Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 105 (11 Dec 2019)
Sequence version 1 (01 May 2000)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Dynein-1-alpha heavy chain, flagellar inner arm I1 complex

Gene

DHC1

Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Force generating protein of eukaryotic cilia and flagella. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for assembly of the I1 inner arm complex and its targeting to the appropriate axoneme location. Also required for phototaxis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi960 – 967ATPSequence analysis8
Nucleotide bindingi1958 – 1965ATPSequence analysis8
Nucleotide bindingi2242 – 2249ATPSequence analysis8
Nucleotide bindingi2588 – 2595ATPSequence analysis8
Nucleotide bindingi2945 – 2952ATPSequence analysis8
Nucleotide bindingi3680 – 3687ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
Biological processCilium biogenesis/degradation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein-1-alpha heavy chain, flagellar inner arm I1 complex
Alternative name(s):
1-alpha DHC
Dynein-1, subspecies f
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DHC1
Synonyms:IDA1, PF9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3055 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Flagellum, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Cells swim slowly with near normal beat frequencies but aberrant waveforms, and are unable to phototax.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001146461 – 4625Dynein-1-alpha heavy chain, flagellar inner arm I1 complexAdd BLAST4625

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9SMH3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By deflagellation.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The I1 inner arm complex (also known as the f dynein complex) is a two-headed isoform composed of two heavy chains (1-alpha and 1-beta), three intermediate chains and three light chains. I1 occupies a specific position proximal to the first radial spoke and repeats every 96 nm along the length of the axoneme.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3055.EDO96546

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9SMH3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1919StemBy similarityAdd BLAST1919
Regioni1920 – 2141AAA 1By similarityAdd BLAST222
Regioni2201 – 2437AAA 2By similarityAdd BLAST237
Regioni2550 – 2800AAA 3By similarityAdd BLAST251
Regioni2906 – 3155AAA 4By similarityAdd BLAST250
Regioni3192 – 3494StalkBy similarityAdd BLAST303
Regioni3542 – 3773AAA 5By similarityAdd BLAST232
Regioni3998 – 4216AAA 6By similarityAdd BLAST219

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1227 – 1259Sequence analysisAdd BLAST33
Coiled coili1339 – 1409Sequence analysisAdd BLAST71
Coiled coili3192 – 3297Sequence analysisAdd BLAST106
Coiled coili3400 – 3494Sequence analysisAdd BLAST95
Coiled coili3701 – 3788Sequence analysisAdd BLAST88

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.
A construct expressing the first 1249 amino acids but lacking the motor domain is able to assemble I1 complexes and target them to their correct location on the axoneme, although motility is not normal. Phototaxis is also restored.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3595 Eukaryota
COG5245 LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.20.180.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 AAA_9
IPR041658 AAA_lid_11
IPR042219 AAA_lid_11_sf
IPR041589 DNAH3_AAA_lid_1
IPR042228 Dynein_2_C
IPR042222 Dynein_2_N
IPR041466 Dynein_AAA5_ext
IPR041228 Dynein_C
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013594 Dynein_heavy_dom-1
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF17857 AAA_lid_1, 1 hit
PF18198 AAA_lid_11, 1 hit
PF08385 DHC_N1, 1 hit
PF08393 DHC_N2, 1 hit
PF17852 Dynein_AAA_lid, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9SMH3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRRLEWVKE KACLGLGVEP NLFEAAIANP ESRARVTAFL DGTVTSSALL
60 70 80 90 100
FALEEATIYV EEYQEVLAEE QAPEAEDGEG EEHDGQEPGE AGGEGAEGST
110 120 130 140 150
APGDSGDGQP EDAPAAAAEA NGANPEDEAA APADGAADGA AGEGGEEGDG
160 170 180 190 200
AEGDEPPAPP APKYVRRVIS VPKVVSKLNV ALGSLPEELS VFPVFYFILN
210 220 230 240 250
RSGHVAAEEL DSAVEFGLLS EGPSLRILEQ MLSSVFVPIL VQMSGGDVAS
260 270 280 290 300
GGVLMQSMTD NSHRELLGNM QKFHSQVTQA LQQLTGDVTL QLPDFPLEDM
310 320 330 340 350
DRAAADTDLV MQLEQYMAEW SQVLASVLQR ESQKHPTGKG PLAEIEFWRE
360 370 380 390 400
RNAVLSSLYE QLNLPQVKRM ILVVEKGSDD RNLMAGFKSQ LGELTKLATE
410 420 430 440 450
ARDNVKFLTT LERHFKNIAT GPLGGILDTL PPMMNALRMV WIISRHYSDD
460 470 480 490 500
QRMGSLFQRI AREIGDRVEA AVDLRHIFRM TSADAVELLK VCKSVLEHWL
510 520 530 540 550
QTYMAMREKI ELSGRDARWE FPKQLLFART NYMAEICTDL IEMVEIVDDF
560 570 580 590 600
FRFLGPELKT VTGDTAGIDR VVHRVVAMYE PIESISFNVF DYGNQHEWKA
610 620 630 640 650
AKQQFYADNE DIKEATRELI DTSFRKLRSA EGACELLQSF KSIKSKGAIQ
660 670 680 690 700
KQVMNKFNDI LEQFAREIEQ TADIFERNKD APPVTKNQPP VAGAIKWVRS
710 720 730 740 750
LLERLKRTMA KLLSTEEEII RTTELGQAVE SKFKSFARSV MLTEKKWFSS
760 770 780 790 800
WSDSINGVAM QHLKQTIFRR SAATNRVEVN FHPDLVRLIR ETRYLDRMGF
810 820 830 840 850
PIPEIALNVA LQEDKFLQWL EGLNSMLFKY YESIDQLTPV ERELMERKLE
860 870 880 890 900
ELESCLQPGF TILNWNSLGI TEFIGTCDKA IATFQQLVKQ VQKNSGIIEQ
910 920 930 940 950
VVYAIAGAQL VTEPEEGAEV MDLQEFYEDI ERQRLAALES LVKKYRTISP
960 970 980 990 1000
LLGKIEEVVA GTNSGKSPAL SSYYSFWERA IFNALNTMVL CAMTKLQDMI
1010 1020 1030 1040 1050
EQRSKHAEGG RKPPLFKVTV SLQSVDVVVQ PPMTEVNKAL GRLVRSLVES
1060 1070 1080 1090 1100
TKAFVRWMDG TCVETPEQRG ATDDDEPIVF TFYWDVAANP QVIKTMLNLN
1110 1120 1130 1140 1150
QSIQRAITSV NKYAESWRRH QALWKTDKNS VLDKFKARDP SAAQFEDKLS
1160 1170 1180 1190 1200
KYAKMATEIS AQAKDFDQDF IRVSCHALAS SVCDEAQAWV RAIAQTMREL
1210 1220 1230 1240 1250
DAVTESQLRD KIAKYQTALH RPPDTLEELK QVLNTVNTIR GESMVMELRY
1260 1270 1280 1290 1300
ADLEERYRTR LLYATNPEEE SQCAHELASA SQVRALWTEL LNEAEAVDWS
1310 1320 1330 1340 1350
LEETKKKFSE TTRSQVSDFA AITAELWEKF RTTGPGLPTV ELASGLDELH
1360 1370 1380 1390 1400
KYESNLADAL RQREQLVLAE KLFGMEITAY PELAQLESEI RKLAQVYGVY
1410 1420 1430 1440 1450
AEHAEAVRQY GGQLWSELDV GKMMAGTEAI LTKLRKLKSL KLLPVYELVE
1460 1470 1480 1490 1500
KEIQGFYNSL PLMKELKSEA LRKRHWTRLM EVTGQEFDMD PKTFTLGNMF
1510 1520 1530 1540 1550
AMQLHKYAEE IGKITNAAVK ELTIESEIRK LADVWREQRF ELGKYMKGPE
1560 1570 1580 1590 1600
DRGWVLRSTE DILVLLEDMG LNLQSMMASP FVRPFLTEVR AWEQKLSLIG
1610 1620 1630 1640 1650
ECIEVWMHVQ RKWMYLESIF VGSDDIRHQL PAEAKRFDNI DRQWQKIMND
1660 1670 1680 1690 1700
TAKNTVVLDA CMADGRLDLL KSLSEQLEVC QKSLSEYLDT KRCAFPRFYF
1710 1720 1730 1740 1750
ISDDELLSIL GTSDPTSVQE HMLKLFDNCA ALVFGRGNKT ITGMVSSEKE
1760 1770 1780 1790 1800
GFEFRNVVPI EGAVELWMTN VEAEMRKTLY QITKEGIFFY AKTPRTKWIS
1810 1820 1830 1840 1850
ENLGMVTLVG SQIWWTWETE DVFRRVRDGN KHSMKEFAAK LTGQLSELTS
1860 1870 1880 1890 1900
MVRSDLSNEV RKKVNTLIII DVHARDIIDT YVRDSIVDAR EFAWESQLRF
1910 1920 1930 1940 1950
YWDRQQDDIL IRQCTGLFKY GYEYMGLNGR LVITALTDRC YMTLTTALTY
1960 1970 1980 1990 2000
RLGGAPAGPA GTGKTETTKD LAKSMALLCV VFNCGEGLDY KAMGSIFSGL
2010 2020 2030 2040 2050
VQCGAWGCFD EFNRIEAEVL SVVSSQIKNI QEALKNDLTR FQFEGKEISI
2060 2070 2080 2090 2100
DPRTGIFITM NPGYAGRTEL PDNLKALFRP VTMVVPDLEQ ICEIMLFSEG
2110 2120 2130 2140 2150
FDSAKVLAKK MTVLYKLSRE QLSKQHHYDF GLRALKSVLV MAGSLKRGAP
2160 2170 2180 2190 2200
DMSEQLVLMR ALRDMNLPKF IFDDVPLFLG LINDLFPGMD CPRVRYPQFN
2210 2220 2230 2240 2250
DVVEADLADQ GFKVLTEPSE QVDKVVQLYE VMMTRHTTMV VGQTGGGKTV
2260 2270 2280 2290 2300
ILNTLARAQT KLGKKTHLYT INPKAISVAE LYGVLDKDTR DWTDGLLSNI
2310 2320 2330 2340 2350
FREMNKPLPA ERDEARYLVF DGDVDAVWVE NMNSVMDDNK LLTLPNGERI
2360 2370 2380 2390 2400
RLQNHCKLLF EVFDLQYASP ATISRCGMVY VDSRNLGYKP YIYTWLNSRA
2410 2420 2430 2440 2450
KQAEVDILRG LFEKYAVPSV DWILEGIDGE ELVRRPKQAV PVTNLNMITQ
2460 2470 2480 2490 2500
LCNLLNATIT DHPRMSDPQI LEAIFIFCTI WSLGAAIVQR PESPDRDRFD
2510 2520 2530 2540 2550
AFVKHIASMG LVDGERVAAT QLPARSLYEY CFDTNEGVWK SWRSYLQPYE
2560 2570 2580 2590 2600
PPADGAFAKI LVPTVDVVRS TWLLNTVVAA GKPCLFVGES GTAKSVTIAN
2610 2620 2630 2640 2650
YLAHLDSTIN IVLNVNFSSR TSSLDVQRAI EDSTEKRTKD TYGPPMGKRL
2660 2670 2680 2690 2700
LMFIDDLNMP RVDTYGTQQP IALLKLFIER KGLYDRGKEL SWKNMKDVQV
2710 2720 2730 2740 2750
VGAMGPPGGA RNPVDPRFIS LFSVFEIQFP SNENLRTIYQ AILSRHLAKL
2760 2770 2780 2790 2800
PTDEIRDQLG ERLTDVTLEL YNFIIDKLPP TPSRFHYIFN LRDLSRIYEG
2810 2820 2830 2840 2850
LLLTVGDVFK TPEQFLRLWR NECLRVLHDR LISTDDKRVM TERLEALVQQ
2860 2870 2880 2890 2900
KFPNLAAHTL ASPVLFGDFK NVINELQGEG EVAPRMYDDL GDYNSIKPLF
2910 2920 2930 2940 2950
EDVMTNFYNR KRKPMNLVFF EDALEHLTRI HRTLRLPQGN CLLVGVGGSG
2960 2970 2980 2990 3000
KQSLSKLAAF TAGCEVFEIT LTRGYDELAF REDLKRLYAM LGSDNKRVMF
3010 3020 3030 3040 3050
LFTDAHVADE GFLELINNML TSGMVPALYD GAEKDGLIGS VRAEVEKKGL
3060 3070 3080 3090 3100
LATKESCWSY YVDKCRNNLH VVLAMSPVGE TLRSRCRNFP GMVNNTVIDW
3110 3120 3130 3140 3150
FEPWPEQALT SVASVFLAEE ALPEALRPQI VEHMVTVHQS VRTFSTRFLE
3160 3170 3180 3190 3200
ELRRYNYVTP KNYLDFINNY KRALATNRRT IEDTVTRLSG GLEKLIQAAV
3210 3220 3230 3240 3250
EVDAMQKELS QAQVVVAQAT KECNELLEVI STNTVDVETK AKAAAIKEAQ
3260 3270 3280 3290 3300
LKVDSEQIAI EKAEAEAALE EAIPALEEAA AALQDLSKDH ITEIRSYAKP
3310 3320 3330 3340 3350
PEQVQKVCEC VVILRNIKDV SWLGAKSMMA DGNFLRSLVE FDKDSLTDKQ
3360 3370 3380 3390 3400
VKKVKEYFKD PKAPLTYDSL RAISTAGAGL LKWVLAMVNY NNVARTVEPK
3410 3420 3430 3440 3450
RKKVAESEKN LRIAQKDLAS TKLELQSLND QLGKLRTQFE EKTAEQQDLK
3460 3470 3480 3490 3500
AKADLMERRL IAASKLIAGL GSERERWTRD IADLESRRDR LIGDCLLTSS
3510 3520 3530 3540 3550
FLSYTGAFTA TYRHAMVYEM WQDDVKARGV PVTQPFRLEA LLTSDVETTG
3560 3570 3580 3590 3600
WASEGLPSDE LSIQNGILTV RANRWPLCID PQMQAVNWIK SREGKMLEGK
3610 3620 3630 3640 3650
VKTFNDSDFL KQLELSIQYG FPFLFENLDE YIDPVIDPVL EKNLVPGDGK
3660 3670 3680 3690 3700
FVIKLGDKEV EWDSNFRLYM TSKLSNPHYG PEISGKTMII NYGVTQQGLT
3710 3720 3730 3740 3750
EQLLNVTLRH ERSDLEEARE ALIKQMSENK ATLQALEDTL LRELSNAQGN
3760 3770 3780 3790 3800
ILDNSELIAT LESAKLKAVE IAEKLEASKV TAAEIEETRV RYSPAAKRGA
3810 3820 3830 3840 3850
ILFFVIAGLS AITNMYEYSL ASFLVVFNGS LHSSRRDASI EGRLRNIIDT
3860 3870 3880 3890 3900
LTYDVYAYTC LGLFERHKLM FSFQMTCKIL EGDTPLDPQL LDFFLKGNLS
3910 3920 3930 3940 3950
LEKAARRKPF DWFPDAGWQD LMRLVELGQK KIGADGRMHA LGSLANDVES
3960 3970 3980 3990 4000
DEAAWRTWYD LEAPEEAELP CGYQSFLSDF EKLCLMRCLR MDRVTVGITR
4010 4020 4030 4040 4050
FVIGVMGEKY VQPPVLEYRS IYKQSTETTP IVFVLSPGAD PAFDVFKLGE
4060 4070 4080 4090 4100
EMGFRPGAKL KYMALGQGMG PKAQELIETG ATRGLWIMLQ NCHLLPTWLK
4110 4120 4130 4140 4150
TLEKILEKIT KPHADFRLWL TTELTDRFPL GVLQRSLKVV TEPPNGLKLN
4160 4170 4180 4190 4200
MRQSYSKITE EVLADCPHQA FRPLVYVLGF FHAVVQERRK YGKLGWNVPY
4210 4220 4230 4240 4250
DFNETDFRIS MALISTYLTK AWDAQDDLIP WGTLRYLIGE AMYGGRVSDS
4260 4270 4280 4290 4300
YDRRILTTYL DEYLGDFLFD TFQPFRFYAC KDYEIAIPQT GSRDTYLKAV
4310 4320 4330 4340 4350
EALPLVQSPE AFGLNANADI SYYTSATKAI WTDLVDLQPR TGGGGGGVAR
4360 4370 4380 4390 4400
EEFIGGVARD IAAKIPEPFD LPQLRKELGT PSPTQVVLLQ ELERWNSVLG
4410 4420 4430 4440 4450
VMVSSLRDLQ RALSGEIGFS SRLEELASSL YNGKLPAMWA RLNPATEKAL
4460 4470 4480 4490 4500
GAWMLWFGRR YRQYKDWTEH GEPKVIWLSG LHIPETYIAA LVQAACRDKG
4510 4520 4530 4540 4550
WPLDKSTLYT KVTKFTDPYQ VSERPKYGCY MSGLYLEGAA WDLEASQLRK
4560 4570 4580 4590 4600
QDPKVLVNEL PILQVIPIEA NKLKLANTFR APVYVTQARR NAMGVGLVFD
4610 4620
ADLASAEHSS HWVLQGVALV LNIDQ
Length:4,625
Mass (Da):522,843
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i875F51048AF99340
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ243806 Genomic DNA Translation: CAB56598.1
U61364 Genomic DNA Translation: AAC49514.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S72239

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

The kink behind the wriggle - Issue 34 of May 2003

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243806 Genomic DNA Translation: CAB56598.1
U61364 Genomic DNA Translation: AAC49514.1
PIRiS72239

3D structure databases

SMRiQ9SMH3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3055.EDO96546

Proteomic databases

PRIDEiQ9SMH3

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA

Family and domain databases

Gene3Di1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.20.180.20, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 AAA_9
IPR041658 AAA_lid_11
IPR042219 AAA_lid_11_sf
IPR041589 DNAH3_AAA_lid_1
IPR042228 Dynein_2_C
IPR042222 Dynein_2_N
IPR041466 Dynein_AAA5_ext
IPR041228 Dynein_C
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013594 Dynein_heavy_dom-1
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF17857 AAA_lid_1, 1 hit
PF18198 AAA_lid_11, 1 hit
PF08385 DHC_N1, 1 hit
PF08393 DHC_N2, 1 hit
PF17852 Dynein_AAA_lid, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 4 hits
SUPFAMiSSF52540 SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYH1A_CHLRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9SMH3
Secondary accession number(s): Q96388
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: May 1, 2000
Last modified: December 11, 2019
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again