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UniProtKB - Q9SIV5 (C3H19_ARATH)

Entry version 113 (07 Apr 2021)
Sequence version 3 (13 Jun 2012)
Previous versions | rss
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Protein

Zinc finger CCCH domain-containing protein 19

Gene

NERD

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a central role in integrating RNA silencing and chromatin signals in 21 nt siRNA-dependent DNA methylation on cytosine pathway leading to transcriptional gene silencing of specific sequences. Involved in a chromatin-based RNA silencing pathway that encompasses both post-transcriptional gene silencing (PTGS) (e.g. RDR1, RDR6 and AGO2) and transcriptional gene silencing (TGS) (e.g. siRNA-dependent DNA methylation and histone H3) components. Mediates siRNA accumulation at specific chromatin loci. Binds H3K4me0 through its PHD to enforce low levels of H3K4 methylation and gene silencing at a subset of genomic loci.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri599 – 665PHD-typePROSITE-ProRule annotationAdd BLAST67
Zinc fingeri1747 – 1773C3H1-typePROSITE-ProRule annotationAdd BLAST27

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processRNA-mediated gene silencing, Transcription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 19
Short name:
AtC3H19
Alternative name(s):
Protein Needed for RDR2-independent DNA methylation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NERD
Ordered Locus Names:At2g16485/At2g16480/At2g16470
ORF Names:F16F14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...Araporti		AT2G16485

The Arabidopsis Information Resource

More...TAIRi		locus:2827287, AT2G16485

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Silencing-deficiency characterized by a lower siRNA accumulation and a transcriptional up-regulation of specific loci that correlates with a local loss of cytosine methylation on DNA and an increased methylation of histone H3 'Lys-4' (e.g. H3K4me2, H3K4me3) and 'Lys-36' (e.g. H3K36me3).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003719781 – 1773Zinc finger CCCH domain-containing protein 19Add BLAST1773

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1281PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9SIV5

PRoteomics IDEntifications database

More...PRIDEi		Q9SIV5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		239086

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9SIV5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in seedlings, mostly in the vasculature and shoot apices of young seedlings.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9SIV5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9SIV5, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with unmethylated histone H3 and AGO2. The interaction with AGO2 in required to direct DNA methylation and silencing.

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		3702.AT2G16485.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9SIV5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini801 – 884SWIB/MDM2PROSITE-ProRule annotationAdd BLAST84
Domaini944 – 1076Plus3PROSITE-ProRule annotationAdd BLAST133
Domaini1307 – 1361GYFPROSITE-ProRule annotationAdd BLAST55

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili196 – 218Sequence analysisAdd BLAST23
Coiled coili403 – 437Sequence analysisAdd BLAST35

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi581 – 588Nuclear localization signal 1By similarity8
Motifi921 – 928Nuclear localization signal 2By similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi122 – 573Glu-richAdd BLAST452

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PHD-type zinc finger (599-665) binds to unmethylated histone H3 'Lys-4' (H3K4me0).1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri599 – 665PHD-typePROSITE-ProRule annotationAdd BLAST67
Zinc fingeri1747 – 1773C3H1-typePROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1081, Eukaryota
KOG1862, Eukaryota
KOG1946, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_236474_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9SIV5

Database of Orthologous Groups

More...OrthoDBi		85697at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd00072, GYF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.245.10, 1 hit
2.170.260.30, 1 hit
3.30.1490.40, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003169, GYF
IPR035445, GYF-like_dom_sf
IPR004343, Plus-3_dom
IPR036128, Plus3-like_sf
IPR019835, SWIB_domain
IPR036885, SWIB_MDM2_dom_sf
IPR003121, SWIB_MDM2_domain
IPR019786, Zinc_finger_PHD-type_CS
IPR000571, Znf_CCCH
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02213, GYF, 1 hit
PF03126, Plus-3, 1 hit
PF02201, SWIB, 1 hit
PF00642, zf-CCCH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00444, GYF, 1 hit
SM00249, PHD, 1 hit
SM00719, Plus3, 1 hit
SM00151, SWIB, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF159042, SSF159042, 1 hit
SSF47592, SSF47592, 1 hit
SSF55277, SSF55277, 1 hit
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50829, GYF, 1 hit
PS51360, PLUS3, 1 hit
PS51925, SWIB_MDM2, 1 hit
PS50103, ZF_C3H1, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9SIV5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSDSERASL ESIKDNSECV HVSNEPNLTA TCVDSSVGEE GVTDVNSSAA 
        60         70         80         90        100
VSELVPPEQG EGALLNSVPE ISERGIPVDV VSSVDGGGEE NAAFNIQEID 
       110        120        130        140        150
SVGGDAAAVE EVPLKSSSVV GEGREEEAGA SIVKEEDFVA EANLSGDRLE 
       160        170        180        190        200
ENKEVSMEEE PSSHELSVCE VNGVDSLNDE ENREVGEQIV CGSMGGEEIE 
       210        220        230        240        250
SDLESKKEKV DVIEEETTAQ AASLVNAIEI PDDKEVACVA GFTEISSQDK 
       260        270        280        290        300
GLDESGNGFL DEEPVKELQI GEGAKDLTDG DAKEGVDVTE DEMDIQVLKK 
       310        320        330        340        350
SKEEEKVDST TELEIETMRL EVHDVATEMS DKTVISSAVV TQFTGETSND 
       360        370        380        390        400
KETVMDDVKE DVDKDSEAGK SLDIHVPEAT EEVDTDVNYG VGIEKEGDGV 
       410        420        430        440        450
GGAEEAGQTV DLEEIREENQ ELSKELAQVD ETKISEMSEV TETMIKDEDQ 
       460        470        480        490        500
EKDDNMTDLA EDVENHRDSS VADIEEGRED HEDMGVTETQ KETVLGKVDR 
       510        520        530        540        550
TKIAEVSEET DTRIEDEDQE KDDEMTDVAE DVKTHGDSSV ADIEEGRESQ 
       560        570        580        590        600
EEMTETQEDS VMADEEPEEV EEENKSAGGK RKRGRNTKTV KGTGKKKEED 
       610        620        630        640        650
VCFMCFDGGD LVLCDRRGCT KAYHPSCVDR DEAFFQTKGK WNCGWHLCSK 
       660        670        680        690        700
CEKTATYLCY TCMFSLCKGC AKDAVFFCIR GNKGLCETCM ETVKLIERKQ 
       710        720        730        740        750
QEKEPAQLDF NDKTSWEYLF KDYWIDLKTQ LSLSPEELDQ AKRPLKGHET 
       760        770        780        790        800
NASKQGTASE TDYVTDGGSD SDSSPKKRKT RSRSKSGSAE KILSSGDKNL 
       810        820        830        840        850
SDETMEWASK ELLDLVVHMR RGDRSFLPML EVQTLLLAYI KRYNLRDPRR 
       860        870        880        890        900
KSQVICDSRL QNLFGKSHVG HFEMLNLLDS HFLKKEQNQA DDIQGDIVDT 
       910        920        930        940        950
EEPNHVDVDE NLDHPVKSGK DKKRKTRKKN VRKGRQSNLD DFAAVDMHNI 
       960        970        980        990       1000
NLIYLRRSLV EDLLEDSTAF EEKVASAFVR LRISGNQKQD LYRLVQVVGT 
      1010       1020       1030       1040       1050
SKAPEPYKVG KKTTDYVLEI LNLDKTEVIS IDIISNQDFT EDECKRLKQS 
      1060       1070       1080       1090       1100
IKCGLINRLT VGDIQEKAIA LQEVRVKNLL EAEILRFSHL RDRASDMGRR 
      1110       1120       1130       1140       1150
KEYPYLLKLS NSLTMLTLRE CVEKLQLLKS PEERQRRLEE IPEIHADPKM 
      1160       1170       1180       1190       1200
DPDCESEDED EKEEKEKEKQ LRPRSSSFNR RGRDPISPRK GGFSSNESWT 
      1210       1220       1230       1240       1250
GTSNYSNTSA NRELSRSYSG RGSTGRGDYL GSSDDKVSDS MWTSAREREV 
      1260       1270       1280       1290       1300
QPSLGSEKPR SVSIPETPAR SSRAIAPPEL SPRIASEISM APPAVVSQPV 
      1310       1320       1330       1340       1350
PKSNDSEKIW HYKDPSGKVQ GPFSMAQLRK WNNTGYFPAK LEIWKANESP 
      1360       1370       1380       1390       1400
LDSVLLTDAL AGLFQKQTQA VDNSYMKAQV AAFSGQSSQS EPNLGFAARI 
      1410       1420       1430       1440       1450
APTTIEIPRN SQDTWSQGGS LPSPTPNQIT TPTAKRRNFE SRWSPTKPSP 
      1460       1470       1480       1490       1500
QSANQSMNYS VAQSGQSQTS RIDIPVVVNS AGALQPQTYP IPTPDPINVS 
      1510       1520       1530       1540       1550
VNHSATLHSP TPAGGKQSWG SMQTDHGGSN TPSSQNNSTS YGTPSPSVLP 
      1560       1570       1580       1590       1600
SQSQPGFPPS DSWKVAVPSQ PNAQAQAQWG MNMVNNNQNS AQPQAPANQN 
      1610       1620       1630       1640       1650
SSWGQGTVNP NMGWVGPAQT GVNVNWGGSS VPSTVQGITH SGWVAPVQGQ 
      1660       1670       1680       1690       1700
TQAYPNPGWG PTGHPQSQSQ SQVQAQAGTT GSGWMQPGQG IQSGNSNQNW 
      1710       1720       1730       1740       1750
GTQNQTAIPS GGSGGNQAGY WGNQQQSQNG DSGYGWNRQS GGQQNNFKGQ 
      1760       1770 
RVCKFFRENG HCRKGASCNY LHN
Length:1,773
Mass (Da):195,051
Last modified:June 13, 2012 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA42B4F2F2238FB7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8B1D0A0A1P8B1D0_ARATH
GW repeat-and PHD finger-containing...
NERD At2g16485, F16F14.1, F16F14_1
1,758Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD22293 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to three different genes At2g16470, At2g16480 and At2g16485.Curated
The sequence AAD22314 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to three different genes At2g16470, At2g16480 and At2g16485.Curated
The sequence AAM15362 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to three different genes At2g16470, At2g16480 and At2g16485.Curated
The sequence ABE65448 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC007047 Genomic DNA Translation: AAD22314.1 Sequence problems.
AC007047 Genomic DNA Translation: AAD22293.1 Sequence problems.
AC007047 Genomic DNA Translation: AAM15362.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC06501.1
DQ446507 Genomic DNA Translation: ABE65448.1 Sequence problems.

Protein sequence database of the Protein Information Resource

More...PIRi		F84540
G84540

NCBI Reference Sequences

More...RefSeqi		NP_179241.4, NM_127202.5

Genome annotation databases

Ensembl plant genome annotation project

More...EnsemblPlantsi		AT2G16485.1; AT2G16485.1; AT2G16485

Database of genes from NCBI RefSeq genomes

More...GeneIDi		816147

Gramene; a comparative resource for plants

More...Gramenei		AT2G16485.1; AT2G16485.1; AT2G16485

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ath:AT2G16485

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007047 Genomic DNA Translation: AAD22314.1 Sequence problems.
AC007047 Genomic DNA Translation: AAD22293.1 Sequence problems.
AC007047 Genomic DNA Translation: AAM15362.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC06501.1
DQ446507 Genomic DNA Translation: ABE65448.1 Sequence problems.
PIRiF84540
G84540
RefSeqiNP_179241.4, NM_127202.5

3D structure databases

SMRiQ9SIV5
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G16485.1

PTM databases

iPTMnetiQ9SIV5

Proteomic databases

PaxDbiQ9SIV5
PRIDEiQ9SIV5
ProteomicsDBi239086

Genome annotation databases

EnsemblPlantsiAT2G16485.1; AT2G16485.1; AT2G16485
GeneIDi816147
GrameneiAT2G16485.1; AT2G16485.1; AT2G16485
KEGGiath:AT2G16485

Organism-specific databases

AraportiAT2G16485
TAIRilocus:2827287, AT2G16485

Phylogenomic databases

eggNOGiKOG1081, Eukaryota
KOG1862, Eukaryota
KOG1946, Eukaryota
HOGENOMiCLU_236474_0_0_1
InParanoidiQ9SIV5
OrthoDBi85697at2759

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q9SIV5

Gene expression databases

ExpressionAtlasiQ9SIV5, baseline and differential
GenevisibleiQ9SIV5, AT

Family and domain databases

CDDicd00072, GYF, 1 hit
Gene3Di1.10.245.10, 1 hit
2.170.260.30, 1 hit
3.30.1490.40, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR003169, GYF
IPR035445, GYF-like_dom_sf
IPR004343, Plus-3_dom
IPR036128, Plus3-like_sf
IPR019835, SWIB_domain
IPR036885, SWIB_MDM2_dom_sf
IPR003121, SWIB_MDM2_domain
IPR019786, Zinc_finger_PHD-type_CS
IPR000571, Znf_CCCH
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF02213, GYF, 1 hit
PF03126, Plus-3, 1 hit
PF02201, SWIB, 1 hit
PF00642, zf-CCCH, 1 hit
SMARTiView protein in SMART
SM00444, GYF, 1 hit
SM00249, PHD, 1 hit
SM00719, Plus3, 1 hit
SM00151, SWIB, 1 hit
SUPFAMiSSF159042, SSF159042, 1 hit
SSF47592, SSF47592, 1 hit
SSF55277, SSF55277, 1 hit
SSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50829, GYF, 1 hit
PS51360, PLUS3, 1 hit
PS51925, SWIB_MDM2, 1 hit
PS50103, ZF_C3H1, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC3H19_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9SIV5
Secondary accession number(s): F4IKD7, Q8S8E0, Q9SIV4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: June 13, 2012
Last modified: April 7, 2021
This is version 113 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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