UniProtKB - Q9SRH5 (VDAC1_ARATH)
Protein
Mitochondrial outer membrane protein porin 1
Gene
VDAC1
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). Involved in plant development at reproductive stage, is important for pollen development and may regulate hydrogen peroxide generation during disease resistance.By similarity1 Publication
GO - Molecular functioni
- porin activity Source: UniProtKB-KW
- voltage-gated anion channel activity Source: TAIR
GO - Biological processi
- defense response Source: UniProtKB-KW
- response to bacterium Source: TAIR
Keywordsi
Molecular function | Porin |
Biological process | Ion transport, Plant defense, Transport |
Protein family/group databases
TCDBi | 1.B.8.1.15, the mitochondrial and plastid porin (mpp) family |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial outer membrane protein porin 1Alternative name(s): Voltage-dependent anion-selective channel protein 1 Short name: AtVDAC1 Short name: VDAC-1 |
Gene namesi | Name:VDAC1 Ordered Locus Names:At3g01280 ORF Names:T22N4.9 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT3G01280 |
TAIRi | locus:2100252, AT3G01280 |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane 4 Publications
Chloroplast
- chloroplast Source: TAIR
- chloroplast envelope Source: TAIR
Cytosol
- cytosol Source: TAIR
Mitochondrion
- mitochondrial outer membrane Source: GO_Central
- mitochondrion Source: TAIR
Plasma Membrane
- plasma membrane Source: TAIR
Vacuole
- vacuolar membrane Source: TAIR
- vacuole Source: TAIR
Other locations
- plastid Source: TAIR
- pore complex Source: UniProtKB-KW
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion outer membranePathology & Biotechi
Disruption phenotypei
In vdac1-6 homozygous plants, normal growth, but small siliques and decreased pollen germination rate and tube length.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 223 | P → H: Alteration of subcellular localization. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000050526 | 2 – 276 | Mitochondrial outer membrane protein porin 1Add BLAST | 275 |
Proteomic databases
PaxDbi | Q9SRH5 |
PRIDEi | Q9SRH5 |
ProteomicsDBi | 243225 |
PTM databases
iPTMneti | Q9SRH5 |
Expressioni
Tissue specificityi
Expressed in shoot meristems, root meristematic zone, lateral roots, leaves, stigma and anthers.1 Publication
Inductioni
By the bacterial pathogen P.syringae pv. tomato.2 Publications
Gene expression databases
ExpressionAtlasi | Q9SRH5, baseline and differential |
Genevisiblei | Q9SRH5, AT |
Interactioni
Binary interactionsi
Q9SRH5
With | #Exp. | IntAct |
---|---|---|
HXK1 [Q42525] | 2 | EBI-1644501,EBI-1644489 |
Protein-protein interaction databases
BioGRIDi | 6248, 3 interactors |
IntActi | Q9SRH5, 4 interactors |
MINTi | Q9SRH5 |
STRINGi | 3702.AT3G01280.1 |
Family & Domainsi
Domaini
Consists mainly of membrane-spanning sided beta-sheets.
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane beta strandPhylogenomic databases
eggNOGi | KOG3126, Eukaryota |
HOGENOMi | CLU_069937_0_0_1 |
InParanoidi | Q9SRH5 |
OMAi | VDYDING |
OrthoDBi | 938262at2759 |
PhylomeDBi | Q9SRH5 |
Family and domain databases
CDDi | cd07306, Porin3_VDAC, 1 hit |
Gene3Di | 2.40.160.10, 1 hit |
InterProi | View protein in InterPro IPR023614, Porin_dom_sf IPR001925, Porin_Euk IPR027246, Porin_Euk/Tom40 |
PANTHERi | PTHR11743, PTHR11743, 1 hit |
Pfami | View protein in Pfam PF01459, Porin_3, 1 hit |
PROSITEi | View protein in PROSITE PS00558, EUKARYOTIC_PORIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9SRH5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVKGPGLYTE IGKKARDLLY KDHNSDQKFS ITTFSPAGVA ITSTGTKKGD
60 70 80 90 100
LLLGDVAFQS RRKNITTDLK VCTDSTFLIT ATVDEAAPGL RSIFSFKVPD
110 120 130 140 150
QNSGKVELQY LHEYAGISTS MGLTQNPTVN FSGVIGSNVL AVGTDVSFDT
160 170 180 190 200
KSGNFTKINA GLSFTKEDLI ASLTVNDKGD LLNASYYHIV NPLFNTAVGA
210 220 230 240 250
EVSHKLSSKD STITVGTQHS LDPLTSVKAR VNSAGIASAL IQHEWKPKSF
260 270
FTISGEVDTK SIDKSAKVGL ALALKP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010676 Genomic DNA Translation: AAF03498.1 CP002686 Genomic DNA Translation: AEE73632.1 AY037217 mRNA Translation: AAK59817.1 AY113169 mRNA Translation: AAM47472.1 |
RefSeqi | NP_186777.1, NM_110994.4 |
Genome annotation databases
EnsemblPlantsi | AT3G01280.1; AT3G01280.1; AT3G01280 |
GeneIDi | 820914 |
Gramenei | AT3G01280.1; AT3G01280.1; AT3G01280 |
KEGGi | ath:AT3G01280 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010676 Genomic DNA Translation: AAF03498.1 CP002686 Genomic DNA Translation: AEE73632.1 AY037217 mRNA Translation: AAK59817.1 AY113169 mRNA Translation: AAM47472.1 |
RefSeqi | NP_186777.1, NM_110994.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 6248, 3 interactors |
IntActi | Q9SRH5, 4 interactors |
MINTi | Q9SRH5 |
STRINGi | 3702.AT3G01280.1 |
Protein family/group databases
TCDBi | 1.B.8.1.15, the mitochondrial and plastid porin (mpp) family |
PTM databases
iPTMneti | Q9SRH5 |
Proteomic databases
PaxDbi | Q9SRH5 |
PRIDEi | Q9SRH5 |
ProteomicsDBi | 243225 |
Protocols and materials databases
DNASUi | 820914 |
Genome annotation databases
EnsemblPlantsi | AT3G01280.1; AT3G01280.1; AT3G01280 |
GeneIDi | 820914 |
Gramenei | AT3G01280.1; AT3G01280.1; AT3G01280 |
KEGGi | ath:AT3G01280 |
Organism-specific databases
Araporti | AT3G01280 |
TAIRi | locus:2100252, AT3G01280 |
Phylogenomic databases
eggNOGi | KOG3126, Eukaryota |
HOGENOMi | CLU_069937_0_0_1 |
InParanoidi | Q9SRH5 |
OMAi | VDYDING |
OrthoDBi | 938262at2759 |
PhylomeDBi | Q9SRH5 |
Miscellaneous databases
PROi | PR:Q9SRH5 |
Gene expression databases
ExpressionAtlasi | Q9SRH5, baseline and differential |
Genevisiblei | Q9SRH5, AT |
Family and domain databases
CDDi | cd07306, Porin3_VDAC, 1 hit |
Gene3Di | 2.40.160.10, 1 hit |
InterProi | View protein in InterPro IPR023614, Porin_dom_sf IPR001925, Porin_Euk IPR027246, Porin_Euk/Tom40 |
PANTHERi | PTHR11743, PTHR11743, 1 hit |
Pfami | View protein in Pfam PF01459, Porin_3, 1 hit |
PROSITEi | View protein in PROSITE PS00558, EUKARYOTIC_PORIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VDAC1_ARATH | |
Accessioni | Q9SRH5Primary (citable) accession number: Q9SRH5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2002 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 136 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families