UniProtKB - Q9SJ40 (VPS11_ARATH)
Protein
Vacuolar protein-sorting-associated protein 11 homolog
Gene
VPS11
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Involved in regulating membrane fusion at the tonoplast and the prevacuolar compartment.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 842 – 877 | RING-type; atypicalPROSITE-ProRule annotationAdd BLAST | 36 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- protein-macromolecule adaptor activity Source: GO_Central
GO - Biological processi
- endosome organization Source: GO_Central
- intracellular protein transport Source: InterPro
- regulation of SNARE complex assembly Source: GO_Central
- vacuole organization Source: GO_Central
- vesicle docking involved in exocytosis Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Vacuolar protein-sorting-associated protein 11 homologShort name: AtVPS11 |
Gene namesi | Name:VPS11 Ordered Locus Names:At2g05170 ORF Names:F5G3.7 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT2G05170 |
TAIRi | locus:2051254, AT2G05170 |
Subcellular locationi
Vacuole
- Vacuole membrane 1 Publication; Peripheral membrane protein 1 Publication
Other locations
- Prevacuolar compartment membrane 1 Publication; Peripheral membrane protein 1 Publication
Endosome
- CORVET complex Source: UniProtKB
- endosome Source: GO_Central
- late endosome membrane Source: UniProtKB-SubCell
Mitochondrion
- mitochondrion Source: TAIR
Vacuole
- plant-type vacuole membrane Source: TAIR
Other locations
- HOPS complex Source: UniProtKB
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
Membrane, VacuolePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000425971 | 1 – 932 | Vacuolar protein-sorting-associated protein 11 homologAdd BLAST | 932 |
Proteomic databases
PaxDbi | Q9SJ40 |
PRIDEi | Q9SJ40 |
ProteomicsDBi | 242565 |
Expressioni
Tissue specificityi
Expressed in roots, leaves, stems, siliques and flowers.1 Publication
Gene expression databases
ExpressionAtlasi | Q9SJ40, baseline and differential |
Genevisiblei | Q9SJ40, AT |
Interactioni
Subunit structurei
Core component of at least two putative endosomal tethering complexes, the homotypic fusion and vacuole protein sorting (HOPS) complex and the class C core vacuole/endosome tethering (CORVET) complex. Their common core is composed of the class C Vps proteins VPS11, VCL1, VPS18 and VPS33, which in HOPS further associates with VPS39 and VPS41 and in CORVET with VPS3 (PubMed:12589039, PubMed:29463724).
Interacts directly with VPS39 and VPS3 (PubMed:29463724).
2 PublicationsProtein-protein interaction databases
BioGRIDi | 465, 1 interactor |
STRINGi | 3702.AT2G05170.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 385 – 536 | CHCR 1Add BLAST | 152 | |
Repeati | 548 – 756 | CHCR 2Add BLAST | 209 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 795 – 841 | Sequence analysisAdd BLAST | 47 |
Sequence similaritiesi
Belongs to the VPS11 family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 842 – 877 | RING-type; atypicalPROSITE-ProRule annotationAdd BLAST | 36 |
Keywords - Domaini
Coiled coil, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2114, Eukaryota |
HOGENOMi | CLU_001287_0_1_1 |
InParanoidi | Q9SJ40 |
OMAi | HDLGTKQ |
OrthoDBi | 429638at2759 |
PhylomeDBi | Q9SJ40 |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR000547, Clathrin_H-chain/VPS_repeat IPR011990, TPR-like_helical_dom_sf IPR016528, VPS11 IPR024763, VPS11_C IPR015943, WD40/YVTN_repeat-like_dom_sf IPR036322, WD40_repeat_dom_sf IPR001841, Znf_RING |
PANTHERi | PTHR23323:SF24, PTHR23323:SF24, 1 hit |
Pfami | View protein in Pfam PF00637, Clathrin, 1 hit PF12451, VPS11_C, 1 hit PF17122, zf-C3H2C3, 1 hit |
PIRSFi | PIRSF007860, VPS11, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50236, CHCR, 2 hits PS50089, ZF_RING_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9SJ40-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYQLRKFDFF EEKYGGKIPE DVTGDIQCCS SGRGKVVIGS NDGSVSFLDR
60 70 80 90 100
GVKFDSGFQA HSSSVLFLQH LKQRNFLVTV GEDEQISPQQ SGMCLKVFDL
110 120 130 140 150
DKVQEEGTSS SAPECIGILR IFTNQFPEAK ITSFLVLEEV PPILLIAIGL
160 170 180 190 200
DNGCIYCVKG DIARERITRF KLQVDGRSAI TGLGFRMDGQ ALLLFAVTPE
210 220 230 240 250
SVNLFSMQAQ PPKLQTLDHI GGSVNTVTMS DRSELIVGRP EAVYFYEVDG
260 270 280 290 300
RGPCWAFEGE KKFMGWFRGY LLCVIDDSKT GNTVFNVYDL RNRLIAYSIV
310 320 330 340 350
VDKVSNMLCE WGNIILIKAD KSLLCITEKD MESKLDMLFK KNLYTVAINL
360 370 380 390 400
VQSQHADAAA TANVMRKYGD HLYGKQDFDE AMLQYINTIG YLEPSFVIQK
410 420 430 440 450
FLDAQRIYNL TNYLEKLHEK GLASKDHTTL LLNCYTKLKD VEKLNTFIRK
460 470 480 490 500
EDGIGELKFD VETAIRVCRA ANYHEHAMYV AKKAGKHEWY LKILLEDLGN
510 520 530 540 550
YDEALQYVSS LEPSQAGVTI EQYGKILIEH KPKETIDILM RLCTEQGIPN
560 570 580 590 600
GVFLSMLPSP VDFITVFVQH PHSLMHFLER YAEIVQDSPA QAEINNTLLE
610 620 630 640 650
LYLSRDLNFP SISLSENGLD KDLIDHSVAA AVSKADPEKK TNADSKDAME
660 670 680 690 700
KDCTERQQKG LELLKMAWPS DLEQPLYDVD LAVILCEMNS FKDGLLYLYE
710 720 730 740 750
KMKFYKEVIA CYMQNHDHEG LIACCKRLGD SSKGGDPSLW ADLLKYFGEI
760 770 780 790 800
GEDCTKEVKE VLTYIERDDI LPPIIVLQTL AKNPCLTLSV IKDYIARKLE
810 820 830 840 850
QESKIIEEDR RAVEKYQETT KNMRKEIEDL RTNARIFQLS KCTACTFTLD
860 870 880 890 900
IPAVHFMCMH SFHQRCLGDN EKECPECAPE YRSVMEMKRS LEQNSKDQDL
910 920 930
FFQQVKGSKD GFSVIAEYFG KGIISKTRDA TS
Sequence cautioni
The sequence AAM60986 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 884 | V → A in AAM60986 (Ref. 4) Curated | 1 | |
Sequence conflicti | 892 | E → Q in AAM60986 (Ref. 4) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007018 Genomic DNA Translation: AAD29055.1 CP002685 Genomic DNA Translation: AEC05900.1 AF436824 mRNA Translation: AAL32006.1 BT002698 mRNA Translation: AAO11614.1 AY084412 mRNA Translation: AAM60986.1 Different initiation. |
PIRi | F84465 |
RefSeqi | NP_027676.1, NM_126544.3 |
Genome annotation databases
EnsemblPlantsi | AT2G05170.1; AT2G05170.1; AT2G05170 |
GeneIDi | 815065 |
Gramenei | AT2G05170.1; AT2G05170.1; AT2G05170 |
KEGGi | ath:AT2G05170 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007018 Genomic DNA Translation: AAD29055.1 CP002685 Genomic DNA Translation: AEC05900.1 AF436824 mRNA Translation: AAL32006.1 BT002698 mRNA Translation: AAO11614.1 AY084412 mRNA Translation: AAM60986.1 Different initiation. |
PIRi | F84465 |
RefSeqi | NP_027676.1, NM_126544.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 465, 1 interactor |
STRINGi | 3702.AT2G05170.1 |
Proteomic databases
PaxDbi | Q9SJ40 |
PRIDEi | Q9SJ40 |
ProteomicsDBi | 242565 |
Genome annotation databases
EnsemblPlantsi | AT2G05170.1; AT2G05170.1; AT2G05170 |
GeneIDi | 815065 |
Gramenei | AT2G05170.1; AT2G05170.1; AT2G05170 |
KEGGi | ath:AT2G05170 |
Organism-specific databases
Araporti | AT2G05170 |
TAIRi | locus:2051254, AT2G05170 |
Phylogenomic databases
eggNOGi | KOG2114, Eukaryota |
HOGENOMi | CLU_001287_0_1_1 |
InParanoidi | Q9SJ40 |
OMAi | HDLGTKQ |
OrthoDBi | 429638at2759 |
PhylomeDBi | Q9SJ40 |
Miscellaneous databases
PROi | PR:Q9SJ40 |
Gene expression databases
ExpressionAtlasi | Q9SJ40, baseline and differential |
Genevisiblei | Q9SJ40, AT |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR000547, Clathrin_H-chain/VPS_repeat IPR011990, TPR-like_helical_dom_sf IPR016528, VPS11 IPR024763, VPS11_C IPR015943, WD40/YVTN_repeat-like_dom_sf IPR036322, WD40_repeat_dom_sf IPR001841, Znf_RING |
PANTHERi | PTHR23323:SF24, PTHR23323:SF24, 1 hit |
Pfami | View protein in Pfam PF00637, Clathrin, 1 hit PF12451, VPS11_C, 1 hit PF17122, zf-C3H2C3, 1 hit |
PIRSFi | PIRSF007860, VPS11, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50236, CHCR, 2 hits PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VPS11_ARATH | |
Accessioni | Q9SJ40Primary (citable) accession number: Q9SJ40 Secondary accession number(s): Q8LG85 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 19, 2014 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families