NGGILRRFGT SSAAAEEIIN
60 70 80 90 100
PSVQVSHTQL LINGNFVDSA SGKTFPTLDP RTGEVIAHVA EGDAEDINRA
110 120 130 140 150
VKAARTAFDE GPWPKMSAYE RSRVLLRFAD LVEKHSEELA SLETWDNGKP
160 170 180 190 200
YQQSLTAEIP MFARLFRYYA GWADKIHGLT IPADGNYQVH TLHEPIGVAG
210 220 230 240 250
QIIPWNFPLL MFAWKVGPAL ACGNTIVLKT AEQTPLTAFY AGKLFLEAGL
260 270 280 290 300
PPGVLNIVSG FGATAGAALA SHMDVDKLAF TGSTDTGKVI LGLAANSNLK
310 320 330 340 350
PVTLELGGKS PFIVFEDADI DKAVELAHFA LFFNQGQCCC AGSRTFVHEK
360 370 380 390 400
VYDEFVEKSK ARALKRVVGD PFRKGIEQGP QIDLKQFEKV MKYIKSGIES
410 420 430 440 450
NATLECGGDQ IGDKGYFIQP TVFSNVKDDM LIAQDEIFGP VQSILKFSDV
460 470 480 490 500
DEVIKRANET KYGLAAGVFT KNLDTANRVS RALKAGTVWV NCFDVFDAAI
510 520 530
PFGGYKMSGN GREKGIYSLN NYLQIKAVVT ALNKPAWI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 125 | L → C in CAA81249 (Ref. 6) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB030820 mRNA Translation: BAA96792.1 AF349447 mRNA Translation: AAM27003.1 AL049658 Genomic DNA Translation: CAB41139.1 CP002686 Genomic DNA Translation: AEE78355.1 AF327426 mRNA Translation: AAG42016.1 AF349522 mRNA Translation: AAK15569.1 AF372911 mRNA Translation: AAK49627.1 AY090443 mRNA Translation: AAL91287.1 BT000752 mRNA Translation: AAN31892.1 BT006371 mRNA Translation: AAP21179.1 Z26417 mRNA Translation: CAA81249.1 |
PIRi | T06683 |
RefSeqi | NP_190383.1, NM_114669.4 |
Genome annotation databases
EnsemblPlantsi | AT3G48000.1; AT3G48000.1; AT3G48000 |
GeneIDi | 823955 |
Gramenei | AT3G48000.1; AT3G48000.1; AT3G48000 |
KEGGi | ath:AT3G48000 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB030820 mRNA Translation: BAA96792.1 AF349447 mRNA Translation: AAM27003.1 AL049658 Genomic DNA Translation: CAB41139.1 CP002686 Genomic DNA Translation: AEE78355.1 AF327426 mRNA Translation: AAG42016.1 AF349522 mRNA Translation: AAK15569.1 AF372911 mRNA Translation: AAK49627.1 AY090443 mRNA Translation: AAL91287.1 BT000752 mRNA Translation: AAN31892.1 BT006371 mRNA Translation: AAP21179.1 Z26417 mRNA Translation: CAA81249.1 |
PIRi | T06683 |
RefSeqi | NP_190383.1, NM_114669.4 |
3D structure databases
SMRi | Q9SU63 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 9274, 2 interactors |
STRINGi | 3702.AT3G48000.1 |
Proteomic databases
PaxDbi | Q9SU63 |
PRIDEi | Q9SU63 |
ProteomicsDBi | 244707 |
Genome annotation databases
EnsemblPlantsi | AT3G48000.1; AT3G48000.1; AT3G48000 |
GeneIDi | 823955 |
Gramenei | AT3G48000.1; AT3G48000.1; AT3G48000 |
KEGGi | ath:AT3G48000 |
Organism-specific databases
Araporti | AT3G48000 |
TAIRi | locus:2097845, AT3G48000 |
Phylogenomic databases
eggNOGi | KOG2450, Eukaryota |
HOGENOMi | CLU_005391_0_1_1 |
InParanoidi | Q9SU63 |
OMAi | RHVMIKH |
OrthoDBi | 153834at2759 |
PhylomeDBi | Q9SU63 |
Enzyme and pathway databases
BioCyci | ARA:AT3G48000-MONOMER |
Miscellaneous databases
PROi | PR:Q9SU63 |
Gene expression databases
ExpressionAtlasi | Q9SU63, baseline and differential |
Genevisiblei | Q9SU63, AT |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AL2B4_ARATH | |
Accessioni | Q9SU63Primary (citable) accession number: Q9SU63 Secondary accession number(s): Q42090 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families