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Entry version 145 (12 Aug 2020)
Sequence version 2 (01 Jun 2002)
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Protein

Ubiquitin domain-containing protein DSK2a

Gene

DSK2A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin domain-containing protein DSK2a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DSK2A
Ordered Locus Names:At2g17190
ORF Names:T23A1.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G17190

The Arabidopsis Information Resource

More...
TAIRi
locus:2059677, AT2G17190

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi61I → A: Abolishes interaction with RPN13. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004231791 – 538Ubiquitin domain-containing protein DSK2aAdd BLAST538

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9SII9

PRoteomics IDEntifications database

More...
PRIDEi
Q9SII9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
222182

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous with a strong expression level in inflorescence.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9SII9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9SII9, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with 'Lys-48'-linked polyubiquitin chains via its UBA domain.

Interacts with RPN10 and RPN13.

Interacts with PEX2 and PEX12.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
1581, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q9SII9, 4 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT2G17190.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9SII9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 93Ubiquitin-likePROSITE-ProRule annotationAdd BLAST76
Domaini138 – 179STI1 1Add BLAST42
Domaini192 – 231STI1 2Add BLAST40
Domaini357 – 394STI1 3Add BLAST38
Domaini398 – 433STI1 4Add BLAST36
Domaini491 – 535UBAPROSITE-ProRule annotationAdd BLAST45

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0010, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_024293_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9SII9

KEGG Orthology (KO)

More...
KOi
K04523

Identification of Orthologs from Complete Genome Data

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OMAi
GMDMFGP

Database of Orthologous Groups

More...
OrthoDBi
1553668at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9SII9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006636, STI1_HS-bd
IPR015940, UBA
IPR009060, UBA-like_sf
IPR015496, Ubiquilin
IPR000626, Ubiquitin-like_dom
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...
PANTHERi
PTHR10677, PTHR10677, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00627, UBA, 1 hit
PF00240, ubiquitin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00727, STI1, 4 hits
SM00165, UBA, 1 hit
SM00213, UBQ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46934, SSF46934, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50030, UBA, 1 hit
PS50053, UBIQUITIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9SII9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGEADSRQP LTAEGVAVAV NVRCSNGTKF SVTTSLDSTV ESFKELIAQN
60 70 80 90 100
SDVPANQQRL IYKGRILKDD QTLLSYGLQA DHTVHMVRGF VPSSPSAPAA
110 120 130 140 150
NAGNQTTAPQ AVGSNDSSNL GGGESLFPGL GFNPLGGGNA MAGLFGSGLP
160 170 180 190 200
DLEQAQQQLA QNPNMIREMM NTPAIQNLMN NPEFMRSMIM NNPQMRELVD
210 220 230 240 250
RNPELGHVLN DPSILRQTLE AARNPELMRE MMRNTDRAMS NIESMPEGFN
260 270 280 290 300
MLRRMYENVQ EPLMNATTMS ENAGNNTSSN PFAALLGNQG VTTQGSDTSN
310 320 330 340 350
NISAPNAETG TPNANPLPNP WGATAGQTTA PGRTNAGLGG LGGLGGLGGL
360 370 380 390 400
GMLGADSPLG ATPDASQLSQ ILQNPAMSQM MQSVLSNPQY MNQLMSLNPQ
410 420 430 440 450
LRSMLDMNPQ LREMMQNPDF LRQFSSPEMM QQMMSLQQSL FSQNRNTAGQ
460 470 480 490 500
DPTQTGAATG TANNGGLDLL MNMFGSLGAG GLSGTNQPNV PPEERFATQL
510 520 530
QQLQEMGFYD RAENIRALLA TNGNVNAAVE RLLGSIGQ
Length:538
Mass (Da):57,285
Last modified:June 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF2BF2BF36413DBD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC007127 Genomic DNA Translation: AAD25137.2
CP002685 Genomic DNA Translation: AEC06596.1
AF360159 mRNA Translation: AAK25869.1
AY042828 mRNA Translation: AAK68768.1
AY081450 mRNA Translation: AAM10012.1
AY113886 mRNA Translation: AAM44934.1
AK228616 mRNA Translation: BAF00527.1

Protein sequence database of the Protein Information Resource

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PIRi
B84549

NCBI Reference Sequences

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RefSeqi
NP_565407.1, NM_127273.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G17190.1; AT2G17190.1; AT2G17190

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
816224

Gramene; a comparative resource for plants

More...
Gramenei
AT2G17190.1; AT2G17190.1; AT2G17190

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G17190

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007127 Genomic DNA Translation: AAD25137.2
CP002685 Genomic DNA Translation: AEC06596.1
AF360159 mRNA Translation: AAK25869.1
AY042828 mRNA Translation: AAK68768.1
AY081450 mRNA Translation: AAM10012.1
AY113886 mRNA Translation: AAM44934.1
AK228616 mRNA Translation: BAF00527.1
PIRiB84549
RefSeqiNP_565407.1, NM_127273.4

3D structure databases

SMRiQ9SII9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi1581, 3 interactors
IntActiQ9SII9, 4 interactors
STRINGi3702.AT2G17190.1

Proteomic databases

PaxDbiQ9SII9
PRIDEiQ9SII9
ProteomicsDBi222182

Genome annotation databases

EnsemblPlantsiAT2G17190.1; AT2G17190.1; AT2G17190
GeneIDi816224
GrameneiAT2G17190.1; AT2G17190.1; AT2G17190
KEGGiath:AT2G17190

Organism-specific databases

AraportiAT2G17190
TAIRilocus:2059677, AT2G17190

Phylogenomic databases

eggNOGiKOG0010, Eukaryota
HOGENOMiCLU_024293_4_0_1
InParanoidiQ9SII9
KOiK04523
OMAiGMDMFGP
OrthoDBi1553668at2759
PhylomeDBiQ9SII9

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9SII9

Gene expression databases

ExpressionAtlasiQ9SII9, baseline and differential
GenevisibleiQ9SII9, AT

Family and domain databases

InterProiView protein in InterPro
IPR006636, STI1_HS-bd
IPR015940, UBA
IPR009060, UBA-like_sf
IPR015496, Ubiquilin
IPR000626, Ubiquitin-like_dom
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR10677, PTHR10677, 1 hit
PfamiView protein in Pfam
PF00627, UBA, 1 hit
PF00240, ubiquitin, 1 hit
SMARTiView protein in SMART
SM00727, STI1, 4 hits
SM00165, UBA, 1 hit
SM00213, UBQ, 1 hit
SUPFAMiSSF46934, SSF46934, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50030, UBA, 1 hit
PS50053, UBIQUITIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDSK2A_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9SII9
Secondary accession number(s): Q9C5L7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2013
Last sequence update: June 1, 2002
Last modified: August 12, 2020
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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