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Protein

Peptidyl-prolyl cis-trans isomerase Pin1

Gene

PIN1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Prolyl cis/trans isomerase with specificity for phospho-Ser-Pro bonds.1 Publication

Miscellaneous

Like all plant Pin1-type PPIases, do not contain the N-terminal WW domain found in other eukaryotic parvulins, but contains a four-amino acid insertion next to the phospho-specific recognition site of the active site. These extra amino acids may be important for mediating the substrate interaction of plant enzymes.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • peptidyl-prolyl cis-trans isomerase activity Source: TAIR

GO - Biological processi

  • gravitropism Source: TAIR
  • regulation of cell cycle Source: TAIR
  • regulation of flower development Source: TAIR
  • regulation of protein localization Source: TAIR

Keywordsi

Molecular functionIsomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase Pin1 (EC:5.2.1.8)
Short name:
PPIase Pin1
Alternative name(s):
PIN1At
Rotamase Pin1
Gene namesi
Name:PIN1
Ordered Locus Names:At2g18040
ORF Names:T27K22.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G18040
TAIRilocus:2060922 AT2G18040

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001934401 – 119Peptidyl-prolyl cis-trans isomerase Pin1Add BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei103PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9SL42
PRIDEiQ9SL42

PTM databases

iPTMnetiQ9SL42

Expressioni

Tissue specificityi

Expressed in roots, leaves, stems and flowers.1 Publication

Gene expression databases

ExpressionAtlasiQ9SL42 baseline and differential
GenevisibleiQ9SL42 AT

Interactioni

Binary interactionsi

Protein-protein interaction databases

IntActiQ9SL42, 2 interactors
STRINGi3702.AT2G18040.1

Structurei

Secondary structure

1119
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9SL42
SMRiQ9SL42
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9SL42

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 119PpiCPROSITE-ProRule annotationAdd BLAST116

Sequence similaritiesi

Belongs to the PpiC/parvulin rotamase family.Curated

Phylogenomic databases

eggNOGiKOG3259 Eukaryota
COG0760 LUCA
HOGENOMiHOG000275331
KOiK09578
OMAiDEVQCLH
OrthoDBiEOG09360TTC
PhylomeDBiQ9SL42

Family and domain databases

InterProiView protein in InterPro
IPR000297 PPIase_PpiC
IPR023058 PPIase_PpiC_CS
PfamiView protein in Pfam
PF00639 Rotamase, 1 hit
PROSITEiView protein in PROSITE
PS01096 PPIC_PPIASE_1, 1 hit
PS50198 PPIC_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9SL42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASRDQVKAS HILIKHQGSR RKASWKDPEG KIILTTTREA AVEQLKSIRE
60 70 80 90 100
DIVSGKANFE EVATRVSDCS SAKRGGDLGS FGRGQMQKPF EEATYALKVG
110
DISDIVDTDS GVHIIKRTA
Length:119
Mass (Da):13,015
Last modified:May 1, 2000 - v1
Checksum:iE926CB566E76A0A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006201 Genomic DNA Translation: AAD20122.1
CP002685 Genomic DNA Translation: AEC06719.1
AF360318 mRNA Translation: AAK26028.1
AY057514 mRNA Translation: AAL09755.1
AY056314 mRNA Translation: AAL07163.1
AY085059 mRNA Translation: AAM61615.1
F13919 mRNA Translation: CAA23077.1
PIRiE84559
RefSeqiNP_179395.1, NM_127360.4
UniGeneiAt.20592

Genome annotation databases

EnsemblPlantsiAT2G18040.1; AT2G18040.1; AT2G18040
GeneIDi816316
GrameneiAT2G18040.1; AT2G18040.1; AT2G18040
KEGGiath:AT2G18040

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006201 Genomic DNA Translation: AAD20122.1
CP002685 Genomic DNA Translation: AEC06719.1
AF360318 mRNA Translation: AAK26028.1
AY057514 mRNA Translation: AAL09755.1
AY056314 mRNA Translation: AAL07163.1
AY085059 mRNA Translation: AAM61615.1
F13919 mRNA Translation: CAA23077.1
PIRiE84559
RefSeqiNP_179395.1, NM_127360.4
UniGeneiAt.20592

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J6YNMR-A1-119[»]
ProteinModelPortaliQ9SL42
SMRiQ9SL42
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9SL42, 2 interactors
STRINGi3702.AT2G18040.1

PTM databases

iPTMnetiQ9SL42

Proteomic databases

PaxDbiQ9SL42
PRIDEiQ9SL42

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G18040.1; AT2G18040.1; AT2G18040
GeneIDi816316
GrameneiAT2G18040.1; AT2G18040.1; AT2G18040
KEGGiath:AT2G18040

Organism-specific databases

AraportiAT2G18040
TAIRilocus:2060922 AT2G18040

Phylogenomic databases

eggNOGiKOG3259 Eukaryota
COG0760 LUCA
HOGENOMiHOG000275331
KOiK09578
OMAiDEVQCLH
OrthoDBiEOG09360TTC
PhylomeDBiQ9SL42

Miscellaneous databases

EvolutionaryTraceiQ9SL42
PROiPR:Q9SL42

Gene expression databases

ExpressionAtlasiQ9SL42 baseline and differential
GenevisibleiQ9SL42 AT

Family and domain databases

InterProiView protein in InterPro
IPR000297 PPIase_PpiC
IPR023058 PPIase_PpiC_CS
PfamiView protein in Pfam
PF00639 Rotamase, 1 hit
PROSITEiView protein in PROSITE
PS01096 PPIC_PPIASE_1, 1 hit
PS50198 PPIC_PPIASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPIN1_ARATH
AccessioniPrimary (citable) accession number: Q9SL42
Secondary accession number(s): Q42334
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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