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Protein

Coatomer subunit alpha-2

Gene

At2g21390

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-ATH-6807878 COPI-mediated anterograde transport
R-ATH-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit alpha-2
Alternative name(s):
Alpha-coat protein 2
Short name:
Alpha-COP 2
Gene namesi
Ordered Locus Names:At2g21390
ORF Names:F3K23.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G21390
TAIRilocus:2050064 AT2G21390

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002856001 – 1218Coatomer subunit alpha-2Add BLAST1218

Proteomic databases

PaxDbiQ9SJT9
PRIDEiQ9SJT9

PTM databases

iPTMnetiQ9SJT9

Expressioni

Gene expression databases

ExpressionAtlasiQ9SJT9 baseline and differential
GenevisibleiQ9SJT9 AT

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.By similarity

Protein-protein interaction databases

BioGridi2031, 2 interactors
STRINGi3702.AT2G21390.1

Structurei

3D structure databases

ProteinModelPortaliQ9SJT9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 48WD 1Add BLAST42
Repeati49 – 88WD 2Add BLAST40
Repeati91 – 132WD 3Add BLAST42
Repeati133 – 172WD 4Add BLAST40
Repeati202 – 241WD 5Add BLAST40
Repeati246 – 285WD 6Add BLAST40
Repeati288 – 326WD 7Add BLAST39
Repeati363 – 404WD 8Add BLAST42

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0292 Eukaryota
ENOG410XPZS LUCA
HOGENOMiHOG000195913
InParanoidiQ9SJT9
KOiK05236
OMAiAVLLCTX
OrthoDBiEOG093600FK
PhylomeDBiQ9SJT9

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR016391 Coatomer_asu
IPR010714 Coatomer_asu_C
IPR006692 Coatomer_WD-assoc_reg
IPR020472 G-protein_beta_WD-40_rep
IPR011048 Haem_d1_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF04053 Coatomer_WDAD, 1 hit
PF06957 COPI_C, 1 hit
PF00400 WD40, 3 hits
PIRSFiPIRSF003354 Coatomer_alpha_subunit, 1 hit
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 2 hits
SSF51004 SSF51004, 2 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q9SJT9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTKFETKSN RVKGLSFHPK RPWILASLHS GVIQLWDYRM GTLIDRFDEH
60 70 80 90 100
EGPVRGVHFH NSQPLFVSGG DDYKIKVWNY KTHRCLFTLL GHLDYIRTVQ
110 120 130 140 150
FHHENPWIVS ASDDQTIRIW NWQSRTCISV LTGHNHYVMC ASFHPKEDLV
160 170 180 190 200
VSASLDQTVR VWDIGALKKK SASPADDLMR FSQMNSDLFG GVDAIVKYVL
210 220 230 240 250
EGHDRGVNWA SFHPTLPLIV SGADDRQVKL WRMNETKAWE VDTLRGHMNN
260 270 280 290 300
VSSVMFHAKQ DIIVSNSEDK SIRVWDATKR TGIQTFRREH DRFWILAVHP
310 320 330 340 350
EINLLAAGHD NGMIVFKLER ERPAFALSGD SLFYAKDRFL RYYEYSTQKD
360 370 380 390 400
SQVIPIRRPG TPSLNQSPRT LSYSPTENAV LICSDLDGGS YELYIIPKDS
410 420 430 440 450
VGRSDVVQDA KRGTGGSAVF IARNRFAVLE KSTSQVLVKN LKNEVVKKSS
460 470 480 490 500
LPIPTDAIFY AGTGNLLCRS EDKVVIFDLQ QRLVLGELQT PFVRYVVWSN
510 520 530 540 550
DMESVALLSK HTIIIASKKL VLQCTLHETI RVKSGAWDDN GVFIYTTLNH
560 570 580 590 600
IKYCLPNGDS GIIRTLDVPI YITKVSGNTI FCLDRDGKNR AITINATEYI
610 620 630 640 650
FKLALLRKKY DHVMSMIKNS QLCGQAMIAY LQQKGFPEVA LHFVEDERIR
660 670 680 690 700
FNLALESGNI SVAVASATEI NEKDHWYRLG VEALRQGNSR IVEFAYQQTK
710 720 730 740 750
NFERLSFLYL ITGNLDKLSK LMKIAEVKNN VMGQFHNALY LGDVKERVKI
760 770 780 790 800
LENAGHLPLA YITASVHGLT DIAERLAIEL GDNVPSLPEG KTPSLLMPPS
810 820 830 840 850
PIMCGGDWPL LRVMKGIFEG GLESANRGAV DEEEEDVEGD WGEGLDKFDV
860 870 880 890 900
DGMENTDIEA ILDGAEAGEE EDDEEGGWGL DLDLPPELDT PKASANARSS
910 920 930 940 950
TFVTPPQGMP VSQIWSQKSS LAAEQAAAGS FDTAMRLLHR QLGIKNFAPL
960 970 980 990 1000
KSMFLDLFSG SHSYLRAFSS SPVVPLAIER GWSESSSPNV RGPPALVFDF
1010 1020 1030 1040 1050
SQLEAKLKSG YKATTAGKLS EALRVFLSIL QTIPLVVVES RREVDEVKEL
1060 1070 1080 1090 1100
VIIVKEYVLG LQLELKRREM KDDPVRQQEL AAYFTHCKLQ TPHLRLAYFS
1110 1120 1130 1140 1150
AMTVCYKSKN MATAAHFARS LLDTNPTIES QARTARQVMQ AAERNMTDAT
1160 1170 1180 1190 1200
TLNYDFRNPF VICGSTYVPI YKGQKDVACP YCTARFVPSQ EGNICSVCDL
1210
AVIGADASGL LCSASQVR
Length:1,218
Mass (Da):136,467
Last modified:May 1, 2000 - v1
Checksum:iAEDBF964C904F267
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006841 Genomic DNA Translation: AAD23699.1
CP002685 Genomic DNA Translation: AEC07173.1
AK228692 mRNA Translation: BAF00596.1
PIRiF84600
RefSeqiNP_179734.1, NM_127711.4
UniGeneiAt.28070

Genome annotation databases

EnsemblPlantsiAT2G21390.1; AT2G21390.1; AT2G21390
GeneIDi816678
GrameneiAT2G21390.1; AT2G21390.1; AT2G21390
KEGGiath:AT2G21390

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006841 Genomic DNA Translation: AAD23699.1
CP002685 Genomic DNA Translation: AEC07173.1
AK228692 mRNA Translation: BAF00596.1
PIRiF84600
RefSeqiNP_179734.1, NM_127711.4
UniGeneiAt.28070

3D structure databases

ProteinModelPortaliQ9SJT9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi2031, 2 interactors
STRINGi3702.AT2G21390.1

PTM databases

iPTMnetiQ9SJT9

Proteomic databases

PaxDbiQ9SJT9
PRIDEiQ9SJT9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G21390.1; AT2G21390.1; AT2G21390
GeneIDi816678
GrameneiAT2G21390.1; AT2G21390.1; AT2G21390
KEGGiath:AT2G21390

Organism-specific databases

AraportiAT2G21390
TAIRilocus:2050064 AT2G21390

Phylogenomic databases

eggNOGiKOG0292 Eukaryota
ENOG410XPZS LUCA
HOGENOMiHOG000195913
InParanoidiQ9SJT9
KOiK05236
OMAiAVLLCTX
OrthoDBiEOG093600FK
PhylomeDBiQ9SJT9

Enzyme and pathway databases

ReactomeiR-ATH-6807878 COPI-mediated anterograde transport
R-ATH-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

PROiPR:Q9SJT9

Gene expression databases

ExpressionAtlasiQ9SJT9 baseline and differential
GenevisibleiQ9SJT9 AT

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR016391 Coatomer_asu
IPR010714 Coatomer_asu_C
IPR006692 Coatomer_WD-assoc_reg
IPR020472 G-protein_beta_WD-40_rep
IPR011048 Haem_d1_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF04053 Coatomer_WDAD, 1 hit
PF06957 COPI_C, 1 hit
PF00400 WD40, 3 hits
PIRSFiPIRSF003354 Coatomer_alpha_subunit, 1 hit
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 2 hits
SSF51004 SSF51004, 2 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOPA2_ARATH
AccessioniPrimary (citable) accession number: Q9SJT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2000
Last modified: June 20, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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