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UniProtKB - Q9SRK7 (AZG1_ARATH)
Protein
Adenine/guanine permease AZG1
Gene
AZG1
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Transports natural purines (adenine and guanine) as well as purine analogs. Confers sensitivity to 8-azaadenine and 8-azaguanine (8-azg).
1 PublicationGO - Molecular functioni
- purine nucleobase transmembrane transporter activity Source: TAIR
GO - Biological processi
- adenine transport Source: UniProtKB
- guanine transport Source: UniProtKB
- purine nucleobase transport Source: TAIR
Keywordsi
Biological process | Transport |
Protein family/group databases
TCDBi | 2.A.40.7.3, the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family |
Names & Taxonomyi
Protein namesi | Recommended name: Adenine/guanine permease AZG1Alternative name(s): AzgA-homolog protein Protein AZAGUANINE RESISTANT 1 Short name: AtAzg1 |
Gene namesi | Name:AZG1 Ordered Locus Names:At3g10960 ORF Names:F9F8.22 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT3G10960 |
TAIRi | locus:2085517, AT3G10960 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Cytosol
- cytosol Source: TAIR
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 52 – 72 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 131 – 151 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 183 – 203 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 221 – 241 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 260 – 280 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 292 – 312 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 320 – 340 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 379 – 399 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 414 – 434 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 459 – 479 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 480 – 500 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 514 – 534 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Disruption phenotypei
Resistance to 8-azaadenine and 8-azaguanine but not to other toxic nucleobase analogs. Deficiency in the uptake of adenine and guanine.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000379905 | 1 – 579 | Adenine/guanine permease AZG1Add BLAST | 579 |
Proteomic databases
PaxDbi | Q9SRK7 |
PRIDEi | Q9SRK7 |
ProteomicsDBi | 240947 |
PTM databases
iPTMneti | Q9SRK7 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q9SRK7, baseline and differential |
Genevisiblei | Q9SRK7, AT |
Interactioni
Protein-protein interaction databases
BioGRIDi | 5601, 6 interactors |
IntActi | Q9SRK7, 3 interactors |
STRINGi | 3702.AT3G10960.1 |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QQ5E, Eukaryota |
HOGENOMi | CLU_024508_3_2_1 |
InParanoidi | Q9SRK7 |
OMAi | LYGMARF |
OrthoDBi | 996173at2759 |
PhylomeDBi | Q9SRK7 |
Family and domain databases
InterProi | View protein in InterPro IPR045018, Azg-like IPR006043, NCS2 |
PANTHERi | PTHR43337, PTHR43337, 1 hit |
Pfami | View protein in Pfam PF00860, Xan_ur_permease, 2 hits |
i Sequence
Sequence statusi: Complete.
Q9SRK7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEQQQQQQLP STTTRPKPKL LNRLNTYVGS SRVGKRFKLA ERNSTFTTEL
60 70 80 90 100
RAGTATFLTM AYILAVNASI LSDSGGTCSV SDCIPLCSNP AIEPSQCTGP
110 120 130 140 150
GLRLIQPDVS CKFNPVNPGY AACVEEIRKD LIVATVAASL IGCVIMGLMA
160 170 180 190 200
NLPLALAPGM GTNAYFAYTV VGFHGSGSIS YRTALAAVFI EGLIFLFISA
210 220 230 240 250
IGFRAKLAKL VPKPVRISSS AGIGLFLAFI GLQNNQGIGL VGYSPSTLVT
260 270 280 290 300
LAACPASSRI SLAPVITSAN GTVSLLAGGS VSGDIMCIHG RMESPTFWLG
310 320 330 340 350
IVGFVIIAYC LVKNVKGAMI YGIVFVTAVS WFRNTEVTAF PNTSAGDAAH
360 370 380 390 400
DYFKKIVDVH VIKHTAGALS FSGINKGHFW EALVTFLYVD ILDTTGTLYS
410 420 430 440 450
MARFAGFVDE KGDFAGQYFA FMSDASAIVI GSLLGTSPVT VFIESSTGIR
460 470 480 490 500
EGGRTGLTAI TVAVYFLLAM FFTPLLASIP AWAVGPPLIL VGVMMMKSVT
510 520 530 540 550
EIDWEDMREA IPAFVTMILM PLTYSVAYGL IGGIGSYVVL HLWDWGEEGL
560 570
VKLGFLKRKV KEEDNNNGVV KASEIDTTV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 26 | T → S in AAM63152 (Ref. 4) Curated | 1 | |
Sequence conflicti | 32 | R → G in BAE99116 (Ref. 5) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC009991 Genomic DNA Translation: AAF01525.1 CP002686 Genomic DNA Translation: AEE74982.1 AY093125 mRNA Translation: AAM13124.1 BT010556 mRNA Translation: AAQ65179.1 AY085941 mRNA Translation: AAM63152.1 AK227056 mRNA Translation: BAE99116.1 |
RefSeqi | NP_566384.1, NM_111933.3 |
Genome annotation databases
EnsemblPlantsi | AT3G10960.1; AT3G10960.1; AT3G10960 |
GeneIDi | 820267 |
Gramenei | AT3G10960.1; AT3G10960.1; AT3G10960 |
KEGGi | ath:AT3G10960 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC009991 Genomic DNA Translation: AAF01525.1 CP002686 Genomic DNA Translation: AEE74982.1 AY093125 mRNA Translation: AAM13124.1 BT010556 mRNA Translation: AAQ65179.1 AY085941 mRNA Translation: AAM63152.1 AK227056 mRNA Translation: BAE99116.1 |
RefSeqi | NP_566384.1, NM_111933.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 5601, 6 interactors |
IntActi | Q9SRK7, 3 interactors |
STRINGi | 3702.AT3G10960.1 |
Protein family/group databases
TCDBi | 2.A.40.7.3, the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family |
PTM databases
iPTMneti | Q9SRK7 |
Proteomic databases
PaxDbi | Q9SRK7 |
PRIDEi | Q9SRK7 |
ProteomicsDBi | 240947 |
Genome annotation databases
EnsemblPlantsi | AT3G10960.1; AT3G10960.1; AT3G10960 |
GeneIDi | 820267 |
Gramenei | AT3G10960.1; AT3G10960.1; AT3G10960 |
KEGGi | ath:AT3G10960 |
Organism-specific databases
Araporti | AT3G10960 |
TAIRi | locus:2085517, AT3G10960 |
Phylogenomic databases
eggNOGi | ENOG502QQ5E, Eukaryota |
HOGENOMi | CLU_024508_3_2_1 |
InParanoidi | Q9SRK7 |
OMAi | LYGMARF |
OrthoDBi | 996173at2759 |
PhylomeDBi | Q9SRK7 |
Miscellaneous databases
PROi | PR:Q9SRK7 |
Gene expression databases
ExpressionAtlasi | Q9SRK7, baseline and differential |
Genevisiblei | Q9SRK7, AT |
Family and domain databases
InterProi | View protein in InterPro IPR045018, Azg-like IPR006043, NCS2 |
PANTHERi | PTHR43337, PTHR43337, 1 hit |
Pfami | View protein in Pfam PF00860, Xan_ur_permease, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | AZG1_ARATH | |
Accessioni | Q9SRK7Primary (citable) accession number: Q9SRK7 Secondary accession number(s): Q0WUT2, Q8LDL2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 28, 2009 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families