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Entry version 129 (12 Aug 2020)
Sequence version 2 (28 Jun 2011)
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Protein

Auxin transport protein BIG

Gene

BIG

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for auxin efflux and polar auxin transport (PAT) influencing auxin-mediated developmental responses (e.g. cell elongation, apical dominance, lateral root production, inflorescence architecture, general growth and development). Controls the elongation of the pedicels and stem internodes through auxin action. Involved in the expression modulation of light-regulated genes. Represses CAB1 and CAB3 genes expression in etiolated seedlings. Confers sensitivity to the auxin transport inhibitors N-1-naphthylphthalamic acid (NPA), 2-carboxyphenyl-3-phenylpropane-l,2-dione (CPD), and methyl-2-chloro-9-hydroxyfluorene-9-carboxylate (CFM). Influences the polarized subcellular distribution of the auxin transporter PIN1 in response to auxin transport inhibitors. Plays a role in the regulation of responses to phytohormones such as auxin, cytokinins, ethylene and gibberellic acid (GA), particularly during light-mediated stimuli (e.g. shade ovoidance, etiolation). Required for pericycle cell activation to form lateral root primordia (LRP) in both high and low phosphate P conditions. Necessary for the plant-growth promotion and lateral root development mediated by the fungus Trichoderma virens.9 Publications

Miscellaneous

May be or regulate a N-1-naphthylphthalamic acid (NPA) binding protein (NBP), an auxin transport inhibitor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1573 – 1644UBR-typePROSITE-ProRule annotationAdd BLAST72
Zinc fingeri2612 – 2659ZZ-typePROSITE-ProRule annotationAdd BLAST48
Zinc fingeri3464 – 3504MYND-type; degenerateAdd BLAST41

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processAuxin signaling pathway
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Auxin transport protein BIG
Alternative name(s):
Protein ATTENUATED SHADE AVOIDANCE 1
Protein CORYMBOSA1
Protein DARK OVER-EXPRESSION OF CAB 1
Protein LOW PHOSPHATE-RESISTANT ROOT 1
Protein TRANSPORT INHIBITOR RESPONSE 3
Protein UMBRELLA 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BIG
Synonyms:ASA1, CRM1, DOC1, GA6, LPR1, TIR3, UMB1
Ordered Locus Names:At3g02260
ORF Names:F14P3.9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT3G02260

The Arabidopsis Information Resource

More...
TAIRi
locus:2076487, AT3G02260

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1150 – 1170HelicalSequence analysisAdd BLAST21
Transmembranei1458 – 1478HelicalSequence analysisAdd BLAST21
Transmembranei2813 – 2833HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Altered expression of light-regulated genes; overexpression of CAB (photosystem II type I chlorophyll a/b-binding proteins) genes in the dark (e.g. CAB1 and CAB3). Reduced auxin transport. Under long-day growth conditions (18 hr light/6 hr dark), reduced apical dominance in mature plants. Reduced plant growth under both short-day (9 hr light/15 hr dark) and long-day conditions resulting in shorter plants. Strong deficiency in lateral root production. Reduced cell elongation in siliques, pedicels, roots, and the inflorescence leading to a compact rosette, more secondary corymb-like inflorescence, and small seeds. Delayed flowering. Reduced sensitivity to auxin transport inhibitors N-1-naphthylphthalamic acid (NPA), 2-carboxyphenyl-3-phenylpropane-l,2-dione (CPD), and methyl-2-chloro-9-hydroxyfluorene-9-carboxylate (CFM). Organ-specific defect in response to cytokinins, ethylene and gibberellic acid (GA). Increased expression of auxin transporters PIN1 and PIN6. Reduced growth-promotion and lateral root development stimulation mediated by the fungus T.virens.9 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1607C → Y in doc1-1; altered expression of multiple light-regulated genes. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004107272 – 5098Auxin transport protein BIGAdd BLAST5097

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9SRU2

PRoteomics IDEntifications database

More...
PRIDEi
Q9SRU2

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
240620

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9SRU2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Constitutively expressed in roots, rosette leaves, inflorescence stems, and flowers. Present in inflorescence meristems, floral meristems and vascular tissues.2 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9SRU2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9SRU2, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
5732, 3 interactors

STRING: functional protein association networks

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STRINGi
3702.AT3G02260.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9SRU2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3537 – 3557Sequence analysisAdd BLAST21
Coiled coili4313 – 4333Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4883 – 4914Ser-richAdd BLAST32

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UBR4 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1573 – 1644UBR-typePROSITE-ProRule annotationAdd BLAST72
Zinc fingeri2612 – 2659ZZ-typePROSITE-ProRule annotationAdd BLAST48
Zinc fingeri3464 – 3504MYND-type; degenerateAdd BLAST41

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1776, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_223526_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9SRU2

KEGG Orthology (KO)

More...
KOi
K10691

Database of Orthologous Groups

More...
OrthoDBi
717at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.60.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR025704, E3_Ub_ligase_UBR4
IPR036322, WD40_repeat_dom_sf
IPR003126, Znf_UBR
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13764, E3_UbLigase_R4, 1 hit
PF00569, ZZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00396, ZnF_UBR1, 1 hit
SM00291, ZnF_ZZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51157, ZF_UBR, 1 hit
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9SRU2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADDLANLCR FLFDDTAFPS LSSSASSDLF SRRLRSDDSI KRGLRSFYLL
60 70 80 90 100
LRWGVAPIGG DDADSSGKLR FETWSDSQLQ ALVSISQAIL LLSRSLLGTD
110 120 130 140 150
LTLNQGLVDQ LEPIVLGVIQ EVMEFSLSFL EKSSFRQNDL KMEINMEILL
160 170 180 190 200
EIASFDGSEK QYDILPDFSP AEVAELWPAF SGEHDNMDAQ SLVKCTFQGG
210 220 230 240 250
RCSNEEKPVD RLLITLMSEC IESDVQAQSV VKSPFQQDCG DLNPFTRHLA
260 270 280 290 300
VVHLRCVCRL IMVCKELVQL PNMLDEKTVD QAVLDKLSFC LRILKLLGSL
310 320 330 340 350
SKDVQSIEND GSLLQAVASF TDAFPKLFRV FFEFTNHTAT EGNIESLSLA
360 370 380 390 400
LVEGFLNLVQ LIFGKSSVFQ NVQACVAASI VSNLDSSVWR YDGSSCNLTP
410 420 430 440 450
PLAYFPRSVI YTLKLIQDLK RQPYHIHDLR VLESEVTYED VSSTVDSVYF
460 470 480 490 500
HLRQEKIPLL KCFTVEDIMR VIFPSSSQWM DNFFHLVYFL HREGVKLRPK
510 520 530 540 550
VERTYSSLRS NSFAEVESQI SHDDEALFGN LFSEGSRSLC SIEPNDQPPV
560 570 580 590 600
SVSSNLLLQA AKELLNFLRA CILCQEWVPS IYEDGCKKLD TGHIDILLNI
610 620 630 640 650
VGCSIEDKAS DGGCMLQDEG RPGHVAFELL LNLLRSRALS DFLESYLFQQ
660 670 680 690 700
ILVVENSDFN YNDKTLALLA HTLLCRPGLA GAQLRAKIYD GFVSFVTERA
710 720 730 740 750
RGICAEALSL KELTACLPSA FHIEILLMAF HLSNEAEKAK FSNLIASCLH
760 770 780 790 800
KVDTPAGICD GPQLSSWAML ISRLLVLLHH MLLHPNTCPT SLMLDLRSKL
810 820 830 840 850
REVRSCGSNL HVTVGDHLSS WASLVARGIT DSWAEDESVS HLMSQMIDFS
860 870 880 890 900
PHPPTFQNDV STAKTLNLDY GDLSASLCRV LGLWKGKKAG KVEDLLVERY
910 920 930 940 950
IFMLSSDIAR INCALDSQPS LHVNYQNVDI SNSVDLISTS HLLVGDINVV
960 970 980 990 1000
GRNIELRNIL IGVLNQLQAA PEQVVEDLGW DYIREGAWLS LLLYFLDGGV
1010 1020 1030 1040 1050
WDYCNKNSCS EIDPFWKECT SVDAKYVAAA EGVVSYLMKT GDIAELLRML
1060 1070 1080 1090 1100
SSLVGKYLRV YKKAFLATFS DWNHHGHSSP SLLLLKHTQF GKSLQGEYAK
1110 1120 1130 1140 1150
IGDNSLHLQC IFYLSKLDSL GDGRGSGVLW KVFWEFMVHG FPTSLQTSSA
1160 1170 1180 1190 1200
ILLSCILSIR CIVLTINGLL KLGNSKEKFG VDTSVLHQLL DSIMIIKFDQ
1210 1220 1230 1240 1250
VFESFHGKCE EIHQNICAVL QLPDLTELFL MKDMEGFVRD ISAEQIDRSQ
1260 1270 1280 1290 1300
VLEGVITKIV DVMDSLSKDS SKSDIFKFYL GVDAVSEHTR EFYELQRGDL
1310 1320 1330 1340 1350
SVFIDSLDYC SLEPVNIKVL NFLVDLLSVA QSPDLRRRVQ QKFIDMDLIS
1360 1370 1380 1390 1400
LSGWLERRLL GSFVEEIDGK KTAKGNSLPF REAAMNFINC LVSSTNDLQT
1410 1420 1430 1440 1450
RELQNHLFEA LLISLDTAFL SFDIHMSMSY FHFVLQLARE DNLMKMVLKR
1460 1470 1480 1490 1500
TIMLMEKLAA EEKLLPGLKF IFGVIGTLLS NRSPSHGESL CGKSLASYKN
1510 1520 1530 1540 1550
TATGPLVPKL SGTTKKSDTL ALPVDQEGSS ISLECDVTSV DEDEDDGTSD
1560 1570 1580 1590 1600
GEVASLDKED EEDANSERYL ASKVCTFTSS GSNFMEQHWY FCYTCDLTVS
1610 1620 1630 1640 1650
KGCCSVCAKV CHRGHRVVYS RSSRFFCDCG AGGVRGSSCQ CLKPRKYNGN
1660 1670 1680 1690 1700
GSAPARGTNN FQSFLPLSED ADQLGESDSD VEEDGFGEEN HVVLYIPKET
1710 1720 1730 1740 1750
QYKMSLLLEE LGIEDRVLEL FSSLLPSITS KRDSGLSKEK QVNLGKDKVL
1760 1770 1780 1790 1800
SFDTDLLQLK KAYKSGSLDL KIKADYTNSK DLKSLLANGS LVKSLLSVSV
1810 1820 1830 1840 1850
RGRLAVGEGD KVAIFDVGQL IGQATIAPIN ADKANVKPLS RNIVRFEIVH
1860 1870 1880 1890 1900
LSFNPVVENY LAVAGLEDCQ ILTLNHRGEV IDRLAVELAL QGAFIRRIDW
1910 1920 1930 1940 1950
VPGSQVQLMV VTNKFVKIYD LSQDSISPTQ YFTLPNDMIV DATLFVASRG
1960 1970 1980 1990 2000
RVFLLVLSEQ GNLYRFELSW GGNAGATPLK EIVQIMGKDV TGKGSSVYFS
2010 2020 2030 2040 2050
PTYRLLFISY HDGSSFMGRL SSDATSLTDT SGMFEEESDC KQRVAGLHRW
2060 2070 2080 2090 2100
KELLAGSGLF ICFSSVKSNA VLAVSLRGDG VCAQNLRHPT GSSSPMVGIT
2110 2120 2130 2140 2150
AYKPLSKDNV HCLVLHDDGS LQIYSHVRSG VDTDSNFTAE KVKKLGSKIL
2160 2170 2180 2190 2200
NNKTYAGAKP EFPLDFFERA FCITADVRLG SDAIRNGDSE GAKQSLASED
2210 2220 2230 2240 2250
GFIESPSPVG FKISVSNPNP DIVMVGIRMH VGTTSASSIP SEVTIFQRSI
2260 2270 2280 2290 2300
KMDEGMRCWY DIPFTVAESL LADEDVVISV GPTTSGTALP RIDSLEVYGR
2310 2320 2330 2340 2350
AKDEFGWKEK MDAVLDMEAR VLGHGLLLPG SSKKRALAQS ASMEEQVIAD
2360 2370 2380 2390 2400
GLKLLSIYYS VCRPRQEVVL SELKCKQLLE TIFESDRETL LQTTACRVLQ
2410 2420 2430 2440 2450
SVFPRKEIYY QVMFLPNSVK DTMRLLGVVK VTSILSSRLG ILGTGGSIVE
2460 2470 2480 2490 2500
EFNAQMRAVS KVALTRKSNF SVFLEMNGSE VVDNLMQVLW GILESEPLDT
2510 2520 2530 2540 2550
PTMNNVVMSS VELIYSYAEC LASQGKDTGV HSVAPAVQLL KALMLFPNES
2560 2570 2580 2590 2600
VQTSSRCVLV LAISSRLLQV PFPKQTMLTT DDLVDNVTTP SVPIRTAGGN
2610 2620 2630 2640 2650
THVMIEEDSI TSSVQYCCDG CSTVPILRRR WHCTVCPDFD LCEACYEVLD
2660 2670 2680 2690 2700
ADRLPPPHTR DHPMTAIPIE VESLGADTNE IQFSADEVGI SNMLPVVTSS
2710 2720 2730 2740 2750
IPQASTPSIH VLEPGESAEF SASLTDPISI SASKRAVNSL ILSEFLQELS
2760 2770 2780 2790 2800
GWMETVSGVQ AIPVMQLFYR LSSAIGGAFM DSSKPEEISL DKLIKWLLGE
2810 2820 2830 2840 2850
INLSKPFAAS TRSSLGEIVI LVFMFFTLML RSWHQPGSDG SSSKLGGSTD
2860 2870 2880 2890 2900
VHDRRIVQSS TVVATQSSLH VQERDDFASQ LVRACSCLRN QEFVNYLMNI
2910 2920 2930 2940 2950
LQQLVHVFKS RAANVEARGS SSGSGCGAML TVRRDLPAGN YSPFFSDSYA
2960 2970 2980 2990 3000
KAHRADIFVD YHRLLLENVF RLVYTLVRPE KQEKMGEKEK VYRNASSKDL
3010 3020 3030 3040 3050
KLDGFQDVLC SYINNPHTAF VRRYARRLFL HLCGSKTQYY SVRDSWQFSN
3060 3070 3080 3090 3100
EVKNLYKHVE KSGGFENNVS YERSVKIVKS LSTIAEVAVA RPRNWQKYCL
3110 3120 3130 3140 3150
RHGDFLSFLL NGVFHFAEES VIQTLKLLNL AFYQGKDVSS SVQKAEATEV
3160 3170 3180 3190 3200
VTGSNRSGSQ SVDSKKKKKG EDGHDSGLEK LYVDMEGVVD IFSANCGDLL
3210 3220 3230 3240 3250
RQFIDFFLLE WNSSSVRTEA KSVIYGLWHH GRHSFKESLL AALLQKVRYL
3260 3270 3280 3290 3300
PAYGQNIVEY TELVSLLLDK APENNSKQAI NELVDRCLNP DVIRCFFETL
3310 3320 3330 3340 3350
HSQNELIANH PNSRIYSTLG NLVEFDGYYL ESEPCVACSS PDVPYSKMKL
3360 3370 3380 3390 3400
ESLKSETKFT DNRIIVKCTG SYTIQSVTMN VHDARKSKSV KVLNLYYNNR
3410 3420 3430 3440 3450
PVSDLSELKN NWSLWKRAKS CHLSFNQTEL KVEFPIPITA CNFMIELDSF
3460 3470 3480 3490 3500
YENLQALSLE PLQCPRCSRP VTDKHGICSN CHENAYQCRQ CRNINYENLD
3510 3520 3530 3540 3550
SFLCNECGYS KYGRFEFNFM AKPSFIFDNM ENDEDMKKGL AAIESESENA
3560 3570 3580 3590 3600
HKRYQQLLGF KKPLLKIVSS IGETEMDSQH KDTVQQMMAS LPGPSCKINR
3610 3620 3630 3640 3650
KIALLGVLYG EKCKAAFDSV SKSVQTLQGL RRVLMSYLHQ KNSNFSSGAS
3660 3670 3680 3690 3700
RCVVSKTPNN CYGCATTFVT QCLEILQVLS KHPRSRKQLV AAGILSELFE
3710 3720 3730 3740 3750
NNIHQGPKTA RAQARAALST FSEGDLSAVN ELNNLVQKKI MYCLEHHRSM
3760 3770 3780 3790 3800
DIALATREEM LLLSEVCSLT DEFWESRLRL VFQLLFSSIK LGAKHPAISE
3810 3820 3830 3840 3850
HIILPCLKII SVACTPPKPD TAEKEQTMGK SAPAVQEKDE NAAGVIKYSS
3860 3870 3880 3890 3900
ESEENNLNVS QKTRDIQLVS YLEWEKGASY LDFVRRQYKA SQSIRGASQK
3910 3920 3930 3940 3950
SRTHRSDFLA LKYTLRWKRR SSRTSKGGLQ AFELGSWVTE LILSACSQSI
3960 3970 3980 3990 4000
RSEMCTLISL LAAQSSPRRY RLINLLIGLL PATLAAGESS AEYFELLFKM
4010 4020 4030 4040 4050
IETQDALLFL TVRGCLTTIC KLISQEVGNI ESLERSLQID ISQGFTLHKL
4060 4070 4080 4090 4100
LELLGKFLEV PNIRSRFMRD NLLSHVLEAL IVIRGLIVQK TKLINDCNRR
4110 4120 4130 4140 4150
LKDLLDGLLL ESSENKRQFI RACVSGLQTH AEENKGRTCL FILEQLCNLI
4160 4170 4180 4190 4200
CPSKPEAVYM LILNKSHTQE EFIRGSMTKN PYSSAEIGPL MRDVKNKICQ
4210 4220 4230 4240 4250
QLDLLGLLED DYGMELLVAG NIISLDLSIA QVYELVWKKS NQSSTSLTNS
4260 4270 4280 4290 4300
ALLASNAAPS RDCPPMTVTY RLQGLDGEAT EPMIKELEED REESQDPEIE
4310 4320 4330 4340 4350
FAIAGAVREY GGLEILLDMI KSLQDDFKSN QEEMVAVLDL LNHCCKIREN
4360 4370 4380 4390 4400
RRALLRLGAL SLLLETARRA FSVDAMEPAE GILLIVESLT LEANESDSIS
4410 4420 4430 4440 4450
AAQSALTVSN EETGTWEQAK KIVLMFLERL SHPSGLKKSN KQQRNTEMVA
4460 4470 4480 4490 4500
RILPYLTYGE PAAMEALIEH FSPYLQNWSE FDQLQQRHEE DPKDDSIAQQ
4510 4520 4530 4540 4550
AAKQRFTVEN FVRVSESLKT SSCGERLKDI VLENGIIAVA VKHIKEIFAI
4560 4570 4580 4590 4600
TGQTGFKSSK EWLLALKLPS VPLILSMLRG LSMGHLPTQT CIDEGGILTL
4610 4620 4630 4640 4650
LHALEGVSGE NDIGARAENL LDTLADKEGK GDGFLGEKVR ALRDATKDEM
4660 4670 4680 4690 4700
RRRALRKREE LLQGLGMRQE LSSDGGERIV VSQPILEGFE DVEEEEDGLA
4710 4720 4730 4740 4750
CMVCREGYKL RPSDLLGVYS YSKRVNLGVG NSGSARGECV YTTVSYFNII
4760 4770 4780 4790 4800
HFQCHQEAKR ADAALKNPKK EWEGAMLRNN ESLCNSLFPV KGPSVPLAQY
4810 4820 4830 4840 4850
LRYVDQYWDN LNALGRADGS RLRLLTYDIV LMLARFATGA SFSADCRGGG
4860 4870 4880 4890 4900
RDSNSRFLPF MFQMARHLLD QGGPVQRTNM ARSVSSYISS SSTSTATAPS
4910 4920 4930 4940 4950
SDSRPLTPGS QLSSTGTEET VQFMMVNSLL SESYESWLQH RRVFLQRGIY
4960 4970 4980 4990 5000
HTFMQHAHGR VASRAAEPTS SGGKTQDAET LTGDELLSIV KPMLVYTGMI
5010 5020 5030 5040 5050
EQLQQLFKPK KPVHIEPIKK EGTSSGVELE PWEIVMKEKL LNVKEMIGFS
5060 5070 5080 5090
KELISWLDEI NSATDLQEAF DIVGVLADVL SEGVTQCDQF VRSAIDKD
Length:5,098
Mass (Da):567,888
Last modified:June 28, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43F7EADD65B23133
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1I9LSK4A0A1I9LSK4_ARATH
Auxin transport protein (BIG)
BIG ASA1, ATTENUATED SHADE AVOIDANCE 1, CORYMBOSA1, CRM1, DARK OVER-EXPRESSION OF CAB 1
5,077Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1I9LSK3A0A1I9LSK3_ARATH
Auxin transport protein (BIG)
BIG ASA1, ATTENUATED SHADE AVOIDANCE 1, CORYMBOSA1, CRM1, DARK OVER-EXPRESSION OF CAB 1
5,087Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1I9LSK5A0A1I9LSK5_ARATH
Auxin transport protein (BIG)
BIG ASA1, ATTENUATED SHADE AVOIDANCE 1, CORYMBOSA1, CRM1, DARK OVER-EXPRESSION OF CAB 1
5,078Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF02112 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAM77595 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF507018 Genomic DNA Translation: AAM77595.1 Sequence problems.
AC009755 Genomic DNA Translation: AAF02112.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE73785.1

NCBI Reference Sequences

More...
RefSeqi
NP_186875.2, NM_111093.2

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT3G02260.1; AT3G02260.1; AT3G02260

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
820398

Gramene; a comparative resource for plants

More...
Gramenei
AT3G02260.1; AT3G02260.1; AT3G02260

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT3G02260

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF507018 Genomic DNA Translation: AAM77595.1 Sequence problems.
AC009755 Genomic DNA Translation: AAF02112.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE73785.1
RefSeqiNP_186875.2, NM_111093.2

3D structure databases

SMRiQ9SRU2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi5732, 3 interactors
STRINGi3702.AT3G02260.1

PTM databases

iPTMnetiQ9SRU2

Proteomic databases

PaxDbiQ9SRU2
PRIDEiQ9SRU2
ProteomicsDBi240620

Genome annotation databases

EnsemblPlantsiAT3G02260.1; AT3G02260.1; AT3G02260
GeneIDi820398
GrameneiAT3G02260.1; AT3G02260.1; AT3G02260
KEGGiath:AT3G02260

Organism-specific databases

AraportiAT3G02260
TAIRilocus:2076487, AT3G02260

Phylogenomic databases

eggNOGiKOG1776, Eukaryota
HOGENOMiCLU_223526_0_0_1
InParanoidiQ9SRU2
KOiK10691
OrthoDBi717at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9SRU2

Gene expression databases

ExpressionAtlasiQ9SRU2, baseline and differential
GenevisibleiQ9SRU2, AT

Family and domain databases

Gene3Di3.30.60.90, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR025704, E3_Ub_ligase_UBR4
IPR036322, WD40_repeat_dom_sf
IPR003126, Znf_UBR
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf
PfamiView protein in Pfam
PF13764, E3_UbLigase_R4, 1 hit
PF00569, ZZ, 1 hit
SMARTiView protein in SMART
SM00396, ZnF_UBR1, 1 hit
SM00291, ZnF_ZZ, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS51157, ZF_UBR, 1 hit
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBIG_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9SRU2
Secondary accession number(s): F4J4S0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: August 12, 2020
This is version 129 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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