Mediator of RNA polymerase II transcription subunit 18

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• transcription coregulator activity Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.6

    "MED18 interaction with distinct transcription factors regulates multiple plant functions."
    Lai Z., Schluttenhofer C.M., Bhide K., Shreve J., Thimmapuram J., Lee S.Y., Yun D.-J., Mengiste T.
    Nat. Commun. 5:3064-3064(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH YY1; ABI4 AND SUF4, SUBCELLULAR LOCATION.

GO - Biological processⁱ

• abscisic acid-activated signaling pathway Source: UniProtKB-KW
• carpel development Source: TAIR <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Mediator subunit18 controls flowering time and floral organ identity in Arabidopsis."
    Zheng Z., Guan H., Leal F., Grey P.H., Oppenheimer D.G.
    PLoS One 8:e53924-e53924(2013) [PubMed] [Europe PMC] [Abstract]
• defense response Source: UniProtKB-KW
• ethylene-activated signaling pathway Source: UniProtKB-KW
• negative regulation of transcription, DNA-templated Source: TAIRInferred from mutant phenotypeⁱ
  • "Mediator subunit18 controls flowering time and floral organ identity in Arabidopsis."
    Zheng Z., Guan H., Leal F., Grey P.H., Oppenheimer D.G.
    PLoS One 8:e53924-e53924(2013) [PubMed] [Europe PMC] [Abstract]
• petal development Source: TAIRInferred from genetic interactionⁱ
  • "Mediator subunit18 controls flowering time and floral organ identity in Arabidopsis."
    Zheng Z., Guan H., Leal F., Grey P.H., Oppenheimer D.G.
    PLoS One 8:e53924-e53924(2013) [PubMed] [Europe PMC] [Abstract]
• production of miRNAs involved in gene silencing by miRNA Source: TAIRInferred from mutant phenotypeⁱ
  • "The role of Mediator in small and long noncoding RNA production in Arabidopsis thaliana."
    Kim Y.J., Zheng B., Yu Y., Won S.Y., Mo B., Chen X.
    EMBO J 30:814-822(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of defense response to fungus Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.6

    "MED18 interaction with distinct transcription factors regulates multiple plant functions."
    Lai Z., Schluttenhofer C.M., Bhide K., Shreve J., Thimmapuram J., Lee S.Y., Yun D.-J., Mengiste T.
    Nat. Commun. 5:3064-3064(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH YY1; ABI4 AND SUF4, SUBCELLULAR LOCATION.
• regulation of DNA-templated transcription, elongation Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.6

    "MED18 interaction with distinct transcription factors regulates multiple plant functions."
    Lai Z., Schluttenhofer C.M., Bhide K., Shreve J., Thimmapuram J., Lee S.Y., Yun D.-J., Mengiste T.
    Nat. Commun. 5:3064-3064(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH YY1; ABI4 AND SUF4, SUBCELLULAR LOCATION.
• regulation of DNA-templated transcription, initiation Source: UniProtKBInferred from direct assayⁱ
  • Ref.6

    "MED18 interaction with distinct transcription factors regulates multiple plant functions."
    Lai Z., Schluttenhofer C.M., Bhide K., Shreve J., Thimmapuram J., Lee S.Y., Yun D.-J., Mengiste T.
    Nat. Commun. 5:3064-3064(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH YY1; ABI4 AND SUF4, SUBCELLULAR LOCATION.
• regulation of DNA-templated transcription, termination Source: UniProtKBInferred from direct assayⁱ
  • Ref.6

    "MED18 interaction with distinct transcription factors regulates multiple plant functions."
    Lai Z., Schluttenhofer C.M., Bhide K., Shreve J., Thimmapuram J., Lee S.Y., Yun D.-J., Mengiste T.
    Nat. Commun. 5:3064-3064(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH YY1; ABI4 AND SUF4, SUBCELLULAR LOCATION.
• regulation of histone H3-K36 trimethylation Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.6

    "MED18 interaction with distinct transcription factors regulates multiple plant functions."
    Lai Z., Schluttenhofer C.M., Bhide K., Shreve J., Thimmapuram J., Lee S.Y., Yun D.-J., Mengiste T.
    Nat. Commun. 5:3064-3064(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH YY1; ABI4 AND SUF4, SUBCELLULAR LOCATION.
• regulation of photoperiodism, flowering Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.6

    "MED18 interaction with distinct transcription factors regulates multiple plant functions."
    Lai Z., Schluttenhofer C.M., Bhide K., Shreve J., Thimmapuram J., Lee S.Y., Yun D.-J., Mengiste T.
    Nat. Commun. 5:3064-3064(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH YY1; ABI4 AND SUF4, SUBCELLULAR LOCATION.
• regulation of salicylic acid mediated signaling pathway Source: TAIRInferred from mutant phenotypeⁱ
  • "MEDIATOR18 and MEDIATOR20 confer susceptibility to Fusarium oxysporum in Arabidopsis thaliana."
    Fallath T., Kidd B.N., Stiller J., Davoine C., Bjorklund S., Manners J.M., Kazan K., Schenk P.M.
    PLoS One 12:e0176022-e0176022(2017) [PubMed] [Europe PMC] [Abstract]
• regulation of timing of transition from vegetative to reproductive phase Source: TAIRInferred from mutant phenotypeⁱ
  • "Mediator subunit18 controls flowering time and floral organ identity in Arabidopsis."
    Zheng Z., Guan H., Leal F., Grey P.H., Oppenheimer D.G.
    PLoS One 8:e53924-e53924(2013) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.6

    "MED18 interaction with distinct transcription factors regulates multiple plant functions."
    Lai Z., Schluttenhofer C.M., Bhide K., Shreve J., Thimmapuram J., Lee S.Y., Yun D.-J., Mengiste T.
    Nat. Commun. 5:3064-3064(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH YY1; ABI4 AND SUF4, SUBCELLULAR LOCATION.
• regulation of transcription by RNA polymerase II Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of vernalization response Source: TAIRInferred from mutant phenotypeⁱ
  • "Mediator subunit18 controls flowering time and floral organ identity in Arabidopsis."
    Zheng Z., Guan H., Leal F., Grey P.H., Oppenheimer D.G.
    PLoS One 8:e53924-e53924(2013) [PubMed] [Europe PMC] [Abstract]
• response to abscisic acid Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.6

    "MED18 interaction with distinct transcription factors regulates multiple plant functions."
    Lai Z., Schluttenhofer C.M., Bhide K., Shreve J., Thimmapuram J., Lee S.Y., Yun D.-J., Mengiste T.
    Nat. Commun. 5:3064-3064(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH YY1; ABI4 AND SUF4, SUBCELLULAR LOCATION.
• response to ethylene Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.6

    "MED18 interaction with distinct transcription factors regulates multiple plant functions."
    Lai Z., Schluttenhofer C.M., Bhide K., Shreve J., Thimmapuram J., Lee S.Y., Yun D.-J., Mengiste T.
    Nat. Commun. 5:3064-3064(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH YY1; ABI4 AND SUF4, SUBCELLULAR LOCATION.
• sepal development Source: TAIRInferred from genetic interactionⁱ
  • "Mediator subunit18 controls flowering time and floral organ identity in Arabidopsis."
    Zheng Z., Guan H., Leal F., Grey P.H., Oppenheimer D.G.
    PLoS One 8:e53924-e53924(2013) [PubMed] [Europe PMC] [Abstract]
• specification of floral organ number Source: TAIRInferred from mutant phenotypeⁱ
  • "Mediator subunit18 controls flowering time and floral organ identity in Arabidopsis."
    Zheng Z., Guan H., Leal F., Grey P.H., Oppenheimer D.G.
    PLoS One 8:e53924-e53924(2013) [PubMed] [Europe PMC] [Abstract]
• stamen development Source: TAIRInferred from genetic interactionⁱ
  • "Mediator subunit18 controls flowering time and floral organ identity in Arabidopsis."
    Zheng Z., Guan H., Leal F., Grey P.H., Oppenheimer D.G.
    PLoS One 8:e53924-e53924(2013) [PubMed] [Europe PMC] [Abstract]
• termination of RNA polymerase II transcription Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSMECVVQGI IETQHVEALE ILLQGLCGVQ RERLRVHELC LRSGPNLGVV 
        60         70         80         90        100
SSEVRLLCDL DQPEPTWTVK HVGGAMRGAG ADQISVLVRN MIESKVSKNA 
       110        120        130        140        150
LRMFYALGYK LDHELLKVGF AFHFQRTAHI SVSVSSVNKM PKVHAIDEAV 
       160        170        180        190        200
PVTPGMQIVD VTAPATSENY SEVAAAVSSF CEFLAPLVHL SKPSISTGVV 
       210 
PTAAAAAASL MSDGGGTTL                                   

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Arabidopsis thaliana
   Arabidopsis thaliana: entries and gene names
2. SIMILARITY comments
   Index of protein domains and families