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Protein

Heat shock 70 kDa protein 6, chloroplastic

Gene

HSP70-6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts redundantly with HSP70-7 in the thermotolerance of germinating seeds. Plays an important role in the protein precursor import into chloroplasts.3 Publications
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity).By similarity

GO - Molecular functioni

  • ATP binding Source: TAIR
  • unfolded protein binding Source: InterPro

GO - Biological processi

  • protein folding Source: InterPro
  • protein targeting to chloroplast Source: TAIR
  • response to cadmium ion Source: TAIR
  • response to cold Source: TAIR
  • viral process Source: UniProtKB-KW

Keywordsi

Molecular functionChaperone
Biological processHost-virus interaction, Protein transport, Stress response, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 6, chloroplastic
Alternative name(s):
Chloroplast heat shock protein 70-1
Short name:
cpHsc70-1
Heat shock protein 70-6
Short name:
AtHsp70-6
Gene namesi
Name:HSP70-6
Synonyms:CPHSC70-1
Ordered Locus Names:At4g24280
ORF Names:T22A6.110
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G24280
TAIRilocus:2135897 AT4G24280

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

Pathology & Biotechi

Disruption phenotypei

Variegated cotyledons, malformed leaves, growth retardation and impaired root growth. Defective in protein import into chloroplasts during early developmental stages.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 92ChloroplastSequence analysisAdd BLAST92
ChainiPRO_000041542593 – 718Heat shock 70 kDa protein 6, chloroplasticAdd BLAST626

Proteomic databases

PaxDbiQ9STW6
PRIDEiQ9STW6

PTM databases

iPTMnetiQ9STW6

Expressioni

Gene expression databases

ExpressionAtlasiQ9STW6 baseline and differential
GenevisibleiQ9STW6 AT

Interactioni

Subunit structurei

Interacts with geminivirus movement protein (MP).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi13820, 8 interactors
STRINGi3702.AT4G24280.1

Structurei

3D structure databases

ProteinModelPortaliQ9STW6
SMRiQ9STW6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0102 Eukaryota
COG0443 LUCA
HOGENOMiHOG000228135
InParanoidiQ9STW6
KOiK03283
OMAiGGTFMPR
OrthoDBiEOG093604GM
PhylomeDBiQ9STW6

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
HAMAPiMF_00332 DnaK, 1 hit
InterProiView protein in InterPro
IPR012725 Chaperone_DnaK
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
TIGRFAMsiTIGR02350 prok_dnaK, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9STW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSAAQIHV LGGIGFASSS SSKRNLNGKG GTFMPRSAFF GTRTGPFSTP
60 70 80 90 100
TSAFLRMGTR NGGGASRYAV GPVRVVNEKV VGIDLGTTNS AVAAMEGGKP
110 120 130 140 150
TIVTNAEGQR TTPSVVAYTK SGDRLVGQIA KRQAVVNPEN TFFSVKRFIG
160 170 180 190 200
RKMNEVDEES KQVSYRVVRD ENNNVKLECP AINKQFAAEE ISAQVLRKLV
210 220 230 240 250
DDASRFLNDK VTKAVITVPA YFNDSQRTAT KDAGRIAGLE VLRIINEPTA
260 270 280 290 300
ASLAYGFDRK ANETILVFDL GGGTFDVSVL EVGDGVFEVL STSGDTHLGG
310 320 330 340 350
DDFDKRVVDW LAAEFKKDEG IDLLKDKQAL QRLTEAAEKA KIELSSLTQT
360 370 380 390 400
NMSLPFITAT ADGPKHIETT LTRAKFEELC SDLLDRVRTP VENSLRDAKL
410 420 430 440 450
SFKDIDEVIL VGGSTRIPAV QELVRKVTGK EPNVTVNPDE VVALGAAVQA
460 470 480 490 500
GVLAGDVSDI VLLDVTPLSI GLETLGGVMT KIIPRNTTLP TSKSEVFSTA
510 520 530 540 550
ADGQTSVEIN VLQGEREFVR DNKSLGSFRL DGIPPAPRGV PQIEVKFDID
560 570 580 590 600
ANGILSVSAV DKGTGKKQDI TITGASTLPK DEVDQMVQEA ERFAKDDKEK
610 620 630 640 650
RDAIDTKNQA DSVVYQTEKQ LKELGEKIPG EVKEKVEAKL QELKDKIGSG
660 670 680 690 700
STQEIKDAMA ALNQEVMQIG QSLYNQPGAG GPGAGPSPGG EGASSGDSSS
710
SKGGDGDDVI DADFTDSQ
Length:718
Mass (Da):76,508
Last modified:May 1, 2000 - v1
Checksum:i8723B345C601B8A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL078637 Genomic DNA Translation: CAB45063.1
AL161561 Genomic DNA Translation: CAB79338.1
CP002687 Genomic DNA Translation: AEE84884.1
AY072138 mRNA Translation: AAL59960.1
BT001950 mRNA Translation: AAN71949.1
PIRiT09891
RefSeqiNP_194159.1, NM_118561.3
UniGeneiAt.25311
At.67055

Genome annotation databases

EnsemblPlantsiAT4G24280.1; AT4G24280.1; AT4G24280
GeneIDi828531
GrameneiAT4G24280.1; AT4G24280.1; AT4G24280
KEGGiath:AT4G24280

Similar proteinsi

Entry informationi

Entry nameiHSP7F_ARATH
AccessioniPrimary (citable) accession number: Q9STW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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