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Entry version 123 (16 Oct 2019)
Sequence version 2 (01 Jun 2002)
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Protein

Vacuolar fusion protein MON1 homolog

Gene

MON1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in membrane trafficking through the secretory apparatus. In complex with CCZ1, acts as a guanine exchange factor (GEF) for RABG3F of the Rab7 protein family. Promotes the exchange of GDP to GTP, converting RABG3F from an inactive GDP-bound form into an active GTP-bound form. The RABG3F active form is involved in protein trafficking from prevacuolar compartments (PVCs) to vacuoles. May serve as a linker between Rab5 and Rab7 protein families in PVCs and mediate PVC maturation.1 Publication

Miscellaneous

Due to the stability of its transcription during plant development, this gene is proposed as a reference gene for transcript normalization.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar fusion protein MON1 homologCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MON11 Publication
Ordered Locus Names:At2g28390Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G28390

The Arabidopsis Information Resource

More...
TAIRi
locus:2057552 AT2G28390

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Severe plant growth defects, such as short root phenotype, retarded growth and dwarf phenotype.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004384791 – 607Vacuolar fusion protein MON1 homologAdd BLAST607

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9SKN1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9SKN1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed at stable levels.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9SKN1 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CCZ1A, CCZ1B and RABF2B.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT2G28390.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9SKN1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4 – 52Ser-richPROSITE-ProRule annotationAdd BLAST49

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MON1/SAND family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0997 Eukaryota
ENOG410XR29 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000030054

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9SKN1

KEGG Orthology (KO)

More...
KOi
K20195

Identification of Orthologs from Complete Genome Data

More...
OMAi
ENTADHI

Database of Orthologous Groups

More...
OrthoDBi
829786at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9SKN1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004353 Mon1

The PANTHER Classification System

More...
PANTHERi
PTHR13027 PTHR13027, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03164 Mon1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01546 YEAST73DUF

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9SKN1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATSDSRSSP SSSDTEFADP NPSSDPETNS ERVQSQLESM NLSQPSEVSD
60 70 80 90 100
GSHTEFSGGG DDNDDEVASA NGNEGGVSNG GLLREGVAGT SGGEVLLRAE
110 120 130 140 150
NPVEMEAGEE PPSPTSSGYD GERGSSGGAT STYKADDGSE DEIREANVDG
160 170 180 190 200
DTASQHEAAW LPGKRHVDED DASTSWRKRK KHFFILSNSG KPIYSRYGDE
210 220 230 240 250
HKLAGFSATL QAIISFVENG GDRVNLVKAG NHQVVFLVKG PIYLVCISCT
260 270 280 290 300
DETYEYLRGQ LDLLYGQMIL ILTKSIDRCF EKNAKFDMTP LLGGTDAVFS
310 320 330 340 350
SLVHSFSWNP ATFLHAYTCL PLPYALRQAT GTILQEVCAS GVLFSLLMCR
360 370 380 390 400
HKVVSLAGAQ KASLHPDDLL LLSNFVMSSE SFRTSESFSP ICLPRYNAQA
410 420 430 440 450
FLHAYVHFFD DDTYVILLTT RSDAFHHLKD CRVRLEAVLL KSNILSVVQR
460 470 480 490 500
SIAEGGMRVE DVPIDRRRRS STTNQEQDSP GPDISVGTGG PFGLWHFMYR
510 520 530 540 550
SIYLDQYISS EFSPPVTSHR QQKSLYRAYQ KLYASMHVKG LGPHKTQYRR
560 570 580 590 600
DENYTLLCWV TPDFELYAAF DPLADKAMAI KICNQVCQRV KDVENEVFLQ

GASPFSW
Length:607
Mass (Da):66,924
Last modified:June 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i41ABB543CFFCC821
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti528A → V in BAD43549 (Ref. 4) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC006283 Genomic DNA Translation: AAD20687.2
CP002685 Genomic DNA Translation: AEC08115.1
AY056801 mRNA Translation: AAL10492.1
AY133524 mRNA Translation: AAM91354.1
AK118037 mRNA Translation: BAC42668.1
AK175575 mRNA Translation: BAD43338.1
AK175699 mRNA Translation: BAD43462.1
AK175786 mRNA Translation: BAD43549.1
AK176064 mRNA Translation: BAD43827.1
AK176154 mRNA Translation: BAD43917.1
AK221211 mRNA Translation: BAD93763.1

Protein sequence database of the Protein Information Resource

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PIRi
C84684

NCBI Reference Sequences

More...
RefSeqi
NP_029426.1, NM_128399.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G28390.1; AT2G28390.1; AT2G28390

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
817387

Gramene; a comparative resource for plants

More...
Gramenei
AT2G28390.1; AT2G28390.1; AT2G28390

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G28390

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006283 Genomic DNA Translation: AAD20687.2
CP002685 Genomic DNA Translation: AEC08115.1
AY056801 mRNA Translation: AAL10492.1
AY133524 mRNA Translation: AAM91354.1
AK118037 mRNA Translation: BAC42668.1
AK175575 mRNA Translation: BAD43338.1
AK175699 mRNA Translation: BAD43462.1
AK175786 mRNA Translation: BAD43549.1
AK176064 mRNA Translation: BAD43827.1
AK176154 mRNA Translation: BAD43917.1
AK221211 mRNA Translation: BAD93763.1
PIRiC84684
RefSeqiNP_029426.1, NM_128399.4

3D structure databases

SMRiQ9SKN1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G28390.1

PTM databases

iPTMnetiQ9SKN1

Proteomic databases

PaxDbiQ9SKN1

Genome annotation databases

EnsemblPlantsiAT2G28390.1; AT2G28390.1; AT2G28390
GeneIDi817387
GrameneiAT2G28390.1; AT2G28390.1; AT2G28390
KEGGiath:AT2G28390

Organism-specific databases

AraportiAT2G28390
TAIRilocus:2057552 AT2G28390

Phylogenomic databases

eggNOGiKOG0997 Eukaryota
ENOG410XR29 LUCA
HOGENOMiHOG000030054
InParanoidiQ9SKN1
KOiK20195
OMAiENTADHI
OrthoDBi829786at2759
PhylomeDBiQ9SKN1

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9SKN1

Gene expression databases

ExpressionAtlasiQ9SKN1 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR004353 Mon1
PANTHERiPTHR13027 PTHR13027, 1 hit
PfamiView protein in Pfam
PF03164 Mon1, 1 hit
PRINTSiPR01546 YEAST73DUF

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMON1_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9SKN1
Secondary accession number(s): Q680T1, Q93ZL8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2016
Last sequence update: June 1, 2002
Last modified: October 16, 2019
This is version 123 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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