UniProtKB - Q9SKB3 (PARG1_ARATH)
Protein
Poly(ADP-ribose) glycohydrolase 1
Gene
PARG1
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase (By similarity). Involved in establishing period length of the circadian oscillator. May regulate post-translational poly(ADP-ribosyl)ation of an oscillator component.By similarity1 Publication
Catalytic activityi
- EC:3.2.1.143By similarity
GO - Molecular functioni
- poly(ADP-ribose) glycohydrolase activity Source: TAIR
GO - Biological processi
- ATP generation from poly-ADP-D-ribose Source: GO_Central
- carbohydrate metabolic process Source: InterPro
- cellular response to DNA damage stimulus Source: TAIR
- defense response to fungus Source: TAIR
- nucleotide-sugar metabolic process Source: GO_Central
- regulation of DNA repair Source: TAIR
- regulation of histone modification Source: GO_Central
- response to osmotic stress Source: TAIR
- response to oxidative stress Source: TAIR
- response to water deprivation Source: TAIR
- rhythmic process Source: UniProtKB-KW
- stomatal closure Source: TAIR
Keywordsi
Molecular function | Hydrolase |
Biological process | Biological rhythms |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PARG1 Synonyms:TEJ Ordered Locus Names:At2g31870 ORF Names:F20M17.9 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT2G31870 |
TAIRi | locus:2045243, AT2G31870 |
Subcellular locationi
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 262 | G → E in tej; loss of function. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000288791 | 1 – 548 | Poly(ADP-ribose) glycohydrolase 1Add BLAST | 548 |
Proteomic databases
PaxDbi | Q9SKB3 |
PRIDEi | Q9SKB3 |
ProteomicsDBi | 236354 [Q9SKB3-1] |
Expressioni
Gene expression databases
ExpressionAtlasi | Q9SKB3, baseline and differential |
Genevisiblei | Q9SKB3, AT |
Interactioni
Protein-protein interaction databases
BioGRIDi | 3092, 4 interactors |
STRINGi | 3702.AT2G31870.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the poly(ADP-ribose) glycohydrolase family.Curated
Phylogenomic databases
eggNOGi | KOG2064, Eukaryota |
InParanoidi | Q9SKB3 |
OrthoDBi | 730627at2759 |
PhylomeDBi | Q9SKB3 |
Family and domain databases
InterProi | View protein in InterPro IPR007724, Poly_GlycHdrlase |
PANTHERi | PTHR12837, PTHR12837, 1 hit |
Pfami | View protein in Pfam PF05028, PARG_cat, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry describes 1 produced by isoform ialternative splicing. AlignAdd to basketNote: A number of isoforms are produced. According to EST sequences.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9SKB3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MENREDLNSI LPYLPLVIRS SSLYWPPRVV EALKAMSEGP SHSQVDSGEV
60 70 80 90 100
LRQAIFDMRR SLSFSTLEPS ASNGYAFLFD ELIDEKESKR WFDEIIPALA
110 120 130 140 150
SLLLQFPSLL EVHFQNADNI VSGIKTGLRL LNSQQAGIVF LSQELIGALL
160 170 180 190 200
ACSFFCLFPD DNRGAKHLPV INFDHLFASL YISYSQSQES KIRCIMHYFE
210 220 230 240 250
RFCSCVPIGI VSFERKITAA PDADFWSKSD VSLCAFKVHS FGLIEDQPDN
260 270 280 290 300
ALEVDFANKY LGGGSLSRGC VQEEIRFMIN PELIAGMLFL PRMDDNEAIE
310 320 330 340 350
IVGAERFSCY TGYASSFRFA GEYIDKKAMD PFKRRRTRIV AIDALCTPKM
360 370 380 390 400
RHFKDICLLR EINKALCGFL NCSKAWEHQN IFMDEGDNEI QLVRNGRDSG
410 420 430 440 450
LLRTETTASH RTPLNDVEMN REKPANNLIR DFYVEGVDNE DHEDDGVATG
460 470 480 490 500
NWGCGVFGGD PELKATIQWL AASQTRRPFI SYYTFGVEAL RNLDQVTKWI
510 520 530 540
LSHKWTVGDL WNMMLEYSAQ RLYKQTSVGF FSWLLPSLAT TNKAIQPP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA8MRN2 | A8MRN2_ARATH | Poly(ADP-ribose) glycohydrolase | TEJ PARG1, Sanskrit for 'bright', At2g31870, F20M17.9, F20M17_9 | 547 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 170 | V → I in BAD95273 (Ref. 4) Curated | 1 | |
Sequence conflicti | 408 | Missing in BAD95273 (Ref. 4) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF394690 mRNA Translation: AAK72256.1 AC006533 Genomic DNA Translation: AAD32285.2 CP002685 Genomic DNA Translation: AEC08597.1 AK222165 mRNA Translation: BAD95273.1 |
PIRi | B84726 |
RefSeqi | NP_565730.1, NM_128745.3 [Q9SKB3-1] |
Genome annotation databases
EnsemblPlantsi | AT2G31870.1; AT2G31870.1; AT2G31870 [Q9SKB3-1] |
GeneIDi | 817745 |
Gramenei | AT2G31870.1; AT2G31870.1; AT2G31870 [Q9SKB3-1] |
KEGGi | ath:AT2G31870 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF394690 mRNA Translation: AAK72256.1 AC006533 Genomic DNA Translation: AAD32285.2 CP002685 Genomic DNA Translation: AEC08597.1 AK222165 mRNA Translation: BAD95273.1 |
PIRi | B84726 |
RefSeqi | NP_565730.1, NM_128745.3 [Q9SKB3-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 3092, 4 interactors |
STRINGi | 3702.AT2G31870.1 |
Proteomic databases
PaxDbi | Q9SKB3 |
PRIDEi | Q9SKB3 |
ProteomicsDBi | 236354 [Q9SKB3-1] |
Genome annotation databases
EnsemblPlantsi | AT2G31870.1; AT2G31870.1; AT2G31870 [Q9SKB3-1] |
GeneIDi | 817745 |
Gramenei | AT2G31870.1; AT2G31870.1; AT2G31870 [Q9SKB3-1] |
KEGGi | ath:AT2G31870 |
Organism-specific databases
Araporti | AT2G31870 |
TAIRi | locus:2045243, AT2G31870 |
Phylogenomic databases
eggNOGi | KOG2064, Eukaryota |
InParanoidi | Q9SKB3 |
OrthoDBi | 730627at2759 |
PhylomeDBi | Q9SKB3 |
Miscellaneous databases
PROi | PR:Q9SKB3 |
Gene expression databases
ExpressionAtlasi | Q9SKB3, baseline and differential |
Genevisiblei | Q9SKB3, AT |
Family and domain databases
InterProi | View protein in InterPro IPR007724, Poly_GlycHdrlase |
PANTHERi | PTHR12837, PTHR12837, 1 hit |
Pfami | View protein in Pfam PF05028, PARG_cat, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PARG1_ARATH | |
Accessioni | Q9SKB3Primary (citable) accession number: Q9SKB3 Secondary accession number(s): Q56W82, Q94ET7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | June 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 117 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries - Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families