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Protein

Profilin

Gene
N/A
Organism
Arachis hypogaea (Peanut)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin
Alternative name(s):
Allergen: Ara h 5
OrganismiArachis hypogaea (Peanut)
Taxonomic identifieri3818 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideae50 kb inversion cladedalbergioids sensu latoDalbergieaePterocarpus cladeArachis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3097 Ara h 5.0101
54 Ara h 5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001996142 – 131ProfilinAdd BLAST130

Interactioni

Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9SQI9
SMRiQ9SQI9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the profilin family.Curated

Family and domain databases

CDDicd00148 PROF, 1 hit
InterProiView protein in InterPro
IPR005455 PFN
IPR036140 PFN_sf
IPR027310 Profilin_CS
PANTHERiPTHR11604 PTHR11604, 1 hit
PfamiView protein in Pfam
PF00235 Profilin, 1 hit
PRINTSiPR00392 PROFILIN
PR01640 PROFILINPLNT
SMARTiView protein in SMART
SM00392 PROF, 1 hit
SUPFAMiSSF55770 SSF55770, 1 hit
PROSITEiView protein in PROSITE
PS00414 PROFILIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SQI9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWQTYVDNH LLCEIEGDHL SSAAILGQDG GVWAQSSHFP QFKPEEITAI
60 70 80 90 100
MNDFAEPGSL APTGLYLGGT KYMVIQGEPG AIIPGKKGPG GVTIEKTNQA
110 120 130
LIIGIYDKPM TPGQCNMIVE RLGDYLIDTG L
Length:131
Mass (Da):14,051
Last modified:May 1, 2000 - v1
Checksum:i05C17151B1BBBA74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059616 mRNA Translation: AAD55587.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059616 mRNA Translation: AAD55587.1

3D structure databases

ProteinModelPortaliQ9SQI9
SMRiQ9SQI9
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3097 Ara h 5.0101
54 Ara h 5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00148 PROF, 1 hit
InterProiView protein in InterPro
IPR005455 PFN
IPR036140 PFN_sf
IPR027310 Profilin_CS
PANTHERiPTHR11604 PTHR11604, 1 hit
PfamiView protein in Pfam
PF00235 Profilin, 1 hit
PRINTSiPR00392 PROFILIN
PR01640 PROFILINPLNT
SMARTiView protein in SMART
SM00392 PROF, 1 hit
SUPFAMiSSF55770 SSF55770, 1 hit
PROSITEiView protein in PROSITE
PS00414 PROFILIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPROF_ARAHY
AccessioniPrimary (citable) accession number: Q9SQI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Allergens
    Nomenclature of allergens and list of entries
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