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Protein

Heat shock 70 kDa protein 8

Gene

HSP70-8

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • response to heat Source: TAIR
  • response to high light intensity Source: TAIR
  • response to hydrogen peroxide Source: TAIR

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 8
Alternative name(s):
Heat shock protein 70-8
Short name:
AtHsp70-8
Heat-shock protein 70T-2
Gene namesi
Name:HSP70-8
Synonyms:HSP70T-2
Ordered Locus Names:At2g32120
ORF Names:F22D22.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G32120
TAIRilocus:2045457 AT2G32120

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00004154272 – 563Heat shock 70 kDa protein 8Add BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9SKY8
PRIDEiQ9SKY8

PTM databases

iPTMnetiQ9SKY8

Expressioni

Gene expression databases

ExpressionAtlasiQ9SKY8 baseline and differential
GenevisibleiQ9SKY8 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G32120.1

Structurei

3D structure databases

ProteinModelPortaliQ9SKY8
SMRiQ9SKY8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi20 – 25Poly-Ser6

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
HOGENOMiHOG000228135
InParanoidiQ9SKY8
KOiK09489
OMAiAAIFNMK
OrthoDBiEOG0936063J
PhylomeDBiQ9SKY8

Family and domain databases

Gene3Di2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
PROSITEiView protein in PROSITE
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SKY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAAYTVAS DSENTGEEKS SSSPSLPEIA LGIDIGTSQC SIAVWNGSQV
60 70 80 90 100
HILRNTRNQK LIKSFVTFKD EVPAGGVSNQ LAHEQEMLTG AAIFNMKRLV
110 120 130 140 150
GRVDTDPVVH ASKNLPFLVQ TLDIGVRPFI AALVNNAWRS TTPEEVLAIF
160 170 180 190 200
LVELRLMAEA QLKRPVRNVV LTVPVSFSRF QLTRFERACA MAGLHVLRLM
210 220 230 240 250
PEPTAIALLY AQQQQMTTHD NMGSGSERLA VIFNMGAGYC DVAVTATAGG
260 270 280 290 300
VSQIKALAGS PIGGEDILQN TIRHIAPPNE EASGLLRVAA QDAIHRLTDQ
310 320 330 340 350
ENVQIEVDLG NGNKISKVLD RLEFEEVNQK VFEECERLVV QCLRDARVNG
360 370 380 390 400
GDIDDLIMVG GCSYIPKVRT IIKNVCKKDE IYKGVNPLEA AVRGAALEGA
410 420 430 440 450
VTSGIHDPFG SLDLLTIQAT PLAVGVRANG NKFIPVIPRN TMVPARKDLF
460 470 480 490 500
FTTVQDNQKE ALIIIYEGEG ETVEENHLLG YFKLVGIPPA PKGVPEINVC
510 520 530 540 550
MDIDASNALR VFAAVLMPGS SSPVVPVIEV RMPTVDDGHG WCAQALNVKY
560
GATLDLITLQ RKM
Length:563
Mass (Da):60,989
Last modified:May 1, 2000 - v1
Checksum:iF537CE0865066D6D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti270N → S in AAM67201 (Ref. 4) Curated1
Sequence conflicti426V → A in AAM67201 (Ref. 4) Curated1
Sequence conflicti522S → T in AAM67201 (Ref. 4) Curated1
Sequence conflicti559L → F in AAM67201 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006223 Genomic DNA Translation: AAD15393.1
CP002685 Genomic DNA Translation: AEC08636.1
CP002685 Genomic DNA Translation: AEC08637.1
AY123990 mRNA Translation: AAM74502.1
BT001079 mRNA Translation: AAN46859.1
AY088895 mRNA Translation: AAM67201.1
PIRiB84729
RefSeqiNP_180771.1, NM_128771.4
NP_850183.1, NM_179852.3
UniGeneiAt.13604

Genome annotation databases

EnsemblPlantsiAT2G32120.1; AT2G32120.1; AT2G32120
AT2G32120.2; AT2G32120.2; AT2G32120
GeneIDi817771
GrameneiAT2G32120.1; AT2G32120.1; AT2G32120
AT2G32120.2; AT2G32120.2; AT2G32120
KEGGiath:AT2G32120

Similar proteinsi

Entry informationi

Entry nameiHSP7H_ARATH
AccessioniPrimary (citable) accession number: Q9SKY8
Secondary accession number(s): Q8L8N8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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