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Protein

Delta-9 acyl-lipid desaturase 2

Gene

ADS2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in delta-9 desaturation of fatty acids.2 Publications

Miscellaneous

Substrate specificity shifts from delta-9 to delta-7 desaturation when the protein is retargeted to the chloroplast.

Cofactori

Fe cationBy similarity

Pathwayi: polyunsaturated fatty acid biosynthesis

This protein is involved in the pathway polyunsaturated fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway polyunsaturated fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

  • unsaturated fatty acid biosynthetic process Source: GO_Central
  • very long-chain fatty acid biosynthetic process Source: TAIR

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandIron

Enzyme and pathway databases

BioCyciARA:AT2G31360-MONOMER
MetaCyc:AT2G31360-MONOMER
ReactomeiR-ATH-75105 Fatty acyl-CoA biosynthesis
UniPathwayi
UPA00658

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-9 acyl-lipid desaturase 2 (EC:1.14.19.-)
Gene namesi
Name:ADS2
Ordered Locus Names:At2g31360
ORF Names:T28P16.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G31360
TAIRilocus:2061260 AT2G31360

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854261 – 307Delta-9 acyl-lipid desaturase 2Add BLAST307

Proteomic databases

PaxDbiQ9SID2
PRIDEiQ9SID2

PTM databases

iPTMnetiQ9SID2

Expressioni

Tissue specificityi

Strongly expressed in flowers, roots, leaves, seedpods, and inflorescence meristems.1 Publication

Inductioni

Up-regulated by cold.1 Publication

Gene expression databases

ExpressionAtlasiQ9SID2 baseline and differential
GenevisibleiQ9SID2 AT

Interactioni

Protein-protein interaction databases

BioGridi3041, 35 interactors
IntActiQ9SID2, 34 interactors
STRINGi3702.AT2G31360.1

Structurei

3D structure databases

ProteinModelPortaliQ9SID2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi85 – 90Histidine box-16
Motifi122 – 126Histidine box-25
Motifi254 – 258Histidine box-35

Domaini

The histidine box domains may contain the active site and/or be involved in metal ion binding.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1600 Eukaryota
COG1398 LUCA
HOGENOMiHOG000270353
InParanoidiQ9SID2
OMAiHATWGWG
OrthoDBiEOG093614S9
PhylomeDBiQ9SID2

Family and domain databases

CDDicd03505 Delta9-FADS-like, 1 hit
InterProiView protein in InterPro
IPR015876 Acyl-CoA_DS
IPR005804 FA_desaturase_dom
PANTHERiPTHR11351 PTHR11351, 1 hit
PfamiView protein in Pfam
PF00487 FA_desaturase, 1 hit
PRINTSiPR00075 FACDDSATRASE

Sequencei

Sequence statusi: Complete.

Q9SID2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVTSTVEEN HQKNPSTPAA VEEKKKRRWV FWDRRWRRLD YVKFSASFTV
60 70 80 90 100
HSLALLAPFY FTWSALWVTF LFYTIGGLGI TVSYHRNLAH RSFKVPKWLE
110 120 130 140 150
YLLAYCALLA IQGDPIDWVS THRYHHQFTD SERDPHSPKE GFWFSHLLWI
160 170 180 190 200
YDSAYLVSKC GRRANVEDLK RQWFYRFLQK TVLFHILGLG FFLFYLGGMS
210 220 230 240 250
FVTWGMGVGA ALEVHVTCLI NSLCHIWGTR TWKTNDTSRN VWWLSVFSFG
260 270 280 290 300
ESWHNNHHAF ESSARQGLEW WQIDISWYIV RFFEIIGLAT DVKVPTEAQR

RRMAIVR
Length:307
Mass (Da):36,376
Last modified:June 1, 2002 - v2
Checksum:i8E26FA0F2E9EEAEB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23E → EE in AAM63359 (Ref. 5) Curated1
Sequence conflicti214V → L in AAM63359 (Ref. 5) Curated1
Sequence conflicti261E → K in AAM63359 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88537 mRNA Translation: BAA25181.1
AC007169 Genomic DNA Translation: AAD26482.2
CP002685 Genomic DNA Translation: AEC08533.1
CP002685 Genomic DNA Translation: ANM61591.1
AY045918 mRNA Translation: AAK76592.1
AY079388 mRNA Translation: AAL85119.1
AY086154 mRNA Translation: AAM63359.1
PIRiG84719
T52109
RefSeqiNP_001323798.1, NM_001336328.1
NP_565721.1, NM_128693.5
UniGeneiAt.14455

Genome annotation databases

EnsemblPlantsiAT2G31360.1; AT2G31360.1; AT2G31360
AT2G31360.2; AT2G31360.2; AT2G31360
GeneIDi817694
GrameneiAT2G31360.1; AT2G31360.1; AT2G31360
AT2G31360.2; AT2G31360.2; AT2G31360
KEGGiath:AT2G31360

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88537 mRNA Translation: BAA25181.1
AC007169 Genomic DNA Translation: AAD26482.2
CP002685 Genomic DNA Translation: AEC08533.1
CP002685 Genomic DNA Translation: ANM61591.1
AY045918 mRNA Translation: AAK76592.1
AY079388 mRNA Translation: AAL85119.1
AY086154 mRNA Translation: AAM63359.1
PIRiG84719
T52109
RefSeqiNP_001323798.1, NM_001336328.1
NP_565721.1, NM_128693.5
UniGeneiAt.14455

3D structure databases

ProteinModelPortaliQ9SID2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi3041, 35 interactors
IntActiQ9SID2, 34 interactors
STRINGi3702.AT2G31360.1

PTM databases

iPTMnetiQ9SID2

Proteomic databases

PaxDbiQ9SID2
PRIDEiQ9SID2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G31360.1; AT2G31360.1; AT2G31360
AT2G31360.2; AT2G31360.2; AT2G31360
GeneIDi817694
GrameneiAT2G31360.1; AT2G31360.1; AT2G31360
AT2G31360.2; AT2G31360.2; AT2G31360
KEGGiath:AT2G31360

Organism-specific databases

AraportiAT2G31360
TAIRilocus:2061260 AT2G31360

Phylogenomic databases

eggNOGiKOG1600 Eukaryota
COG1398 LUCA
HOGENOMiHOG000270353
InParanoidiQ9SID2
OMAiHATWGWG
OrthoDBiEOG093614S9
PhylomeDBiQ9SID2

Enzyme and pathway databases

UniPathwayi
UPA00658

BioCyciARA:AT2G31360-MONOMER
MetaCyc:AT2G31360-MONOMER
ReactomeiR-ATH-75105 Fatty acyl-CoA biosynthesis

Miscellaneous databases

PROiPR:Q9SID2

Gene expression databases

ExpressionAtlasiQ9SID2 baseline and differential
GenevisibleiQ9SID2 AT

Family and domain databases

CDDicd03505 Delta9-FADS-like, 1 hit
InterProiView protein in InterPro
IPR015876 Acyl-CoA_DS
IPR005804 FA_desaturase_dom
PANTHERiPTHR11351 PTHR11351, 1 hit
PfamiView protein in Pfam
PF00487 FA_desaturase, 1 hit
PRINTSiPR00075 FACDDSATRASE
ProtoNetiSearch...

Entry informationi

Entry nameiADS2_ARATH
AccessioniPrimary (citable) accession number: Q9SID2
Secondary accession number(s): O65798, Q8LD80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2002
Last modified: October 10, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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