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Protein

Formin-like protein 18

Gene

FH18

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei126Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-ATH-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Formin-like protein 18
Short name:
AtFH18
Gene namesi
Name:FH18
Ordered Locus Names:At2g25050
ORF Names:F27C12.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G25050

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003085441 – 1144Formin-like protein 18Add BLAST1144

Proteomic databases

PaxDbiQ9SK28

Expressioni

Gene expression databases

ExpressionAtlasiQ9SK28 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G25050.2

Structurei

3D structure databases

ProteinModelPortaliQ9SK28
SMRiQ9SK28
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 193Phosphatase tensin-typePROSITE-ProRule annotationAdd BLAST177
Domaini199 – 338C2 tensin-typePROSITE-ProRule annotationAdd BLAST140
Domaini735 – 1135FH2PROSITE-ProRule annotationAdd BLAST401

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi542 – 722Pro-richPROSITE-ProRule annotationAdd BLAST181

Sequence similaritiesi

Belongs to the formin-like family. Class-II subfamily.Curated

Phylogenomic databases

eggNOGiENOG410IIBD Eukaryota
ENOG410XT5Z LUCA
HOGENOMiHOG000029518
InParanoidiQ9SK28
PhylomeDBiQ9SK28

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR015425 FH2_Formin
IPR029021 Prot-tyrosine_phosphatase-like
IPR014020 Tensin_C2-dom
IPR029023 Tensin_phosphatase
PfamiView protein in Pfam
PF02181 FH2, 1 hit
PF10409 PTEN_C2, 1 hit
SMARTiView protein in SMART
SM00498 FH2, 1 hit
SM01326 PTEN_C2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51444 FH2, 1 hit
PS51181 PPASE_TENSIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9SK28-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALFRKFFHR KPPEGLLEIS ERVYVFDCCL TTDMLEDEDY RVYVSRIMSQ
60 70 80 90 100
LREQFPGASF MVFNFRDGDS RSRMESVLTE YDMTIMDYPR HYEGCPLLTM
110 120 130 140 150
ETVHHFLKSA ESWLLLSQQN ILLSHCELGG WPTLAFMLAS LLLYRKQFSG
160 170 180 190 200
EHRTLEMIYK QAPRELLQLM SPLNPLPSQL RFLQYISRRN VGSQWPPLDQ
210 220 230 240 250
ALTLDCVNLR LIPDFDGEGG CRPIFRIYGQ DPFMASDRTS KVLFSMPKRS
260 270 280 290 300
KAVRQYKQAD CELVKIDINC HILGDVVLEC ITLGSDLERE EMMFRVVFNT
310 320 330 340 350
AFLRSNILTL NRGEIDVLWN TTDRFPKDFS AEVIFSEMGA GKKLASVDLP
360 370 380 390 400
HMEEKDVLPM EAFAKVQEIF SEAEWLDPNS DVAVTVFNQI TAANILQESL
410 420 430 440 450
DSGSPRSPDS RSLLESALEK VKEKTKLMIS ENIVSSPDTS SPEKEKDTMS
460 470 480 490 500
SHKSYADPNS ILKKVDESRG LRVSVQRNVH SKIFSPRMVQ SPVTSPLPNR
510 520 530 540 550
SPTQGSPASI SRFHSSPSSL GITSILHDHG SCKDEESTSS SPASPSISFL
560 570 580 590 600
PTLHPLTSSQ PKKASPQCPQ SPTPVHSNGP PSAEAAVTSS PLPPLKPLRI
610 620 630 640 650
LSRPPPPPPP PPISSLRSTP SPSSTSNSIA TQGPPPPPPP PPLQSHRSAL
660 670 680 690 700
SSSPLPPPLP PKKLLATTNP PPPPPPPLHS NSRMGAPTSS LVLKSPPVPP
710 720 730 740 750
PPAPAPLSRS HNGNIPPVPG PPLGLKGRGI LQNLKGQGQT RKANLKPYHW
760 770 780 790 800
LKLTRAVQGS LWAEAQKSDE AATAPDFDIS ELEKLFSAVN LSSDSENNGG
810 820 830 840 850
KSGRRARPKV EKVQLIELRR AYNCEIMLSK VKIPLPDLMS SVLALDESVI
860 870 880 890 900
DVDQVDNLIK FCPTKEEAEL LKGFTGNKET LGRCEQFFLE LLKVPRVETK
910 920 930 940 950
LRVFSFKIQF HSQVTDLRRG LNTIHSAANE VRGSAKLKRI MQTILSLGNA
960 970 980 990 1000
LNHGTARGSA IGFRLDSLLK LTDTRSRNSK MTLMHYLCKV LAEKLPELLN
1010 1020 1030 1040 1050
FPKDLVSLEA ATKIQLKYLA EEMQAISKGL EKVVQEFTAS ETDGQISKHF
1060 1070 1080 1090 1100
RMNLKEFLSV AEGEVRSLAS LYSTVGGSAD ALALYFGEDP ARVPFEQVVS
1110 1120 1130 1140
TLQNFVRIFV RSHEENCKQV EFEKKRAQKE AENEKLKKGV YNEN
Length:1,144
Mass (Da):127,171
Last modified:January 31, 2018 - v3
Checksum:i927C573AC391204B
GO

Sequence cautioni

The sequence AAD23008 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AEC07650 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006585 Genomic DNA Translation: AAD23008.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC07650.2 Sequence problems.
PIRiF84643
RefSeqiNP_001318287.1, NM_001335971.1

Genome annotation databases

GeneIDi817043
KEGGiath:AT2G25050

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006585 Genomic DNA Translation: AAD23008.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC07650.2 Sequence problems.
PIRiF84643
RefSeqiNP_001318287.1, NM_001335971.1

3D structure databases

ProteinModelPortaliQ9SK28
SMRiQ9SK28
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G25050.2

Proteomic databases

PaxDbiQ9SK28

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi817043
KEGGiath:AT2G25050

Organism-specific databases

AraportiAT2G25050

Phylogenomic databases

eggNOGiENOG410IIBD Eukaryota
ENOG410XT5Z LUCA
HOGENOMiHOG000029518
InParanoidiQ9SK28
PhylomeDBiQ9SK28

Enzyme and pathway databases

ReactomeiR-ATH-6798695 Neutrophil degranulation

Miscellaneous databases

PROiPR:Q9SK28

Gene expression databases

ExpressionAtlasiQ9SK28 baseline and differential

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR015425 FH2_Formin
IPR029021 Prot-tyrosine_phosphatase-like
IPR014020 Tensin_C2-dom
IPR029023 Tensin_phosphatase
PfamiView protein in Pfam
PF02181 FH2, 1 hit
PF10409 PTEN_C2, 1 hit
SMARTiView protein in SMART
SM00498 FH2, 1 hit
SM01326 PTEN_C2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51444 FH2, 1 hit
PS51181 PPASE_TENSIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFH18_ARATH
AccessioniPrimary (citable) accession number: Q9SK28
Secondary accession number(s): A0A2H1ZE40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: January 31, 2018
Last modified: May 23, 2018
This is version 101 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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