Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peroxisomal isocitrate dehydrogenase [NADP]

Gene

ICDH

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in response to oxidative stresses.By similarity

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg2+ or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei79SubstrateBy similarity1
Binding sitei84NADPBy similarity1
Binding sitei111SubstrateBy similarity1
Binding sitei134SubstrateBy similarity1
Sitei141Critical for catalysisBy similarity1
Sitei213Critical for catalysisBy similarity1
Metal bindingi253Magnesium or manganeseBy similarity1
Binding sitei261NADPBy similarity1
Metal bindingi276Magnesium or manganeseBy similarity1
Binding sitei329NADP; via amide nitrogen and carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi77 – 79NADPBy similarity3
Nucleotide bindingi311 – 316NADPBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processStress response, Tricarboxylic acid cycle
LigandMagnesium, Manganese, Metal-binding, NADP

Enzyme and pathway databases

BioCyciARA:AT1G54340-MONOMER
ReactomeiR-ATH-389542 NADPH regeneration
R-ATH-6798695 Neutrophil degranulation
R-ATH-71403 Citric acid cycle (TCA cycle)

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Gene namesi
Name:ICDH
Ordered Locus Names:At1g54340
ORF Names:F20D21.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G54340
TAIRilocus:2020128 AT1G54340

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004219621 – 416Peroxisomal isocitrate dehydrogenase [NADP]Add BLAST416

Proteomic databases

PaxDbiQ9SLK0
PRIDEiQ9SLK0

Expressioni

Gene expression databases

ExpressionAtlasiQ9SLK0 baseline and differential
GenevisibleiQ9SLK0 AT

Interactioni

Protein-protein interaction databases

BioGridi27100, 1 interactor
STRINGi3702.AT1G54340.1

Structurei

3D structure databases

ProteinModelPortaliQ9SLK0
SMRiQ9SLK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni96 – 102Substrate bindingBy similarity7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi414 – 416Peroxisomal targeting signalCurated3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1526 Eukaryota
COG0538 LUCA
HOGENOMiHOG000019858
InParanoidiQ9SLK0
KOiK00031
OMAiENYETKW
OrthoDBiEOG09360AQU
PhylomeDBiQ9SLK0

Family and domain databases

InterProiView protein in InterPro
IPR019818 IsoCit/isopropylmalate_DH_CS
IPR004790 Isocitrate_DH_NADP
IPR024084 IsoPropMal-DH-like_dom
PANTHERiPTHR11822 PTHR11822, 1 hit
PfamiView protein in Pfam
PF00180 Iso_dh, 1 hit
PIRSFiPIRSF000108 IDH_NADP, 1 hit
SMARTiView protein in SMART
SM01329 Iso_dh, 1 hit
TIGRFAMsiTIGR00127 nadp_idh_euk, 1 hit
PROSITEiView protein in PROSITE
PS00470 IDH_IMDH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q9SLK0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFEKIKVIN PVVEMDGDEM TRVIWKFIKD KLIFPFLELD IKYFDLGLPN
60 70 80 90 100
RDFTDDKVTI ETAEATLKYN VAIKCATITP DEARVREFGL KKMWRSPNGT
110 120 130 140 150
IRNILNGTVF REPIICRNIP RLVPGWTKPI CIGRHAFGDQ YRATDLIVNE
160 170 180 190 200
PGKLKLVFEP SGSSQKTEFE VFNFTGGGVA LAMYNTDESI RAFAESSMYT
210 220 230 240 250
AYQKKWPLYL STKNTILKIY DGRFKDIFQE VYEANWRSKY EAAGIWYEHR
260 270 280 290 300
LIDDMVAYAM KSEGGYVWAC KNYDGDVQSD FLAQGYGSLG MMTSVLVCPD
310 320 330 340 350
GKTIEAEAAH GTVTRHYRVH QKGGETSTNS IASIFAWSRG LAHRAKLDSN
360 370 380 390 400
AALLSYTEKL EAACMGTVES GKMTKDLALL IHGAKVRRDQ YVNTEEFIDA
410
VAWELKRRLL GNNSRL
Length:416
Mass (Da):47,234
Last modified:May 1, 2000 - v1
Checksum:iEEAAAC9E5C6B2FA5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8ASL1A0A1P8ASL1_ARATH
Isocitrate dehydrogenase
ICDH isocitrate dehydrogenase, At1g54340, F20D21.16, F20D21_16
297Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF316501 mRNA Translation: AAK06592.1
AC005287 Genomic DNA Translation: AAD25614.1
CP002684 Genomic DNA Translation: AEE33082.1
BT025983 mRNA Translation: ABG25072.1
PIRiA96585
RefSeqiNP_175836.1, NM_104312.3
UniGeneiAt.11811
At.37230

Genome annotation databases

EnsemblPlantsiAT1G54340.1; AT1G54340.1; AT1G54340
GeneIDi841875
GrameneiAT1G54340.1; AT1G54340.1; AT1G54340
KEGGiath:AT1G54340

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF316501 mRNA Translation: AAK06592.1
AC005287 Genomic DNA Translation: AAD25614.1
CP002684 Genomic DNA Translation: AEE33082.1
BT025983 mRNA Translation: ABG25072.1
PIRiA96585
RefSeqiNP_175836.1, NM_104312.3
UniGeneiAt.11811
At.37230

3D structure databases

ProteinModelPortaliQ9SLK0
SMRiQ9SLK0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi27100, 1 interactor
STRINGi3702.AT1G54340.1

Proteomic databases

PaxDbiQ9SLK0
PRIDEiQ9SLK0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G54340.1; AT1G54340.1; AT1G54340
GeneIDi841875
GrameneiAT1G54340.1; AT1G54340.1; AT1G54340
KEGGiath:AT1G54340

Organism-specific databases

AraportiAT1G54340
TAIRilocus:2020128 AT1G54340

Phylogenomic databases

eggNOGiKOG1526 Eukaryota
COG0538 LUCA
HOGENOMiHOG000019858
InParanoidiQ9SLK0
KOiK00031
OMAiENYETKW
OrthoDBiEOG09360AQU
PhylomeDBiQ9SLK0

Enzyme and pathway databases

BioCyciARA:AT1G54340-MONOMER
ReactomeiR-ATH-389542 NADPH regeneration
R-ATH-6798695 Neutrophil degranulation
R-ATH-71403 Citric acid cycle (TCA cycle)

Miscellaneous databases

PROiPR:Q9SLK0

Gene expression databases

ExpressionAtlasiQ9SLK0 baseline and differential
GenevisibleiQ9SLK0 AT

Family and domain databases

InterProiView protein in InterPro
IPR019818 IsoCit/isopropylmalate_DH_CS
IPR004790 Isocitrate_DH_NADP
IPR024084 IsoPropMal-DH-like_dom
PANTHERiPTHR11822 PTHR11822, 1 hit
PfamiView protein in Pfam
PF00180 Iso_dh, 1 hit
PIRSFiPIRSF000108 IDH_NADP, 1 hit
SMARTiView protein in SMART
SM01329 Iso_dh, 1 hit
TIGRFAMsiTIGR00127 nadp_idh_euk, 1 hit
PROSITEiView protein in PROSITE
PS00470 IDH_IMDH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiICDHX_ARATH
AccessioniPrimary (citable) accession number: Q9SLK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2013
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again