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UniProtKB - Q9SRK7 (AZG1_ARATH)

Entry version 114 (23 Feb 2022)
Sequence version 1 (01 May 2000)
Previous versions | rss
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Protein

Adenine/guanine permease AZG1

Gene

AZG1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transports natural purines (adenine and guanine) as well as purine analogs. Confers sensitivity to 8-azaadenine and 8-azaguanine (8-azg).

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • purine nucleobase transmembrane transporter activity Source: TAIR
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.40.7.3, the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adenine/guanine permease AZG1
Alternative name(s):
AzgA-homolog protein
Protein AZAGUANINE RESISTANT 1
Short name:
AtAzg1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AZG1
Ordered Locus Names:At3g10960
ORF Names:F9F8.22
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Arabidopsis Information Portal

More...Araporti		AT3G10960

The Arabidopsis Information Resource

More...TAIRi		locus:2085517, AT3G10960

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Transmembranei414 – 434HelicalSequence analysisAdd BLAST21
Transmembranei459 – 479HelicalSequence analysisAdd BLAST21
Transmembranei480 – 500HelicalSequence analysisAdd BLAST21
Transmembranei514 – 534HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Resistance to 8-azaadenine and 8-azaguanine but not to other toxic nucleobase analogs. Deficiency in the uptake of adenine and guanine.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003799051 – 579Adenine/guanine permease AZG1Add BLAST579

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9SRK7

PRoteomics IDEntifications database

More...PRIDEi		Q9SRK7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		240947

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9SRK7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9SRK7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9SRK7, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		5601, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q9SRK7, 3 interactors

STRING: functional protein association networks

More...STRINGi		3702.AT3G10960.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QQ5E, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_024508_3_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9SRK7

Identification of Orthologs from Complete Genome Data

More...OMAi		LYGMARF

Database of Orthologous Groups

More...OrthoDBi		996173at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9SRK7

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR045018, Azg-like
IPR006043, NCS2

The PANTHER Classification System

More...PANTHERi		PTHR43337, PTHR43337, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00860, Xan_ur_permease, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9SRK7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQQQQQQLP STTTRPKPKL LNRLNTYVGS SRVGKRFKLA ERNSTFTTEL 
        60         70         80         90        100
RAGTATFLTM AYILAVNASI LSDSGGTCSV SDCIPLCSNP AIEPSQCTGP 
       110        120        130        140        150
GLRLIQPDVS CKFNPVNPGY AACVEEIRKD LIVATVAASL IGCVIMGLMA 
       160        170        180        190        200
NLPLALAPGM GTNAYFAYTV VGFHGSGSIS YRTALAAVFI EGLIFLFISA 
       210        220        230        240        250
IGFRAKLAKL VPKPVRISSS AGIGLFLAFI GLQNNQGIGL VGYSPSTLVT 
       260        270        280        290        300
LAACPASSRI SLAPVITSAN GTVSLLAGGS VSGDIMCIHG RMESPTFWLG 
       310        320        330        340        350
IVGFVIIAYC LVKNVKGAMI YGIVFVTAVS WFRNTEVTAF PNTSAGDAAH 
       360        370        380        390        400
DYFKKIVDVH VIKHTAGALS FSGINKGHFW EALVTFLYVD ILDTTGTLYS 
       410        420        430        440        450
MARFAGFVDE KGDFAGQYFA FMSDASAIVI GSLLGTSPVT VFIESSTGIR 
       460        470        480        490        500
EGGRTGLTAI TVAVYFLLAM FFTPLLASIP AWAVGPPLIL VGVMMMKSVT 
       510        520        530        540        550
EIDWEDMREA IPAFVTMILM PLTYSVAYGL IGGIGSYVVL HLWDWGEEGL 
       560        570 
VKLGFLKRKV KEEDNNNGVV KASEIDTTV
Length:579
Mass (Da):61,669
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i153B0DCF2A095355
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti26T → S in AAM63152 (Ref. 4) Curated1
Sequence conflicti32R → G in BAE99116 (Ref. 5) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC009991 Genomic DNA Translation: AAF01525.1
CP002686 Genomic DNA Translation: AEE74982.1
AY093125 mRNA Translation: AAM13124.1
BT010556 mRNA Translation: AAQ65179.1
AY085941 mRNA Translation: AAM63152.1
AK227056 mRNA Translation: BAE99116.1

NCBI Reference Sequences

More...RefSeqi		NP_566384.1, NM_111933.3

Genome annotation databases

Ensembl plant genome annotation project

More...EnsemblPlantsi		AT3G10960.1; AT3G10960.1; AT3G10960

Database of genes from NCBI RefSeq genomes

More...GeneIDi		820267

Gramene; a comparative resource for plants

More...Gramenei		AT3G10960.1; AT3G10960.1; AT3G10960

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ath:AT3G10960

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009991 Genomic DNA Translation: AAF01525.1
CP002686 Genomic DNA Translation: AEE74982.1
AY093125 mRNA Translation: AAM13124.1
BT010556 mRNA Translation: AAQ65179.1
AY085941 mRNA Translation: AAM63152.1
AK227056 mRNA Translation: BAE99116.1
RefSeqiNP_566384.1, NM_111933.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi5601, 6 interactors
IntActiQ9SRK7, 3 interactors
STRINGi3702.AT3G10960.1

Protein family/group databases

TCDBi2.A.40.7.3, the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family

PTM databases

iPTMnetiQ9SRK7

Proteomic databases

PaxDbiQ9SRK7
PRIDEiQ9SRK7
ProteomicsDBi240947

Genome annotation databases

EnsemblPlantsiAT3G10960.1; AT3G10960.1; AT3G10960
GeneIDi820267
GrameneiAT3G10960.1; AT3G10960.1; AT3G10960
KEGGiath:AT3G10960

Organism-specific databases

AraportiAT3G10960
TAIRilocus:2085517, AT3G10960

Phylogenomic databases

eggNOGiENOG502QQ5E, Eukaryota
HOGENOMiCLU_024508_3_2_1
InParanoidiQ9SRK7
OMAiLYGMARF
OrthoDBi996173at2759
PhylomeDBiQ9SRK7

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q9SRK7

Gene expression databases

ExpressionAtlasiQ9SRK7, baseline and differential
GenevisibleiQ9SRK7, AT

Family and domain databases

InterProiView protein in InterPro
IPR045018, Azg-like
IPR006043, NCS2
PANTHERiPTHR43337, PTHR43337, 1 hit
PfamiView protein in Pfam
PF00860, Xan_ur_permease, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAZG1_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9SRK7
Secondary accession number(s): Q0WUT2, Q8LDL2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 1, 2000
Last modified: February 23, 2022
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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