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Protein

Alcohol dehydrogenase-like 2

Gene

At1g22440

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.By similarity
A secondary alcohol + NAD+ = a ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi51Zinc 1; catalyticBy similarity1
Metal bindingi53Zinc 1By similarity1
Binding sitei53NADBy similarity1
Binding sitei53SubstrateBy similarity1
Metal bindingi74Zinc 1; catalyticBy similarity1
Binding sitei74SubstrateBy similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi107Zinc 2By similarity1
Metal bindingi110Zinc 2By similarity1
Metal bindingi118Zinc 2By similarity1
Metal bindingi183Zinc 1; catalyticBy similarity1
Binding sitei232NADBy similarity1
Binding sitei237NADBy similarity1
Binding sitei329NAD; via amide nitrogenBy similarity1
Binding sitei379NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi208 – 213NADBy similarity6
Nucleotide bindingi302 – 304NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciARA:AT1G22440-MONOMER
ReactomeiR-ATH-2161541 Abacavir metabolism
R-ATH-5365859 RA biosynthesis pathway
R-ATH-71384 Ethanol oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase-like 2 (EC:1.1.1.1By similarity)
Gene namesi
Ordered Locus Names:At1g22440
ORF Names:F12K8.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G22440
TAIRilocus:2009512 AT1G22440

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002991841 – 386Alcohol dehydrogenase-like 2Add BLAST386

Proteomic databases

PaxDbiQ9SK87
PRIDEiQ9SK87

Expressioni

Gene expression databases

ExpressionAtlasiQ9SK87 baseline and differential
GenevisibleiQ9SK87 AT

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi24089, 1 interactor
IntActiQ9SK87, 1 interactor
STRINGi3702.AT1G22440.1

Structurei

3D structure databases

ProteinModelPortaliQ9SK87
SMRiQ9SK87
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
HOGENOMiHOG000294674
InParanoidiQ9SK87
KOiK00121
OMAiHFVTSME
OrthoDBiEOG09360CLU
PhylomeDBiQ9SK87

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9SK87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKASITEGK PIRCKAAILR KAGEPLVIEE IQVDPPQAYE VRIKILCTSL
60 70 80 90 100
CHTDVTFWKL DSGPLARFPR ILGHEAVGVV ESIGEKVDGF KQGDVVLPVF
110 120 130 140 150
HPQCEECKEC ISPKSNWCTK YTNDYLSNTR RYGMTSRFKD SRGEDIHHFI
160 170 180 190 200
FVSSFTEYTV VDIAHLVKIS PEIPVDIAAL LSCSVATGLG AAWKVADVEE
210 220 230 240 250
GSTVVIFGLG AVGLAVAEGV RLRGAAKIIG VDLNPAKFEI GKRFGITDFV
260 270 280 290 300
NPALCGEKTI SEVIREMTDV GADYSFECIG LASLMEEAFK STRPGSGKTI
310 320 330 340 350
VLGMEQKALP ISLGSYDLLR GRTVCGTLFG GLKPKLDIPI LVDRYLKKEL
360 370 380
NLEDLITHEL SFEEINKAFH LLAEGNSIRC IIWMDK
Length:386
Mass (Da):42,383
Last modified:May 1, 2000 - v1
Checksum:i53BB1BD04E88293A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006551 Genomic DNA Translation: AAF18533.1
CP002684 Genomic DNA Translation: AEE30242.1
BT015046 mRNA Translation: AAT71918.1
BT015637 mRNA Translation: AAU15136.1
PIRiE86357
RefSeqiNP_173660.1, NM_102093.5
UniGeneiAt.41601

Genome annotation databases

EnsemblPlantsiAT1G22440.1; AT1G22440.1; AT1G22440
GeneIDi838850
GrameneiAT1G22440.1; AT1G22440.1; AT1G22440
KEGGiath:AT1G22440

Similar proteinsi

Entry informationi

Entry nameiADHL2_ARATH
AccessioniPrimary (citable) accession number: Q9SK87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 1, 2000
Last modified: July 18, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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